Loading...



  • mechanism
  • The mechanism by which specific regions of the chromosome are organized and segregated prior to division remains a mystery. (wiley.com)
  • The selected Xi becomes the target of a chromosome‐wide mechanism of transcriptional silencing, which constitutes an exciting paradigm for epigenetic regulations and confirms interest in the molecular dissection of the X‐inactivation centre ( Xic ), a locus on the X chromosome that contains the Xist gene and the elements involved in counting, choice and silencing. (embopress.org)
  • protein
  • Duplication in Amyloid precursor protein (APP) locus (duplicated segment varies in length but includes APP) on Chromosome 21 was found to cause early onset familial Alzheimer's disease in a French family set (Rovelet-Lecrux et al. (wikipedia.org)
  • IL-21 is an important regulator of plasma cell differentiation, and it controls the master regulator of plasma cell differentiation, B lymphocyte-induced maturation protein-1 (BLIMP-1), via STAT3 and IRF4. (jimmunol.org)
  • The protein structure of C21orf62 in humans consists of a combination of alpha helices and beta sheets. (wikipedia.org)
  • The protein has been predicted to localize in the nucleus, and possesses a cut signal peptide at amino acid 21. (wikipedia.org)
  • Proline-rich protein 21 (PRR21) is a protein of the family of proline-rich proteins. (wikipedia.org)
  • The NDUFB10 protein weighs 21 kDa and is composed of 172 amino acids. (wikipedia.org)
  • Molecular
  • Human Molecular Genetics. (wikipedia.org)
  • We explored the molecular basis for this repression and identify primary miR-21 transcription as a direct target of BLIMP-1-dependent repression, despite continued STAT3 activation and phospho-STAT3 binding to the primary miR-21 promoter. (jimmunol.org)
  • The presence of the Philadelphia chromosome can help predict how the cancer will progress and provides a target for molecular therapies. (wikipedia.org)
  • occur
  • Alleles occur at different frequencies in different human populations, with populations that are more geographically and ancestrally remote tending to differ more, a phenomenon known as isolation-by-distance. (wikipedia.org)
  • For medicine, study of human genetic variation may be important because some disease-causing alleles occur more often in people from specific geographic regions. (wikipedia.org)
  • Population differences occur due to several causes, including random genetic drift, the influence of small migrant populations (the "founder effect"), and differences in selective pressures acting on human populations in different environments. (wikipedia.org)
  • Chromosome anomalies usually occur when there is an error in cell division following meiosis or mitosis. (wikipedia.org)
  • 2016
  • Retrieved 2016-05-21. (wikipedia.org)
  • In 2016, a study performed an association analysis on chromosome 22 at 31203 markers in order to determine if high blood pressure and smoking were correlated. (wikipedia.org)
  • mRNA
  • Thus, STAT3 and BLIMP-1 constitute an incoherent feed-forward loop downstream of IL-21 that can coordinate microRNA with mRNA expression during plasma cell differentiation. (jimmunol.org)
  • It encodes a 3182 base pair mRNA which possesses one Pleckstrin homology-like domain. (wikipedia.org)
  • disruption
  • An earlier RNAi screen in 2007 showed the disruption of Topoisomerase II activity impairs somatic pairing within Drosophila tissue culture, indicating a role for topoisomerase-mediated organisation (or the direct interactions of topoisomerase enzymes) in pairing. (wikipedia.org)
  • downstream
  • miR-21 is the most frequently deregulated microRNA in malignancy, including B cell lymphomas, and it has oncogenic potential downstream of STAT3. (jimmunol.org)
  • While 6,770 base pairs downstream from RUFY2 is a DNA2 conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. (wikipedia.org)
  • transcriptional
  • Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewal. (nih.gov)
  • mechanism
  • The mechanism by which specific regions of the chromosome are organized and segregated prior to division remains a mystery. (wiley.com)
  • The selected Xi becomes the target of a chromosome‐wide mechanism of transcriptional silencing, which constitutes an exciting paradigm for epigenetic regulations and confirms interest in the molecular dissection of the X‐inactivation centre ( Xic ), a locus on the X chromosome that contains the Xist gene and the elements involved in counting, choice and silencing. (embopress.org)
  • Targets
  • Multiplex ligation-dependent probe amplification (MLPA) is a variation of the multiplex polymerase chain reaction that permits amplification of multiple targets with only a single primer pair. (wikipedia.org)
  • MLPA facilitates the amplification and detection of multiple targets with a single primer pair. (wikipedia.org)
  • Molecular
  • Two teeth coming from fossil human skeletons were examined in the Molecular Technology Institute of Forensic Medicine Department, Wroclaw Medical University. (blogspot.com)
  • Human Molecular Genetics. (wikipedia.org)
  • Fluorescent in situ hybridization (FISH) is a molecular cytogenetic technique that uses fluorescent probes that bind to only those parts of the chromosome with a high degree of sequence complementarity. (wikipedia.org)
  • The molecular composition of the human telomerase enzyme complex was determined by Dr Scott Cohen and his team at the Children's Medical Research Institute (Sydney Australia) and consists of two molecules each of human telomerase reverse transcriptase (TERT), telomerase RNA (TR or TERC), and dyskerin (DKC1). (wikipedia.org)
  • Homo
  • The timeline of human evolution outlines the major events in the development of the human species, Homo sapiens, and the evolution of our ancestors. (wikipedia.org)
