• nucleic acids
  • The biophysicists participating in QBM (Braun, Jungmann, Rädler, Schwille) bring a wealth of advanced expertise and novel methodologies, permitting the high-resolution quantitative and dynamic analysis of regulatory processes, including protein folding/conformation and the interaction of proteins with small molecules, nucleic acids, or other proteins in different settings (single molecule, purified/crude extracts). (lmu.de)
  • It deals with the structure and function of cellular components such as proteins, carbohydrates, lipids, nucleic acids and other biomolecules. (wikipedia.org)
  • amino
  • Fucci-G 1 Orange is a fusion protein of a fragment of human Cdt1 (amino acids 30-120) with the orange fluorescent mKO2 (monomeric Kusabira-Orange2) that indicates the G 1 phase. (mbl.co.jp)
  • Fucci-S/G 2 /M Green is a fusion protein of a fragment of human Geminin (amino acids 1-110) with the green fluorescent protein mAG1 (monomeric Azami-Green1) that visualizes S, G 2 and M phases. (mbl.co.jp)
  • Δ324 found at low levels in human and mouse cells - an alternative splice variant encoding an 88kDa protein lacking zinc fingers 6 and 7 Δ105 variant is unique to mice, and results in a protein truncated by 105 amino acids at the acidic C-terminus. (wikipedia.org)
  • Apoptosis
  • Consistent with this role, Histone H3 phosphorylated at threonine 3 has been shown to be recognized by the BIR domain Survivin, a member of the inhibitor of apoptosis (IAP) family. (merckmillipore.com)
  • Caspase 3 is responsible for cellular differentiation, although it is unclear how this kind of protein can promote the cell apoptosis. (wikipedia.org)
  • In one such pathway, caspase-independent apoptosis, the E3 ligase C-terminal of Hsc-70 interacting protein (CHIP), a regulator of EndoG expression, functions as a protective mechanism against oxidative stress. (wikipedia.org)
  • TGF-β, along with other TGF-β family ligands such as bone morphogenic protein (BMP) and activin are involved in regulating important cellular functions such as proliferation, differentiation, apoptosis, and matrix production. (wikipedia.org)
  • cluster
  • MBS9320646 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the histone cluster 1, H3b (HIST1H3B) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • target proteins
  • The APCCdh1 (anaphase promoting complex) and SCFSkp2 (SKP-Cullin-F-box) complexes are E3 ligase activities that modify the corresponding target proteins with ubiquitin in a cell cycle-dependent manner. (mbl.co.jp)
  • Translocation
  • The chimeric gene of AML1-MDS1-EVI1 (AME) formed by the chromosomal translocation (3;21)(q26;q22) has also been shown in vitro to upregulate the cell cycle and block granulocytic differentiation of murine hematopoietic cells, as well as to delay the myeloid differentiation of bone marrow progenitors. (wikipedia.org)
  • replication
  • This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. (wikipedia.org)
  • DNA replication licensing factor MCM6 is a protein that in humans is encoded by the MCM6 gene. (wikipedia.org)
  • The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. (wikipedia.org)
  • cellular
  • However, the mechanisms linking protein aggregation to cellular toxicity and death remain poorly understood. (lmu.de)
  • The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. (merckmillipore.com)
  • There were several control experiments and additional experiments showing that the presence of other cellular proteins on the DNA didn't have much of an effect. (blogspot.com)
  • nucleosome
  • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. (mybiosource.com)
  • binds
  • Ribonuclease inhibitor (RNH1) is an ubiquitously expressed protein that binds to and inhibits pancreatic-type ribonucleases. (jci.org)
  • The lac repressor protein is a dimer of two identical subunits and each one binds a short segment with the core sequence ATTGT. (blogspot.com)
  • The most obvious explanation is that the protein binds non-specifically to any piece of DNA and checks to see if it's a specific binding site. (blogspot.com)
  • If it is, the protein binds very tightly and doesn't fall off. (blogspot.com)
  • mRNA
  • In Rnh1-deficient embryos, mRNA levels of Gata1 are normal, but GATA1 protein levels are decreased. (jci.org)
  • subunits
  • Mutations in RNA pol II include both overexpression of truncated forms of the two largest subunits (Rpb1 and Rpb2) and reduced levels of these proteins. (genetics.org)
  • DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. (wikipedia.org)
  • regulatory
  • MDS1 and EVI1 complex locus protein EVI1 (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain zinc finger protein 3 (PRDM3) is a protein that in humans is encoded by the MECOM gene. (wikipedia.org)
  • MCM6 contains two of the regulatory regions for LCT, the gene encoding the protein lactase, located in two of the MCM6 introns, approximately 14 kb (-13910) and 22 kb (-22018) upstream of LCT. (wikipedia.org)
  • Rabbit
  • Western blot analysis of whole cell lysates probed with histone H2BJ antibody followed by detection with HRP conjugated Goat anti Rabbit (1/10,000, STAR208P ) and visualized on the ChemiDoc MP with 10 second exposure. (bio-rad-antibodies.com)
  • Anti-phospho-Histone H3 (Thr3) Antibody, clone JY325 is a Rabbit Monoclonal Antibody for detection of phospho-Histone H3 (Thr3) also known as Histone H3.1 & has been validated in WB, PIA. (merckmillipore.com)
  • cell
  • The DNA in a cell is covered with lots of other proteins that could block sliding and the concentrations of salts (ionic strength) in the cell are different than the concentrations used in the test tube. (blogspot.com)
  • In this phase, the cell increases its supply of proteins, increases the number of organelles (such as mitochondria, ribosomes), and grows in size. (wikipedia.org)
  • endonuclease
  • The caspase-3 His-237 stabilizes the target Aspartate causing the break of the association of ICAD and CAD leaving the endonuclease CAD active allowing it to degrade chromosomal DNA. (wikipedia.org)
  • cells
  • To address this question, we study the detailed architecture of protein aggregates inside cells using advanced cryo electron microscopy techniques. (lmu.de)
  • enzyme
  • 17. A method of producing a soybean plant with modified fatty acid metabolism or modified carbohydrate metabolism wherein the method comprises transforming the soybean plant of claim 2 with a transgene encoding a protein selected from the group consisting of phytase, fructosyltransferase, levansucrase, α-amylase, invertase and starch branching enzyme or encoding an antisense of stearyl-ACP desaturase. (patentsencyclopedia.com)
  • The MCM complex consisting of MCM6 (this protein) and MCM2, 4 and 7 possesses DNA helicase activity, and may act as a DNA unwinding enzyme. (wikipedia.org)
  • double-stranded
  • Many proteins bind to double-stranded DNA and most of them bind specifically to a particular target site. (blogspot.com)
  • If you look closely at the structure shown above, you can see how parts of the protein lie in the grove of double-stranded DNA where they can detect the sequence by "reading" the chemical groups on the edges of the base pairs. (blogspot.com)
  • I think we can safely conclude that most specific DNA binding proteins find their target sites by binding non-specifically to DNA then sliding along the double-stranded helix until they find their specific binding site. (blogspot.com)