• In a previous report using the resources of the New Hampshire Birth Cohort Study (NHBCS), we found that low-to-moderate i n utero exposure to arsenic, a highly toxic and widespread pollutant, was associated with altered expression of several key developmental genes in the fetal portion of the placenta. (biomedcentral.com)
  • Using NanoString technology, we further analyzed the fetal placenta samples from the NHBCS for the expression of genes encoding arsenic transporters and metabolic enzymes. (biomedcentral.com)
  • We found that maternal arsenic exposure was strongly associated with expression of the AQP9 gene, encoding an aquaglyceroporin transporter, in female but not male fetal placenta. (biomedcentral.com)
  • Based on these results and prior studies, increased AQP9 expression may lead to increased arsenic transport in the female fetal placenta, which in turn may alter the expression patterns of key developmental genes that we have previously shown to be associated with arsenic exposure. (biomedcentral.com)
  • Syncytin is expressed mainly in the human placenta and is implicated in placental syncytiotrophoblast cell fusion. (ecancer.org)
  • The placenta is a promising tissue for identifying DNA methylation changes at genes that also function in the fetal brain. (ameridisability.com)
  • hCG, produced in the placenta, partially passes the placental barrier. (medscape.com)
  • The dramatic rise in ASD suggests that there's an environmental component to this because genetics don't change that fast," Kaur said, "We know that steroid hormones play an important role in brain development. (missouri.edu)
  • The syncytiotrophoblast covers the villous tree and has several functions, such as transport of gases, nutrients, and waste products and synthesis of peptide and steroid hormones that regulate placental, fetal, and maternal systems. (medscape.com)
  • They can act as classic endocrine modulators (hormones) via entry into the circulation or locally (cytokines) through juxtacrine, paracrine and autocrine modes of action. (biomedcentral.com)
  • However, the range of additional associations is expanding and includes disrupted placental development, poor post-natal growth, and other endocrine features. (eurospe.org)
  • functions as an endocrine organ, producing hormones such as leptin, etc. (cityofhope.org)
  • After an initial surge of LH and testosterone at birth, lasting about 12 hours, gonadotropin (LH and follicle stimulating hormone [FSH]) and testosterone levels are low during the first few days of life. (medscape.com)
  • The alpha-subunit is identical to that for luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH). (medscape.com)
  • however, the underlying mechanisms are largely unknown.ResultsWe here observed a rapid histone deacetylation process between two waves of active transcription mediated by the follicle-stimulating hormone. (deepdyve.com)
  • Gestational trophoblastic diseases (GTD) encompass a spectrum of interrelated conditions: Hydatidiform mole (HM) Invasive mole (IM) Choriocarcinoma (CC) Placental site trophoblastic tumour (PSTT) This article is available only as. (annals.edu.sg)
  • Although there have been 4 STAT proteins identified as transducer molecules of PRLR, STAT5 is recognised as the most important transducer of PRLR isoforms, with a role in inhibiting regulation of gene transcription. (wikipedia.org)
  • Also, significant discoveries including new embryological molecular genetic transcription factors, the role of active placental mineral transport, and hormone regulation factors have changed the understanding of calcium and phosphate homeostasis in the fetus and the newborn. (frontiersin.org)
  • Sex hormones and genes on the sex chromosomes are not only key factors in the regulation of sexual differentiation and reproduction but they are also deeply involved in brain homeostasis. (mdpi.com)
  • Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)
  • This determined how hierarchical interactions between regulatory elements orchestrate robust parent-specific expression, with implications for non-imprinted gene regulation. (nature.com)
  • Mammalian parental imprinting is a form of epigenetic regulation that causes genes to be expressed from only one chromosome homolog according to parent-of-origin 1 , 2 . (nature.com)
  • Insertions of TEs influence the transcriptional regulation of some genes as well as the termination of transcription. (ecancer.org)
  • There are mechanisms by which environmental exposures induces epigenetic changes by affecting regulation and gene expression. (cloudfront.net)
  • This thesis describes the cloning and recombinant expression of domains from the human RBBP6 protein for future in vitro binding studies with pRb and p53. (uwc.ac.za)
