• Prevention of heterotopic ossification after spinal cord injury with indomethacin. (scireproject.com)
  • Banovac K, Williams JM, Patrick LD, Levi A. Prevention of heterotopic ossification after spinal cord injury with COX-2 selective inhibitor (rofecoxib). (scireproject.com)
  • We could not prove the efficacy of oral Pex administration in the prevention of heterotopic ossifications in FOP. (biomedcentral.com)
  • Diphosphonate treatment for heterotopic ossification in spinal cord injury patients. (scireproject.com)
  • Neurogenic heterotopic ossification - This condition is the one that comes to mind when the generic phrase heterotopic ossification is used. (medscape.com)
  • Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal-dominant genetic disorder of aberrant joint formation and heterotopic bone formation, and is the result of a mutation in an as-yet-unidentified gene. (researchwithnj.com)
  • A global, patient-reported registry has been established to characterize the course of disease and track clinical outcomes in patients with fibrodysplasia ossificans progressiva (FOP), an ultra-rare genetic condition of progressive heterotopic ossification (HO) that results in ankylosis of joints and renders most affected individuals immobile by the second decade of life. (amsterdamumc.org)
  • Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder characterized by progressive heterotopic ossification (HO), often heralded by flare-ups, leading to reduced movement and life expectancy. (elsevierpure.com)
  • Currently, there are no effective medical treatment options to prevent the formation of heterotopic bones in fibrodysplasia ossificans progressiva (FOP). (biomedcentral.com)
  • Fibrodysplasia ossificans progressiva (FOP) (OMIM: 135100) is a severely disabling heritable disorder of connective tissue characterized by congenital malformations of the great toes and progressive heterotopic ossification in various extraskeletal sites. (biomedcentral.com)
  • Neurological heterotopic ossification (NHO) involves the formation of bone in soft tissue following a neurological condition, of which the most common are brain and spinal cord injuries. (monash.edu)
  • A comparison of heterotopic ossification treatment within the traumatic brain and spinal cord injured population: An evidence based systematic review. (scireproject.com)
  • Intravenous disodium etidronate therapy in spinal cord injury patients with heterotopic ossification. (scireproject.com)
  • Banovac K, Gonzalez F, Evaluation and management of heterotopic ossification in patients with spinal cord injury. (scireproject.com)
  • Treatment of heterotopic ossification after spinal cord injury. (scireproject.com)
  • Banovac K, The effect of etidronate on late development of heterotopic ossification after spinal cord injury. (scireproject.com)
  • Risk factors for heterotopic ossification in patients with spinal cord injury: A case-control study of 264 patients. (scireproject.com)
  • Durovic A, Miljkovic D, Brdareski Z, Plavsic A, Jevtic M. Pulse low intensity electromagnetic field as prophylaxis of heterotopic ossification in patients with traumatic spinal cord injury. (scireproject.com)
  • Emami Razavi S, Aryan A, Kazemi S, Rostamian A, Jahangiri A, Ghajarzadeh M. Prevalence of hip ossification and related clinical factors in cases with spinal cord injury. (scireproject.com)
  • Heterotopic ossification following hip replacement or spinal cord injury. (scireproject.com)
  • Resection of heterotopic ossification in patients with spinal cord injuries. (scireproject.com)
  • Genet F, Jourdan C, Lautridou C, Chehensse C, Minooee K, Denormandie P, Schnitzler A. The Impact of Preoperative Hip Heterotopic Ossification Extent on Recurrence in Patients with Head and Spinal Cord Injury: A Case Control Study. (scireproject.com)
  • Also, the higher osteoinductivity of whitlockite raised concern of ectopic ossification, which was a complication of spinal fusion surgery that should be avoided. (biomedcentral.com)
  • Whitlockite had a potential of being a better bone substrate hydroxyapatite and tricalcium phosphate in spinal fusion with low risk of inducing ectopic ossification. (biomedcentral.com)
  • Several terms have been used to describe the condition, including heterotopic ossification, ectopic ossification, and myositis ossificans. (medscape.com)
