Potential for improving of citation metrics is among the important advantages for authors considering publishing their databases in dataset journals. (biomed-data.eu)
Skeletal muscle3
In skeletal muscle, dantrolene sodium dissociates the excitation-contraction coupling, probably by interfering with the release of Ca ++ from the sarcoplasmic reticulum. (nih.gov)
This heat is very noticeable during exercise, when sustained muscle movement causes body temperature to rise, and in cases of extreme cold, when shivering produces random skeletal muscle contractions to generate heat. (openstax.org)
Unlike cardiac and smooth muscle, the only way to functionally contract a skeletal muscle is through signaling from the nervous system. (openstax.org)
Cardiomyocytes1
Gene therapy displacement of endogenous MCUb with a dominant-negative MCUb transgene (MCUb W246R/V251E ) in vivo rescued T2D cardiomyocytes from metabolic inflexibility and stimulated cardiac contractile function and adrenergic responsiveness by enhancing phospholamban phosphorylation via protein kinase A. We conclude that MCUb represents one newly discovered molecular effector at the interface of metabolism and cardiac function, and its repression improves the outcome of the chronically stressed diabetic heart. (diabetesjournals.org)
Hypertrophy5
CRT effects are related to alterations in genes and microRNAs (miRs) expression, which regulate cardiac processes involved in cardiac apoptosis, cardiac fibrosis, cardiac hypertrophy and angiogenesis, and membrane channel ionic currents. (hindawi.com)
A pathological cardiac hypertrophy model, junctate-1 transgenic mice and control mice, were analyzed using label-free quantitative phosphoproteomics to identify differentially phosphorylated proteins and sites. (molcells.org)
Cardiac hypertrophy can be characterized as the response of the heart to various hemodynamic stresses. (molcells.org)
Although cardiac hypertrophy is initiated by various receptors at cell membranes sensing biomechanical signals and hormones, it is generally mediated by cellular signaling cascades. (molcells.org)
In cardiac hypertrophy, phosphorylation-dependent functional modulation of proteins, especially sarcoplasmic reticulum (SR) and sarcomere proteins, has been demonstrated. (molcells.org)
Dilated cardiomyopathy1
Here, we show that tamoxifen-inducible adult CM-specific Tead1 ablation led to lethal acute-onset dilated cardiomyopathy, associated with impairment in excitation-contraction coupling. (jci.org)
Inhibition5
As part of the "flight or fight" response, protein kinase A phosphorylates phospholamban (PLN), thereby relieving a tonic inhibition of the endo/sarco-plasmic reticulum calcium pump, which results in an increased force of cardiac contraction. (elifesciences.org)
Based on the fact that seizure activity is frequently associated with autism and that abnormal evoked potentials have been observed in autistic individuals in response to tasks that require attention, several investigators have recently proposed that autism might be caused by an imbalance between excitation and inhibition in key neural systems including the cortex. (neurotransmitter.net)
Among those, several candidate genes have been shown to control the early patterning and/or the late synaptic maturation of specific neuronal subpopulations controlling the balance between excitation and inhibition in the developing cortex and cerebellum. (neurotransmitter.net)
In the present article, we review our current understanding of the developmental mechanisms patterning the balance between excitation and inhibition in the context of the neurobiology of autism. (neurotransmitter.net)
Cell-based functional screening against 18 selected phosphorylation sites identified three phosphorylation sites (Ser-98, Ser-179 of Ldb3, and Ser-1146 of palladin) displaying near-complete inhibition of cardiac hypertrophic growth of NRVMs. (molcells.org)
Myocardial2
The CRT-induced "reverse molecular remodeling" in responders patients is related to an increase in the expression of genes involved in the regulation of excitation-contraction coupling and a reversal in the isoforms switching of the contractile genes [ 9 ] ultimately leading to remodeling effects and improving of myocardial performance. (hindawi.com)
Diabetes results in a cardiomyopathy characterized by decreased cardiomyocyte function, increased myocardial fatty acid utilization, decreased glucose utilization, increased myocardial oxygen consumption, and decreased cardiac efficiency ( 4 , 5 ), primarily as the result of changes in metabolism and Ca 2+ handling within the myocyte ( 3 , 6 , 7 ). (diabetesjournals.org)
Improves1
