He is the principal investigator for a clinical trial of neoadjuvant gemcitabine and cisplatin followed by extrapleural pneumonectomy and high-dose radiation. (wikipedia.org)
This study analyses the outcome after trimodal therapy including extrapleural pneumonectomy. (smw.ch)
Sugarbaker DJ, Mentzer SJ, Strauss G. Extrapleural pneumonectomy in the treatment of malignant pleural mesothelioma. (smw.ch)
Extrapleural pneumonectomy for malignant pleural mesothelioma: outcomes of treatment and prognostic factors. (smw.ch)
If so, they underwent a surgery called extrapleural pneumonectomy (EPP), which is a huge surgery that removes an entire lung with the surrounding pleural cavity, pericardium, and hemidiaphragm as a single piece. (cancergrace.org)
Dr. Mason suggested the Extrapleural Pneumonectomy (EPP) immediately, as he felt that with my age at the time (38) and my good health I could not only handle the procedure but be able to bounce back from it better than most patients who are older and less healthy. (survivingmesothelioma.com)
He has also led the investigation for trials of neoadjuvant Alimta/cisplatin, extrapleural pneumonectomy, and high-dose radiation. (mesotheliomahub.com)
METHODS: Tumor specimens and clinical data were collected prospectively from patients who underwent extrapleural pneumonectomy (EPP) or pleurectomy and decortication (PD) during 2007 to 2014. (bvsalud.org)
This procedure is less invasive than an extrapleural pneumonectomy (EPP) and may be recommended for patients with early-stage cancer. (antarnews.com)
1 To date, the best survival has been observed in patients undergoing multimodality therapy with surgery, either extrapleural pneumonectomy (EPP) or pleurectomy/decortication (P/D), plus chemotherapy and/or radiation therapy. (mhmedical.com)
The overall treatment regimen consisted of three rounds of Cisplatin and Alimta, then the EPP surgery (including removal of the right lung, right pleura, right half of my diaphragm, and pericardium), and then 27 radiation sessions. (survivingmesothelioma.com)
In 2017, the Seattle Cancer Care Alliance opened a phase II clinical trial combining Imfinzi with cisplatin and pemetrexed chemotherapy drugs (Alitma). (asbestos.com)
The most common chemotherapy drugs for mesothelioma are cisplatin and pemetrexed, which have been shown to improve survival rates and quality of life for some patients. (mesothelioma.id)
Gemcitabine1
REGIMEN 3: Patients receive gemcitabine hydrochloride IV over 30 minutes on days 1 and 8 and cisplatin IV over 60 minutes on day 1 immediately following gemcitabine administration. (ucsf.edu)
Carboplatin1
Related drugs include carboplatin and oxaloplatin, which still have some renal toxicity but substantially less than cisplatin. (renalfellow.org)
Neoadjuvant1
The patient underwent two courses of neoadjuvant chemotherapy (NAC) with docetaxel, cisplatin, and 5-fluorouracil (DCF). (springeropen.com)
Extra-pleural4
A review of 83 consecutive extra-pleural pneumonectomies. (smw.ch)
Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study. (smw.ch)
Debulk the tumor removing as much of the cancer as possible that has invaded the lung and surrounding tissues- extra pleural pneumonectomy. (mesolawyerscare.org)
Twenty animals underwent local application of cisplatin solution (100 mg/m 2 ), whereas the same quantity of cisplatin was topically applied as a gel with the Vivostat (Vivolution) system in 20 other animals. (mesothelioma-line.com)
Of these patients, 21/194 (11%) underwent a resection of less than a lobe, 154/194 (79%) a lobectomy, 9/l 94 (5%) a bilobectomy, and IO/194 (5%) a pneumonectomy. (coek.info)
He underwent an en bloc resection, and pathological findings concluded to a metastasis of a pulmonary combined small cell carcinoma and adenocarcinoma. (hindawi.com)
The patient underwent a pneumonectomy with lymph node dissection confirming the same diagnosis. (hindawi.com)
Docetaxel1
REGIMEN 2: Patients receive docetaxel IV over 1 hour on day 1 and cisplatin over 1 hour on day 1 immediately following docetaxel administration. (ucsf.edu)
Patients6
Since 2001, select patients with mesothelioma at Prince Margaret Hospital and Toronto General Hospital in Toronto, Canada, have been treated with an aggressive regimen that begins with 3 cycles of cisplatin-based chemotherapy followed by staging to see if they were still possibly resectable. (cancergrace.org)
5751. All patients were treated with cisplatin-containing combination chemotherapy. (coek.info)
