• Genes
  • We found striking differences among tissues in methylation, which were apparent at the chromosomal scale and when genes and transposable elements were examined. (biomedcentral.com)
  • This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. (genecards.org)
  • Silencing of neuronal specific genes requires the recruitment of an associated corepressor, CoREST, that serves as a functional molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval, including transcriptional units that do not themselves contain REST response elements. (abcam.com)
  • In the cell nucleus, it seems that promoters are distributed preferentially at the edge of the chromosomal territories, likely for the co-expression of genes on different chromosomes. (wikipedia.org)
  • So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. (wikipedia.org)
  • This gene contains introns and its mRNA is poyadenylated, unlike most histone genes. (wikipedia.org)
  • Unlike most histone genes, H3F3B is not located in a cluster, but rather is isolated in the telomeric region of chromosome 17. (wikipedia.org)
  • deacetylase
  • REST (RE1 silencing transcription factor 1) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long term gene silencing using a distinct functional complex. (abcam.com)
  • amino
  • Fucci-G 1 Orange is a fusion protein of a fragment of human Cdt1 (amino acids 30-120) with the orange fluorescent mKO2 (monomeric Kusabira-Orange2) that indicates the G 1 phase. (mbl.co.jp)
  • Fucci-S/G 2 /M Green is a fusion protein of a fragment of human Geminin (amino acids 1-110) with the green fluorescent protein mAG1 (monomeric Azami-Green1) that visualizes S, G 2 and M phases. (mbl.co.jp)
  • Δ324 found at low levels in human and mouse cells - an alternative splice variant encoding an 88kDa protein lacking zinc fingers 6 and 7 Δ105 variant is unique to mice, and results in a protein truncated by 105 amino acids at the acidic C-terminus. (wikipedia.org)
  • Histones
  • Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). (blogspot.com)
  • Apoptosis
  • Consistent with this role, Histone H3 phosphorylated at threonine 3 has been shown to be recognized by the BIR domain Survivin, a member of the inhibitor of apoptosis (IAP) family. (merckmillipore.com)
  • Caspase 3 is responsible for cellular differentiation, although it is unclear how this kind of protein can promote the cell apoptosis. (wikipedia.org)
  • In one such pathway, caspase-independent apoptosis, the E3 ligase C-terminal of Hsc-70 interacting protein (CHIP), a regulator of EndoG expression, functions as a protective mechanism against oxidative stress. (wikipedia.org)
  • TGF-β, along with other TGF-β family ligands such as bone morphogenic protein (BMP) and activin are involved in regulating important cellular functions such as proliferation, differentiation, apoptosis, and matrix production. (wikipedia.org)
  • target proteins
  • The APCCdh1 (anaphase promoting complex) and SCFSkp2 (SKP-Cullin-F-box) complexes are E3 ligase activities that modify the corresponding target proteins with ubiquitin in a cell cycle-dependent manner. (mbl.co.jp)
  • transcription
  • NC2 operates by interacting with the core promoter and components of the basal transcription machinery, like the TATA-binding protein (TBP). (genetics.org)
  • GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and identical protein binding . (genecards.org)
  • Promoters contain specific DNA sequences such as response elements that provide a secure initial binding site for RNA polymerase and for proteins called transcription factors that recruit RNA polymerase. (wikipedia.org)
  • A promoter is induced in response to changes in abundance or conformation of regulatory proteins in a cell, which enable activating transcription factors to recruit RNA polymerase. (wikipedia.org)
  • DDB1 has been shown to interact with Transcription initiation protein SPT3 homolog, GCN5L2, DDB2, CUL4A, CUL4B and P21. (wikipedia.org)
  • Upon binding to 17-β-estradiol, estriol or related ligands, the encoded protein forms homo-dimers or hetero-dimers with estrogen receptor α that interact with specific DNA sequences to activate transcription. (wikipedia.org)
  • The MECOM protein contains 2 domains characterized by 7 zinc finger motifs followed by a proline-rich transcription repression domain, 3 more zinc finger motifs and an acidic C-terminus. (wikipedia.org)
  • binds
  • Ribonuclease inhibitor (RNH1) is an ubiquitously expressed protein that binds to and inhibits pancreatic-type ribonucleases. (jci.org)
  • The lac repressor protein is a dimer of two identical subunits and each one binds a short segment with the core sequence ATTGT. (blogspot.com)
  • The most obvious explanation is that the protein binds non-specifically to any piece of DNA and checks to see if it's a specific binding site. (blogspot.com)
  • If it is, the protein binds very tightly and doesn't fall off. (blogspot.com)
  • The encoded protein is secreted and binds hydroxyapatite with high affinity. (blogspot.com)
  • nucleosome
  • The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. (merckmillipore.com)
  • recruitment
  • The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. (wikipedia.org)
  • mRNA
  • In Rnh1-deficient embryos, mRNA levels of Gata1 are normal, but GATA1 protein levels are decreased. (jci.org)
  • cellular
  • There were several control experiments and additional experiments showing that the presence of other cellular proteins on the DNA didn't have much of an effect. (blogspot.com)
  • It deals with the structure and function of cellular components such as proteins, carbohydrates, lipids, nucleic acids and other biomolecules. (wikipedia.org)
  • subunits
  • Mutations in RNA pol II include both overexpression of truncated forms of the two largest subunits (Rpb1 and Rpb2) and reduced levels of these proteins. (genetics.org)
  • DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. (wikipedia.org)
  • enzyme
  • 17. A method of producing a soybean plant with modified fatty acid metabolism or modified carbohydrate metabolism wherein the method comprises transforming the soybean plant of claim 2 with a transgene encoding a protein selected from the group consisting of phytase, fructosyltransferase, levansucrase, α-amylase, invertase and starch branching enzyme or encoding an antisense of stearyl-ACP desaturase. (patentsencyclopedia.com)
  • The MCM complex consisting of MCM6 (this protein) and MCM2, 4 and 7 possesses DNA helicase activity, and may act as a DNA unwinding enzyme. (wikipedia.org)
  • regulatory
  • MCM6 contains two of the regulatory regions for LCT, the gene encoding the protein lactase, located in two of the MCM6 introns, approximately 14 kb (-13910) and 22 kb (-22018) upstream of LCT. (wikipedia.org)
  • cell
  • The DNA in a cell is covered with lots of other proteins that could block sliding and the concentrations of salts (ionic strength) in the cell are different than the concentrations used in the test tube. (blogspot.com)
  • The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. (blogspot.com)
  • In this phase, the cell increases its supply of proteins, increases the number of organelles (such as mitochondria, ribosomes), and grows in size. (wikipedia.org)
  • The chimeric gene of AML1-MDS1-EVI1 (AME) formed by the chromosomal translocation (3;21)(q26;q22) has also been shown in vitro to upregulate the cell cycle and block granulocytic differentiation of murine hematopoietic cells, as well as to delay the myeloid differentiation of bone marrow progenitors. (wikipedia.org)
  • double-stranded
  • Many proteins bind to double-stranded DNA and most of them bind specifically to a particular target site. (blogspot.com)
  • If you look closely at the structure shown above, you can see how parts of the protein lie in the grove of double-stranded DNA where they can detect the sequence by "reading" the chemical groups on the edges of the base pairs. (blogspot.com)
  • I think we can safely conclude that most specific DNA binding proteins find their target sites by binding non-specifically to DNA then sliding along the double-stranded helix until they find their specific binding site. (blogspot.com)