  • Growth hormone circulates bound to a specific binding protein (GHBP), which is the extracellular portion of the growth hormone receptor. (medscape.com)
  • Prolactin-like protein-f subfamily of placental hormones/cytokines: responsiveness to maternal hypoxia. (genscript.com)
  • GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. (genscript.com)
  • Protein expression is influenced by many factors that may vary between experiments or laboratories. (genscript.com)
  • In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)
  • The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)
  • Expression analysis of mutant XY gonads at the same stage also reveals a dramatic reduction in Sox9 and, crucially, Sry at the transcript and protein levels. (plos.org)
  • The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including the expression of critical autosomal genes such as SOX9 . (plos.org)
  • This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)
  • the DNA encoding the gene is transcribed into messenger RNA, which then produces a single Sry protein. (asu.edu)
  • The Sry protein is also called the testis-determining factor (TDF), a protein that initiates male development in humans, placental mammals, and marsupials. (asu.edu)
  • The scientists claimed that the gene would encode for the testis-determining factor (TDF), a protein responsible for causing testis to develop in embryos. (asu.edu)
  • Unlike other protein hormones, its production and secretion are stimulated by decreased intracellular calcium concentrations, which reflect serum calcium concentrations. (medscape.com)
  • Four transcript variants encoding three different isoforms (a proteoglycan, glycoprotein and cell surface protein) [2] have been found for this gene. (meddic.jp)
  • What does this gene/protein do? (cancerindex.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • However, hormone receptor negative (triple negative) tumors overwhelmingly overexpress p53 protein in tumor cells. (cancerindex.org)
  • The oxytocin peptide is synthesized as an inactive precursor protein from the OXT gene . (wikidoc.org)
  • Co-expression of Ov-phy-1 with the O. volvulus homologue of protein disulfide isomerase in a baculovirus system resulted in the production of enzymatically active O. volvulus prolyl 4-hydroxylase. (embl.de)
  • How is the expression of the ANXA4 protein regulated? (creativebiomart.net)
  • TCDD for every step of the mechanism described for 2,3,7,8-TCDD carcinogenesis in humans including receptor binding, gene expression, protein activity changes, cellular replication, oxidative stress, promotion in initiation-promotion studies and complete carcinogenesis in laboratory animals. (who.int)
  • The prolactin (PRL) and growth hormone (GH) gene families represent species-specific expansions of pregnancy-associated hormones/cytokines. (biomedcentral.com)
  • Prolactin (PRL) and growth hormone (GH) are hormones/cytokines responsible for the coordination of a wide range of biological processes in vertebrates. (biomedcentral.com)
  • The expression of ANXA4 can be regulated by various factors, including cellular differentiation, hormones, and cytokines. (creativebiomart.net)
  • The prolactin receptor (PRLR) is a type I cytokine receptor encoded in humans by the PRLR gene on chromosome 5p13-14. (wikipedia.org)
  • Prolactin Growth hormone Human placental lactogen Placental growth hormone S179D-hPRL Prolactin receptor antagonists such as Del1-9-G129R-hPRL have been developed. (wikipedia.org)
  • Stressors increase corticoreleasing hormone, adrenocorticoreleasing hormone, cortisol and prolactin and decrease prostaglandin E2 release and vasoconstriction induced/potentiated by angiotensin II, nitric oxide, acetylcholine and serotonin. (gremjournal.com)
  • Parathyroid hormone related peptide (PTHrP) was first described in 1985 as a new compound with parathyroid hormone (PTH)-like bioactivity that accounted for the discrepancy between human umbilical cord and maternal PTH levels ( 1 ). (frontiersin.org)
  • The imprinted isoform of the Mest gene in mice is involved in key mammalian traits such as placental and fetal growth, maternal care and mammary gland maturation. (bvsalud.org)
  • Adaptive responses to maternal hypoxia include activation of placental PLP-Falpha/E gene expression, which may then participate in maternal hematological adjustments required for maintaining maternal and fetal oxygen delivery. (genscript.com)
  • While imprinting perturbations are widely associated with developmental abnormalities, the intricate regional interplay between imprinted genes makes interpreting the contribution of gene dosage effects to phenotypes a challenging task. (nature.com)
