OsteoarthritisArticular cartilageHypertrophic chondrocytesCells called chondrocytesImplantationHypertrophyDifferentiationOsteoarthritic and normalProliferationCulturesDifferentiateTissueViable chondrocytesCatabolismDegradationExamined in cartilageMineralizationApoptosisOsteoblastsVitroCollagenInflammatoryMesenchymalPorcineMethodsInduceMetalloproteinaseProteoglycansHumanMRNACartilage integrityExpressionFgfr3FetalPhenotypeCharacteristicsSynthesisTransplantationPrimaryViabilityMaintenance of cartilageResponsesHomeostasisTissuesInflammation
Osteoarthritis5
- Effects of Superoxide Dismutase 1 on cartilage chondrocyte metabolism: a protective mechanism against ankle osteoarthritis? (cardiff.ac.uk)
- The inflammatory environment is correlated with extracellular matrix (ECM) degradation and chondrocyte hypertrophy in the development of osteoarthritis (OA). (oncotarget.com)
- Chondrocytes are involved in cartilage responses to diseases like osteoarthritis. (difference.wiki)
- In osteoarthritis (OA), the most common form of arthritis, chondrocytes exhibit aberrant and increased production of pro-inflammatory mediators and matrix degrading enzymes such as IL-1β and MMP-13. (harvard.edu)
- Variations in chondrocyte density and organization in cartilage histology sections are associated with osteoarthritis progression. (cdc.gov)
Articular cartilage12
- Similar to chondrocytes present in articular cartilage, NC express extracellular matrix proteins such as glycosaminoglycans and collagen. (wikipedia.org)
- Articular chondrocytes have typically been the cell type used for cartilage tissue engineering strategies for articular cartilage repair. (wikipedia.org)
- Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes. (ca.gov)
- To examine the impact of the gp130 cytokine family on murine articular cartilage and to explore a potential regulatory role of suppressor of cytokine signaling 3 (SOCS-3) in murine chondrocytes. (nih.gov)
- Chondrocyte apoptosis and expression of Bcl-2, Bax, Fas, and iNOS in articular cartilage in patients with Kashin-Beck disease. (jrheum.org)
- Chondrocytes were isolated from articular cartilage of ten patients with primary OA undergoing knee replacement surgery and six normal donors undergoing fracture repair surgery without history of joint disease and no OA clinical manifestations. (biomedcentral.com)
- The most advanced cartilage repair techniques is the articular chondrocyte implantation (ACI), which leads to a normally functioning articular cartilage and provides the stability to the joint. (phoenixshoulderandknee.com)
- Autologous Chondrocyte Implantation (ACI) is an advanced surgical procedure used to treat larger articular cartilage defects in joints. (thekneesurgeon.com)
- To investigate the expression of granzyme B (GrB) in normal and rheumatoid arthritis (RA) articular cartilage, and to analyze the relationship between the expression of GrB and apoptotic chondrocytes in RA cartilage. (elsevierpure.com)
- Samples underwent automated controlled freezing at various stages of preparation: as intact articular cartilage discs, as minced articular cartilage, and as chondrocytes immediately after enzymatic isolation from fresh articular cartilage. (ox.ac.uk)
- This experiment demonstrated that it is possible to isolate viable chondrocytes from cryopreserved intact human articular cartilage which can then be successfully cultured. (ox.ac.uk)
- The chondrocytes are responsible for the synthesis, maintenance, degradation, and repair of articular cartilage. (drlintner.com)
Hypertrophic chondrocytes2
- In vitro, tenocyte-like cells extracted from the rotator cuff were able to mineralize in osteogenic cultures, and expressed , , and , which are hypertrophic chondrocytes markers. (iasp-pain.org)
- At a terminal differentiation stage, cells expressing an osteoblast-like phenotype appeared either by transdifferentiation from hypertrophic chondrocytes or directly from osteoblast precursor cells. (uni-luebeck.de)
Cells called chondrocytes2
- The CCN6 protein is made in cells called chondrocytes, which produce and maintain cartilage, and is associated with the production of certain proteins that make up cartilage, but its role in their production is unclear. (medlineplus.gov)
- Articulate cartilage is a firm gel-like complex material, composed of collagenous fibers and cells called chondrocytes. (lu.se)
Implantation3
- Autologous Chondrocyte Implantation (ACI) is a procedure suitable for larger cartilage defects in the knee (larger than 2 by 3 cm). (goravdatta.com)
