• Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid). (wikipedia.org)
  • Some of these GlcA residues may be epimerized into L-iduronic acid (IdoA) at which point the resulting glycosaminoglycan is then referred to as dermatan sulfate, previously referred to as chondroitin sulfate B. Chondroitin sulfate is sourced from natural products, with high variability in terms of chain length and sulfation pattern. (wikipedia.org)
  • Placental malaria infection is mediated by the binding of the malarial VAR2CSA protein to the placental glycosaminoglycan, chondroitin sulfate. (lu.se)
  • Glycosaminoglycan (GAG) assembly initiates through the formation of a linkage tetrasaccharide region serving as a primer for both chondroitin sulfate (CS) and heparan sulfate (HS) chain polymerization. (dundee.ac.uk)
  • Chondroitin Sulfate is a glycosaminoglycan extracted from shark cartilage. (sodiumhyaluronate-powder.com)
  • Chondroitin Sulfate by NOW Foods Joint Mobility and Comfort* Tissue Elasticity* Chondroitin Sulfate is a glycosaminoglycan (GAG) naturally present in many body tissues, and is an especially important component of joint cartilage and synovial tissue. (mynutritiondepot.com)
  • Chondroitin Sulfate is a glycosaminoglycan (GAG) naturally present in many body tissues, and is an especially important component of joint cartilage and synovial tissue. (mynutritiondepot.com)
  • Chondroitin sulfate is a precursor to glycosaminoglycan. (satterwhitechiropractic.com)
  • Chondroitin sulfate is needed to develop glycosaminoglycan and support its existence in the disc's nucleus pulposus (the middle of the disc). (satterwhitechiropractic.com)
  • To understand the relationship of chondroitin sulfate, glycosaminoglycan and aging benefits treatment of the degenerated disc and its possible regeneration and repair. (satterwhitechiropractic.com)
  • The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. (planteome.org)
  • Chondroitin sulfate is a type of glycosaminoglycan (GAG), which are long chains of complex sugars that are found in the extracellular matrix of connective tissues such as cartilage, bone, skin, and blood vessels. (hakalife.com)
  • Immunoablation of cells expressing the NG2 chondroitin sulphate proteoglycan. (atsbio.com)
  • Leoni G, Rattray M, Fulton D, Rivera A, Butt AM (2014) Immunoablation of cells expressing the NG2 chondroitin sulphate proteoglycan. (atsbio.com)
  • Summary: In this work the authors use an antibody against the NG2-glia marker chondroitin sulphate proteoglycan (CSPG) along with Mab-ZAP (Cat. (atsbio.com)
  • Link to all annotated objects annotated to chondroitin sulfate proteoglycan metabolic process. (planteome.org)
  • Link to all direct and indirect annotations to chondroitin sulfate proteoglycan metabolic process. (planteome.org)
  • Transient transfection of the human breast cancer cell line MDA-MB-231 with the siRNAs for carbohydrate (chondroitin 4) sulfotransferase-11 ( CHST11 ) and chondroitin sulfate proteoglycan 4 ( CSPG4 ) was used to investigate the involvement of these genes in expression of surface P-selectin ligands. (biomedcentral.com)
  • An associated change with the cervical ripening process is an increase in cervical decorin (dermatan sulfate proteoglycan 2), leading to collagen fiber separation. (medscape.com)
  • NOW Foods Chondroitin Sulfate, 600 mg, 120 Capsules, has been a game-changer for my joint health. (iherb.com)
  • If you're looking for a reliable solution to support your joint health, NOW Foods Chondroitin Sulfate is the way to go! (iherb.com)
  • NOW Foods' Chondroitin Sulfate is a natural supplement designed to support joint health and mobility. (iherb.com)
  • As someone who suffers from joint pain and stiffness, I found that taking NOW Foods' Chondroitin Sulfate supplement helped me manage my symptoms effectively. (iherb.com)
  • Pharmacokinetic studies performed on humans and experimental animals after oral administration of chondroitin sulfate revealed that it can be absorbed orally. (wikipedia.org)
  • (3) One study reported that repeated oral administration of chondroitin sulfate significantly decreased pain sensation . (satterwhitechiropractic.com)
  • Chondroitin is the substance that enables cartilage to provide cushion to healthy joints, and it is what the body uses to make new cartilage. (springtimeinc.com)
  • ChondroCare is designed to provide broad support for healthy joints by featuring high quality glucosamine sulfate and chondroitin sulfate, nutritional factors known to help support cartilage health and soft tissue formation. (vitaliving.com)