  • In this study, we compared the osteoinductivity of whitlockite, hydroxyapatite, and tricalcium phosphate porous particles with SD rat spine posterolateral fusion model and investigated whether whitlockite could induce ectopic ossification with SD rat abdominal pouch model. (biomedcentral.com)
  • Nonunion occurs in approximately 0-7% of cases [ 11 - 13 ] and heterotopic ossification has a varying prevalence in the literature. (sicot-j.org)
  • Heterotopic ossification (HO) is the abnormal growth of bone in soft connective tissues that occurs as a frequent complication in individuals with traumatic brain injury (TBI) and in rare genetic disorders. (mdpi.com)
  • The term heterotopic ossification (HO) describes bone formation at an abnormal anatomical site, usually in soft tissue. (medscape.com)
  • Heterotopic ossification (HO) is the abnormal bone formation within skeletal soft tissues. (ruralneuropractice.com)
  • Additionally, many pathological ailments, such as cancer and heterotopic ossification, are believed to be the consequence of abnormal progenitor cell behavior. (uconn.edu)
  • The specific cause and pathophysiology of heterotopic ossification (HO) remain uncertain, but the condition appears to involve the inappropriate differentiation of mesenchymal cells into osteoblastic stem cells in response to still-unidentified inducing agents. (medscape.com)
  • X-ray films of multiple joints revealed heterotopic ossification over left shoulder, hip and knee joint with bony ankylosis of left hip and soft tissue contractures. (ruralneuropractice.com)
  • Apart from neurological deficits, musculoskeletal involvement is also seen in very few cases in the form of heterotopic ossification around immobile joints. (ruralneuropractice.com)
  • Affecting roughly 400 people in the United States and 900 worldwide, FOP is an autosomal dominant condition in which bone develops in soft connective tissue areas of the body where it isn't normally present (heterotopic ossification), such as the ligaments, tendons, and skeletal muscles. (medscape.com)
  • Arduini M, Mancini F, Farsetti P, Piperno A, Ippolito E. A new classification of peri-articular heterotopic ossification of the hip associated with neurological injury: 3D CT scan assessment and intra-operative findings. (scireproject.com)
  • Brady D, Shultz S, McDonald S, O'Brien T. Neurological heterotopic ossification: Current understanding and future directions. (scireproject.com)
  • Skeletal muscle, a known and plentiful source of progenitor cells is commonly associated with extraskeletal pathologies such as muscular dystrophy and heterotopic ossification. (uconn.edu)
  • Cite this: Therapy Insight: Bladder Dysfunction Associated With Multiple Sclerosis - Medscape - Oct 01, 2005. (medscape.com)
  • The efficacy of Pex for preventing heterotopic ossifications was evaluated by the presence of flare-ups, measurements of serum bone markers, and changes in the total bone volume calculated by the three-dimensional computed tomography (3D-CT) images. (biomedcentral.com)
  • The risks of infection and blood clots are always present, and Ganz and his colleagues cite complications such as heterotopic ossification (new bone formation around the hip), nerve injuries, failure of the greater trochanter to heal back properly, persistent pain following the formation of scar tissue (adhesions) in the hip joint, and a small risk of damage of the blood supply to the femoral head. (wikipedia.org)
  • In 1918, Dejerine and Ceillier first described heterotopic ossification (HO) in paraplegic patients injured in World War I, referring to the process as paraosteoarthropathy. (medscape.com)
  • As a clinician caring for patients with FOP, I personally see the daily challenges and stresses that our patients and their families must contend with…since the accumulation of heterotopic ossification in FOP is progressive, irreversible, and life altering. (medscape.com)
  • According to Hsiao, who was a MOVE investigator, the study "showed that Sohonos can decrease new heterotopic ossification, and that palovarotene can be tolerated by many patients with FOP. (medscape.com)
  • Heterotopic ossification occurred in 8 patients, all being asymptomatic. (biomedcentral.com)
