• homologous
  • Second, the neo-sex chromosome is homologous to the sex chromosomes of mammals, which makes it possible - for the first time - to study mammalian X gene homologs in a novel, avian Z-linked environment where females are the heterogametic sex (ZW), and thus to draw direct parallels over the avian ZW-mammalian XY boundary. (lu.se)
  • In meiosis I, chromosomes pair and recombine with their homologous partners, then segregate away from their partners at anaphase I. Most human birth defects (Down syndrome, for example) occur when a pair of homologs fails to segregate away from each other, instead moving to the same pole of the spindle at anaphase I. This failure of homologs to segregate away from each other is correlated with a failure to recombine. (omrf.org)
  • mutations
  • Finally, we use our unique 30-year ecological dataset and rich collection of DNA samples of the great reed warbler to test the widely accepted but poorly supported sexual antagonism hypothesis suggesting that sexually antagonistic mutations accumulate on the sex chromosomes and drive their evolution. (lu.se)
  • To understand the interplay between sex chromosomes and sexual conflicts by studying whether sexually antagonistic mutations accumulate on sex chromosomes, and whether sexual conflicts drive sex chromosome evolution. (lu.se)
  • However, in a ZW system one can separate the effect of the hemizygous chromosome from the male-biased mutations, providing an excellent system for understanding the evolution of SCD. (royalsocietypublishing.org)
  • lack
  • This lack of detailed knowledge about sex chromosome evolution compromises our understanding of fundamental biological questions (e.g. the evolution of sexual conflicts) as well as more practical ones (e.g. about sex-linked genetic diseases). (lu.se)