Proteins1992ProteoglycansHyaluronanMembraneFibroblastsStructuralPericellular matrixGeneDifferencesHeparinMacromoleculesFibroticSubstrateModulatePhenotypeProteinHumanTypesProliferationCellsNetworkExtracellular matrixHeparan sulfateSulfate proteoglycanSulfatesMRNATissueGene familyGlucosamineEnzymesPathophysiologyRegulation
Proteins4
- Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. (wikipedia.org)
- The molecular changes characterising OA include the differential expression of matrix proteins, proteoglycans, collagens, metalloproteinases and their inhibitors in both cartilage and bone. (biomedcentral.com)
- Contrary to reef building corals, the red coral organic matrix possesses a large number of collagen-like proteins. (biomedcentral.com)
- The inferred regulatory function of these OM proteins suggests that the difference between the two biominerals is due to the modeling of the matrix network, rather than the presence of specific structural components. (biomedcentral.com)
19921
- Nutr.Most cancers 1992;17(1):77-83. (fairpeel.com)
Proteoglycans2
- This growth factor also stimulates production of collagens, proteoglycans, elastin, fibronectin, tenascin and thrombospondin, diminishes production of extracellularly active neutral endoproteinases belonging to the matrix metalloproteinase (MMP) and serine proteinase families, and stimulates production of endogenous MMP inhibitors (tissue inhibitor of metallo-proteinase [TIMP]) and serpins (plasminogen activator inhibitor-1). (biomedcentral.com)
- Muir H. Proteoglycans as organizers of the intercellular matrix. (lievers.net)
Hyaluronan1
- hyaluronan (HA), chondroitin sulfate (CS) and dermatan sulfate (DS), heparin and heparan sulphate (HS), and keratan sulfate (KS). (hindawi.com)
Membrane2
- Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. (wikipedia.org)
- GAGs bound into PGs are located to the extracellular matrix, basal membrane, and cell surface [ 7 ]. (hindawi.com)
Fibroblasts1
- The second occurs by influx of growth factors secreted by macrophages, platelets and fibroblasts, by fibroblast proliferation and subsequent synthesis and remodelling of collagenous dermal matrix. (worldwidewounds.com)
Structural1
- Structural differences of matrix metalloproteinases. (wikipedia.org)
Pericellular matrix2
- Some cytokines act as competence rather than progression factors, some lack secretory signals, and some must be processed and released from the pericellular matrix or basement membranes (eg transforming growth factor beta [TGF-β ] binding to chondroitin or the keratan sulfate of biglycan, decorin and fibromodulin, or basic fibroblast growth factor and platelet derived growth factor binding to the heparin sulfate of glypican, perlecan and syndecan). (biomedcentral.com)
- Free GAGs chains are secreted to the extracellular space and distributed both in the pericellular matrix and extracellular matrix proper. (hindawi.com)
Gene1
- Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene. (wikipedia.org)
Differences1
- Furthermore, comprehensive analysis of acellular matrix ECM details significant compositional differences between normal and fibrotic lungs, paving the way for further study of novel hypotheses. (atsjournals.org)
Heparin1
- Glycosaminoglycans (GAGs) comprise a class of linear, negatively charged polysaccharides composed of repeating disaccharide units of acetylated hexosamines (N-acetyl-galactosamine in the case of chondroitin sulphate and dermatan sulfate or N-acetyl-glucosamine in the case of heparin sulphate and heparin) and mainly of uronic acids (d-glucuronic acid or l-iduronic acid) being sulfated at various positions. (hindawi.com)
Macromolecules2
- Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules. (lookformedical.com)
- The model focuses on the role of charged matrix macromolecules in determining the mechanical behavior of the tissue. (lievers.net)
Fibrotic2
- in this manner we show that fibrotic matrices clearly promote transforming growth factor-β-independent myofibroblast differentiation compared with normal matrices. (atsjournals.org)
