• autonomic nervou
  • Based on multiple clinical studies in adults and our own work in fetal autonomic nervous system, we gauged the degree of CAP activity in vivo using heart rate variability measure RMSSD that reflects fluctuations in vagus nerve activity. (biomedcentral.com)
  • Nicotine alone has been shown to be a teratogen which affects the autonomic nervous system, leading to increased susceptibility to hypoxia-induced brain damage. (wikipedia.org)
  • metabolic
  • He termed this "fuel-mediated teratogenesis," defined as alterations occurring subsequent to organogenesis during the differentiation and proliferation of fetal cells, and wrote "such changes could cause long-range effects upon behavioral, anthropometric, and metabolic functions" ( 8 ). (diabetesjournals.org)
  • resultant
  • We determined if pneumoperitoneal pressure sustained to the hand during hand assisted laparoscopic nephrectomy poses an occupational risk, contributing to local hand hypoxia and resultant extremity pain. (biomedsearch.com)
  • hyperoxia
  • Seeking a better understanding of brain injury in premature infants caused by adverse perinatal environmental factors, such as inflammation, hypoxia-ischemia, corticosteroid exposure, hyperoxygenation (hyperoxia), among others. (umc.edu)
  • disturbances
  • Although teratogenic effects of cocaine on the human fetal brain, such as destructive lesions and disturbances of the neurodevelopmental program are well documented [ 3 , 6 ], the underlying mechanisms remain controversial. (medsci.org)
  • Play media Cerebral palsy is defined as "a group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain. (wikipedia.org)
  • mechanisms
  • To understand the possible mechanisms underlying cocaine-induced apoptosis in the developing brain, we measured the activities of caspase-3, caspase-8, and caspase-9 and examined the effects of cocaine on Bax and Bcl-2 protein expression in fetal rat brain. (medsci.org)
  • Central venous blood pressure (P(ven)) increases in response to hypoxia in rainbow trout (Oncorhynchus mykiss), but details on the control mechanisms of the venous vasculature during hypoxia have not been studied in fish. (biomedsearch.com)
  • prenatal exposure
  • We speculate that a prolonged myocyte repolarization induced by prenatal exposure to smoke may establish a period of vulnerability for life-threatening arrhythmias in infancy. (ahajournals.org)
  • 5 Little is known about the effects of prenatal exposure to smoke or to CO on the electrophysiological properties of the heart. (ahajournals.org)
  • Prenatal exposure to alcohol is associated with a variable spectrum of effects referred to as fetal alcohol spectrum disorders (FASD), with fetal alcohol syndrome at the most severe end of that spectrum. (medscape.com)
  • [ 3 ] In a Canadian study involving 26 children (aged 6-14 y) and 32 control children, Keiver et al found significantly elevated cortisol levels in the afternoon and at bedtime in those with known high prenatal exposure to alcohol (alcohol exposure rank 4) relative to those with low/unknown levels of prenatal alcohol exposure (alcohol exposure rank 3) and the control group. (medscape.com)
  • inflammation
  • Afferent fetal CAP may translate increased vagal cholinergic signaling into suppression of cerebral inflammation in response to near-term hypoxic acidemia as might occur during labor. (biomedcentral.com)
  • susceptible
  • This combination of studies will provide an understanding of how endotoxin interacts with other potentially toxic exposures in the susceptible host to cause persistent, problematic asthma. (epa.gov)
  • umbilical
  • We measured microglial activation in the ovine fetal brain near term 24 h after the umbilical cord occlusions mimicking human labor versus controls (no occlusions) by quantifying HMGB1 nucleus-to-cytosol translocation in the Iba1+ and α7nAChR+ microglia. (biomedcentral.com)
  • cortical
  • A previous study demonstrated that cocaine induced apoptosis in cultured cortical neuronal cells of fetal mice [ 22 ]. (medsci.org)
  • Current efforts are aimed at understanding whether both genetic (MAO or SERT gene) and/or environmental factors (prenatal stress and/or perinatal antidepressant exposure) play a critical role on cortical network mis-wiring and abnormal behaviors. (umc.edu)
  • oxygen
