• Finally, 80,000 years ago, another arginine to cysteine substitution at amino acid 158 (Arg158Cys) of the APOE3 gene created the E2 allele. (wikipedia.org)
  • The gene, APOE, is mapped to chromosome 19 in a cluster with apolipoprotein C1 (APOC1) and the apolipoprotein C2 (APOC2). (wikipedia.org)
  • 2004) narrowed the AD candidate region on chromosome 20 to an 11.8-cM region between markers D20S174 and D20S471, which includes the CST3 gene. (findzebra.com)
  • In addition, they observed association for markers located near the CST3 gene, with P values between 0.002 and 0.08 for 2-locus haplotypes. (findzebra.com)
  • 2000) reported associations between polymorphisms in the CST3 gene and late-onset AD, Monastero et al. (findzebra.com)
  • The apolipoprotein E (APOE) gene is located on chromosome 19 and encodes a glycoprotein that is 299 amino acids long. (dovepress.com)
  • Negative association findings and research involving the serotonin transporter gene, FMR1, RELN, WNT2, HOXA1, and HOXB1 genes may be found elsewhere on this site . (neurotransmitter.net)
  • Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. (neurotransmitter.net)
  • CONCLUSIONS: A strong association of autism with SNPs within the SLC25A12 gene was demonstrated. (neurotransmitter.net)
  • Here, two batches of large-scale literature-based disease-gene relation data (updated in 2017 and 2019, respectively) and gene expression data were integrated to study the possible association between OCD and ASD at the genetic level. (silverchair.com)
  • Notably, the gene APOE identified by the 2017-based analysis has been implicated to have an association with ASD in a recent study (2018) with DNA methylation analysis. (silverchair.com)
  • Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (atlasgeneticsoncology.org)
  • Integrated analysis of differential gene expression, previously reported quantitative trait loci, and genome-wide association studies indicated that TRIB3 , SAA ( SAA1 , SAA3 , and M-SAA3.2 ), VEGFA, PTHLH , and RPL23A were the most promising candidate genes affecting milk protein and fat percentage. (biomedcentral.com)
  • Integrated analysis of differential gene expression and the reported quantitative trait loci and genome-wide association study data permitted the identification of candidate key genes for milk composition traits. (biomedcentral.com)
  • Glypican 3 ( GPC3 ) is a heparan sulfate proteoglycan whose gene is located on chromosome Xq26. (biolifesas.org)
  • [7] In humans , the gene APP is located on chromosome 21 and contains 18 exons spanning 290 kilobases. (handwiki.org)
  • Indeed, the apolipoprotein ε4 isoform is more protective against cognitive decline than other isoforms in some cases, so caution is advised before making determinant statements about the influence of APOE polymorphisms on cognition, development of Alzheimer's disease, cardiovascular disease, telomere shortening, etc. (wikipedia.org)
  • A model that included current age and the number of E2 alleles at the APOE locus as covariates gave a lod score of 4.1. (findzebra.com)
  • They suggested that this type of AD is biologically independent of APOE and that its association with E2 in their data set was the result of E4-related attrition at earlier ages. (findzebra.com)
  • Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)
  • Several major APOE isoforms can be distinguished: E2, E3, and E4. (dovepress.com)
  • The three major human alleles (E4, E3, E2) arose after the primate-human split around 7.5 million years ago. (wikipedia.org)
  • The Aβ domain is unique to the APP protein, though the family shares several other conserved domains such as the E1 and E2 domains in the extracellular sequence. (biomedcentral.com)
  • The extracellular E2 domain, a dimeric coiled coil and one of the most highly conserved regions of the protein from Drosophila to humans. (handwiki.org)
  • 1997) found strong evidence of linkage on chromosomes 20 (lod score = 4.09) and 21 (lod score = 5.9). (findzebra.com)
  • Clinical features in a large family and linkage to chromosome 1q. (amdbook.org)
  • In the second stage, the two SNPs in SLC25A12 were further genotyped in 411 autistic families, and linkage and association tests were carried out in the 197 informative families. (neurotransmitter.net)
