Chromatin chromosomal proteins non histone. Medical search. Frequent questions

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. (nih.gov)
Histones are a group of similar, small, highly conserved nuclear proteins that bind to DNA by their many basic residues. (calbiotech.com)
We have classified these motifs into three types according to their sequence similarity and have found that they are prevalent in many eukaryotic nuclear proteins in single or multiple copies. (embl.de)
Chromatin, a complex nuclear structure comprised of DNA, histones, RNA, and other nuclear proteins, is one of the most critical components within the cell because it houses the genetic information and its organization regulates important cellular functions, such as transcription, replication, and repair. (northwestern.edu)
Emerin is a ubiquitous inner nuclear membraneprotein, presentin nearly all cell types, although its highest expression is in skeletal and cardiacmuscle.Emerin binds to many nuclear proteins, including several gene-regulatory proteins (eg, barrier-to-autointegration factor, germ cell-less, Btf), nesprins (proteins that act as molecular scaffolds), F-actin, and lamins. (medscape.com)

Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. (nih.gov)
DNA in chromatin is organized in arrays of nucleosomes 1 .Two copies of each histone protein, H2A, H2B, H3 and H4, are assembled into an octamer that has 145?147 base pairs (bp) of DNA wrapped around it to form a nucleosome core (of relative molecular mass 206K). (nature.com)
A histone chaperone that facilitates nucleosome assembly by mediating the formation of the histone octamer and its transfer to DNA. (lookformedical.com)
Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). (nih.gov)
[5] Within the nucleosome, Kornberg found that roughly 200 bp of DNA are wrapped around an octamer of histone proteins. (chemeurope.com)
This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). (abclonal.com)

H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. (fishersci.com)
The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modifications that influence cellular processes. (fishersci.com)
The repeating nucleosome cores further assemble into higher-order structures which are stabilized by the linker histone H1 and these compact linear DNA overall by a factor of 30?40. (nature.com)
Binding of sequence-specific transcription factors and associated chromatin-modifying enzymes can induce post-translational modification of histone tails and can facilitate nucleosome removal [ 3 - 5 ], which can turn functional sequences such as promoters and enhancers into active, nucleosome-depleted sites [ 2 ]. (biomedcentral.com)
DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (nih.gov)
While a postdoctoral fellow working with Aaron Klug and Francis Crick at the MRC in the 1970s, Kornberg discovered the nucleosome as the basic protein complex packaging chromosomal DNA in the nucleus of eukaryotic cells (chromosomal DNA is often termed "chromatin" to reflect this protein packaging). (chemeurope.com)
Here we show that a plant homeodomain (PHD) finger of nucleosome remodelling factor (NURF), an ISWI-containing ATP-dependent chromatin-remodelling complex, mediates a direct preferential association with H3K4me3 tails. (ox.ac.uk)

The Bedford lab studies one such modification, the methylation of arginine amino acids in histones and other chromatin-associated proteins. (mdanderson.org)
Over 10 years ago, arginine methylation of histone tails was identified as an epigenetic mark that was linked to gene activation. (mdanderson.org)
The researchers studied the two proteins in breast cancer cell lines, where they discovered that TDRD3 recruits TOP3B to active chromatin (where genes are turned on) that is marked by arginine methylation. (mdanderson.org)
Immunodetection of chromosomal proteins and DNA methylation. (tsukuba.ac.jp)
Dynamic protein methylation in chromatin biology. (ox.ac.uk)
In particular, histone lysine and arginine methylation play important roles in regulating transcription, maintaining genomic integrity, and contributing to epigenetic memory. (ox.ac.uk)
Recently, the use of new approaches to analyse histone methylation, the generation of genetic model systems, and the ability to interrogate genome wide histone modification profiles has aided in defining how histone methylation contributes to these processes. (ox.ac.uk)
Here we focus on the recent advances in our understanding of the histone methylation system and examine how dynamic histone methylation contributes to normal cellular function in mammals. (ox.ac.uk)
Lysine methylation of histones is recognized as an important component of an epigenetic indexing system demarcating transcriptionally active and inactive chromatin domains. (ox.ac.uk)