  • Protocol For Life Balance Glucosamine & Chondroitin with MSM combines three of the best known nutrients available for the support of healthy joints in one dietary supplement. (vitaliving.com)
  • Glucosamine and chondroitin sulfates are not likely to be helpful with diseases involving other types of joints (i.e. the vertebrae and intervertebral discs). (vin.com)
  • Chondroitin sulfate and glucosamine are frequently taken together and are marketed as agents that support healthy joints. (news-medical.net)
  • 2. Injectable chondroitin sulfate is the chondroitin sulfate utilized for the creation of intra-articular application infusions, particularly for the joints. (chondroitinpowder.com)
  • 2. Ponders recommends that Chondroitin sulfate may keeps the separating of ligaments in joints. (chondroitinpowder.com)
  • Chondroitin sulfate (CS) is one of the main components of the extracellular matrix of articular cartilage and plays an important role in skeletal formation, being essential for proper functioning of the joints [ 7 ]. (biomedcentral.com)
  • Everyone knows that Chondroitin Sulfate is great for joints. (iherb.com)
  • When taken as a dietary supplement, chondroitin sulfate is absorbed into the bloodstream and transported to the joints where it can exert its beneficial effects. (hakalife.com)
  • Chondroitin sulfate also has anti-inflammatory properties that can help reduce pain and swelling in arthritic joints. (hakalife.com)
  • Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate. (lu.se)
  • Dive into the research topics of 'Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate. (lu.se)
  • abstract = "The presence of iduronic acid in chondroitin/dermatan sulfate changes the properties of the polysaccharides, as it generates a more flexible chain with increased binding potentials. (lu.se)
  • Iduronic acid in chondroitin/dermatan sulfate influences multiple cellular properties such as migration, proliferation, differentiation, angiogenesis and regulation of cytokine/growth factor activities. (lu.se)
  • The role of IdoA in chondroitin/dermatan sulfate is underlined by the vast changes of connective tissue features in patients with a new type of Ehler-Danlos syndrome, adducted thumb-clubfoot syndrome. (lu.se)
  • Further, a better definition of chondroitin/dermatan sulfate functions using different knock-out models is needed. (lu.se)
  • Mizumoto, S., Yamada, S. & Sugahara, K. (2015) Molecular interactions between chondroitin-dermatan sulfate and growth factors/receptors/matrix proteins. (iduron.co.uk)
  • The major chondroitin sulfate (CS) and dermatan sulfate (DS) proteoglycans are aggrecan, versican, biglycan and decorin. (openbiochemistryjournal.com)
  • Intercalated among the collagen molecules are glycosaminoglycans and proteoglycans, predominantly dermatan sulfate, hyaluronic acid, and heparin sulfate. (medscape.com)
  • The amount of dermatan sulfate decreases, leading to reduced bridging among the collagen fibers and a corresponding decrease in cervical firmness. (medscape.com)
  • Glucosamine and chondroitin sulfates are extracted from sea mollusks (such as Perna canaliculus, also known as the New Zealand green-lipped mussel), from shark skeleton, as well as from cattle and chicken bones. (vin.com)
  • Satterwhite Chiropractic presents to our Oxford back pain patients that back pain due to a degenerated disc profits from the combination of chiropractic treatment and nutritional supplementation with chondroitin sulfate from perna canaliculus (a green lipped mussel). (satterwhitechiropractic.com)
  • (3,4,5) Cox created a spinal nutritional formula called Discat Plus that incorporates chondroitin sulfate from a green lipped mussel called perna canaliculus to enhance any potential disc regeneration. (poulinchiro.com)
  • However, until more is known, do not take chondroitin sulfate if you have prostate cancer or are at high risk for developing it (you have a brother or father with prostate cancer). (medlineplus.gov)
  • Summit Nutritionals International, a world leader of raw Chondroitin Sulfate, is proud to offer Droi-Kon® a specialized, 100% water soluble chondroitin powder supplement that has been shown through scientific studies to play an integral role in the formation and maintenance of joint cartilage. (droi-kon.com)
  • We recently received another order of Droi-Kon Chondroitin Sulfate from Summit Nutritionals International Inc. which is helpful in our daily preventative maintenance to keep our K-9 partners healthy and mobile. (droi-kon.com)
  • Chondroitin sulfate has been shown to have anti-aging effects on skin cells by increasing collagen synthesis and reducing oxidative stress caused by UV radiation exposure [^1]. (hakalife.com)
