• interstrand
  • The planar compound links to nucleobases through water displacement of one or both of its chloride groups, allowing cisplatin to form monoadducts to DNA or RNA, intrastrand DNA crosslinks, interstrand DNA crosslinks, and DNA-protein crosslinks. (wikipedia.org)
  • When cisplatin forms interstrand crosslinks (5'-GC), there is a severe distortion to the DNA helix due to a shortened distance between guanines on opposite strands and a cytosine that is flipped out of the helix as a consequence of the GG interaction. (wikipedia.org)
  • chemotherapy agents
  • cisplatin is one of the most emetogenic chemotherapy agents, but this symptom is managed with prophylactic antiemetics ( ondansetron , granisetron , etc.) in combination with corticosteroids . (wikipedia.org)
  • Nausea and vomiting: cisplatin is one of the most emetogenic chemotherapy agents, but this symptom is managed with prophylactic antiemetics (ondansetron, granisetron, etc.) in combination with corticosteroids. (wikipedia.org)
  • ototoxicity
  • The ototoxicity of both the aminoglycosides and cisplatin may be related to their ability to bind to melanin in the stria vascularis of the inner ear or the generation of reactive oxygen species. (wikipedia.org)
  • intrastrand
  • When cisplatin generates DNA crosslinks, it more frequenlty forms 1,2-intrastrand crosslinks (5'-GG), but also forms 1,3-intrastrand crosslinks (5-GNG) at lower percentages. (wikipedia.org)
  • treatment
  • Cisplatin is also being studied in the treatment of other types of cancer . (cancer.gov)
  • An ethanolic extract of T. camphoratus treatment further enhanced the tumor suppression efficiency of cisplatin and doxorubicin. (greenmedinfo.com)
  • The way in which cisplatin is administered, as well as dosing and schedules is dependent upon many factors, including the condition being treated, the overall medical condition of the patient, the patient's tolerance of treatment, the patient's height and weight, and the particular treatment regimen being utilized. (unm.edu)
  • Given the complex pathogenesis of kidney injury, which involves both local events in the kidney and interconnected and interdependent systemic effects in the body, cisplatin rodent model is indispensable in the investigation of underlying mechanisms and potential treatment strategies of both acute and chronic kidney injury. (hindawi.com)
  • Etoposide and cisplatin, known as EP (or sometimes PE), is a combination chemotherapy treatment used to treat different cancers. (macmillan.org.uk)
  • In mice the addition of 1 µL of fish oil to cisplatin was sufficient to induce chemoresistance, to the degree that treatment no longer inhibited tumor growth. (denvernaturopathic.com)
  • This research study is evaluating how well triple negative breast cancer responds to preoperative treatment with Cisplatin or Paclitaxel chemotherapy, and if use of a research test Homologous Recombination Deficiency (HRD) assay can predict response to preoperative treatment. (clinicaltrials.gov)
  • This is a phase I dose escalation study of cisplatin and radiation to determine the toxicity of this combined treatment and establish an MTD. (knowcancer.com)
  • Similar to nitrogen mustards, cisplatin is used frequently in chemotherapy treatment - especially for testicular and ovarian cancers. (wikipedia.org)
  • kidneys
  • Extra intravenous fluid is given prior to and following administration of cisplatin to reduce side effects to the kidneys. (unm.edu)
  • intraperitoneally
  • When cisplatin was administered intraperitoneally, alternately with croton oil application to the skin, papillomas and carcinomas of the skin were produced, along with small numbers of internal neoplasms. (inchem.org)
  • resistance
  • Baicalein reversed the resistance of human A549 lung adenocarcinoma cells to cisplatin. (greenmedinfo.com)
  • TMEM205 has been shown to be involved in Cisplatin resistance. (wikipedia.org)
  • Cleft lip and palate transmembrane protein 1-like protein (CLPTM1-like protein), also known as cisplatin resistance-related protein 9 (CRR9p), is a protein that in humans is encoded by the CLPTM1L gene. (wikipedia.org)
  • LUC7 like 3 pre-mRNA splicing factor (LUC7L3), also known as Cisplatin resistance-associated overexpressed protein, or CROP, is a human gene. (wikipedia.org)
  • This gene encodes a cisplatin resistance-associated overexpressed protein (CROP). (wikipedia.org)
  • ovarian
  • Epidermal growth factor regulates the in vitro sensitivity of human ovarian carcinoma cells to cisplatin. (springer.com)
  • Modulation of cisplatin sensitivity and growth rate of an ovarian carcinoma cell line by bombesin and tumor necrosis factor alpha. (springer.com)
  • Bitter melon extract functions as a natural AMPK activator in the inhibition of ovarian cancer cell growth and might be useful as a supplement to improve the efficacy of cisplatin. (greenmedinfo.com)
  • mechanism
  • The former is more accepted owing to the similarity of the leaving groups with its predecessor cisplatin, while the latter hypothesis envisages a biological activation mechanism to release the active Pt2+ species. (wikipedia.org)
  • regimen
  • The NET01 trial was designed to investigate whether capecitabine combined with streptozocin was an acceptable regimen with or without adding cisplatin. (nih.gov)
  • kidney
  • Kidney function tests and some electrolyte levels may be taken prior to each administration of cisplatin. (unm.edu)
  • The investigation of the development of CKI was not gaining any attention, although it was known that cisplatin can have long term effects on the structure and function of the rat kidney after single [ 10 - 12 ] or multiple [ 13 - 15 ] administration. (hindawi.com)
  • humans
  • The available data were insufficient for the Working Group to evaluate the carcinogenicity of cisplatin to humans. (inchem.org)
  • It has been shown to be located at the plasma membrane in humans tissues and translocates to the nuclear envelope when cells become resistant to Cisplatin. (wikipedia.org)
  • dosage
  • The present paper is aimed at giving a concise insight into the complex characteristics of cisplatin rodent model and heterogeneity of cisplatin dosage regimens as well as outlining factors that can severely influence the outcome of the model and the study. (hindawi.com)
  • lung
  • Cisplatin was tested by intraperitoneal administration in mice, increasing the incidence of lung tumours. (inchem.org)
  • cancer
  • The amount of cisplatin that you receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer that you have. (chemocare.com)
  • Cisplatin produces its anti-cancer effects by causing a chemical reaction that damages the DNA in a cell. (unm.edu)
  • known
  • Recent studies have shown that cisplatin noncompetitively inhibits an archetypal, membrane-bound mechanosensitive sodium-hydrogen ion transporter known as NHE-1 . (wikipedia.org)