CavityHyaline cartilageArticular cartilageNoseDeformityTissueCellsAnteriorCultureSpecificLowerBiopsyTracheaCartilage tissueGraftsAutologousDeviationImplantationReproducibleReconstructionExtracellularCollagenDifferentiationProminenceCaudalFacialValveDefectsBiomechanicalProcedureMethodsNoseCorrectionSurgeryPresentShapeExternalYearTechnique
Cavity4
- Several bones that help form the walls of the nasal cavity have air-containing spaces called the paranasal sinuses, which serve to warm and humidify incoming air. (usk.ac.id)
- Its purpose is not only to condition and cleanse inhaled air, but also to facilitate a transnasal airstream which contributes to maintaining the inner milieu of the nasal cavity and thus the noses' function [ 1 ]. (degruyter.com)
- This pressure is equal to the pressure within the nasopharynx where both sides of the nasal cavity merge. (degruyter.com)
- upper respiratory tract - consisting of the nose, nasal cavity and the pharynx. (edu.au)
Hyaline cartilage6
- Nasal chondrocytes (NC) are present in the hyaline cartilage of the nasal septum and in fact are the only cell type within the tissue. (wikipedia.org)
- The remaining cartilaginous part (characterized as hyaline cartilage) of the human nasal septum has a specific three-dimensional organization with regards to local differences in cell size and the amounts of extracellular matrix. (wikipedia.org)
- Similar to other chondrocytes from hyaline cartilage tissues in other locations in the human body, NC undergo a process of cell de-differentiation during monolayer culture. (wikipedia.org)
- Although hyaline cartilage's regenerative capacity is limited, certain areas such as the nasal septum and ear can regenerate small amounts of hyaline cartilage. (facts.net)
- Hyaline cartilage is composed of chondrocytes, which are specialized cells responsible for the production and maintenance of the extracellular matrix. (facts.net)
- Hyaline cartilage is a type of connective tissue that consists of chondrocytes (cartilage cells) embedded in a matrix of collagen and proteoglycans. (medicalcafe.org)
Articular cartilage3
- Similar to chondrocytes present in articular cartilage, NC express extracellular matrix proteins such as glycosaminoglycans and collagen. (wikipedia.org)
- Articular chondrocytes have typically been the cell type used for cartilage tissue engineering strategies for articular cartilage repair. (wikipedia.org)
- Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational. (thenakedscientists.com)
Nose7
- This is because,, except for some small bones at the bridge, the bulk of the nose is built from nasal cartilage. (thenakedscientists.com)
- The root, or radix, of the nose is located where the nasal bones project from the frontal bone. (medscape.com)
- Nasal height (NH) measures the distance from the radix to the base of the nose. (medscape.com)
- A saddle nose has a concave nasal dorsum. (medscape.com)
- Paradoxically, in the short nose with an upwardly rotated tip, nasal height may be perfectly normal. (medscape.com)
- Although the nasal tip has several ideal qualities, the 2 most important qualities of the short nose, for purposes of discussion, are critical-tip projection and tip rotation. (medscape.com)
- This method allows assessment of the nasal resistance of both sides of the nose as function of the volume flow rate through that side of the nose. (degruyter.com)
Deformity1
- This type of deformity typically involves all 3 layers of nasal tissue (ie, skin, internal lining, skeletal support). (medscape.com)
Tissue3
- Nasal cartilage is tightly connected to perichondrium, consisting of several layers of connective tissue fibers (mainly based on type I collagen) running parallel to the cartilage. (wikipedia.org)
- Cell yield after enzymatic digestion of the nasal cartilage was estimated to be 2,100 - 3,700 cells/mg of tissue. (wikipedia.org)
- connective tissue - bounded by fibrous (interlobular) septa and containing internal (interlobular) septa. (edu.au)
Cells3
- Cartilage is the slippery "anatomical Teflon" secreted by specialised cells called chondrocytes. (thenakedscientists.com)
- Our findings confirm the safety and feasibility of cartilage grafts engineered from nasal cells to repair damaged knee cartilage. (thenakedscientists.com)
- Then the cultured chondrocyte cells are grafted into the region of cartilage damage. (apollospectra.com)
Anterior4