All of our chromosomes are made from chromatin, which is half histone (or structural) proteins and half DNA, organized into long strings with bead-like structures (nucleosomes) on them. (ualberta.ca)
Chromosomes are structured such that domains with a similar chromatin signature cluster spatially, a phenomenon first appreciated by traditional microscopy studies. (biomedcentral.com)
DNA is tightly packaged into chromosomes along with histone proteins. (mdanderson.org)
Chromatin is packaged → chromatin fibres → coiled and condensed at metaphase stage → chromosomes. (bankofbiology.com)
General overview of chromosomes behavior during cell cycles - mitosis and meiosis, chromatin strcuture and molecular organization of the chromosomes. (tsukuba.ac.jp)
The accurate segregation of chromosomes requires the kinetochore, a complex protein machine that assembles onto centromeric DNA to mediate attachment of replicated sister chromatids to the mitotic spindle apparatus. (johnshopkins.edu)
Both sth1 and sfh1 mutants exhibit altered centromeric and centromere-proximal chromatin structure and increased missegregation of authentic chromosomes. (johnshopkins.edu)

The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. (nih.gov)
Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. (yeastgenome.org)
To fit it into a nucleus with a diameter of ~10 μm, DNA is wrapped around histone octamers, creating strings of nucleosomes that can be further organized into higher-order levels of compaction [ 1 ]. (biomedcentral.com)
A histone chaperone protein that plays a role in the deposition of NUCLEOSOMES on newly synthesized DNA. (lookformedical.com)
The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. (nih.gov)
Finally, RSC is not required for centromeric deposition of the histone H3 variant Cse4p, suggesting that RSC plays a role in reconfiguring centromeric and flanking nucleosomes following Cse4p recruitment for proper chromosome transmission. (johnshopkins.edu)

In addition to mutations in TP53 and KRAS, we identify genetic alterations in chromatin remodelling genes, ARID1A and ARID1B, in histone methyltransferase MLL3, in histone deacetylase modifier SPOP and in chromatin assembly factor BAZ1A, in nearly two thirds of cases. (nih.gov)
Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
KDM5A-mediated histone H3 lysine 4 demethylation contributes to silencing of retinoblastoma target genes (Chicas et al. (atlasgeneticsoncology.org)
Results in deregulation of HOXA genes through recruitment of the histone acetyltransferase CBP / p300 (Thiollier et al. (atlasgeneticsoncology.org)
Enhancers promote transcription by providing a binding platform for transcription factors [ 12 ] that can act on (distal) target genes through three-dimensional chromatin looping [ 13 - 15 ]. (biomedcentral.com)
Furthermore, Omics.org indicated that the main focus of omics is on 1) mapping information objects such as genes, proteins and ligands, 2) finding interaction relationships among the objects, 3) engineering the networks and objects to understand and manipulate the regulatory mechanisms and 4) integrating various omes and omics subfields. (scialert.net)
A new study by Mark Bedford, Ph.D. , professor of Molecular Carcinogenesis , and colleagues published in Molecular Cell sheds light on the mechanism by which TDRD3 - a protein that 'reads' epigenetic marks on chromosomal proteins - turns on certain genes. (mdanderson.org)
Several types of chemical modifications of the five major histone protein families give rise to a complex 'histone code' that signals the transcriptional machinery to turn genes on or off. (mdanderson.org)
Both genes are highly conserved, and their proteins are thought to have 2 functions: (1) formation of a bridge or scaffold between the DNA-binding transcription factors and the RNA polymerase II complex and (2) serving as histone acetyltransferases that open the chromatin structure, a process essential for gene expression. (medscape.com)
The chromosomal protein SMCHD1 plays an important role in epigenetic silencing at diverse loci, including the inactive X chromosome, imprinted genes, and the facioscapulohumeral muscular dystrophy locus. (ox.ac.uk)
Trimethylation of histone H3 lysine 4 (H3K4me3) marks transcription start sites of virtually all active genes. (ox.ac.uk)
This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. (multxpert.com)
Mutations in genes encoding two core subunits of RSC, the ATPase Sth1p and the Snf5p homolog Sfh1p, interact genetically with mutations in genes encoding kinetochore proteins and with a mutation in centromeric DNA. (johnshopkins.edu)

A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. (lookformedical.com)

High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by the HMGB2 gene. (wikipedia.org)
In humans, the multisubunit complex cohesin is made up of SMC1, SMC3, RAD21 and a STAG protein. (nih.gov)

This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. (nih.gov)
This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. (epigentek.com)
This gene encodes a member of the histone H2A family. (absave.com)

Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. (fishersci.com)
First, histones collaborate with transcription factors to provide for their own removal or structural modification, resulting in gene derepression. (nature.com)
This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)