  • https://www.theguardian.com/science/2017/jun/07/oldest-homo-sapiens-bones-ever-found-shake-foundations-of-the-human-story "'Experiments with sex have been very hard to conduct,' Goddard said. (wikipedia.org)
  • organisms
  • TTC39B is conserved in organisms from human to platyhelminthes and is not conserved in yeast and fungi. (wikipedia.org)
  • Mechanisms for this include simple dilution (an egg contains on average 200,000 mtDNA molecules, whereas a healthy human sperm was reported to contain on average 5 molecules ), degradation of sperm mtDNA in the male genital tract, in the fertilized egg, and, at least in a few organisms, failure of sperm mtDNA to enter the egg. (wikipedia.org)
  • various
  • The various tarantula hawk wasps are of a similar size and can overpower a spider many times its own weight, and move it to its burrow, with a sting that is excruciatingly painful to humans. (wikipedia.org)
  • Clonal populations of bacteria, each population maintaining a single artificial chromosome, are stored in various laboratories around the world. (wikipedia.org)
  • populations
  • So-called physiological stress markers are extremely valuable in assessing life conditions of old human populations. (blogspot.com)
  • probe
  • If a and b are the signals from two amplicons in the patient sample, and A and B are the corresponding amplicons in the experimental control, then the dosage quotient DQ = (a/b) / (A/B). Although dosage quotients may be calculated for any pair of amplicons, it is usually the case that one of the pair is an internal reference probe. (wikipedia.org)
  • Fluorescence microscopy can be used to find out where the fluorescent probe is bound to the chromosomes. (wikipedia.org)
  • Each probe for the detection of mRNA and lncRNA is composed of 20 oligonucleotide pairs, each pair covering a space of 40-50 bp. (wikipedia.org)
  • A target-specific probe, composed of 20 oligonucleotide pairs, hybridizes to the target RNA(s). (wikipedia.org)
  • The probe is then applied to the chromosome DNA and incubated for approximately 12 hours while hybridizing. (wikipedia.org)
  • cell
  • In the experiment, four primary human airway smooth muscle cell lines were treated with 1 micromolar dexamethasone for 18 hours. (bioconductor.org)
  • In the mid-1990s, my research group began to devise a method to establish endothelial cell cultures from human peripheral blood, with an ultimate goal of examining interindividual heterogeneity of endothelial biology. (jci.org)
  • The role of telomeres and telomerase in cell aging and cancer was established by scientists at biotechnology company Geron with the cloning of the RNA and catalytic components of human telomerase and the development of a polymerase chain reaction (PCR) based assay for telomerase activity called the TRAP assay, which surveys telomerase activity in multiple types of cancer. (wikipedia.org)
  • species
  • In most species, including humans, mtDNA is inherited solely from the mother. (wikipedia.org)
  • It includes brief explanations of some of the species, genera, and the higher ranks of taxa that are seen today as possible ancestors of modern humans. (wikipedia.org)
  • It does not address the origin of life, which discussion is provided by abiogenesis, but presents one possible line of evolutionary descent of species that eventually led to humans. (wikipedia.org)
  • It is not threatened with extinction, but human activities, such as hunting, habitat destruction, and the introduction of foreign predatory species and parasites, have reduced its distribution in Australia. (wikipedia.org)
  • single
  • It is important to know if the sequencing experiment was single-end or paired-end, as the alignment software will require the user to specify both FASTQ files for a paired-end experiment. (bioconductor.org)
  • Within 100 generations in humans (about 2100 years in ancient times) one expects a few hundred of these 'blending' events to have occurred across a single chromosome, the average size is 1 centiMorgan (or 1 cM). (wikipedia.org)
  • major
  • HLA A1-B8-DR3-DQ2 haplotype (Also: AH8.1, COX, Super B8, ancestral MHC 8.1 or 8.1 ancestral haplotype) is a multigene haplotype that covers a majority of the human major histocompatibility complex on chromosome 6 (not to be confused with the HLA-DQ heterodimer DQ8.1). (wikipedia.org)
  • Haplogroup C is a major Y-chromosome haplogroup, defined by UEPs M130/RPS4Y711, P184, P255, and P260, which are all SNP mutations. (wikipedia.org)
  • final stage
  • The aim of this study is to estimate the influence of general environmental conditions on human organism at the final stage of the Neolithic period - in the Corded Ware culture. (blogspot.com)
  • regions
  • This is usually accomplished on human mitochondrial DNA by sequencing the hypervariable control regions (HVR1 or HVR2), and sometimes the complete molecule of the mitochondrial DNA, as a genealogical DNA test. (wikipedia.org)
  • These 440 base pairs are then compared to the control regions of other individuals (either specific people or subjects in a database) to determine maternal lineage. (wikipedia.org)
  • cause
  • Spiral wave breakup is believed to be a cause of ventricular fibrillation in human hearts(see movie). (blogspot.com)
  • Other changes in the number or structure of chromosome 7 can cause delayed growth and development, mental disorder, characteristic facial features, skeletal abnormalities, delayed speech, and other medical problems. (wikipedia.org)
  • currently
  • Close Orthologs: Distant Orthologs: The Domain of Unknown Function 3808 (DUF3808) domain is conserved from fungi to humans and is currently has an unknown function. (wikipedia.org)