• mitotic
  • By using in situ hybridization with alphoid probes to chromosome 7 and 11 we showed that loss of a single sister is much more frequent than loss of both sisters from the same chromosome in anatelophases from human primary fibroblasts released from a nocodazole-induced mitotic arrest, as predicted from merotelic orientation of single kinetochores. (biologists.org)
  • Kinetochores of lagging chromosomes in anaphase human cells were found to be devoid of the mitotic checkpoint phosphoepitopes recognized by the 3F3/2 antibody, suggesting that they attached kinetochore microtubules prior to anaphase onset. (biologists.org)
  • Mitotic chromosome malsegregation produces aneuploidy and genome instability. (biologists.org)
  • Hence, the activation of the mitotic checkpoint prevents the unbalanced distribution of chromosomes during mitosis and the production of aneuploid cells. (biologists.org)