  • PURPOSE: Supernumerary marker chromosome (SMC) could be associated with various phenotypic abnormalities based on the chromosomal origin of SMCs. (koreamed.org)
  • A birth defect is any developmental abnormality present at birth that can be caused by a variety of factors, including drug and alcohol use by the mother during prenancy, exposure of the mother to pathogens during pregnancy, abnormalities in chromosome number, issues with gene expression, etc. (repropedia.org)
  • Chromosome abnormalities may cause about half of recurrent miscarriages. (msdmanuals.com)
  • Miscarriages due to chromosome abnormalities are more common during early pregnancy. (msdmanuals.com)
  • The annotation of genes from genome sequencing projects has provided considerable insight into the existence of species-specific gene expansion. (biomedcentral.com)
  • An expanded five-member GH gene cluster spans approximately 48 kb on chromosome 17 of the human genome, whereas the sole human PRL gene is present on chromosome 6 [ 2 ]. (biomedcentral.com)
  • It has been suggested that TEs are a source of variation as a result of the insertion of fragments of their sequence into functioning genes elsewhere in the genome. (ecancer.org)
  • By taking an unbiased approach to investigating placental DNA methylation differences, we discovered a novel gene in a poorly mapped region of the genome associated with autism, " said Janine LaSalle , lead author on the study and professor of microbiology and immunology at UC Davis Health. (ameridisability.com)
  • The gene encoding the Ov-phy-1 open reading frame contained 11 introns, similar in structure to the gene encoding human prolyl 4-hydroxylase isoform I. Genomic Southern blot, EST and genomic PCR studies demonstrated that the O. volvulus genome contained between three and eight genes closely related to Ov-phy-1. (embl.de)
  • Chromosome conformation capture outlined genome segregation into large scale A and B compartments corresponding mainly to transcriptionally active and repressive chromatin. (deepdyve.com)
  • Common bioidentical hormones include synthesized estrogen and progesterone, both often used in hormone therapy. (repropedia.org)
  • The syncytiotrophoblast produces regular hCG, which promotes progesterone production by the corpus luteum until placental progesterone production becomes established (after 6 weeks of gestation). (medscape.com)
  • Expression of Y chromosome genes may influence aspects of brain maturation in the 46,XY fetus, but the contribution of different Y genes is unknown. (eurospe.org)
  • PTH secretion is suppressed in the fetus because of high placental transfer of calcium, particularly in the third trimester. (medscape.com)
  • It regulates oxygen supply and metabolism and provides hormones and neurotransmitters critical for the fetus' developing brain. (ameridisability.com)
  • Female pseudohermaphroditism due to placental aromatase deficiency, which has recently been reported by several investigators, illustrates the critical role of placental aromatization in protecting the fetus from excess androgen exposure. (health.am)
  • Detection of mutations in this gene has confirmed the fundamental role of aromatase for the fetal-placental unit and for sexual differentiation of the female fetus. (health.am)
  • Secretion of growth hormone (GH) by the pituitary is stimulated by growth hormone-releasing hormone (GHRH) from the hypothalamus. (medscape.com)
  • Micropenis may be caused by a defect anywhere along the hypothalamic-pituitary-gonadal axis, a defect in peripheral androgen action, isolated growth hormone deficiency, a primary structural anomaly, or may be part of a genetic syndrome. (medscape.com)
  • Gestational and nongestational trophoblasts are by far the most common sources of hCG, but a small amount of the hormone may also be produced by the pituitary gland and nontrophoblastic malignancies. (medscape.com)
  • Hypoparathyroidism results from defective synthesis or secretion of parathyroid hormone (PTH), end-organ resistance, or inappropriate regulations that result from the activated or antibody-stimulated calcium-sensing receptor (CaSR). (medscape.com)
  • Genetically inherited forms arise from defects of parathyroid gland development, defects in the parathyroid hormone (PTH) gene, defects in the calcium-sensing receptor gene, defects in PTH action, defects in the autoimmune regulator gene, and genetic syndromes. (medscape.com)
  • These data demonstrate that MAP3K4-dependent signalling events are required for normal expression of Sry during testis development, and create a novel entry point into the molecular and cellular mechanisms underlying sex determination in mice and disorders of sexual development in humans. (plos.org)
