• Surrogate Marker
  • Other biomarkers can be based on measures of the electrical activity of the brain (using Electroencephalography (so-called Quantitative electroencephalography (qEEG)) or Magnetoencephalography), or volumetric measures of certain brain regions (using Magnetic resonance imaging) or saliva testing of natural metabolites, such as saliva nitrite, a surrogate marker for nitric oxide. (wikipedia.org)
  • diseases
  • Managed care organizations have not focused on chronic pain, not the way they have on other high cost, easily identifiable chronic diseases," says Stephen Lande, PhD, former chairman of the managed care committee of the American Pain Society (APS). (managedcaremag.com)
  • Only a few serious nonalcohol-related liver diseases like primary biliary cirrhosis, chronic active hepatitis, severly decompensated liver cirrhosis and advanced cirrhosis with ascites may elevate CDT, as well as rare cases of atypical transferrin variants and an inherited disorder - carbohydrate deficient glycoprotein syndrome or CDG (Stiebler 1991, Heyne and Weidinger 1992, Allen et al 1994). (druglibrary.org)
  • The downside of explant culture is that it does not provide sufficient time to study chronic diseases. (wikipedia.org)
  • It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. (wikipedia.org)
  • oxidative
  • Lead exposure and a marker of oxidative stress (gamma-glutamyl transferase-GGT), and their effects on life course variables (age, country of birth, education levels, gender, ethnicity, income, and occupation) were explored in this cross-sectional study of United States (U.S.) adults' ≥ 20 years of age via the National Health and Nutrition Examination Survey (NHANES) 2007-2010 datasets. (mdpi.com)
  • digestion
  • A microwave-assisted wet acid digestion procedure was developed as a sample pretreatment, for the determination of Cd, Pb, and Ni in biological samples of night blindness children. (springer.com)
  • cardiac
  • His particular research interests include the pathophysiology and treatment of acute and chronic heart failure (CHF), cardiac device therapy, clinical evaluation of cardiovascular biomarkers, pathophysiology of muscle wasting, cachexia therapy in CHF, ageing, sarcopenia and cancer. (wikipedia.org)
  • Human MSCs increased the thickness of the infarcted ventricular wall without improving cardiac function in this chronic ischaemic heart failure model. (biomedsearch.com)
  • outcomes
  • In the model, there is a belief that many of the chronic and adverse health outcomes are created early in development in utero and then bring forth lasting damage to the adult later on. (mdpi.com)
  • researchers
  • Researchers at The University of Western Ontario have provided the first direct evidence using a biological marker, to show chronic stress plays an important role in heart attacks. (eurekalert.org)
  • A survey of 118 health plan medical directors was conducted recently by researchers associated with Thomas Jefferson University in Philadelphia to determine the extent to which managed care organizations are managing chronic pain. (managedcaremag.com)
  • Investigated the antecedents, correlates, and consequences of changes in biological measures and health among the elderly in Taiwan (collaboration with researchers at Princeton University and Georgetown University on an NIH-funded project ). (sonic.net)
  • research
  • The main focus of the Innovative Clinical Trials department was research in the field of chronic heart failure, including the development and clinical testing of new therapies. (wikipedia.org)
  • Historically, explant culture has been used in several areas of biological research. (wikipedia.org)
  • findings
  • Radiographic findings in individuals with chronic sinusitis may demonstrate osteoblastic response in the affected sinus walls, mucoperiosteal thickening, opacification of sinus cavity, and even reduction of cavity size. (medscape.com)
  • blood
  • The results indicated significantly higher levels of Cd, Pb, and Ni in the biological samples (blood, scalp hair, and urine) of male and female night blindness children, compared with control subjects of both genders. (springer.com)
  • Studies
  • Studies of chronic sinusitis have demonstrated no correlation between nasal flora and culture from the sinuses. (medscape.com)
  • Several studies point at CDT as the most specific marker of alcoholism or - reduced to the actual meaning - of an average daily consumption of at least 60g ethanol, with specifities up to 99% resp. (druglibrary.org)
  • known
  • false negatives) are limited in most known markers. (druglibrary.org)
  • We examined whether the induction of tenascin-C (TN-C), an extracellular matrix glycoprotein known to promote tissue fibrosis, was associated with chronic hydrocephalus after SAH. (biomedsearch.com)
  • During the third month of fetal development, a space forms between two septal laminae, known as the cave of septum pellucidum (CSP), which is a marker for fetal neural maldevelopment. (wikipedia.org)
  • specific
  • CDT has been described as a more sensitive and especially specific marker of recent heavy alcohol consumption than others like GGT. (druglibrary.org)
  • N-acetyl-neuraminic acid, resulting in tri-, di-, mono- or asialotransferrins - is a fairly sensitive, but outstandingly specific marker for excessive alcohol consumption. (druglibrary.org)
  • process
  • Downregulation of post-synaptic 5-HT2A receptor is an adaptive process provoked by chronic administration of selective serotonin reuptake inhibitors (SSRIs) and classical antipsychotics. (wikipedia.org)
  • members
  • They should make a commitment to understanding the medical and financial impact of chronic pain and its treatment on their members. (managedcaremag.com)
  • Not surprising, then, only a third of the surveyed MCOs had some kind of formalized mechanism for identifying members with chronic pain and only 18 percent systematically used clinical practice guidelines for pain management. (managedcaremag.com)
  • Children
  • These data present guidance to clinicians and other professional investigating toxicity of trace metals in biological samples of night blindness children. (springer.com)