  • You can be exposed to these oxides by breathing polluted air, which is most commonly found in areas with heavy motor vehicle traffic Exposure to high levels of Nitrogen oxides damages tissues of the throat and upper respiratory tract and can interfere with the body's ability to carry oxygen. (wikipedia.org)
  • vivo
  • Following gas exposures, diaphragm muscle contractile, and endurance properties were examined ex vivo . (frontiersin.org)
  • Similarly, early life exposure to CIH did not affect muscle tolerance of severe hypoxic stress determined ex vivo . (frontiersin.org)
  • cerebral palsy
  • Long-term disabilities such as cerebral palsy, hearing loss, retinopathies, and chronic lung disease are associated with a substantial emotional burden for affected families and health care costs to the society [ 1 ]. (hindawi.com)
  • persistent
  • We hypothesize that higher levels of endotoxin exposure cause persistent, problematic asthma and that key environmental (ozone and allergens) and genetic modifiers (endotoxin receptor polymorphisms) contribute to endotoxin susceptibility and pathological asthmatic responses. (epa.gov)
  • development
  • Chronic intermittent hypoxia (CIH) is a central feature of disordered breathing and is increasingly recognized as a major driving force in the development of a wide range of morbidities, including maladaptive remodeling in cardiorespiratory control ( O'Halloran, 2016 ). (frontiersin.org)
  • The increased apoptosis of neuronal cells in the fetal brain is likely to play a key role in cocaine-induced neuronal defects during fetal development. (medsci.org)
  • effects
  • Neither gCIH nor pCIH exposure had effects on diaphragm muscle force-generating capacity or endurance in either sex. (frontiersin.org)
  • Effects of acetazolamide on ventilatory, cerebrovascular, and pulmonary vascular responses to hypoxia. (biomedsearch.com)
  • This pathway reflects the effects of hypernutrition during fetal life and sets the stage for further amplification of the pathophysiological effects of encountering an obesogenic environment postnatally. (diabetesjournals.org)
  • The purpose of this article is to outline how vehicular pollutants affect the health of expectant mothers and the adverse health effects these exposure have on the unborn babies. (wikipedia.org)
  • Vitamin B12, in the form of hydroxocobalamin (also spelled hydroxycobalamin), may reduce the negative effects of chronic exposure, and a deficiency can lead to negative health effects following exposure. (wikipedia.org)
  • studies
  • These studies will help us to determine the levels of endotoxin exposure that are likely to be problematic for children with asthma, and to develop environmental educational and intervention programs to improve outcomes. (epa.gov)
  • Although careful comprehensive studies have not been performed and though passive surveillance systems are inadequate to measure the incidence of fetal alcohol syndrome or fetal alcohol syndrome disorder, the incidence of fetal alcohol syndrome in the United States is estimated to be 1-2 cases per 1000 live births. (medscape.com)
  • Previous studies have found correlations between exposure to vehicle pollutants and certain diseases such as asthma, lung and heart disease, and cancer among others. (wikipedia.org)
  • In Los Angeles County, researchers found a higher risk in premature birth (10-20%) and low birth weight for infants whose mothers lived near high traffic areas Studies conducted on populations living near the 405 and 710 interstates in Southern California found their exposure to particulate vehicle emissions to be almost 25 times higher than for people living 1000 ft from the freeways. (wikipedia.org)
  • impact
  • Because of the cumulative impact of age and exposure to noise and other acoustic insults, 'typical' hearing may not be normative. (wikipedia.org)
  • risk
  • Genotype DD of the I/D polymorphism of the ACE gene is associated with the risk of lower birth weight percentile, but not with the increased risk of a fetal hypotrophy. (medcraveonline.com)
  • Obesity is an important risk factor for many chronic physical and mental illnesses that people suffer from. (wikipedia.org)
  • disorder
  • Children with fetal alcohol syndrome disorder may have clinically significant CNS involvement but few or no characteristic physical features. (medscape.com)
  • acute
  • The degree of pulmonary hypertension in healthy subjects exposed to acute hypobaric hypoxia at high altitude was found to be related to increased plasma endothelin (ET)-1. (biomedsearch.com)