• and Michigan State University, East Lansing, Michi- induces cell death through cleavage of the endoplasmic gan, USA (T.S. Whittam) reticulum chaperone, BiP/GRP78 ( 14 ). (cdc.gov)
  • Most of these enzymes belong to the cytochrome P450 class and are heme protein monooxygenases. (pharmacology2000.com)
  • This gene is located in the class III region of the human major histocompatibility complex. (wikipedia.org)
  • The CYP2C19 gene provides instructions for making an enzyme that is found primarily in liver cells. (medlineplus.gov)
  • This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). (nih.gov)
  • Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). (nih.gov)
  • I am a plant cell biologist and protein biochemist at Oxford Brookes University with expertise in the structure and function of the plant endoplasmic reticulum (ER), membrane proteins and auxin biosynthesis using biochemical techniques as well as high-resolution live cell imaging. (brookes.ac.uk)
  • Nucleus and Endoplasmic Reticulum - Cell Biology - Class 9 - Science for Class 9 2023 is part of CBSE Class 9 Biology(CELLS)-Videos & Documents by Let's tute preparation. (edurev.in)
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  • A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins. (ox.ac.uk)
  • Buxton ILO Chapter 2: Pharmcokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimiation in Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14e, (Brunton LL H Knollmann BC, eds) McGraw-Hill Education, 2023. (pharmacology2000.com)
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  • Research involves a particular focus on angiogenesis, endoplasmic reticulum stress, multi-potent progenitor cells and osteogenesis. (otago.ac.nz)
  • Soengas, who is an assistant professor of dermatology in the U-M Medical School said, "Our results support the direct role of the endoplasmic reticulum as an important gatekeeper of tumor control," "Until now, no one knew there was a connection between ER stress and the very early stages of tumor initiation," he added. (healthjockey.com)
  • Endoplasmic reticulum stress (ERS) is a self-protective mechanism resulting from an imbalance in quality control of unfolded proteins when cells are stressed, which plays an active role in lung cancer development, but the relationship between ERS and the pathological characteristics and clinical prognosis of LUAD patients remains unclear. (biomedcentral.com)
  • 5. Can the endoplasmic reticulum be found in all types of cells? (edurev.in)
  • Maria S. Soengas, Ph.D., and other U-M scientists have found the answer to this important question in an unexpected place -- a structure inside cells called the endoplasmic reticulum. (sciencedaily.com)
  • Maria S. Soengas, Ph.D., and other scientists in the Multidisciplinary Melanoma Clinic at the University of Michigan Comprehensive Cancer Center, have found the answer to this important question in an unexpected place -- a structure inside cells called the endoplasmic reticulum, or ER. (sciencedaily.com)
  • But now they have found the answer to this important question in an unexpected place - a structure inside cells called the endoplasmic reticulum, or ER. (healthjockey.com)
  • Major histocompatibility complex class I (MHC I) molecules present antigenic peptides to cytotoxic T cells to eliminate infected or cancerous cells. (researchgate.net)
  • The endoplasmic reticulum is present as a rough endoplasmic and smooth endoplasmic reticulum in animal cells. (myguitarsolo.com)
  • In addition, cowpox virus has been shown to inhibit intracellular transport of major histocompatibility class I molecules, allowing it to evade cytotoxic T cells. (medscape.com)
  • Major histocompatibility complex class I-restricted T-cell epitopes can be generated from these proteins by the proteasome after retrotranslocation into the cytosol. (ox.ac.uk)
  • Our results support the direct role of the endoplasmic reticulum as an important gatekeeper of tumor control," says Soengas, who is an assistant professor of dermatology in the U-M Medical School. (sciencedaily.com)
  • Perhaps the clearest analogy that can be made to describe the role of the rough endoplasmic reticulum is that of a factory assembly line. (vidque.com)
  • Obligatory mediator for the interaction between newly assembled MHC class I molecules, clareticulin, erp57 and TAP. (lu.se)
  • Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). (lu.se)
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  • Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. (sigmaaldrich.com)
  • The process begins when chains of amino acids are deposited in the ER membrane in response to coded instructions from genes. (sciencedaily.com)
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