In patients under optimal medical therapy with moderate to severe HF and cardiac dyssynchrony, cardiac resynchronization therapy (CRT) with a defibrillator improves contractile function and reverse ventricular remodeling, ameliorating symptoms, quality of life (QoL), and clinical outcomes [ 7 , 8 ]. (hindawi.com)
Outcomes1
Previous hypothesis-driven experiments have highlighted the role of sex hormones on distinct inflammatory responses, mitochondrial proteins, extracellular remodeling and estrogen-mediated cardioprotective signaling pathways related to post-ischemic recovery, which were associated with better cardiac functional outcomes in females. (biomedcentral.com)
Vivo1
The major drawback of the former approach is that the excised heart might not accurately represent in vivo cardiac function, while the disadvantage of the latter method is that echocardiographic functional parameters are largely dependent on loading conditions (changes in preload or afterload). (biomedcentral.com)
Functionally1
For instance, despite the intuitive separation between systole and diastole as two consecutive phases of the cardiac cycle, it is impossible to separate them functionally. (biomedcentral.com)
Phosphorylation1
Cardiac hypertrophic signaling cascades resulting in heart failure diseases are mediated by protein phosphorylation. (molcells.org)
Generate1
They need filed to provide state by Painful products, develop period and volume, Determine or generate the pulmonary priority and supplies designed with patient coupling, restore a vexing formation of heart at ventricular-vascular vision, or provide a sexual or maximum management blood. (siriuspixels.com)
Https1
Aug 9, 2014 ยท - If you use this textbook as a bibliographic reference, please include https://openstax.org/details/books/american-government in your citation. (clickzengage.com)
Interactions1
In the last 40 years, over 20% of drugs discontinued at all phases of development, including discovery, preclinical and clinical evaluation, and post-market surveillance has been due to cardiac toxicity, where unintended interactions with cardiac ion channels result in pro-arrhythmic effects 4 . (nature.com)
Periods1
Surprisingly, large lack of understanding exists for the pre-ejection and post-ejection phases despite that these brief periods of the cardiac cycle are crucial for pressure buildup and loss that are essential for systolic ejection and diastolic filling, respectively. (biomedcentral.com)
Muscle5
Her research focuses on super resolution microscopy, biophysics, cardiac muscle and microscopy instrument development. (wikipedia.org)
To initiate cardiac muscle contraction, an action potential depolarizes the sarcolemma and activates the voltage-gated calcium channel, Ca V 1.2, which mediates Ca 2+ influx ( Bers, 2002 ). (elifesciences.org)
Muscle contraction requires energy, and when ATP is broken down, heat is produced. (openstax.org)
The tension created by contraction of the muscle fibers is then transferred though the mysia, to the tendon, and then to the periosteum to pull on the bone for movement of the skeleton. (openstax.org)
They indicate a close coupling between the spinal interneuronal systems used by the reticulospinal neurons to coordinate muscle contractions ipsilaterally and contralaterally. (jneurosci.org)
Genes1
Other TLR-related genes (TLR2, 3, and 9) were demonstrated to be involved in sepsis-induced cardiac dysfunction from recent studies. (frontiersin.org)
Function1
Heart disease remains the leading cause of death worldwide, highlighting a pressing need to identify novel regulators of cardiomyocyte (CM) function that could be therapeutically targeted. (jci.org)
Inhibitors1
Sirius Pixels UHDe HEVC Encoder book Investigators: paced junctions of the conceptual kidney in which gastroesophageal inhibitors of exercise need produced. (siriuspixels.com)
Result1
As a result, an integrative (both cell-level and multicellular) view is essential, and current regulations need to be revisited (see Supplementary Fig. 1 overviewing the Comprehensive in Vitro Pro-arrhythmia Assay 5 Concept). (nature.com)
Development2
The mammalian Hippo/Tead pathway is critical in embryonic cardiac development and perinatal CM proliferation. (jci.org)
In response, international regulatory agreements were developed that mandate testing of all new drugs, both cardiac and non-cardiac, for cardiac liability, including drug-induced long QT interval (LQT) and risk for development of life-threatening arrhythmias, such as Torsade de Pointes (TdP) 5 . (nature.com)
however, the septic shock in the early onset of sepsis, which induced by cytokine storm and cardiac dysfunction, is also an important cause of death for septic patients, especially for the young patients with toxic shock syndrome or meningococcemia ( 2 ). (frontiersin.org)
Specific1
It is encouraged that you do further research to find specific resources that fit the needs of your assignment. (msjc.edu)