• interstrand
  • The planar compound links to nucleobases through water displacement of one or both of its chloride groups, allowing cisplatin to form monoadducts to DNA or RNA, intrastrand DNA crosslinks, interstrand DNA crosslinks, and DNA-protein crosslinks. (wikipedia.org)
  • When cisplatin forms interstrand crosslinks (5'-GC), there is a severe distortion to the DNA helix due to a shortened distance between guanines on opposite strands and a cytosine that is flipped out of the helix as a consequence of the GG interaction. (wikipedia.org)
  • chemotherapy agents
  • cisplatin is one of the most emetogenic chemotherapy agents, but this symptom is managed with prophylactic antiemetics ( ondansetron , granisetron , etc.) in combination with corticosteroids . (wikipedia.org)
  • Nausea and vomiting: cisplatin is one of the most emetogenic chemotherapy agents, but this symptom is managed with prophylactic antiemetics (ondansetron, granisetron, etc.) in combination with corticosteroids. (wikipedia.org)
  • Ototoxic drugs include antibiotics such as gentamicin, loop diuretics such as furosemide and platinum-based chemotherapy agents such as cisplatin. (wikipedia.org)
  • ototoxicity
  • The ototoxicity of both the aminoglycosides and cisplatin may be related to their ability to bind to melanin in the stria vascularis of the inner ear or the generation of reactive oxygen species. (wikipedia.org)
  • kidneys
  • Extra intravenous fluid is given prior to and following administration of cisplatin to reduce side effects to the kidneys. (unm.edu)
  • intraperitoneally
  • When cisplatin was administered intraperitoneally, alternately with croton oil application to the skin, papillomas and carcinomas of the skin were produced, along with small numbers of internal neoplasms. (inchem.org)
  • resistance
  • Baicalein reversed the resistance of human A549 lung adenocarcinoma cells to cisplatin. (greenmedinfo.com)
  • TMEM205 has been shown to be involved in Cisplatin resistance. (wikipedia.org)
  • Cleft lip and palate transmembrane protein 1-like protein (CLPTM1-like protein), also known as cisplatin resistance-related protein 9 (CRR9p), is a protein that in humans is encoded by the CLPTM1L gene. (wikipedia.org)
  • LUC7 like 3 pre-mRNA splicing factor (LUC7L3), also known as Cisplatin resistance-associated overexpressed protein, or CROP, is a human gene. (wikipedia.org)
  • This gene encodes a cisplatin resistance-associated overexpressed protein (CROP). (wikipedia.org)
  • ovarian
  • Epidermal growth factor regulates the in vitro sensitivity of human ovarian carcinoma cells to cisplatin. (springer.com)
  • Modulation of cisplatin sensitivity and growth rate of an ovarian carcinoma cell line by bombesin and tumor necrosis factor alpha. (springer.com)
  • Bitter melon extract functions as a natural AMPK activator in the inhibition of ovarian cancer cell growth and might be useful as a supplement to improve the efficacy of cisplatin. (greenmedinfo.com)
  • mechanism
  • The former is more accepted owing to the similarity of the leaving groups with its predecessor cisplatin, while the latter hypothesis envisages a biological activation mechanism to release the active Pt2+ species. (wikipedia.org)
  • lung
  • Cisplatin was tested by intraperitoneal administration in mice, increasing the incidence of lung tumours. (inchem.org)
  • cancer
  • The amount of cisplatin that you receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer that you have. (chemocare.com)
  • Cisplatin produces its anti-cancer effects by causing a chemical reaction that damages the DNA in a cell. (unm.edu)
  • cells
  • Cisplatin is a mutagen in bacterial and cultured mammalian cells. (inchem.org)
  • It has been shown to be located at the plasma membrane in humans tissues and translocates to the nuclear envelope when cells become resistant to Cisplatin. (wikipedia.org)
  • known
  • Recent studies have shown that cisplatin noncompetitively inhibits an archetypal, membrane-bound mechanosensitive sodium-hydrogen ion transporter known as NHE-1 . (wikipedia.org)