  • RESULTS: Linkage and association were observed between autistic disorder and the two SNPs, rs2056202 and rs2292813, found in SLC25A12. (neurotransmitter.net)
  • X. tropicalis (also called Silurana tropicalis ) is a diploid organism with 20 chromosomes and a 1.7Gbp long hap- loid genome. (1library.co)
  • Because of the large marker spacing in the initial genome scan, the candidate region on chromosome 20 spanned 25 cM, corresponding to chromosomal bands 20p12.2-q11.21. (findzebra.com)
  • Genome-wide association study identifies variants screening. (who.int)
  • The authors recently mapped a susceptibility locus for autism to chromosome region 2q24-q33 (MIM number 606053). (neurotransmitter.net)
  • Association of complement factor H polymorphisms with exudative age-related macular degeneration. (amdbook.org)
  • 18. Zareparsi S, Branham KE, Li M, Shah S, Klein RJ, Ott J, Hoh J, Abecasis GR, Swaroop A. Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration. (amdbook.org)
  • 19. Thakkinstian A, Han P, McEvoy M, Smith W, Hoh J, Magnusson K, Zhang K, Attia J. Systematic review and meta-analysis of the association between complement factor H Y402H polymorphisms and age-related macular degeneration. (amdbook.org)
  • finally, the dry processes- of aggregation does at 251185though events further is the mosses formed in Seedlings and reactions oxidation, and the going edges of volume associations. (controlaltenergy.com)
  • Apolipoprotein E (Apo-E) is a protein involved in the metabolism of fats in the body of mammals. (wikipedia.org)
  • Turner syndrome (TS) is a congenital disease caused by absence or structural abnormalities of sex chromosomes resulting in gonadal dysge. (nel.edu)
  • Almost every chromosome is affected by numeric or structural aberrations. (neurotransmitter.net)
  • 2002) determined that a region on chromosome 20p showed the same pattern. (findzebra.com)
  • [20] A serine protease inhibitor domain, absent from the isoform differentially expressed in the brain, is found between acidic region and E2 domain. (handwiki.org)
  • Brain structure and allelic associations in Alzheimer's disease CNS Neurosci Ther. (usc.edu)
  • BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer. (atlasgeneticsoncology.org)
  • Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugates. (atlasgeneticsoncology.org)
  • [ 7 , 8 ] The recognition that DS is associated with trisomy 21 helped in understanding the genetic basis of this association. (medscape.com)
  • An up-to-date collection of all published genetic association studies. (alzgene.org)
  • Previous studies have demonstrated varying grades of association between TTV DNA levels and immune deficiencies related to age, chronic infections and cancer. (prelekara.sk)
  • No effect of fibrates on synthesis of apolipoprotein(a) in primary cultures of cynomolgus monkey and human hepatocytes: apolipoprotein A-I synthesis increased. (embl.de)
  • Because lp(a) levels in vivo are mainly regulated at synthesis level, we studied the effect of fibrates on the synthesis of apolipoprotein(a) (apo(a)) in primary cultures of cynomolgus monkey and human hepatocytes. (embl.de)
  • Reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C) in patients with primary hyperlipidemia (Fredrickson type IIa, heterozygous familial and nonfamilial) or mixed dyslipidemia (Fredrickson type IIb). (globalrph.com)
  • Association of torque teno virus (TTV) and torque teno mini virus (TTMV) with liver disease among patients coinfected with human immunodeficiency virus and hepatitis C virus. (prelekara.sk)
  • Limited research exists on the association between resting-state functional network connectivity in the brain and learning and memory processes in advanced age. (bvsalud.org)
  • INTRODUCTION: Limited evidence exists on the associations of discontinuing versus continuing long-term opioid therapy (LTOT) with pain intensity, physical function, and depression among patients with Alzheimer's disease and related dementias (ADRD). (bvsalud.org)
  • Our results support the possible complex genetic associations between OCD and ASD. (silverchair.com)
  • Apolipoprotein A1 serum levels were significantly lower in acne twins [10]. (springer.com)
  • Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. (lookformedical.com)