  • This effect has not been shown with chondroitin sulfate supplements. (medlineplus.gov)
  • The chondroitin used in dietary supplements is extracted from the cartilage and connective tissues of animals. (springtimeinc.com)
  • Manganese is a co-factor in joint fluid synthesis and is often included in glucosamine/chondroitin sulfate supplements as are numerous other supplements such as omega-3 fatty acids, creatine, and more. (vin.com)
  • Glucosamine and chondroitin sulfate are considered nutritional supplements. (vin.com)
  • Chondroitin sulfate chains are linked to hydroxyl groups on serine residues of certain proteins. (wikipedia.org)
  • To investigate this, we determined whether sulfate substitution of galactose (Gal) residues of the linkage region or of N-acetylgalactosamine (GalNAc) of the disaccharide unit influences activity and specificity of chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1), a key glycosyltransferase of CS biosynthesis. (dundee.ac.uk)
  • Intriguingly, a crucial loop from A4 DBL 3X which provides the important Gly and Lys residues that chelate the bound sulphate is missing or significantly altered in all other DBL domains that interact with CSA. (biomedcentral.com)
  • Further analysis of the proposed sulphate and predicted CSA-binding site indicates either none or very low level of conservation among the critical interacting residues. (biomedcentral.com)
  • Degradation kinetics models and chemical composition data of LMCS showed the GlcA residues of chondroitin -4- sulfate (CSA) may be preferentially attacked. (bvsalud.org)
  • Chondroitin helps principally to fight arthrosis , which is characterised by degeneration of the joint cartilage and the bones. (anastore.com)
  • Disc degeneration is a deficiency of chondroitin sulfate in the disc which leads to a loss of water and reduction of the disc. (satterwhitechiropractic.com)
  • (2) Satterwhite Chiropractic relieves pain from disc degeneration for many Oxford chiropractic patients with a combined approach of spinal manipulation , exercise and often nutrition for the disc with chondroitin sulfate. (satterwhitechiropractic.com)
  • Dr. Greenwood presents the disc anatomy, disc degeneration and its complication for neck patients and how spinal nutrition with chondroitin sulfate supplementation along with Cox® Technic eased the pain. (satterwhitechiropractic.com)
  • Now, today, research grows in volume and recognition of chondroitin sulfate's role in disc degeneration . (poulinchiro.com)
  • Chiropractic author Cox often cites literature on not only reversing disc degeneration but actually enhancing regeneration of degenerated discs with chondroitin sulfate and distraction manipulation . (poulinchiro.com)
  • Glucosamine and chondroitin sulfate are not only cartilage building blocks, but they can have anti-inflammatory properties of their own, making them excellent additions to any joint support protocol. (vin.com)
  • Anti-Inflammatory Effects: Chondroitin sulfate possesses anti-inflammatory properties, which can help reduce joint inflammation and associated pain. (optiwizehealth.com)
  • Chondroitin sulfate is an important structural component of cartilage, and provides much of its resistance to compression. (wikipedia.org)
  • Chondroitin sulfate is a natural component of cartilage. (msdmanuals.com)
  • The supplement contains 600 mg of chondroitin sulfate, which is a vital component of cartilage and plays a crucial role in maintaining healthy joint function. (iherb.com)
  • The results after six months of treatment proved that the combination of chondroitin and glucosamine reduces pain, functional disability, stiffness, inflammation and joint liquid effusion in a clinically relevant way, and that this combination, unlike anti-inflammatory drugs, has a high safety profile. (bioiberica.com)
  • Chondroitin sulfate hampers inflammation and prevents atherosclerotic plaques in heart disease! (poulinchiro.com)
  • In line with this, CHPF and CHPF2, which encode proteins required for chondroitin polymerization, are significantly upregulated in most cancer types. (lu.se)
  • Sequestration of malaria parasite in the human placenta is mediated by interactions between chondroitin sulphate A (CSA) on the syncytiotrophoblasts and proteins expressed on the surface of infected human erythrocytes. (biomedcentral.com)
  • We offer a series of chondroitin sulphates (CS) and dermatan sulphates (DS) that cover the principal isomers found in mammalian tissues. (iduron.co.uk)
