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  • therapies
  • The study suggests that chlorambucil is superior to fludarabine in older patients, and that CD20 antibody therapies such as rituximab are beneficial as front-line therapy for all CLL patients, regardless of age," says Byrd, who is the D. Warren Brown Designated Chair in Leukemia Research. (bio-medicine.org)
  • treatment
  • While testing a new drug to treat chronic leukemia, Cleveland Clinic researchers discovered new markers that could identify which patients would receive maximum benefit from the treatment. (medindia.net)
  • In the same mouse model, treatment with ibrutinib significantly delayed leukemia onset compared with controls (10.7 versus 7.0 months) and extended overall survival (14.5 versus 12.3 months, respectively). (medindia.net)
  • Ibrutinib was superior to chlorambucil in CLL patients with no prior treatment, as measured by progression-free survival, overall survival, and response" said Burger, an associate professor in Leukemia. (eurekalert.org)
  • In addition, the team plans to use an antibody fragment to add a second target to the treatment--the receptor tyrosine kinase ROR1, which is expressed exclusively on leukemia cells. (eurekalert.org)
  • This dual-targeting strategy will lay the foundation for further preclinical and clinical investigations in the treatment of this form of leukemia," said Rader. (eurekalert.org)
  • There are different types of leukemia and they require different types of treatment. (healthtap.com)
  • First of all, the treatment for any type of leukemia should be coordinated by a hematologist/oncologist. (healthtap.com)
  • This is important because treatment varies among different types of leukemia. (kidshealth.org)
  • Treatment of CML takes into account things like the phase of the leukemia (whether it's in the early or later stages of the disease), the number of cancerous cells in the body, and how well the other organs of the body are working. (kidshealth.org)
  • chromosome
  • In the past, antimetabolites (e.g., cytarabine, hydroxyurea), alkylating agents, interferon alfa 2b, and steroids were used as treatments of CML in the chronic phase, but since the 2000s have been replaced by Bcr-Abl tyrosine-kinase inhibitors drugs that specifically target BCR-ABL, the constitutively activated tyrosine kinase fusion protein caused by the Philadelphia chromosome translocation. (wikipedia.org)
  • A minute Chromosome in Human Chronic Granulocytic Leukemia. (wikipedia.org)
  • chemotherapy
  • While chemotherapy and radiation are used to treat this slow-growing form of leukemia, currently there are no therapeutic options for the disease in which physicians can selectively target the malignant cells yet spare normal cells and tissues. (eurekalert.org)
  • malignant
  • The scientists plan to use the recently discovered cell surface receptor TOSO, which is overexpressed in leukemia cells, to create a rapid and effective entry point for delivering drugs to these malignant cells while bypassing normal cells as much as possible. (eurekalert.org)
  • ibrutinib
  • Ibrutinib also disables tissue anchor signals on the leukemia cells, removing CLL cells from the lymph nodes' nurturing environment, causing them to starve. (eurekalert.org)
  • kinase
  • CLL cell growth is driven by the B cell receptor (BCR), a molecule on the surface of the leukemia cells, which transmits growth signals into the cells using enzymes, including Bruton's tyrosine kinase (BTK). (eurekalert.org)