  • This study was to identify the risk factors of heterotopic ossification (HO) after total hip arthroplasty (THA) in ankylosing spondylitis. (amrita.edu)
  • Background: Heterotopic ossification most commonly occurs after burn injury, joint arthroplasty, and trauma. (usuhs.edu)
  • Candidate signaling pathways for FOP are those whose dysregulation during embryonic development could account for the malformation of the great toes and whose postnatal dysregulation could explain the progressive, heterotopic endochondral ossification that is such a disabling feature of the disorder. (researchwithnj.com)
  • The term myositis ossificans is not used anymore because primary muscle inflammation is not a necessary precursor and ossification does not always occur in muscle tissue. (ruralneuropractice.com)
  • Egan K P, Duque G, Keenan MA, Pignolo R J. Circulating osteogentic precursor cells in non-hereditary heterotopic ossification. (scireproject.com)
  • Freed JH, Hahn H, Menter R, Dillon T. The use of the three-phase bone scan in the early diagnosis of heterotopic ossification (HO) and in the evaluation of didronel therapy. (scireproject.com)
  • Areas of focus include heterotopic ossification, an unintended consequence of CDA, and accelerated adjacent-segment degeneration, which may lead to additional surgeries. (mcw.edu)
  • This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (ruralneuropractice.com)
  • At present, there is no definitive pharmacotherapy to prevent progressive heterotopic ossifications in FOP. (biomedcentral.com)
  • For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. (mdpi.com)
  • In this article, we describe a rare case of Massive ossification of the right patella and surrounding soft tissues, mainly caused by open trauma, and describe its treatment. (aseanjournalofpsychiatry.org)
  • We present studies examining the parameters of the timing of bone healing, and remodeling when heterotopic ossification (HO) is used for bone fracture repair using an adenovirus gene therapy approach. (researchwithrutgers.com)
  • Serum levels of ALP and BAP appear to be promising biomarkers for monitoring the development of ectopic ossifications and efficacy of the therapy. (biomedcentral.com)
  • This bone formation correlated with increased pSmad and insulin-like growth factor 1 signaling at the heterotopic ossification site in male mice. (usuhs.edu)
  • Attempts to remove heterotopic bones usually lead to explosive new bone formation. (biomedcentral.com)
  • In this study, the authors use their validated tenotomy/burn model to explore differences in heterotopic ossification between male and female mice. (usuhs.edu)
  • By the drug repositioning strategy, we confirmed that perhexiline maleate (Pex) potentially ameliorates heterotopic ossification in model cells and mice. (biomedcentral.com)
  • Clinical outcomes including a range of motion, pain, revision surgery for stiffness and/or heterotopic ossification (HO), nonunion, and persistent ulnar nerve symptoms requiring revision neurolysis were recorded. (sicot-j.org)
  • Myositis ossificans circumscripta without trauma - Also referred to as neurogenic HO, this is a localized soft-tissue ossification occurring after neurologic injury or burns. (medscape.com)
  • They include nonunion, ulnar nerve injury, and stiffness secondary to heterotopic ossification, all of which may require revision surgery. (sicot-j.org)
  • If you are taking etidronate to treat Paget's disease of bone or to prevent or treat heterotopic ossification, it may take some time for your condition to improve. (medlineplus.gov)
  • Very few reports have been published in the literature for association of heterotopic ossification with tubercular meningitis with such extensive joint involvement which compels us to report this clinical association of tubercular meningitis. (ruralneuropractice.com)
  • In this regard, we have concentrated on the tissue resident adult progenitors in skeletal muscle and specifically, their role in soft tissue associated heterotopic ossification. (uconn.edu)
  • The hypothesis of the present study was, therefore, that the limited range of motion in arthrofibrosis is caused by BMP-2 induced heterotopic ossifications, the quantity of which is dependent on the BMP-2 concentration in the synovial fluid. (openorthopaedicsjournal.com)