- Efficacy and safety of autologous chondrocyte implantation for. (mysciencework.com)
- Efficacy and safety of autologous chondrocyte implantation for osteochondral defects of the talus: a systematic review and meta-analysis. (mysciencework.com)
Hypertrophy4
- While hypertrophy of chondrocytes is a physiological process implicated in the longitudinal growth of long bones, hypertrophy-like alterations in chondrocytes play a major role in OA. (biomedcentral.com)
- Wogonoside also inhibited hypertrophy and the generation of vascular endothelial growth factor (VEGF) in interleukin-1β (IL-1β)-induced chondrocytes. (oncotarget.com)
- In conclusion, our stduy demonstrates that wogonoside attenuates IL-1β-induced ECM degradation and hypertrophy in mouse chondrocytes via suppressing the activation of NF-κB/HIF-2α by the PI3K/AKT pathway. (oncotarget.com)
- WISP-2 expression is modulated along chondrocyte differentiation and downregulated at the onset of hypertrophy by inflammatory mediators. (harvard.edu)
Differentiation5
- Similar to other chondrocytes from hyaline cartilage tissues in other locations in the human body, NC undergo a process of cell de-differentiation during monolayer culture. (wikipedia.org)
- Studies that directly compared the re-differentiation of articular chondrocytes to NC have shown that the cartilage forming capacity of NC was higher and more reproducible than that of articular chondrocytes with lower donor-related dependency. (wikipedia.org)
- The transcriptional cofactor Jab1/Cops5 is crucial for BMP-mediated mouse chondrocyte differentiation by repressing p53 activity. (ouhsc.edu)
- In clonal cultures of chondrocytes isolated from embryoid bodies, additional mesenchymal cell types expressing adipogenic properties were observed, which suggests that the subcultured chondrocytes indeed exhibit a certain differentiation plasticity. (uni-luebeck.de)
- A fibroblast growth factor receptor that regulates CHONDROCYTE growth and CELL DIFFERENTIATION. (bvsalud.org)
Osteoarthritic and normal2
- Here, we show that in primary human femoral head osteoarthritic and normal bovine chondrocytes, TWHF partially or completely inhibited mRNA and protein expression of tumor necrosis factor-α, interleukin (IL)-1, and IL-17-inducible MMP-3 and MMP-13. (aspetjournals.org)
- We performed a quantitative proteomic analysis in osteoarthritic and normal chondrocytes followed by functional analyses to investigate proteome changes and molecular pathways involved in OA pathogenesis. (biomedcentral.com)
Proliferation7
- Although articular chondrocytes derived from older individuals have been shown to have a lower proliferation capacity than from younger donors, NC have been shown to have significantly less age-dependence. (wikipedia.org)
- In the present study we investigated Dexa's in vitro effects on the growth of cell proliferation and the induction of apoptosis in canine Achilles tendon cells and chondrocytes. (vin.com)
- The results showed that Dexa could inhibit the proliferation of tendon cells and chondrocytes at increasing concentrations (0.1-50 µg/ml) in compared with untreated cells. (vin.com)
- Platelet-rich plasma stimulates porcine articular chondrocyte proliferation and matrix biosynthesis. (qxmd.com)
- The purpose of this study was to examine the effects of PRP on cell proliferation and matrix synthesis by porcine chondrocytes cultured in alginate beads, conditions that promote the retention of the chondrocytic phenotype, in order to determine the plausibility of using this plasma-derived material for engineering cartilage. (qxmd.com)
- The viability and proliferation of human chondrocytes following cryopreservation. (ox.ac.uk)
- Isolated chondrocytes were then cultured and Alamar blue assay was used for estimation of cell proliferation at days zero, four, seven, 14, 21 and 28 after seeding. (ox.ac.uk)
Cultures4
- Primary cell cultures obtained from gonarthrosis patients were divided into four groups, two of which were designated as control cultures of chondrocyte and osteocyte, and the other two groups were exposed to BAs administered via the culture medium. (biomedcentral.com)
- Moreover we assay, on NCTC 2544 and chondrocytes cultures, the flavonoids capacity to modulate NO and glycosamminoglycans levels, index of antidegenerative capacity. (unict.it)
- As a first step we attempted to induce cartilage mineralization in vitro, using micromass primary chondrocyte cultures, incubated with BMP2 and/or WISP1, which were examined histologically following a 3-week culture period. (iucc.ac.il)