  • BackgroundAllele-specific methylation of the imprinting control region (ICR) is the molecular basis for the genomic imprinting phenomenon that is unique to placental mammals. (deepdyve.com)
  • Gene expression profiling of ErbB receptor and ligand-dependent transcription. (rochester.edu)
  • Topoisomerases are essential nuclear enzymes with a multiplicity of cellular functions involving DNA replication, RNA transcription, mitosis, and chromosome condensation. (annals.edu.sg)
  • The defect in the gene is thought to have built a resistance to chemotherapy, and has lost the ability to regulate the apoptosis of cells with mutated DNA. (wikipedia.org)
  • Major phosphaturic hormones that regulate renal phosphate handling are PTH and FGF23. (frontiersin.org)
  • Here, we examined similarities and differences in the MEST gene locus across mammals using a marsupial, the tammar wallaby, a monotreme, the platypus, and a eutherian, the mouse, to investigate how imprinting of this gene evolved in mammals. (bvsalud.org)
  • By confirming the presence of the short isoform in all mammalian groups (which is imprinted in eutherians), this study suggests that an alternative promoter for the short isoform evolved at the MEST gene locus in the common ancestor of mammals. (bvsalud.org)
  • Sex determination in mammals is controlled by the presence or absence of the Y-linked gene SRY . (plos.org)
  • In mammals, whether an individual develops as a male or female depends on its sex chromosome constitution: those with a Y chromosome become males because of the development of the embryonic gonad into a testis. (plos.org)
  • One of the largest imprinted clusters in mammals is a 1.2 Mb domain encompassing the Dlk1 and Dio3 genes. (nature.com)
  • One of the potential effects of TEs is the generation of new gene sequences [ 3 , 6 , 7 ] such as the envelope (env) genes of retroviral origin found in several mammals. (ecancer.org)
  • The Sex-determining Region Y ( Sry in mammals but SRY in humans) is a gene found on Y chromosomes that leads to the development of male phenotypes, such as testes. (asu.edu)
  • Scientists first scanned the Y chromosomes of several mammals for the presence of genes involved in testis formation. (asu.edu)
  • The team found a sequence on the Y chromosomes of several species of mammals. (asu.edu)
  • The alignment of genes along the mouse PRL family locus primarily reflects sequence conservation. (biomedcentral.com)
  • Commonalities in cell-specific and/or temporal-specific aspects of gene expression do not appear to be main factors governing alignment within the locus. (biomedcentral.com)
  • We previously showed that the ICR at the mouse H19 gene locus (H19 ICR) was unexpectedly established after fertilization. (deepdyve.com)
  • New UC Davis MIND Institute research has identified a novel human gene linked to fetal brain development and autism spectrum disorder (ASD). (ameridisability.com)
  • Short stature may be the normal expression of genetic potential, in which case the growth rate is normal, or it may be the result of a condition that causes growth failure with a lower-than-normal growth rate. (medscape.com)
  • Using mouse models with distinct deletions in an intergenic region controlling imprinting across the Dlk1-Dio3 domain, we link changes in genetic and epigenetic states to allelic-expression and phenotypic outcome in vivo. (nature.com)
  • Based upon her research on sex determination in insect species, Stevens concluded that the Y chromosome carries the genetic material that leads to male development. (asu.edu)
  • Her results supported the theory proposed in the early 1890s by zoologist researcher Walter Sutton at Columbia University in New York City, New York and biologist Theodore Boveri at University of Würzburg in Würzburg, Germany, that chromosomes contain genetic material. (asu.edu)
  • In 1944 Oswald Avery, Colin Macleod, and Maclyn McCarthy, at the Rockefeller Institute for Medical Research in New York City, New York, discovered that chromosomes contain DNA, the molecule that encodes an organism's genetic information. (asu.edu)
  • PURPOSE: Placental corticotropin-releasing hormone receptor type 1 (CRHR1) expression is reduced in pregnancies with abnormal placental function such as preeclampsia (PE), and the levels and/or function of CRHR1 are genetically. (koreamed.org)
  • 3. Advances in genetics have identified new gene mutations in which have clarified the causes of several conditions previously thought to be "idiopathic. (frontiersin.org)
  • Confirmation of the Sry gene encoding the TDF came from several experiments that focused on mutations in the SRY gene. (asu.edu)
  • That research showed that mutations in the Sry gene halted the embryonic development of testes, resulting in organisms that possessed a Y chromosome but expressed female phenotypic characteristics. (asu.edu)