- Extracellular matrix is important in driving cellular phenotypic responses in fibrotic and other lung disorders. (atsjournals.org)
Substrate2
- This precompiled information serves as a substrate and matrix to embed your contributions, but it is by no means the final word - Homo sapiens can do much better! (wikigenes.org)
- This process results in a more physiologic substrate that retains normal stiffness, architecture, and matrix composition compared with native lungs. (atsjournals.org)
Modulate2
- Specifically, these extracellular matrix (ECM) components critically modulate the tumor cell "motile phenotype" affecting their adhesive/migratory abilities which are directly correlated to the metastatic cascade [ 5 , 6 ]. (hindawi.com)
- Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. (lookformedical.com)
Phenotype2
- Extracellular matrix (ECM) is a dynamic tissue that contributes to organ integrity and function, and its regulation of cell phenotype is a major aspect of cell biology. (atsjournals.org)
- We define a new method to prepare acellular lung matrix that can be used to study the impact of extracellular matrix on lung cell phenotype. (atsjournals.org)
Protein1
- In order to gain insight into the red coral biomineralization process and cnidarian biomineralization evolution, we studied the protein repertoire forming the organic matrix (OM) of its two biominerals. (biomedcentral.com)
Human1
- By using human lungs and cells, this new system provides a novel way to culture cells in vitro to investigate matrix contributions to lung pathology in a disease-specific manner. (atsjournals.org)
Types1
- A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. (lookformedical.com)
Proliferation1
- The TGF-β family forms an important group of growth factors, consisting of three isoforms in man, and is important for matrix deposition because it modulates fibroblast recruitment and proliferation. (biomedcentral.com)
Cells1
- The resultant matrices can be sectioned as uniform slices within which cells were cultured. (atsjournals.org)
Network1
- A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. (lookformedical.com)
Extracellular matrix17
- Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. (wikipedia.org)
- Converging lines of evidence point to a critical role of brain extracellular matrix (ECM) molecules in the pathophysiology of substance use disorders. (frontiersin.org)
- The turnover of hyaluronan in the mammalian body is surprisingly high for an extracellular matrix (ECM) component. (gr.jp)
- Chondrocytes are exposed to an inflammatory micro-environment in the extracellular matrix (ECM) of articular cartilage in joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). (biomedcentral.com)
- There is evidence that cartilage extracellular matrix (ECM) undergoes alterations during OA pathogenesis in terms of glycosaminoglycan (GAG) and water content [ 4 ]. (biomedcentral.com)
- Our findings suggest that TGF beta 1 has a protective effect on the extracellular matrix of human articular chondrocytes. (uni-bielefeld.de)
- MMPs in turn increase proteolysis of different protein substrates in the extracellular matrix particularly collagen and elastin, leading to weakening of the vein wall. (oaepublish.com)
- MMPs are Zn 2+ -dependent endopeptidases that cause degradation of different protein substrates in the extracellular matrix (ECM). (oaepublish.com)
- In biology , the extracellular matrix ( ECM ) is the extracellular part of animal tissue that usually provides structural support to the cells in addition to performing various other important functions. (wikidoc.org)
- The extracellular matrix is the defining feature of connective tissue in animals. (wikidoc.org)
- Extracellular matrix includes the interstitial matrix and the basement membrane . (wikidoc.org)
- Formation of the extracellular matrix is essential for processes like growth , wound healing and fibrosis . (wikidoc.org)
- An understanding of ECM structure and composition also helps in comprehending the complex dynamics of tumor invasion and metastasis in cancer biology [1] as metastasis often involves the destruction of extracellular matrix [3] by enzymes such as serine and Threonine proteases and Matrix metalloproteinase . (wikidoc.org)
