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LipoxygenaseLipoxygenasesArachidonate 12-LipoxygenaseArachidonate 5-LipoxygenaseArachidonate 15-LipoxygenaseArachidonate LipoxygenasesLipoxygenase InhibitorsArachidonic AcidChromosomes12-Hydroxy-5,8,10,14-eicosatetraenoic AcidArachidonic AcidsChromosome MappingMasoprocolLeukotrienesHydroxyeicosatetraenoic AcidsLinoleic AcidsChromosome BandingX ChromosomeLipid PeroxidesChromosome Aberrations5-Lipoxygenase-Activating Proteins4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amineSex ChromosomesEicosanoids5,8,11,14-Eicosatetraynoic AcidChromosomes, Human, Pair 1Chromosomes, HumanLeukotriene B4SoybeansLinoleic AcidChromosomes, BacterialChromosome SegregationChromosomes, Human, Pair 7Chromosomes, Human, Pair 17Chromosomes, Human, Pair 11Chromosomes, Human, Pair 6Prostaglandin-Endoperoxide SynthasesChromosome DeletionChromosomes, Human, Pair 9Chromosomes, Human, Pair 21Molecular Sequence DataLipoxinsChromosomes, PlantChromosomes, FungalChromatography, High Pressure LiquidChromosomes, Human, 6-12 and XFatty Acids, UnsaturatedChromosomes, Human, Pair 2Chromosomes, Human, Pair 16Chromosomes, Human, Pair 22Chromosome PairingCalcimycinChromosomes, MammalianChromosomes, Human, Pair 13Cyclooxygenase InhibitorsPhospholipases AChromosomes, Human, Pair 4Chromosomes, Human, Pair 10Chromosomes, Human, YChromosomes, Human, Pair 8Chromosomes, Human, Pair 19Chromosome DisordersBase SequencePhospholipases A2Chromosomes, Artificial, BacterialChromosomes, Human, XBlood PlateletsChromosomes, Human, 1-3Chromosomes, Human, Pair 12Chromosome PaintingChromosomes, Human, Pair 5Chromosomes, Human, Pair 15KaryotypingLeukotriene A4IndomethacinChromosomes, Human, Pair 14KineticsChromosomes, Human, Pair 18Chromosomes, Human, 16-18In Situ Hybridization, FluorescenceSolanum tuberosumChromosomes, Human, Pair 20Chromosomes, Artificial, YeastLinolenic AcidsEicosanoic AcidsFlavanonesCorylusFatty AcidsAmino Acid SequenceChromosomes, Human, 13-15Genetic LinkageSRS-ACloning, MolecularReticulocytesChromosome BreakageChromosomes, Human, 21-22 and YIsoenzymesOxidation-ReductionSubstrate SpecificityGas Chromatography-Mass Spectrometry
GeneGenesAminoFunctionsActivityType
Gene4
  • Kelavkar and Badr (1999) described experiments yielding data that supported the hypothesis that loss of the TP53 gene, or gain-of-function activities resulting from the expression of its mutant forms, regulates ALOX15 promoter activity in human and in mouse, albeit in directionally opposite manners. (wikipedia.org)
  • Kelavkar and Badr (1999) referred to this as evidence that 15-lipoxygenase is a mutator gene. (wikipedia.org)
  • In humans, it is encoded by the ALOX15 gene located on chromosome 17p13.3. (wikipedia.org)
  • Effect of dietary fatty acids on inflammatory gene expression in healthy humans. (springer.com)
Genes2
  • 1992) demonstrated that genes for 12-lipoxygenase and 15-lipoxygenase are located on human chromosome 17, whereas the most unrelated lipoxygenase (5-lipoxygenase) was mapped to chromosome 10. (wikipedia.org)
  • In spite of biological plausibility, evidence from human population-based studies on the associations of OS biomarker concentrations with DNA methylation of OS-related genes is sparse and the potential impact of OS-related DNA methylation alteration on cancer development is even sparser [ 15 , 16 ]. (biomedcentral.com)
Amino2
  • and mouse, rat, and rabbit rodent orthologs of human ALOX15, which share 74-81% amino acid identity with the human enzyme, are commonly termed Alox15, 12/15-lipoxygenase, 12/15-LOX, or 12/15-LO). (wikipedia.org)
  • Matsumoto T, Funk CD, Radmark O, Hoog JO, Jornvall H, Samuelsson B: Molecular cloning and amino acid sequence of human 5-lipoxygenase. (t3db.ca)
Functions1
  • this, along with their different principal product formation (e.g. 12-HETE rather than 15-HETE) has made the findings of Alox15 functions in rat, mouse, or rabbit models difficult to extrapolate to the function of ALOX15 in humans. (wikipedia.org)
Activity1
  • Many of the latter Alox15 enzymes nonetheless possess predominantly or exclusively 12-lipoxygenase rather than 15-lipoxygenase activity. (wikipedia.org)
Type1