A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. (lookformedical.com)
As part of its charge, the committee was asked to prepare a subreport evaluating methods for detecting potential unintended compositional changes across the spectrum of messenger ribonucleic acid (mRNA), proteins, metabolites and nutrients that may occur in food derived from cloned animals that have not been genetically modified via genetic engineering methods. (nationalacademies.org)
Application of recombinant bST is a biotechnology in which a recombinant-derived protein is administered by injection to the recipient animal without changing the animal's genetic composition or genome. (nationalacademies.org)

The mechanisms effecting establishment, maintenance, and modification of that specific physical conformation of CHROMATIN determining the transcriptional accessibility or inaccessibility of the DNA. (lookformedical.com)
CBP and EP300 are ubiquitously expressed homologous proteins that act as transcriptional co-activators. (medscape.com)

Hence, TADs are believed to represent structural chromosomal units that are of functional importance for the regulatory cross talk that determines gene expression programs. (biomedcentral.com)
The repeating structural units of chromatin, each consisting of approximately 200 base pairs of DNA wound around a protein core. (lookformedical.com)
Methylated and non methylated DNA sequences are involved in gene expression of RNA and proteins, beside their role in the structural organization of the DNA sequence and the chromosome. (scialert.net)
They bind to structural components (emerin, nesprin), chromatin components (histone), signal transduction molecules (protein kinase C), and several gene regulatory molecules. (medscape.com)
The first suggests that disruption of the inner nuclear membrane and the nuclear lamina causes disorganization of nuclear chromatin and gene expression, while the second proposes that the mechanical strength of the cell nucleus is disrupted when the nuclear lamina is weakened leading to structural and signaling defects in mechanically stressed tissue such as muscle and heart. (medscape.com)

This system has been applied in vitro to explore changes in higher-order chromatin structure and dynamics that occur due to a variety of biological processes, such as cellular fixation, stem cell differentiation, and ultraviolet (UV) light irradiation. (northwestern.edu)

SMC3 is acetylated during S-phase to establish cohesiveness of chromatin-loaded cohesin, and in yeast, the class I histone deacetylase Hos1 deacetylates SMC3 during anaphase. (nih.gov)
It is found as a subunit of protein complexes that are in involved in the enzymatic modification of histones including the Mi2 and Sin3 histone deacetylase complexes and the polycomb repressive complex 2. (lookformedical.com)

The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. (wikipedia.org)
Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. (fishersci.com)
In contrast to bacterial RNA polymerases, eukaryotic RNA polymerases are alone incapable of gene transcription, and require a complex assembly of accessory proteins to accomplish this task in an accurate and efficient manner. (chemeurope.com)

Michael Hendzel (right) co-led a study that revealed the gel-like nature of chromatin, the complex package of DNA and proteins contained within the nucleus of our cells. (ualberta.ca)

Landmark discovery of the physical state of complex DNA and protein "packages"-called chromatin-in a cell's nucleus could lead to better understanding of diseases such as cancer. (ualberta.ca)
University of Alberta researchers have found an answer to a fundamental question in genomic biology that has eluded scientists since the discovery of DNA: Within the nucleus of our cells, is the complex package of DNA and proteins called chromatin a solid or a liquid? (ualberta.ca)
Previously, fields such as biochemistry operated under the assumption that chromatin and other elements of the nucleus operated in a liquid state, Hendzel said. (ualberta.ca)
In the case of chromatin, it's about scaling this principle down to the level of the cell nucleus, because it is all connected. (ualberta.ca)
Inside the nucleus of a cell, the chromatin fibre interacts with itself to condense into a chromosome. (ualberta.ca)
and nonhistone proteins ( chromosomal proteins, non-histone) found within the nucleus of a cell. (usda.gov)
Proteins found in the nucleus of a cell. (lookformedical.com)
Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (lookformedical.com)

Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. (fishersci.com)
The chromatin fibre also supports gene expression and replication of chromosomal DNA. (ualberta.ca)
Recombination, replication, mitotic condensation and transcrip- tion involve the chromatin substrate and are thus affected by its structure. (nature.com)
HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. (embl.de)

Loosely packed and transcriptionally active chromatin and stains light. (bankofbiology.com)

The same study showed the highest anti-histone reactivity to be in patients with rheumatoid arthritis with vasculitis, while the highest reactivity in SLE sera was in those patients with a history of photosensitivity (3). (calbiotech.com)

Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
A retinoblastoma-binding protein that has an affinity for core HISTONES. (lookformedical.com)

retinoblastoma binding protein 2. (atlasgeneticsoncology.org)
The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in chromatin remodeling. (lookformedical.com)

Trouvez Histone H4 Anticorps pour une variété d'espèces telles que anti-Human Histone H4, anti-Rat Histone H4, anti-Mouse Histone H4. (anticorps-enligne.fr)

Histones are also classified by relatively high levels of lysine and arginine. (calbiotech.com)

Enzymes that catalyze acyl group transfer from ACETYL-CoA to HISTONES forming CoA and acetyl-histones. (lookformedical.com)
This is accomplished by a class of enzymes called protein arginine methyltransferases (PRMTs). (mdanderson.org)

SMC3 with retained acetylation is loaded onto chromatin, and chromatin immunoprecipitation sequencing analysis demonstrates decreased occupancy of cohesin localization sites that results in a consistent pattern of altered transcription seen in CdLS cell lines with either NIPBL or HDAC8 mutations. (nih.gov)
Disruption of the human CBP gene, either by gross chromosomal rearrangements or by point mutations, leads to Rubinstein-Taybi syndrome. (medscape.com)
In 5 of 6 gene mutations that have been shown to cause EDMD, the affected protein is present in the LINC (linker of nucleoskeleton and cytoskeleton) complex. (medscape.com)
EDMD1 is caused by mutations in the EMD gene on the X chromosome that codes for the nuclear envelope protein emerin. (medscape.com)
New mutations have been found in the synaptic nuclear envelope protein 1 ( SYNE1 ) gene and in the synaptic nuclear envelope protein 2 ( SYNE2 ) gene in a few families, also termed Nesprin-1 and Nesprin-2, respectively. (medscape.com)
Lastly, mutations in the transmembrane protein 43 (TMEM43), also termed LUMA, which binds to emerin and SUN2, has also been reported to cause an EDMD phenotype in a few families. (medscape.com)
Whatever the true mechanism, the discovery of mutations in several different nuclear membrane proteins that cause similar diseases will likely eventually lead to a better understanding of nuclear membrane physiology and the pathophysiology of diseases caused by mutations in these proteins. (medscape.com)

This Histone H3 acetyl antibody was raised against a peptide including acetyl-lysines contained in the N-terminal tail of histone H3. (fishersci.com)
Western blot analysis of extracts of various cell lines, using Histone H2A.Z Polyclonal Antibody at 1:1000 dilution. (epigentek.com)
It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. (absave.com)
Free shipping on catalog antibody and protein orders over $999. (abclonal.com)
This antibody is purified through a protein G column, followed by dialysis against PBS. (absin-reagents.com)
Histone H3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. (absin-reagents.com)
Western blot analysis of lysates from rat C6,Hela cell line (from left to right), using Histone H3 Antibody (Cat. (absin-reagents.com)

Relaxed Chromatin Formation and Weak Suppression of Homologous Pairing by the Testis-Specific Linker Histone H1T. (nih.gov)
Linker histone variant H1T targets rDNA repeats. (nih.gov)
These results suggested that the testis-specific linker histone, H1T, possesses a specific function to produce the chromatin architecture required for proper chromosome regulation, such as homologous recombination. (nih.gov)

Histone amino-terminal tails pass over and between the gyres of the DNA superhelix to contact neighbouring particles. (nature.com)
A few years ago the lab identified TDRD3, a protein that 'reads' methyl-arginine marks on histone tails. (mdanderson.org)

Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each. (lookformedical.com)

RSC also interacts genetically and physically with the histone and histone variant components of centromeric chromatin. (johnshopkins.edu)

DNA unwinding component of the nonhistone chromatin proteins. (tamu.edu)
A subclass of nonhistone chromatin proteins from rat liver, previously shown to exhibit high affinity for DNA, has been fractionated by single-stranded DNA-agarose affinity chromatography. (tamu.edu)
This nonhistone protein fraction specific for single strands binds to DNA in a non-species-specific manner, and causes helix-coil transition of synthetic poly[d(A-T)-d(A-T)] at 25 degrees, as indicated by the increase in absorbance of ultraviolet light at 260 nm. (tamu.edu)

The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes. (lookformedical.com)
Through the work of Kornberg and others, it has become clear that these protein components are remarkably conserved across the full spectrum of eukaryotes, from yeast to human cells. (chemeurope.com)

