Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
Finally, elevation of serum AMH above normal male prepubertal levels may be indicative of rare cases of sex-cord stromal tumors or Sertoli cell-limited disturbance in the McCune Albright syndrome. (biomedcentral.com)
Testicular cell2
Oxidative stress and reactive oxygen species (ROS), which are majorly sourced from macrophages [ 5 ], may be the major contributory factors leading to testicular cell apoptosis and acute inflammation of testes [ 6 ]. (hindawi.com)
Ex vivo exposure of first trimester testes to CBD, THC, or CBD/THC [ratio 1:1] at 10 −7 to 10 −5 M altered testosterone secretion by Leydig cells, AMH secretion by Sertoli cells, and impacted testicular cell proliferation and viability as early as 72 h post-exposure. (biomedcentral.com)
Testosterone2
During puberty, testosterone induces Sertoli cell maturation, and prevails over FSH on AMH regulation. (biomedcentral.com)
The expression of SRY induces the organization of indifferent gonads to Sertoli cell differentiation 2, Antimullerian hormone production AMH 3, and secondary to testosterone hvh from the Leydig cells 4. (pmwdo.org)
Wilms15
This GeneReview is intended to help clinicians determine if a genetic basis can be identified in an individual with Wilms tumor in order to provide families with natural history and recurrence risk information. (nih.gov)
Provide an evaluation strategy to determine if a proband with Wilms tumor has a predisposition to Wilms tumor, identify the genetic or epigenetic mechanism for Wilms tumor, and determine risks for additional medical complications. (nih.gov)
Review management (e.g., tumor screening) recommendations for individuals with a genetic predisposition to Wilms tumor. (nih.gov)
Wilms tumor (nephroblastoma), an embryonal malignancy of the kidney, is the most common renal tumor of childhood [ Fernandez et al 2021 ]. (nih.gov)
Approximately 5%-10% of individuals with Wilms tumor have bilateral or multicentric tumors. (nih.gov)
The prevalence of bilateral involvement is higher in individuals with a predisposition to Wilms tumor than in those without a genetic predisposition (see Mechanisms of Predisposition to Wilms Tumor ), but unilateral, unifocal Wilms tumor does not preclude an underlying germline or epigenetic cause. (nih.gov)
A definitive diagnosis of Wilms tumor can be made only on histologic assessment of the tumor. (nih.gov)
Nephrogenic rests, benign foci of embryonal kidney cells that persist abnormally into postnatal life, are considered to be Wilms tumor precursors. (nih.gov)
Additional pathogenic variants transform nephrogenic rests into a Wilms tumor [ Fernandez et al 2021 ]. (nih.gov)
In 10%-15% of individuals with Wilms tumor, the cause is considered to be a germline pathogenic variant or an epigenetic alteration occurring early during embryogenesis [ Mahamdallie et al 2019 ]. (nih.gov)
Clinical features of Wilms tumor predisposition syndromes (See Table 1 and Table 2 . (nih.gov)
Approximately 1%-2% of individuals with Wilms tumor have at least one relative also diagnosed with Wilms tumor. (nih.gov)
Wilms' tumor suppressor gene 1 (WT1) is the gene responsible for the developmental process of AGP. (biomedcentral.com)
Tissue5
This is produced in the trophoblast cells of the placental tissue. (wikipedia.org)
Depending on the molecules and testis age, highly deleterious effects of phytocannabinoid exposure were observed on testis tissue after 14 days, including Sertoli and germ cell death. (biomedcentral.com)
A teratoma is a tumor made up of several different types of tissue , such as hair , muscle , teeth , or bone . (mdwiki.org)
Mature teratoma of the mediastinum: A horizontal slice of the resected tumor reveals fibrofatty tissue, calcified areas, and a few cystic spaces lined with smooth membrane and containing a hair. (mdwiki.org)
Induces1
ATZ also induces morphological changes similar to apoptosis and initiates mitochondria-dependent cell death in several experimental models. (frontiersin.org)
Epithelial2
Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
Mixed mesenchymal and epithelial tumors are of Mullerian origin. (cytojournal.com)
Somatic3
