• vein
  • In addition, cisplatin may cause damage to tissues it comes into contact with if it should leak out of the vein through which it is being administered. (unm.edu)
  • ototoxicity
  • The ototoxicity of both the aminoglycosides and cisplatin may be related to their ability to bind to melanin in the stria vascularis of the inner ear or the generation of reactive oxygen species. (wikipedia.org)
  • treatment
  • Cisplatin is also being studied in the treatment of other types of cancer . (cancer.gov)
  • Common neurological side effects of cisplatin include visual perception and hearing disorder, which can occur soon after treatment begins. (wikipedia.org)
  • The way in which cisplatin is administered, as well as dosing and schedules is dependent upon many factors, including the condition being treated, the overall medical condition of the patient, the patient's tolerance of treatment, the patient's height and weight, and the particular treatment regimen being utilized. (unm.edu)
  • This research study is evaluating how well triple negative breast cancer responds to preoperative treatment with Cisplatin or Paclitaxel chemotherapy, and if use of a research test Homologous Recombination Deficiency (HRD) assay can predict response to preoperative treatment. (clinicaltrials.gov)
  • This is a phase I dose escalation study of cisplatin and radiation to determine the toxicity of this combined treatment and establish an MTD. (knowcancer.com)
  • Diuresis employs intravenous fluids to perfuse the kidneys and assist them in their toxin filtration duties which means your pet will have to be hospitalized on the day of treatment and receive intravenous fluids for several hours along with the intravenous cisplatin. (marvistavet.com)
  • Cisplatin concentrates in the liver, intestines and kidneys and is still present in the body six months after treatment but 80% eliminated in urine after 48 hours. (marvistavet.com)
  • Cisplatin is excreted in body waste for two days following treatment. (marvistavet.com)
  • Similar to nitrogen mustards, cisplatin is used frequently in chemotherapy treatment - especially for testicular and ovarian cancers. (wikipedia.org)
  • resistance
  • Baicalein reversed the resistance of human A549 lung adenocarcinoma cells to cisplatin. (greenmedinfo.com)
  • TMEM205 has been shown to be involved in Cisplatin resistance. (wikipedia.org)
  • Cleft lip and palate transmembrane protein 1-like protein (CLPTM1-like protein), also known as cisplatin resistance-related protein 9 (CRR9p), is a protein that in humans is encoded by the CLPTM1L gene. (wikipedia.org)
  • LUC7 like 3 pre-mRNA splicing factor (LUC7L3), also known as Cisplatin resistance-associated overexpressed protein, or CROP, is a human gene. (wikipedia.org)
  • This gene encodes a cisplatin resistance-associated overexpressed protein (CROP). (wikipedia.org)
  • mechanism
  • While triggering apoptosis through interfering with DNA replication remains the primary mechanism of cisplatin, this has not been found to contribute to neurological side effects. (wikipedia.org)
  • The former is more accepted owing to the similarity of the leaving groups with its predecessor cisplatin, while the latter hypothesis envisages a biological activation mechanism to release the active Pt2+ species. (wikipedia.org)
  • lung
  • Cisplatin was tested by intraperitoneal administration in mice, increasing the incidence of lung tumours. (inchem.org)
  • kidney
  • Before and/or after the cisplatin infusion, extra IV fluids are given and care is taken to ensure adequate hydration before both during and after cisplatin, to protect your kidney function. (chemocare.com)
  • Kidney function tests and some electrolyte levels may be taken prior to each administration of cisplatin. (unm.edu)
  • Cisplatin can cause kidney damage. (marvistavet.com)
  • Cisplatin has a number of side effects that can limit its use: Nephrotoxicity (kidney damage) is a major concern. (wikipedia.org)
  • humans
  • No data were available to evaluate the teratogenic potential or the mutagenicity or chromosomal effects of cisplatin in humans. (inchem.org)
  • The available data were insufficient for the Working Group to evaluate the carcinogenicity of cisplatin to humans. (inchem.org)
  • In humans, a cisplatin-associated neuropathy has been described (involving a sensory nerve interference). (marvistavet.com)
  • It has been shown to be located at the plasma membrane in humans tissues and translocates to the nuclear envelope when cells become resistant to Cisplatin. (wikipedia.org)
  • cancer
  • The amount of cisplatin that you receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer that you have. (chemocare.com)
  • loss
  • A neurologic exam, including testing reflexes, will be performed as cisplatin may result in loss of sensation in hands, feet or extremities. (unm.edu)
  • studies
  • Recent studies have shown that cisplatin noncompetitively inhibits an archetypal, membrane-bound mechanosensitive sodium-hydrogen ion transporter known as NHE-1 . (wikipedia.org)