- Micromass cultures exhibited an osseous inducing trend following WISP1 administration, which was maintained in chondrocyte seeded scaffolds. (iucc.ac.il)
Differentiate6
- Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline Phosphatase-Dependent Manner. (iasp-pain.org)
- We provide evidence that tenocytes have a propensity to differentiate into hypertrophic chondrocyte-like cells to produce TNAP-dependent calcium deposits. (iasp-pain.org)
- As they age and become surrounded by the matrix they've produced, chondroblasts differentiate into chondrocytes. (difference.wiki)
- Chondroblasts differentiate into chondrocytes once encased in the matrix. (difference.wiki)
- Here, we show that embryonic stem cells differentiate into chondrocytes, which progressively develop into hypertrophic and calcifying cells. (uni-luebeck.de)
- Mesenchymal stem cells are activated and differentiate into chondrocytes which produce type I and II collagen to fill the defect. (drlintner.com)
Tissue12
- Nasal chondrocytes (NC) are present in the hyaline cartilage of the nasal septum and in fact are the only cell type within the tissue. (wikipedia.org)
- Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. (karger.com)
- Calcifications were amorphous areas surrounded by a fibrocartilaginous metaplasia containing hypertrophic chondrocyte-like cells that expressed tissue non-specific alkaline phosphatase (TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), which are two key enzymes of the mineralization process. (iasp-pain.org)
- Moreover, the relative expression level of lncRNA GAS5 in cartilage tissue and chondrocytes was detected using reverse transcription‑quantitative PCR. (spandidos-publications.com)
- Western blot analysis was used to detect protein expression levels of MMP‑9, MMP‑13, TIMP‑1, TIMP‑3 and type II collagen in cartilage tissue and chondrocytes. (spandidos-publications.com)
- Furthermore, silencing of lncRNA GAS5 expression in IL‑1β‑treated chondrocytes downregulated the protein expression of MMP-9 and MMP-13 whilst upregulating the expression of tissue inhibitor matrix metalloproteinase (TIMP)-1, TIMP-3 and type II collagen. (spandidos-publications.com)
- The present study examines whether hypoxia can influence chondrocyte NHE activity and pH(i) over shorter timescales using the pH-sensitive fluoroprobe BCECF in cells isolated not only from equine cartilage but also from bovine tissue. (ox.ac.uk)
- PRP isolated from autologous blood may be useful as a source of anabolic growth factors for stimulating chondrocytes to engineer cartilage tissue. (qxmd.com)
- The harvested cartilage tissue is sent to a laboratory, where the cartilage cells (chondrocytes) are isolated and cultured. (thekneesurgeon.com)
- Chondrocytes implanted into critical cranial defect expedite the formation of native-like osseous tissue, especially after WISP1 priming in culture. (iucc.ac.il)
- Achondroplasia is caused by a mutation in the fibroblast growth factor receptor 3 ( FGFR3 ) gene that results in inhibited mineralization of chondrocytes (cartilage cells) in the growth plate (growing tissue near the ends of the long bones). (medscape.com)
- The tissue damage stimulates chondrocytes to attempt repair, which increases production of proteoglycans and collagen. (msdmanuals.com)
Viable chondrocytes2
- Developing an accessible and cost-effective model to generate viable chondrocytes and to assess their response to different bioactive compounds can significantly advance our knowledge of cartilage biology and contribute to the discovery of novel therapeutic approaches. (lu.se)
- Results: The established protocol successfully generated a large quantity of viable chondrocytes, characterized by alcian blue and toluidine blue staining, and demonstrated versatility in assessing the anti-inflammatory effects of various bioactive compounds. (lu.se)
Catabolism2
- We also investigated the effect of WISP-2 on cartilage catabolism and performed WISP-2 loss-of-function experiments using RNA interference technology in human T/C-28a2 immortalized chondrocytes. (harvard.edu)
- We demonstrated that recombinant human WISP-2 protein reduced IL-1β-mediated chondrocyte catabolism, that IL-1β and WNT/b-catenin signaling pathways are involved in rhWISP-2 protein and IL-1β effects in human chondrocytes, and that WISP-2 has a regulatory role in attenuating the catabolic effects of IL-1β in chondrocytes. (harvard.edu)
Degradation3