This new understanding of the physical properties of chromatin challenges that idea, and could lead to a more accurate understanding of how the genome is encoded and decoded. (ualberta.ca)
The OMICS field ranges from genomics (focused on the genome) to proteomics (focused on large sets of proteins, the proteome) and metabolomics (focused on large sets of small molecules, the metabolome). (bmj.com)

The Lid/KDM5 histone demethylase complex activates a critical effector of the oocyte-to-zygote transition. (ens-lyon.fr)

In most cases, proteins perform a cellular function specified by the gene. (chemeurope.com)

This gene encodes a member of the non-histone chromosomal high-mobility group protein family. (wikipedia.org)
The EP300 gene on band 22q13 encodes a protein, p300, that is highly similar to CREBBP. (medscape.com)

Both histone/histone and histone/DNA interactions depend on the histone fold domains and additional, well ordered structure elements extending from this motif. (nature.com)
The chromatin organization modifier domain (chromodomain) was first identified as a motif associated with chromatin silencing in Drosophila. (ox.ac.uk)
The SET domain is a 130 to 140 amino acid, evolutionary well conserved sequence motif that was initially characterised in the Drosophila proteins Su(var)3-9, Enhancer-of-zeste and Trithorax. (embl.de)
The AT-hook is a small DNA-binding protein motif which was first described in the high mobility group non-histone chromosomal protein HMG-I(Y). Since its discovery, this motif has been observed in other DNA-binding proteins from a wide range of organisms. (embl.de)
In general, it appears that the AT-hook motif is an auxiliary protein motif cooperating with other DNA-binding activities and facilitating changes in the structure of the DNA either as a polypeptide on its own [e.g. (embl.de)
It is most interesting that this motif seems to be quite specific to known or predicted chromosomal/DNA-binding proteins, suggesting that it may act as a versatile minor groove tether. (embl.de)
The high-mobility group (HMG) domain is a DNA-binding motif that is shared abundant non-histone components of chromatin and by specific regulators of transcription and cell differentiation. (embl.de)

The HMG family of proteins comprises members with multiple HMG domains that bind DNA with low sequence specificity, and members with single HMG domains that recognize specific nucleotide sequences. (embl.de)

The Drosophila chromosomal protein Mst77F is processed to generate an essential component of mature sperm chromatin. (ens-lyon.fr)
Unlocking sperm chromatin at fertilization requires a dedicated egg thioredoxin in Drosophila. (ens-lyon.fr)
Histone storage and deposition in the early Drosophila embryo. (ens-lyon.fr)
Two bromodomain proteins functionally interact to recapitulate an essential BRDT-like function in Drosophila spermatocytes. (ens-lyon.fr)

However, this histone methyltransferase (HMTase) activity is probably restricted to a subset of SET domain proteins as it requires the combination of the SET domain with the adjacent cysteine-rich regions, one located N-terminally (pre-SET) and the other posterior to the SET domain (post-SET). (embl.de)

Loss of HDAC8 activity results in increased SMC3 acetylation and inefficient dissolution of the 'used' cohesin complex released from chromatin in both prophase and anaphase. (nih.gov)
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. (yeastgenome.org)
When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. (yeastgenome.org)
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. (yeastgenome.org)
The observed hyperchromicity does not result from any nuclease activity in the protein fraction, because addition of Mg+2 results in partial hypochromic shift, and the protein/DNA complex is retained by nitrocellulose filters. (tamu.edu)
They found that TDRD3 forms a complex with a protein called topoisomerase 3B (TOP3B), an enzyme that unwinds DNA and, in so doing, prevents DNA structures from forming that impede gene transcription. (mdanderson.org)
ASF1 is required to load histones on the HIRA complex in preparation of paternal chromatin assembly at fertilization. (ens-lyon.fr)
This study reveals an important role for the yeast RSC ATP-dependent chromatin-remodeling complex at the kinetochore in chromosome transmission. (johnshopkins.edu)
This complex includes nuclear membrane integral and associated proteins including emerin, lamin A/C, SUN1, SUN2, nesprin-1, and nesprin-2 that are proposed to form a mechanical link between the nucleoskeleton and cytoskeleton. (medscape.com)

This gene is found in the large histone gene cluster on chromosome 6. (nih.gov)
This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. (abclonal.com)
This gene is found in a histone cluster on chromosome 1. (anticorps-enligne.fr)