At the Brigham and Women's Hospital & the Dana Farber Cancer Institute, there is an ongoing trial of using pneumonectomy and injected, heated cisplatin into the pleural space for patients with malignant mesothelioma , a condition with an overall poor oncologic prognosis and limited treatment options. (renalfellow.org)
REGIMEN 1: Patients receive vinorelbine ditartrate intravenously (IV) over 10 minutes on days 1 and 8 and cisplatin IV over 60 minutes on day 1 immediately following vinorelbine ditartrate administration. (ucsf.edu)
REGIMEN 4 (non-squamous histology only): Patients receive pemetrexed disodium IV over 10 minutes and cisplatin IV over 1 hour on day 1 immediately following pemetrexed disodium administration. (ucsf.edu)
Is combined chemotherapy with cisplatin, etoposide and irinotecan the new standard treatment for patients with sensitive relapsed small cell lung cancer? (amegroups.org)
Surgical1
We sought to investigate whether intrapleural topical application of cisplatin with a surgical carrier has a prolonged local tissue level in comparison with cisplatin solution while reducing systemic toxicity. (mesothelioma-line.com)
Toxicity3
Intrapleural administration of cisplatin with the carrier Vivostat significantly provides sustained higher platinum concentrations up to 1 week in tissue in comparison with application of cisplatin solution without conferring systemic toxicity in this model. (mesothelioma-line.com)
Unlike standard chemotherapy where cisplatin may be held once renal toxicity has occurred, the injected cisplatin has a very slow, continuous absorption and therefore there is no opportunity for reversal once this sets in. (renalfellow.org)
The mechanisms of cisplatin-induced acute kidney injury are still being worked out but generally result in tubular toxicity (ATN). (renalfellow.org)
Involves1
it involves dissection of the parietal pleura and division of the pulmonary vessels, as well as en bloc resection of the lung, pleura, pericardium, and diaphragm, followed by reconstruction. (medscape.com)
Rounds1
Cisplatin/taxotere 4 rounds 3 weeks apart) after the 2nd cycle, Cisplatin discontinued due to tinnitus (should have lowered dose but not touching That) and the last two cycles had taxotere alone. (lungevity.org)
Treatments1
Chemotherapy using cisplatin in combination with a variety of other agents and immunotherapy treatments may be indicated. (rnpedia.com)
Alkylating agents1
Cisplatin falls under the category of platinum-containing alkylating agents. (renalfellow.org)
Extrapleural20
He is the principal investigator for a clinical trial of neoadjuvant gemcitabine and cisplatin followed by extrapleural pneumonectomy and high-dose radiation. (wikipedia.org)
1. Combined modality treatment for malignant pleural mesothelioma: a single-centre long-term survival analysis using extrapleural pneumonectomy. (nih.gov)
2. Neoadjuvant chemotherapy and extrapleural pneumonectomy of malignant pleural mesothelioma with or without hemithoracic radiotherapy (SAKK 17/04): a randomised, international, multicentre phase 2 trial. (nih.gov)
3. Long-term results in malignant pleural mesothelioma treated with neoadjuvant chemotherapy, extrapleural pneumonectomy and intensity-modulated radiotherapy. (nih.gov)
4. Trimodality strategy for treating malignant pleural mesothelioma: results of a feasibility study of induction pemetrexed plus cisplatin followed by extrapleural pneumonectomy and postoperative hemithoracic radiation (Japan Mesothelioma Interest Group 0601 Trial). (nih.gov)
6. Induction chemotherapy, extrapleural pneumonectomy, and postoperative high-dose radiotherapy for locally advanced malignant pleural mesothelioma: a phase II trial. (nih.gov)
7. Clinical experience of volumetric modulated arc therapy for malignant pleural mesothelioma after extrapleural pneumonectomy. (nih.gov)
12. Interim results of pleurectomy/decortication and intraoperative intrapleural hyperthermic cisplatin perfusion for patients with malignant pleural mesothelioma intolerable to extrapleural pneumonectomy. (nih.gov)
13. Impact of induction therapy on postoperative outcome after extrapleural pneumonectomy for malignant pleural mesothelioma: does induction-accelerated hemithoracic radiation increase the surgical risk? (nih.gov)
14. Is Pleurectomy/Decortication Superior to Extrapleural Pneumonectomy for Patients with Malignant Pleural Mesothelioma? (nih.gov)
15. Induction chemotherapy, extrapleural pneumonectomy, and adjuvant radiotherapy for malignant pleural mesothelioma: experience of Guy's and St Thomas' hospitals. (nih.gov)