- Treatment of Socs3(Δ/Δcol2) mouse cartilage explants and chondrocytes with gp130 cytokines prolonged JAK/STAT signaling, enhanced cartilage degradation, increased the expression of Adamts4, Adamts5, and RANKL, and elevated the production of IL-6, granulocyte colony-stimulating factor, CXCL1, and CCL2. (nih.gov)
- The results indicated that ABPS delayed the degradation of the ECM by chondrocytes in addition to reducing lncRNA GAS5 expression both in vivo and in vitro . (spandidos-publications.com)
- The targets and precise functions of GrB expressed in chondrocytes remain to be determined, but GrB may be involved in the remodeling mechanism of matrix macromolecules and the endogenous degradation of RA cartilage. (elsevierpure.com)
Examined in cartilage1
Mineralization3
- The primary goal of this research is to further our understanding of events controlling formation of calcified tissues by defining the factors in- fluencing matrix mineralization in cultured chondrocytes. (grantome.com)
- They will also utilize chondrocyte transfection assays to test the hypothesis that high levels of alkaline phosphatase or type X collagen induce changes leading to mineralization. (grantome.com)
- Vosoritide, a biologic analog of C-type natriuretic peptide, prevents the inhibition of mineralization of chondrocytes caused by the FGFR3 mutation. (medscape.com)
Apoptosis3
- Dexa increased the apoptosis of canine tendon cells and chondrocytes in a time-dependent manner. (vin.com)
- In addition, culturing with Dexa and the glucocorticoid receptor blocker mifepristone significantly arrested apoptosis of tendon cells and chondrocytes. (vin.com)
- Xu XX, Zhang XH, Diao Y and Huang YX: Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro. (spandidos-publications.com)
Osteoblasts6
- Scholars@Duke publication: Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes. (duke.edu)
- The goal of this study was to determine the elastic and viscoelastic properties of three primary cell types of mesenchymal lineage (chondrocytes, osteoblasts, and adipocytes) and to test the hypothesis that primary differentiated cells exhibit distinct mechanical properties compared to adult stem cells (adipose-derived or bone marrow-derived mesenchymal stem cells). (duke.edu)
- In an adherent, spread configuration, chondrocytes, osteoblasts, and adipocytes all exhibited significantly different mechanical properties, with osteoblasts being stiffer than chondrocytes and both being stiffer than adipocytes. (duke.edu)
- Factors leading to formation of mineralized matrix have been extensively studied in cultured osteoblasts and, to a lesser extent, in cultured chondrocytes. (grantome.com)
- Here we show that bone marrow endosteal SSCs are defined by fibroblast growth factor receptor 3 ( Fgfr3 ) and osteoblast-chondrocyte transitional (OCT) identities with some characteristics of bone osteoblasts and chondrocytes. (nature.com)
- Of note, we define OCT identities as a state with some characteristics of both osteoblasts and chondrocytes, instead of cell-type plasticity between osteoblasts and chondrocytes. (nature.com)
Vitro3
- In in vitro experiments, IL‑1β‑treated chondrocytes were infected with Lenti‑lncRNA GAS5. (spandidos-publications.com)
- used in B-cell-inhibiting treatments on human primary chondrocytes and osteocytes in vitro ). (biomedcentral.com)
- Next, chondrocyte seeded collagen scaffolds were evaluated in vitro for expression profiles and ALP activity. (iucc.ac.il)
Collagen6
- Moreover, wogonoside promoted the expression of anabolic factors Sox-9, type two collagen and aggrecan while inhibiting the expression of catabolic factors such as matrix metalloproteinases (MMPs) and thrombospondin motifs 5 (ADAMTS-5) in mouse chondrocytes. (oncotarget.com)
- We have shown that in cultured chondrocytes, ascorbic acid will also induce a transition from type II collagen to type X collagen. (grantome.com)
- Finally, chondrocyte-seeded collagen scaffolds were implanted in a Lewis rats 8 mm critical calvaria defect model, which was imaged via live CT for 12 weeks until sacrifice. (iucc.ac.il)
- Accordingly, in vivo analysis was carried out to assess the impact of WISP1-pretreated chondrocytes (WCS) versus untreated chondrocytes (UCS) in calvaria defect model and compared to untreated control comprised of a defect-associated blood clot (BC) or empty collagen scaffold (CS) implant. (iucc.ac.il)
- AC is composed of an extracellular matrix of mainly type II hyaline collagen and proteoglycan aggregate produced by a small population of chondrocytes. (drlintner.com)
- WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes. (medlineplus.gov)
Inflammatory6