- In the second half of the first year of life, the septum progressively ossifies in posterior-anterior direction by a process of endochondral ossification. (wikipedia.org)
- On anterior view, the border of the nasal dorsum should be evident as a smooth, gentle curve from the eyebrow through the glabella into the shadow line of the nasal dorsum and into the alar facial crease. (medscape.com)
- Anterior rhinomanometry is the current gold standard for the objective assessment of nasal breathing by determining the nasal resistance. (degruyter.com)
- The current gold standard in the assessment of nasal airflow is the anterior rhinomanometry (RMM). (degruyter.com)
Culture2
- Alternatively, NC can be isolated by outgrowth culture of nasal cartilage fragments. (wikipedia.org)
- This was treated with enzymes to release the cartilage-producing chondrocytes which were then incubated in a culture vessel containing a suitable growth medium for fourteen days to increase their numbers. (thenakedscientists.com)
Specific1
- Thus, identifying a specific cause of the perception of impaired nasal breathing is often difficult. (degruyter.com)
Lower1
- Studies that directly compared the re-differentiation of articular chondrocytes to NC have shown that the cartilage forming capacity of NC was higher and more reproducible than that of articular chondrocytes with lower donor-related dependency. (wikipedia.org)
Biopsy2
- Cartilage grafts used in the procedure were cultured from chondrocytes removed via biopsy from the nasal septum. (medscape.com)
- There were no adverse reactions during the 24 months after implantation, and no adverse reactions in the sites of septum cartilage biopsy. (medscape.com)
Trachea2
- During stage 13 (embryo is 28 days old), the trachea and lung buds become more evident as the esophagus, respiratory tract, and tracheoesophageal septum elongates. (medscape.com)
- At the beginning of the fetal period (30 mm crown-rump [C-R] stage), the chondrocytes are well identified within the incomplete rings of the trachea. (medscape.com)
Cartilage tissue3
- Cells from the nasal septum can be used to generate cartilage tissue grafts for knee repair, according to a proof-of-principle study that enrolled 10 patients. (medscape.com)
- Bone marrow-derived stem cells (BMSCs) and chondrocytes have been reported to present "dedifferentiation" and "phenotypic loss" during the chondrogenic differentiation process in cartilage tissue engineering, and cartilage progenitor cells (CPCs) are novel seeding cells for cartilage tissue engineering. (biomedcentral.com)
- Cartilage progenitor cells may undergo chondrogenesis without chondrogenic induction and are better at chondrogenesis than BMSCs but worse than chondrocytes in the application of cartilage tissue engineering. (biomedcentral.com)
Grafts1
- Nasal chondrocytes maintained their chondrogenic properties even after extensive expansion in culture and were able to generate biochemically and biomechanically mature tissue grafts large enough to be clinically useful. (medscape.com)
Autologous1
- The researchers harvested nasal chondrocytes from 6-mm-diameter punch biopsies of autologous septal cartilage. (medscape.com)
Deviation2
- The study demonstrated the degree of nasal deviation correction which can be obtained from the use of a cartilage graft, when placed underneath the nostril from inside the nose. (newfaceny.com)
- Linear nasal deviation has a consistent pattern which is typically seen in patients with developmentally crooked noses and can be measured pre-operatively. (newfaceny.com)
Implantation1
- The chondrocyte-PHBV constructs and CPC-PHBV constructs became an ivory-whitish cartilage-like tissue, while the BMSC-PHBV constructs became vascularized 6 weeks after the subcutaneous implantation. (biomedcentral.com)
Reproducible2
- Studies that directly compared the re-differentiation of articular chondrocytes to NC have shown that the cartilage forming capacity of NC was higher and more reproducible than that of articular chondrocytes with lower donor-related dependency. (wikipedia.org)
- Compared with articular chondrocytes, chondrocytes derived from the nasal septum have superior and more reproducible capacity to generate hyaline-like cartilage tissues, with the plasticity to adapt to a joint environment," the authors write. (medscape.com)
Reconstruction2
