• mechanism
  • The mechanism by which specific regions of the chromosome are organized and segregated prior to division remains a mystery. (wiley.com)
  • We recently provided evidence from immunofluorescence and electron microscopy studies that merotelic kinetochore orientation is a major mechanism for lagging chromosomes during mitosis in PtK1 cells. (biologists.org)
  • The selected Xi becomes the target of a chromosome‐wide mechanism of transcriptional silencing, which constitutes an exciting paradigm for epigenetic regulations and confirms interest in the molecular dissection of the X‐inactivation centre ( Xic ), a locus on the X chromosome that contains the Xist gene and the elements involved in counting, choice and silencing. (embopress.org)
  • random
  • Furthermore, the lagging of pairs of separated sisters was higher than expected from random chance indicating that merotelic orientation of one sister may promote merotelic orientation of the other. (biologists.org)
  • Studies
  • We use yeast as a model for our studies, as yeast and humans use the same basic machinery, but the yeast system allows us to obtain data much more quickly. (omrf.org)