- The results of this study highlight a key role for SOCS-3 in regulating chondrocyte responses during inflammatory arthritis. (nih.gov)
- The gp130 cytokine-driven production of RANKL in chondrocytes may link chondrocyte activation and bone remodeling during inflammatory arthritis. (nih.gov)
- A proinflammatory chondrocyte model was created by treating the chondrocytes with lipopolysaccharide and was subsequently used to evaluate the anti-inflammatory effects of vitamin D, curcumin, and resveratrol. (lu.se)
- Conclusions: Our novel protocol offers an accessible and cost-effective approach for generating chondrocytes from BMSCs and for evaluating potential therapeutic leads in the context of inflammatory chondrocyte-related diseases. (lu.se)
- Gene silencing of WISP-2 increased the induction of the catabolic markers MMP-13 and ADAMTS-5 and the inflammatory mediators IL-6 and IL-8 triggered by IL-1β in human primary OA chondrocytes in a Wnt/β-catenin dependent manner. (harvard.edu)
- Inflammatory mediators trigger an inflammatory cycle that further stimulates the chondrocytes and synovial lining cells, eventually breaking down the cartilage. (msdmanuals.com)
Mesenchymal2
- Objective: We developed a novel, streamlined protocol for generating chondrocytes from bone marrow-derived mesenchymal stem cells (BMSCs) in a 3D culture system that offers. (lu.se)
- Objective: We developed a novel, streamlined protocol for generating chondrocytes from bone marrow-derived mesenchymal stem cells (BMSCs) in a 3D culture system that offers significant implications for the study of cartilage biology and the discovery of potential therapeutic interventions for cartilage-related and associated disorders. (lu.se)
Porcine2
- Adult porcine chondrocytes were cultured in the presence of 10% PRP, 10% PPP or 10% fetal bovine serum (FBS) for 3 days. (qxmd.com)
- Biochemical analyses revealed that treatment with PRP growth factors did not markedly affect the types of PGs and collagens produced by porcine chondrocytes, suggesting that the cells remained phenotypically stable in the presence of PRP. (qxmd.com)
Methods2
- Methods: We developed a streamlined protocol for generating chondrocytes from BMSCs in a 3D culture system using an "in-tube" culture approach. (lu.se)
- Although our approach has several advantages, further investigation is required to address its limitations, such as the potential differences between chondrocytes generated using our protocol and those derived from other established methods, and to refine the model for broader applicability and clinical translation. (lu.se)
Induce2
- This study used etoposide, to induce DNA damage-related senescence or chronic exposure to IL-1β to entail inflammation-related senescence in human OA chondrocytes. (aging-us.com)
- Chronic exposure to IL-1β induces only partial expression of senescence markers and does not allow us to conclude on its ability to induce senescence in chondrocytes. (aging-us.com)
Metalloproteinase1
- Human monocyte or recombinant interleukin 1's are specific for the secretion of a metalloproteinase from chondrocytes. (ucdenver.edu)
Proteoglycans1
- The chondrocyte cells produce proteoglycans which bind to hyaluronic acid, forming large highly hydrophilic aggregates. (lu.se)
Human8
- CaMKII inhibition in human primary and pluripotent stem cell-derived chondrocytes modulates effects of TGFbeta and BMP through SMAD signaling. (ca.gov)
- Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes. (ca.gov)
- On the other hand, etoposide treatment reliably induces DNA damage-related senescence in human articular chondrocytes evidenced by loss of proliferative capacity, DNA damage accumulation, and expression of some SASP components. (aging-us.com)
- Specific attentions were to characterize pediatric auricular chondrocyte growth in a combination culture medium and to assess the possibility of elastic cartilage regeneration using human fibrin. (afpm.org.my)
- In the present study, we determined the expression of WISP-2 in healthy and OA human chondrocytes. (harvard.edu)
- Are biological agents toxic to human chondrocytes and osteocytes? (biomedcentral.com)
- GrB and PFN expression is present in normal human articular chondrocytes and elevated in RA chondrocytes. (elsevierpure.com)
- ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala(271). (rush.edu)
MRNA2
- Cartilage sections were analyzed by immunohistochemistry for the presence of GrB, and the mRNA expression of GrB in chondrocytes was analyzed by in situ hybridization and nonquantitative and semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR). (elsevierpure.com)
