We have eliminated expression of the macrophage metalloelastase (MME) gene by targeted disruption to assess the role of this protein in macrophage-mediated proteolysis. (labome.org)
in which certain white adipose tissue depots significantly increase gene expression for the uncoupling protein UCP1 and thus supposedly acquire thermogenic, fat-burning properties, has attracted considerable attention. (labome.org)
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. (labome.org)
physiological effects could be demonstrated in several mouse models ectopically expressing uncoupling protein 1 ( UCP1 ). (labome.org)
Role2
An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice. (labome.org)
A critical role for ras-mediated, epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis. (labome.org)
Effects2
We developed mice with germline endogenous expression of oncogenic Hras to study effects on development and mechanisms of tumor initiation. (labome.org)
Gene dosage effects of the imprinted delta-like homologue 1 (dlk1/pref1) in development: implications for the evolution of imprinting. (labome.org)