- Described below are the different types of proteoglycan found within the extracellular matrix. (wikidoc.org)
- It occurs as a proteoglycan (PG) in which two or three HS chains are attached in close proximity to cell suface or extracellular matrix proteins. (wikidoc.org)
- In the extracellular matrix, especially basement membranes , the multi-domain proteins perlecan , agrin and collagen XVIII are the main proteins to which heparan sulfate is attached. (wikidoc.org)
- In biology , the extracellular matrix ( ECM ), also called intercellular matrix , [1] [2] is a network consisting of extracellular macromolecules and minerals, such as collagen , enzymes , glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells. (knowpia.com)
Heparan sulfate2
- 16. Matrix metalloproteinase-dependent shedding of syndecan-3, a transmembrane heparan sulfate proteoglycan, in Schwann cells. (nih.gov)
- 18. Membrane-anchored proteoglycans of mouse macrophages: P388D1 cells express a syndecan-4-like heparan sulfate proteoglycan and a distinct chondroitin sulfate form. (nih.gov)
Sulfate proteoglycan1
- 11. Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain. (nih.gov)
Sulfates2
- They have both hydrolytic and transglycosidase activities a and can degrade hyaluronan and chondroitin sulfates (CS), specifically C4-S and C6-S, as well as, to a small extent, dermatan sulfate (DS). (gr.jp)
- Chondroitin sulfates contribute to the tensile strength of cartilage, tendons , ligaments and walls of the aorta . (wikidoc.org)
MRNA2
- Pro-inflammatory IL-1beta and/or TNF-alpha up-regulate matrix metalloproteases-1 and -3 mRNA in chondrocyte subpopulations potentially pathogenic in osteoarthritis: in situ hybridization studies on a single cell level. (uni-bielefeld.de)
- Alterations in the mRNA expression, protein levels and proteolytic activity of matrix metalloproteinases (MMPs) have been detected in VVs and VLU. (oaepublish.com)
Tissue3
- To investigate the role of interleukin-6 (IL-6) and transforming growth factor beta 1 (TGF beta 1) in the regulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) synthesis in human articular chondrocytes. (uni-bielefeld.de)
- Other lines of treatment including induction of endogenous tissue inhibitors of metalloproteinases and administration of exogenous synthetic inhibitors of MMPs are being explored, and could provide alternative strategies in the treatment of CVD. (oaepublish.com)
- MMPs are negatively controlled by endogenous tissue inhibitors of metalloproteinases (TIMPs), and an imbalance between MMPs and TIMPs could contribute to venous dysfunction and CVD [ 1 , 5 ] . (oaepublish.com)
Gene family1
- 17. Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans. (nih.gov)
Glucosamine2
- Taking glucosamine with or without chondroitin increases the effects of warfarin. (nih.gov)
- Glucosamine-chondroitin and glucosamine or chondroitin sulfate alone show medium-term benefits with no long-term benefits for pain or function. (medscape.com)
Enzymes1
- It is now widely accepted that inflammatory mediators produced by chondrocytes and synoviocytes such as pro-inflammatory cytokines, nitric oxide (NO), reactive oxygen species (ROS) and matrix degrading enzymes play a role in the initiation and propagation of pathogenic OA processes [ 3 ]. (biomedcentral.com)
Pathophysiology1
- More specifically, alterations observed in brain connectivity, as well as in activation of brain stem, hypothalamic, and thalamocortical circuits are suspected to play key roles in the disorder [ 4. Charles A. The pathophysiology of migraine: implications for clinical management. Lancet Neurol. 2018; 17: 174-182. [ CrossRef ] ">4 ]. (lidsen.com)
Regulation1
- v DISSERTATION ABSTRACT DIFFERENTIAL MODULATION OF GLUTAMATERGIC SYNAPTIC TRANSMISSION BY POLYSIALIC ACID Catrina Sims-Robinson Doctor of Philosophy, December 17, 2007 (B.S., Auburn University, 2004) 180 Typed Pages Directed by Vishnu Suppiramaniam Controlled modulation and regulation of glutamate receptors are essential for synaptogenesis and synaptic plasticity. (auburn.edu)