  • Saethre-Chotzen syndrome is an autosomal dominant craniosynostosis syndrome, usually involving unior bilateral coronal synostosis and mild limb deformities, and is induced by loss-of-function mutations of the TWIST1 gene. (koreamed.org)
  • Cloning and sequencing of the CYP19 aromatase gene has provided new opportunities for identifying mutations. (health.am)
  • Backsround: The Cancer/testis (CT) antigens are a division of germ cell specific genes not expressed in somatic cells, exceptions being placental cells and 20Vo - 4OVo of cancer types. (uwc.ac.za)
  • These techniques enabled researchers to describe the mechanisms that underlie developmental pathways, including the role of SRY gene in sex determination. (asu.edu)
  • Mammalian parental imprinting represents an exquisite form of epigenetic control regulating the parent-specific monoallelic expression of genes in clusters. (nature.com)
  • Cell type-specific deletion of the Hdc gene, which encodes HDC (histidine decarboxylase), an enzyme essential for histamine synthesis, would shed light on the role of histamine synthesis and secretion by the minor histamine-producing cells. (healthjade.com)
  • The Sry gene, located on the short branch of the Y chromosome, initiates male embryonic development in the XY sex determination system. (asu.edu)
  • When follicles have reached an adequate size and the eggs are mature enough, an injection of the hormone hCG initiates the ovulation process. (wikipedia.org)
  • Curated eutherian third party data gene data sets. (genscript.com)
  • Third party data gene data set of eutherian growth hormone genes. (genscript.com)
  • Somatostatin secreted by the hypothalamus inhibits growth hormone secretion. (medscape.com)
  • Estrogen has been found to increase the secretion of oxytocin and to increase the expression of its receptor , the oxytocin receptor , in the brain . (wikidoc.org)
  • The aim of this study was to investigate the forensic usefulness of various Y-chromosome short tandem repeat loci among South African sub-populations. (uwc.ac.za)
  • Our work indicates that parental origin of an epigenetic state is irrelevant as long as appropriate balanced gene expression is established and maintained at imprinted loci. (nature.com)
  • Therefore, in the present study, we performed lncRNA and mRNA microarray analyses to explore the lncRNA and mRNA expression profile in response to oligohydramnios in pregnant women. (researchsquare.com)
  • Oxytocin ( Oxt ) is a peptide hormone and neuropeptide . (wikidoc.org)
  • P53 overexpression is less frequent in hormone receptor positive breast cancers. (cancerindex.org)
  • Signal control is monitored by a variety of genes, and the PRLR gene has been identified in the tissue of metastatic primary breast cancer cells. (wikipedia.org)
  • A defect in the placental conversion of androgens to estrogens causes virilization in female offspring. (health.am)
  • DiGeorge syndrome and velocardiofacial syndrome are variants of the chromosome arm 22q11 microdeletion syndrome. (medscape.com)
  • Particular human PPARD gene versions demonstrate zero crystal clear connection to CVD however connections among variants as well as way of life components may possibly effect ailment risk. (aktsignals.com)
  • BackgroundHigh-throughput sequencing (HTS) offers unprecedented opportunities for the discovery of causative gene variants in multiple human disorders including cancers, and has revolutionized clinical diagnostics. (deepdyve.com)
  • Stevens's work identified the Y chromosome as a heritable structure that somehow caused sex determination in the embryo. (asu.edu)
  • In this minireview we examine the structure, expression patterns, and biological actions of the PRL and GH families from rodents (primarily rat and mouse), ruminants (primarily ovine and bovine), and primates (primarily human). (biomedcentral.com)
  • The best known of the human env-derived genes is syncytin-1, or ERVWE1, which originated from a human endogenous retrovirus (HERV) of the HERV-W family inserted on chromosome 7q21 in human-pre-hominoids 40-45 million years ago [ 11 , 10 ]. (ecancer.org)
  • Another important novel finding was made in 2000, when bone-derived hormone Fibroblast Growth Factor-23 (FGF23) was found to cause autosomal dominant hypophosphataemic rickets (ADHR), which provided the underlying mechanism for the previously unknown "phosphaturic factor" causing hypophosphataemia ( 2 , 3 ). (frontiersin.org)
  • At that time, however, researchers couldn't detail the mechanism through which chromosomes work to induce changes in the cell. (asu.edu)
  • Yet, the intricate form of epigenetic control over the parent-specific expression of multiple genes in an imprinted cluster poses difficulties when trying to decipher the relative contribution of changes in imprinted gene dosage to the resulting physiological phenotypes. (nature.com)