  • Three reports that were published from the Glucosamine/chondroitin Arthritis Intervention Trial (GAIT), which was funded by the US National Institutes of Health (NIH), found that there were no clinically meaningful differences between glucosamine and chondroitin sulfate when compared to celecoxib and placebo. (news-medical.net)
  • Chondroitin sulfate chains are unbranched polysaccharides of variable length containing two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). (wikipedia.org)
  • Furthermore, marine chondroitin sulfate chains tend to be longer, with molecular weight of up to 70 kDa in chondroitin sulfate from shark, while in terrestrial animals molecular weight is typically below 45 kDa. (wikipedia.org)
  • Finally, utilizing a cell-based glycocalyx model, we showed that rVAR2 binding correlates with the length of the chondroitin sulfate chains in the cellular glycocalyx. (lu.se)
  • These data demonstrate that the total amount and cellular accessibility of chondroitin sulfate chains impactrVAR2 binding and thus malaria infection. (lu.se)
  • No GalNAcT activity was detected toward sulfated and unsulfated analogs of the CS constitutive disaccharide (GlcA-beta 1,3-GalNAc), indicating that CSGalNAcT-1 was involved in initiation but not in elongation of CS chains. (dundee.ac.uk)
  • An injectable solution containing chondroitin sulfate and sodium hyaluronate is approved by the FDA to protect the eye during cataract surgery. (medlineplus.gov)
  • Recombinant subfragments of VAR2CSA (rVAR2) have also been shown to bind specifically and with high affinity to cancer cells and tissues, suggesting the presence of a shared type of oncofetal chondroitin sulfate (ofCS) in the placenta and in tumors. (lu.se)
  • Here, we show that both placenta and tumors contain significantly more chondroitin sulfate moieties of higher molecular weight than other tissues. (lu.se)
  • The basis for the amassing of parasitized erythrocytes (PEs) in the placenta was unknown until it was shown that PEs from placenta primarily bind to chondroitin sulfate A (CSA) [ 3 ]. (biomedcentral.com)
  • Two days before admission she had re- questration of infected red blood cells in ceived 5 injections of chloroquine after the placenta through binding to chondroitin confirmation of P. falciparum infection sulfate [ 3,4 ]. (who.int)
  • We synthesized a series of sulfated and unsulfated analogs of the linkage oligosaccharide and of the constitutive unit of CS and tested these molecules as potential acceptor substrates for the recombinant human CSGalNAcT-1. (dundee.ac.uk)
  • Scientific studies have demonstrated that Glucosamine and Chondroitin can promote normal joint mobility and comfort. (vitaliving.com)
  • This liquid formula has Glucosamine and Chondroitin, which have been shown to support proper joint mobility and comfort. (vitaliving.com)
  • In addition, chondroitin inhibits the enzymes responsible for cell deterioration in the cartilage and reinforces the mobility of blood clots, lipids and cholesterol deposits at joint level. (anastore.com)
  • Since starting my K-9 Kayne on Droi-Kon chondroitin sulfate in 2014, I have noticed he has continued to have excellent joint health and mobility as he is currently working as a 10-year-old dual purpose Police K-9 and continues to show energy and vitality. (droi-kon.com)
  • Poulin Chiropractic of Herndon and Ashburn is here to help with chiropractic care that includes a nutritional approach to disc health, especially with the long-studied component, chondroitin sulfate . (poulinchiro.com)
  • Glucosamine and chondroitin sulfates might be used in any joint condition involving the classical joint structure (2 bones with cartilage-covered ends articulating, a fibrous capsule with ligaments connecting the bones, and lubricating fluid assisting the smooth motion of the joint). (vin.com)
  • Aging influences the structure and level of chondroitin sulfate in the system and how its sulfation acts for the disc's health. (satterwhitechiropractic.com)
  • Quantitative real-time PCR (qRT-PCR) and flow cytometry assays were used to detect the expression of genes involved in the sulfation and presentation of chondroitin in several human breast cancer cell lines. (biomedcentral.com)
  • Notwithstanding the enormous efforts of academic researchers, numerous problems and difficulties also astrict the utilization of marine fucosylated chondroitin sulfates, including digestive absorption of the macromolecular polysaccharides, polysaccharide modifications, the novel structures and source of fucosylated chondroitin sulfates, structure-function relationships, etc. (mdpi.com)
  • J-Flex is pure, high-grade chondroitin sulfate - a natural ingredient for healthy joint lubrication and a normal inflammatory response. (springtimeinc.com)