• genetic
  • The results did not show an increased rate of later aberrations indicative of genetic instability. (rerf.jp)
  • Statistical analysis will be performed to ascertain the association between occupational exposure to antineoplastic drugs and biomarkers of DNA and chromosome damage, after taking into account the effects of individual genetic susceptibility, and the presence of confounding exposures. (biomedcentral.com)
  • While the genetic lesions that cause chromosome instability remain undefined, mouse ES cells harbouring homozygous adenomatous polyposis coli ( APC ) mutations are frequently tetraploid. (biologists.org)
  • The project is directed by Daniela S. Gerhard, and includes sub-projects or initiatives, with notable ones including the Cancer Chromosome Aberration Project (CCAP) and the Genetic Annotation Initiative (GAI). (wikipedia.org)
  • Cancer
  • A recent review noted that "It was first published in 1983 as a book named "The Catalog of Chromosome Aberrations in Cancer", containing 3,844 cases. (wikipedia.org)
  • Furthermore, aberrations can be used for applications in biodosimetry and more generally as biomarkers of exposure and risk, that is the case for cancer patients monitored during Carbon-ion therapy and astronauts exposed to space radiation. (unipv.it)
  • The aim is to assess in hospital nurses preparing and/or administering therapy to cancer patients the current level of occupational exposure to antineoplastic drugs, DNA and chromosome damage as cancer predictive effects, and the association between the two. (biomedcentral.com)
  • 21)), and TMPRSS2-ERG with an interstitial deletion on chromosome 21, often occurring in prostate cancer. (wikipedia.org)
  • This suggest that the rearrangements took place at a time that both parental copies of the chromosome were present and hence early on the development of the cancer cell. (wikipedia.org)
  • exposure
  • A mouse study also confirmed that chromosome aberrations were not seen in offspring 20 weeks after in utero radiation exposure, although they were seen in mothers after exposure in adulthood. (rerf.jp)
  • Human fetuses do not register chromosome damage inflicted by radiation exposure in lymphoid precursor cells except for a small but significant effect at low doses. (rerf.jp)
  • instability
  • Clonally expanded T-cell populations in atomic bomb survivors do not show excess levels of chromosome instability. (rerf.jp)
  • The majority of human tumour cells are aneuploid owing to an underlying chromosome instability phenotype. (biologists.org)
  • These observations suggest that truncating APC mutations can exert dominant effects which in turn can initiate chromosome instability. (biologists.org)
  • 1985
  • In 1985 it was clearly established that the fusion gene on chromosome 22 produced an abnormal chimeric BCR/ABL1 protein with the capacity to induce chronic myeloid leukemia. (wikipedia.org)
  • vivo
  • We assessed these properties using the standard battery of tests recommended by the Korea Food and Drug Administration (KFDA): the bacterial reverse mutation test (Ames test), the chromosome aberration test, and the in vivo micronucleus test. (biomedcentral.com)
  • induction
  • After a brief introduction on the main general features of chromosome aberrations, in this work we will address key aspects of the current knowledge on chromosome aberration induction, both from an experimental and from a theoretical point of view. (unipv.it)
  • Finally, two of the few available models of chromosome aberration induction by ionizing radiation (including heavy ions) will be described and compared, focusing on the different assumptions adopted by the authors and on how these models can deal with heavy ions. (unipv.it)
  • dose
  • The small but consistent differences between the two cities may be due either to different scoring efficiency of aberrations in the two laboratories or to differential errors in DS86 dose assignments. (rerf.jp)
  • Syndrome
  • In 2015, it was found that chromothripsis can also be curative: a woman who had WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome, an extremely rare autosomal dominant combined immunodeficiency disease, found her symptoms disappeared during her 30s after chromothripsis of chromosome 2 deleted the disease allele. (wikipedia.org)
  • cells
  • Inhibition of topo II activity may also predispose cells to aneuploidy because this enzyme is needed for removing regions of DNA catenation prior to chromosome segregation. (mysciencework.com)
  • This results in parts of the chromatids or chromosomes being broken off and enveloped as an extra nucleus in one of the daughter cells. (wikipedia.org)
  • This technique works well in recognizing HeLa because these cells have distinctive chromosome aberrations. (wikipedia.org)
  • risk
  • Please make a reservation by sending a check to Windhover, PO Box 2249, Rockport, MA, 01966 or download chromosome aberrations reprint of in your risk year. (windhover.org)
  • No increased risk for AML with complex CCA or with total or partial losses of chromosomes 5 or 7 were observed, but a higher risk was found for AML with trisomy 8 (OR 11, 95% CI 2.7-42) as the sole aberration. (sjweh.fi)
  • specific
  • Based on these lines, 88 markers specific for chromosome 2R were physically mapped to 13 different blocks of 2R with three in arm 2RS and 10 in arm 2RL. (springer.com)