• deletions
  • Chromosomal deletion syndromes typically involve larger deletions that are visible using karyotyping techniques. (wikipedia.org)
  • Smaller deletions result in Microdeletion syndrome, which are detected using fluorescence in situ hybridization (FISH) Examples of chromosomal deletion syndromes include 5p-Deletion (cri du chat syndrome), 4p-Deletion (Wolf-Hirschhorn syndrome), Prader-Willi syndrome, and Angelman syndrome. (wikipedia.org)
  • High frequency of deletions at breakpoints within these fragile sites has been associated with many cancers, including breast, lung, and gastric cancers (for review, see ) MicroRNA genes, which are preferentially involved in chromosomal alterations, are frequently located at fragile sites. (wikipedia.org)
  • haplogroup
  • In 2013, the discovery of a previously unknown Y-chromosomal haplogroup was announced, which resulted in a slight adjustment of the estimated age of the human Y-MRCA. (wikipedia.org)
  • Subsequent research using twelve Y-STR markers indicated that about half of contemporary Jewish Kohanim shared Y-chromosomal J1 M267, (specifically haplogroup J-P58, also called J1c3), while other Kohanim share a different ancestry, including haplogroup J2a (J-M410). (wikipedia.org)
  • widely
  • Since the first edition, major advances and discoveries have made chromosomal mutagenesis a widely used technique and one that is available to any molecular biology laboratory, and this collection provides detailed protocols, case-studies, and reviews from thought-leaders in the field. (springer.com)
  • Adam
  • As with "Mitochondrial Eve", the title of "Y-chromosomal Adam" is not permanently fixed to a single individual, but can advance over the course of human history as paternal lineages become extinct. (wikipedia.org)
  • Y-chromosomal data taken from a Neanderthal from El SidrĂ³n, Spain produced a Y-T-MRCA of 588,000 years ago for neanderthal and Homo sapiens patrilineages, dubbed ante Adam and 275,000 years ago for Y-MRCA. (wikipedia.org)
  • The techniques used to find Y-chromosomal Aaron were first popularized in relation to the search for the patrilineal ancestor of all contemporary living humans, Y-chromosomal Adam. (wikipedia.org)
  • human
  • In fact, only a small fraction of the initial damage is transduction of late chromosomal damage has also been measured in the progeny of human lymphocytes that were exposed with much higher frequency in the progeny of cells that were exposed to heavy ions compared to gamma rays. (wikipedia.org)
  • test
  • Our baby died at 15 weeks and he was able to get some tissue to test for chromosomal issues and also hopefully we might know the sex of the baby. (dailystrength.org)