  • A discrepancy between marked virilization in the mother and a minimal androgen effect in female offspring indicates placental aromatase activity, which converts androgens to estrogens, or androgen metabolism, which thus becomes less active. (health.am)
  • In humans, it is encoded by a single gene which contains 11 exons and is located on chromosome 5. (wikipedia.org)
  • In the tammar, the short isoform of MEST shared the putative promoter CpG island with an antisense lncRNA previously identified in humans and an isoform of a neighbouring gene CEP41. (bvsalud.org)
  • In humans the first step in the development of an organism's sex is the inheritance of an X chromosome from the mother, and either an X or Y chromosome from the father. (asu.edu)
  • Growth failure in length and weight with a normal head circumference in an infant with growth hormone deficiency. (medscape.com)
  • When growth hormone pulses are secreted into the systemic circulation, insulin-like growth factor (IGF)-1 is released, either locally or at the site of the growing bone. (medscape.com)
  • The IGFBP that most depends on growth hormone is IGFBP-3. (medscape.com)
  • Hyperinsulinism decreases: the number of insuin receptors, insulin-like factor receptors, insulin-like growth factor binding globulin-1 and sex hormone binding globulin. (gremjournal.com)
  • Also, growth hormone and thyroid hormones directly influence implantation. (gremjournal.com)
  • The orphan nuclear receptor NUR77 promotes trophoblast invasion at early pregnancy through paracrine placental growth factor. (sjtu.edu.cn)
  • Growth hormone also plays a role in penis growth as micropenis has been observed in children with isolated growth hormone deficiency. (medscape.com)
  • Plant hormones are described as integrators of external signal and internal developmental process in plants. (uwc.ac.za)
  • Multivariable linear regression analysis was used to examine their relationship with arsenic exposure and with key developmental genes, after stratification by fetal sex. (biomedcentral.com)
  • Hypothyroidism Hypothyroidism is underactivity of the thyroid gland that leads to inadequate production of thyroid hormones and a slowing of vital body functions. (msdmanuals.com)
  • Assessment of F-MuLV-induced tumorigenesis reveals new candidate tumor genes including Pecam1, St7, and Prim2. (rochester.edu)
  • Characterization and expression of enzymatically active recombinant filarial prolyl 4-hydroxylase. (embl.de)
  • Our data indicate, for the first time, a requirement for MAPK signaling in the developing XY gonad in order to facilitate normal expression of SRY and the downstream testis-determining genes and also suggest that reduced dosage of MAP3K4 may be the cause of a previously described autosomal sex-reversing mutation in the mouse. (plos.org)
  • Starting in the early 1980s, research teams in London, UK led by Robin Lovell-Badge at the National Institute for Medical Research and Peter Goodfellow at the Cancer Research UK London Research Institute sought to identify the genes present on the Y chromosome that induced male development. (asu.edu)
  • Robin Lovell-Badge and her team at the National Institute for Medical Research later confirmed Sry gene's role in sex determination in an experiment where researchers injected Sry gene sequences into chromosomally female (XX) mice embryos during early embryonic development, and the embryos developed into males. (asu.edu)
  • The authors of the present study report the prenatal detection of a chromosomal abnormality with additional satellites on the distal short arm of chromosome 8. (koreamed.org)
  • Once the baby is born, loss of placental delivery of minerals causes a sudden drop in serum concentrations of these bone minerals which triggers a rise in regulating factors such as PTH, 1,25-dihydroxyvitamin D [1,25(OH) 2 D, calcitriol] and FGF23 to maintain postnatal homeostasis. (frontiersin.org)
  • The following Prl7a3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)
  • ORF sequences can be delivered in our standard vector, pcDNA3.1 + /C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. (genscript.com)
  • The purpose of this study is to study expression level and possible role of lncRNAs in oligohydramnios. (researchsquare.com)
  • This study examined basal coactivator expression in rat uterus to investigate if expression of these genes is regulated by estradiol-17β or tamoxifen. (bioone.org)
  • [4] Oxytocin is released into the bloodstream as a hormone in response to stretching of the cervix and uterus during labor and with stimulation of the nipples from breastfeeding . (wikidoc.org)