The histones are divided into fractions, with each fraction having a distinct amino acid composition and sequence. (calbiotech.com)
Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human H2AFZ (NP_002097.1). (epigentek.com)
Using pattern searches and position-dependent matrices, we have extracted the AT-hook motifs present in a non-redundant protein sequence database. (embl.de)

Histone Variants: The Nexus of Developmental Decisions and Epigenetic Memory. (ens-lyon.fr)

Structure and expression of the human gene encoding testicular H1 histone (H1t). (nih.gov)
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. (lookformedical.com)
Histone Nomenclature in the Structure and Function of Chromatin. (calbiotech.com)

Intellectual disability-associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3. (ens-lyon.fr)

Proteins obtained from the species SACCHAROMYCES CEREVISIAE. (lookformedical.com)

The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)

The enzyme responsible for the synthesis of protein-coding mRNA is termed RNA polymerase II . (chemeurope.com)

Poly(ADP-ribose) binding properties of histone H1 variants. (nih.gov)
The lackof uniformity between multiple histone/DNA-binding sites causesthe DNA to deviate from ideal superhelix geometry. (nature.com)
The protein fraction that bound to DNA-agarose in 0.19 M NaCl-buffer and was eluted with 2 M NaCl-buffer is enriched for a protein component of approximately 20,000 daltons and exhibits preferential binding to denatured DNA. (tamu.edu)
Specific protein-binding measures are often used as assays in diagnostic assessments. (lookformedical.com)
d) Helicases and single-strand binding proteins that work at the 5' end. (brainkart.com)
The locus of Rubinstein-Taybi syndrome is located on band 16p13.3, which includes a gene encoding a binding protein for cyclic adenosine monophosphate-response element binding protein (CBP) ( CREBBP or CBP gene) that is responsible for the phenotype of Rubinstein-Taybi syndrome. (medscape.com)
We show here that methyl K810 is read by the tandem tudor domain containing tumor protein p53 binding protein 1 (53BP1). (ox.ac.uk)
High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. (embl.de)
AT-hook motifs identified in a wide variety of DNA-binding proteins. (embl.de)
Furthermore, AT-hook motifs are frequently associated with known functional domains seen in chromatin proteins and in DNA-binding proteins (e.g. histone folds, homeodomains and zinc fingers). (embl.de)

Although originally reported as histone H3 methyllysine readers, the chromodomain functions have now expanded to recognition of other histone and non-histone partners as well as interaction with nucleic acids. (ox.ac.uk)

The team's findings bridge research done over the past 50 years on chromatin gels produced in the laboratory to demonstrate its existence in living cells, which has major implications for interpreting their elastic and mechanical properties, Hendzel explained. (ualberta.ca)
For example, recent studies have shown that the deformability of chromatin in cancer cells is an important determinant of their ability to squeeze through small spaces to travel outside a tumour and metastasize elsewhere in the body-something that is much easier to explain if chromatin is gel-like rather than a liquid. (ualberta.ca)
Cancer cells do that by chemically changing the histone part of the chromatin to make it less sticky, Hendzel said. (ualberta.ca)

These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. (wikipedia.org)
The authors set out to find clues to TDRD3's function by looking for physical interactions between TDRD3 and other proteins in the cell. (mdanderson.org)

Although homology with canonical SMC family proteins suggests a role in chromosome organization, the mechanisms underlying SMCHD1 function and target site selection remain poorly understood. (ox.ac.uk)

Anatomy32

Organisms13

Diseases1

Chemicals and Drugs104

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes94

Disciplines and Occupations1

Information Science3

Nuclear Proteins5

Octamer6

Nucleosome7

Methylation9

Chromosomes7

Nucleosomes6

Genes13

Disassembly1

Humans2

Member of the histone3

Transcription Factors3

Genetic3

Transcriptional2

Structural5

Higher order chromatin1

Deacetylase2

Eukaryotic3

Nature of chromatin1

Nucleus8

Replication4

Active chromatin1

Reactivity1

Core histones2

Retinoblastoma binding2

Human histone1

Lysine and arginine1

Enzymes2

Mutations7

Antibody7

Linker3

Tails2

Arginine1

Interacts1

Nonhistone3

Eukaryotes2

Genome2

Demethylase1

Cellular1

Encodes2

Motif7

Sequences1

Drosophila4

Methyltransferase1

Complex9

Cluster3

Sequence3

Epigenetic1

Structure3

Deposition1

Saccharomyces1

Single-Stranded1

MRNA1

Binding10

Nucleic1

Cells3

Interactions2

Organization1