Annals of Thoracic and Cardiovascular Surgery 2018 January [Epub ahead of print] [Link] Miyazaki T, Yamasaki N, Tsuchiya T, Matsumoto K, Kamohara R, Hatachi G, Nagayasu T Abstract PURPOSE: This study was performed to compare the outcome of pleurectomy/decortication (P/D) with that of extrapleural pneumonectomy (EPP) for patients with malignant pleural mesothelioma (MPM). (mesothelioma-line.com)
To describe the initial experience at Dana-Farber Cancer Institute/Brigham and Women's Hospital with intensity-modulated radiation therapy (IMRT) as adjuvant therapy after extrapleural pneumonectomy (EPP) and adjuvant chemotherapy. (nih.gov)
Treatment, however, tends to be different for a mesothelioma recurrence - especially if a patient already had a more extensive surgery, such as an extrapleural pneumonectomy, during their first round of treatment. (moffitt.org)
Another option is extrapleural pneumonectomy (EPP), which involves removing the affected lung, the pleural lining, and other nearby tissues. (mesotheliomausa.net)
This study aimed at analyzing a 20-year single center perioperative experience in MPM surgery at our high-volume thoracic surgery center and comparing the overall survival after trimodal extrapleural pneumonectomy (EPP) and extended pleurectomy and decortication combined with hyperthermic intrathoracic chemoperfusion (EPD/HITOC) and adjuvant chemotherapy with that after chemotherapy (CTx) alone. (medscape.com)
Since Sugarbaker and his team reported good outcomes after extrapleural pneumonectomy (EPP) in 1999, it has been performed in several high-volume thoracic surgery centers for early-stage MPM. (medscape.com)
In 1992, Dr. Sugarbaker improved the long-term survival and life expectancy for mesothelioma patients with his redesign of the extrapleural pneumonectomy. (mesotheliomahub.com)
Chemotherapy14
[ 1 , 2 ] For early-stage NSCLC, surgical resection is the treatment of choice, and adjuvant cisplatin-based chemotherapy is recommended for routine use in patients with stages II-IIIA disease. (medscape.com)
[ 3 ] Three recent randomized studies have demonstrated a reduction of 14% to 30% in the risk of death with 4 planned cycles of cisplatin-based chemotherapy. (medscape.com)
Multimodality therapy incorporating radical surgery (extrapulmonary pneumonectomy or radical pleurectomy with decortication) with or without chemotherapy, administered with or without radiation, may be considered for patients with limited disease and has been associated with a relatively long survival in observational series. (cancer.gov)
Two patients received neoadjuvant intravenous cisplatin/pemetrexed, and 10 patients received adjuvant cisplatin/pemetrexed chemotherapy after EPP but before radiation therapy. (nih.gov)
Some common chemotherapy drugs used for sarcomatous mesothelioma include cisplatin, gemcitabine, and pemetrexed. (diet2x.com)
Dr. Vallieres suggested a multi-modality regimen which included induction chemotherapy, a right-sided extra-pleural pneumonectomy (EPP) and adjuvant radiation treatments. (worthingtoncaron.com)
He received induction Cisplatin and Pemetrexed (Alimta) chemotherapy and completed his four cycles on November 5, 2004. (worthingtoncaron.com)
Unlike the former trimodal concept with neoadjuvant chemotherapy followed by EPP and adjuvant radiotherapy, the new therapeutic concept is a combination of upfront cytoreductive surgery and HITOC, followed by four cycles of adjuvant cisplatin/pemetrexed chemotherapy. (medscape.com)
This pilot study will determine the highest dose of magnesium that can be given safely to mesothelioma patients receiving intraoperative chemotherapy with cisplatin and are at risk for acute kidney injury. (mesotheliomahub.com)
66-year-old female was diagnosed, following persistent cough, with non-operable tumor of her lung with satellite nodules, and chemotherapy was initiated (first Cisplatin and Gemcitabine, and then switched to Tarceva). (doctorsmedicalopinion.com)
Continuous fluorouracil plus mitomycin C versus mitomycin C plus Cisplatin as chemotherapy combination in combined radiochemotherapy for locally advanced anal cancer. (trialstracker.net)
Vinorelbine1
Future trials should better define the best strategy in terms of efficacy, toxicity, and quality of life between this combination and the standard regimen, cisplatin plus vinorelbine. (medscape.com)
it involves dissection of the parietal pleura and division of the pulmonary vessels, as well as en bloc resection of the lung, pleura, pericardium, and diaphragm, followed by reconstruction. (medscape.com)
A pneumonectomy removes an entire lung, which is sometimes necessary when the tumor is near the center of your chest. (popularhealth.net)
In extreme circumstances, a 'pneumonectomy' is implemented to take out an entire lung. (drpramojjindal.com)