While sperm production has classically been the focus of adult reproductive function, somatic cells are crucial for the maintenance of spermatogenesis and gamete production. (biomedcentral.com)
Tumors with anaplastic histology usually have somatic mutation of TP53 and inferior prognosis compared to tumors with favorable histology [ Ooms et al 2016 , Daw et al 2020 ]. (nih.gov)
Immature teratoma has one of the lowest rates of somatic mutation of any tumor type and results from one of five mechanisms of meiotic failure. (mdwiki.org)
Squamous1
The report shows squamous cell carcinoma on several biopsies. (pdfcoffee.com)
Adolescents1
Adolescents have unique nutritional needs when compared to young children and adults. (nshealth.ca)
Pediatric patients3
and (3) treatment of germ cell tumors in pediatric patients. (dana-farber.org)
In clinical care, Dr. Frazier is the national expert on germ cell tumors in pediatric patients and oversees the care of these patients referred to DFCI. (dana-farber.org)
Evaluation of prevalence and outcomes of serial tyrosine kinase inhibitor use in pediatric patients with advanced solid tumors. (dana-farber.org)
For example, hCG-treated endometrial cells induce an increase in T cell apoptosis (dissolution of T cells). (wikipedia.org)
citation needed] Human chorionic gonadotropin also plays a role in cellular differentiation/proliferation and may activate apoptosis. (wikipedia.org)
Testis2
Measurement of serum anti-Müllerian hormone (AMH) has become increasingly widespread since it provides information about the activity of the male gonad without the need for dynamic tests, and also reflects the action of FSH and androgens within the testis. (biomedcentral.com)
We determined the expression of components of the ECS in the human fetal testis from 6 to 17 developmental weeks and assessed the direct effects of phytocannabinoids Δ9-trans-tetrahydrocannabinol (THC) and cannabidiol (CBD) on the testis morphology and cell functions ex vivo. (biomedcentral.com)
This review focuses on the differential responses of cell types to ATZ toxicity, testicular effects of ATZ in both in vitro and in vivo models and chemopreventive strategies, so as to highlight the current state of the art on the toxicological outcomes of ATZ exposure in several experimental model systems. (frontiersin.org)
In clinical practice, she concentrates on germ cell tumors, while her epidemiologic research primarily focuses on colorectal cancer screening and prevention. (dana-farber.org)
Reproductive1
Atrazine (ATZ) is an environmental pollutant that interferes with several aspects of mammalian cellular processes including germ cell development, immunological, reproductive and neurological functions. (frontiersin.org)
Practice2
The Acceptability of Online Learning Action Cell Session Practice to Tagumpay National High School Teachers. (philarchive.org)
This quantitative study explores the acceptability of Online Learning Action Cell (LAC) practice as a school-based professional development strategy for Tagumpay National High School (TNHS) teachers. (philarchive.org)
Genetically2
citation needed] Like any other gonadotropins, it can be extracted from the urine of pregnant women or produced from cultures of genetically modified cells using recombinant DNA technology. (wikipedia.org)
Through genetic studies of exome sequence, it was found that gliomatosis is genetically identical to the parent ovarian tumor and developed from cells that disseminate from the ovarian teratoma. (mdwiki.org)
Membrane2
Upon performing GO analysis, we found that some DEGs correlated with an integral part of membrane, protein complex, cell surface, ATP binding, immune system process, signal transduction and metabolic process which are responsible for the epididymal injury. (biomedcentral.com)
Know normal platelet count, increased bleeding time, increased PTT *Captopril is a teratogen *MOA of Amphotericin B Punches holes in ergosterol of the fungal cell membrane *Tons of biostats. (pdfcoffee.com)
Histological2
It was found that methane significantly prolonged rat survival, decreased the W/D ratio, alleviated LPS-induced histological changes, and reduced apoptotic cells in the testes. (hindawi.com)
Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the majority of definitions are written with sufficient generality to hold across multiple species. (philarchive.org)
Genes1
Hence, it is a valuable source to identify the expression of all genes with a specific time and space in the cell. (biomedcentral.com)
Sperm1
They are a type of germ cell tumor (a tumor that begins in the cells that give rise to sperm or eggs ). (mdwiki.org)
Types6
When in vitro experimental models are exposed to ATZ, they are faced with increased levels of reactive oxygen species (ROS), cytotoxicity and decreased growth rate at dosages that may vary with cell types. (frontiersin.org)
This results in differing cytotoxic responses that are influenced by the nature of target cells, assay types and concentrations of ATZ. (frontiersin.org)
Specific maturational changes take place both in these organs as a whole and in the different cell types that make them up. (biomedcentral.com)
Transcriptomic analysis is one of the most common high-throughput techniques, which identify the types and copy numbers of mRNAs, while the cells are living in a functional state [ 11 ]. (biomedcentral.com)
An improved ontological representation of dendritic cells as a paradigm for all cell types. (philarchive.org)
The Cell Ontology (CL) is designed to provide a standardized representation of cell types for data annotation. (philarchive.org)
Results1
If these needs go undetected and remain unaddressed, the results can derail physical and social maturation and include life-long effects on health. (nshealth.ca)
Treatment1
In addition, she is cochair of two national protocols that opened in 1999 for the treatment of low-risk and high-risk pediatric germ cell tumors and chair of the COG Germ Cell subcommittee in COG Rare Tumors. (dana-farber.org)
Common1
Teratomas occur in the coccyx in about one in 30,000 newborns, making them one of the most common tumors in this age group. (mdwiki.org)
Factor2
Inflammatory cytokines in the testes and serum, including interleukin-1 β (IL-1 β ), IL-6, IL-10, and tumor necrosis factor- α (TNF- α ), were measured using ELISA and RT-qPCR. (hindawi.com)
Increasing evidences indicate that the imbalance among these pro- and anti-inflammatory molecules, such as interleukin-1 β (IL-1 β ), IL-6, tumor necrosis factor- α (TNF- α ), and IL-10, in testicular cells can result in orchitis [ 3 , 4 ]. (hindawi.com)
Tests1
However, the use of non-classical biomarkers, like anti-Müllerian hormone (AMH), has become increasingly widespread since it not only informs about the activity of the male gonad without the need for dynamic tests but also reflects the action of FSH and androgens within the gonad [ 2 ]. (biomedcentral.com)
Development1
As youth go through physical, cognitive, and behavioral development, nutrition needs are dynamic and changing. (nshealth.ca)
Term1
You need to be able to know when they are talking about absolute risk reduction (they won't ever say this term) and be able to calculate it. (pdfcoffee.com)
Cases1
Gliomatosis peritoneii, which presents as a deposition of mature glial cells in the peritoneum, is almost exclusively seen in conjunction with cases of ovarian teratoma. (mdwiki.org)
Small2
Among sarcomas, Botryoid rhabdomyosarcoma needs to be looked for, as a small biopsy may miss it. (cytojournal.com)
[4] Symptoms may be minimal if the tumor is small. (mdwiki.org)
Review1
The citation of the peer review panel should not be understood to imply its approval of the profile's final content. (cdc.gov)
Human3
Human chorionic gonadotropin (hCG) is a hormone for the maternal recognition of pregnancy produced by trophoblast cells that are surrounding a growing embryo (syncytiotrophoblast initially), which eventually forms the placenta after implantation. (wikipedia.org)
citation needed] Human chorionic gonadotropin is a glycoprotein composed of 237 amino acids with a molecular mass of 36.7 kDa, approximately 14.5kDa αhCG and 22.2kDa βhCG. (wikipedia.org)
citation needed] Naturally, it is produced in the human placenta by the syncytiotrophoblast. (wikipedia.org)
Medical1
needs a note from the doctor saying he has medical condition to get his money back from the cruise ship company for missing his cruise. (pdfcoffee.com)