- In situ hybridization and RT-PCR confirmed the expression of GrB and PFN mRNA, and semiquantitative RT-PCR showed elevated concentrations of GrB and PFN expression in RA chondrocytes. (elsevierpure.com)
Cartilage integrity2
- Background: Chondrocytes are the primary cells responsible for maintaining cartilage integrity and function. (lu.se)
- The conserved nature and rapidity of the response to hypoxia has considerable implications for chondrocyte homeostasis and potentially for the maintenance of cartilage integrity. (ox.ac.uk)
Expression6
- In wild-type (WT) mouse chondrocytes, baseline receptor expression levels and gp130 cytokine-induced JAK/STAT signaling were determined by flow cytometry, and expression of SOCS-3 was assessed by quantitative polymerase chain reaction. (nih.gov)
- Fluorescence in situ hybridization assay was performed to measure the expression of the lncRNA GAS5 in chondrocytes. (spandidos-publications.com)
- To conclude, the present study provides evidence that ABPS can inhibit the expression of lncRNA GAS5 in chondrocytes to regulate the homeostasis of ECM, which in turn may delay the occurrence of cartilage degeneration during OA. (spandidos-publications.com)
- Sun X, Zhang J, Li Y, Ren W and Wang L: Etomidate ameliorated advanced glycation end-products (AGEs)-induced reduction of extracellular matrix genes expression in chondrocytes. (spandidos-publications.com)
- The immunohistochemical analyses revealed GrB and PFN expression in normal chondrocytes and a larger number of GrB and PFN-positive chondrocytes in RA cartilage. (elsevierpure.com)
- High level of expression detected in chondrocytes. (lu.se)
Fgfr31
- In this study, we report a novel population of SSCs with osteoblast-chondrocyte transitional (OCT) identities in the bone marrow endosteal space, which highly expresses Fgfr3 and contributes to both normal and aberrant osteogenesis. (nature.com)
Fetal1
- Ultrastructure of chondrocytes of fetal metarsals flown on IML-2, a preliminary report. (vu.nl)
Phenotype1
- This study provides evidence for further testing on the molecular mechanism of the disease and also propose proteins as candidate markers of OA chondrocyte phenotype. (biomedcentral.com)
Characteristics2
- Under certain stimuli, chondrocytes displayed chondroblast-like characteristics. (difference.wiki)
- Chondrocytes isolated from embryoid bodies initially dedifferentiated in culture but later re-expressed characteristics of mature chondrocytes. (uni-luebeck.de)
Synthesis1
- Chondrocyte intracellular pH (pH(i)) is a powerful modulator of matrix synthesis and is principally regulated by Na(+)-H(+) exchange (NHE). (ox.ac.uk)
Transplantation1
- Autologous chondrocyte transplantation (Carticel) was first performed to treat patellar defects in rabbits in 1984. (drlintner.com)
Primary2
- Chondrocytes from OA patients were used in primary culture and stimulated with 10 ng/ml interleukin(IL)-1β in the presence or absence of AD-MSC microvesicles, exosomes or conditioned medium. (karger.com)
- Chondrocytes then become the primary cells in mature cartilage, residing in spaces called lacunae. (difference.wiki)
Viability1
- The inhibitory doses had no adverse effect on the viability of chondrocytes. (aspetjournals.org)
Maintenance of cartilage1
- Chondroblasts and chondrocytes both play crucial roles in the formation and maintenance of cartilage. (difference.wiki)
Responses2
- Within the gp130 cytokine family, OSM is a potent stimulus of chondrocyte responses, while IL-6 probably signals via trans-signaling. (nih.gov)
- These results show that translational control provides a rapid and potentially important mechanism for controlling the synthetic responses of articular chondrocytes in response to different types of mechanical load. (ox.ac.uk)
Homeostasis2
- Therefore, the present study aimed to investigate the potential mechanism of ABPS by focusing on its effects on the regulation of chondrocyte extracellular matrix (ECM) homeostasis, with particular emphasis on lncRNA GAS5. (spandidos-publications.com)
- Rapid effects of hypoxia on H+ homeostasis in articular chondrocytes. (ox.ac.uk)
Tissues1
- Articular chondrocytes experience low oxygen (O(2)) levels compared with many other tissues, and values fall further in disease states. (ox.ac.uk)
Inflammation1
- The chondrocytes exhibited reduced inflammation, as evidenced by the decreased tumor necrosis factor-α levels, in response to vitamin D, curcumin, and resveratrol treatment. (lu.se)