- Indeed, a retrospective, single-surgeon study by Okland et al indicated that a bilobed flap, adequately thinned of excess subcutaneous tissue, can effectively serve as a transposition flap for the reconstruction of small nasal tip defects. (medscape.com)
- The radial forearm flap is based off of the radial artery and vein and some soft tissue and can be used to reconstruct the nasal lining or perform a total reconstruction using multiple paddles. (medscape.com)
Extracellular1
- Cartilages are a type of connective tissue that is made up of chondrocytes and an extracellular matrix. (pediaa.com)
Collagen2
- Nasal cartilage is tightly connected to perichondrium, consisting of several layers of connective tissue fibers (mainly based on type I collagen) running parallel to the cartilage. (wikipedia.org)
- Fibrocartilage is a cartilage that is made up of thick, compact, parallel collagen bundles and chondrocytes. (pediaa.com)
Differentiation2
- However, an increasing number of studies have demonstrated that although chondrogenically differentiated BMSCs show chondrogenic potential in advance, these cells tend to eventually vascularize or ossify, undergo terminal chondrocyte differentiation and are replaced by osseous tissue, which indicates that the chondrogenic differentiation of BMSCs represents a transient state only [ 10 ]. (biomedcentral.com)
- It is characterized by the presence of spindle cells with myoblastic differentiation, a myxoid stroma, and fibrous septa. (nih.gov)
Prominence2
- These defects, even though they may involve small defects of the nasal tip, can be difficult to repair because of the prominence of the nasal tip. (medscape.com)
- During normal development the frontonasal mass begins as wide prominence but then the nasal pits relocate to the midline, causing dramatic medio-lateral narrowing. (ubc.ca)
Caudal1
- It is of utmost importance that cartilage is only harvested from the central part of the septum, with preservation of at least 1 cm of the caudal and dorsal septal struts. (medscape.com)
Facial2
- The fate of the frontonasal mass is to form the premaxilla, nasal septum and facial midline. (ubc.ca)
- This chapter explored the current understanding of facial asymmetry and how it affects nasal positioning. (newfaceny.com)
Valve1
- Potential adverse reactions at the harvest site-eg, septal deviations or disturbances of the nasal valve or external nasal shape-should be examined and reported with special care. (medscape.com)
Defects1
- A study by Kelly-Sell et al indicated that a superiorly based bilobed flap can be used to repair larger, more cephalic, or more lateral nasal defects while minimizing the risk for lower nasal distortion that would be encountered if a laterally based bilobed flap were used for such defects. (medscape.com)
Biomechanical1
- This paper presented a new theory for nasal tip support which was based on biomechanical testing of cartilage strength as well as review of previous models. (newfaceny.com)
Procedure2
- Harvesting of nasal cartilage is minimally invasive, can be performed in an outpatient procedure under local anesthesia and is associated with minimal morbidity. (wikipedia.org)
- clinical improvements with nasal chondrocyte tissue implants did not fade between 6 and 24 months, as had been seen with the older procedure. (medscape.com)
Methods1
- The researchers turned to nasal chondrocytes in an attempt to improve on previous methods that used chondrocytes taken from healthy cartilage in the injured joint. (medscape.com)
Nose1
- The use of this graft allows for correction of the crooked nose without having to perform nasal tip surgery. (newfaceny.com)
Correction1
- When read in chronological order, it shows how his techniques for nasal correction have evolved, based on scientific evidence. (newfaceny.com)
Surgery2
- The subalar graft can be harvested during routine surgery on the septum. (newfaceny.com)
- The fast development of more atraumatic and refined operative techniques in the last decade, and the importance of good long-term results and dwindling mishaps in nasal surgery, emphasize the need for an up-to-date, step-by-step operative guide. (rhinoplasty.nl)
Present1
- Histological examination showed that many typical cartilage structures were present in the chondrocyte group, some typical cartilage structures were observed in the CPC group, while no typical cartilage structures were observed in the BMSC group. (biomedcentral.com)
Shape1
- the cartilage shape requirements for an aesthetically pleasing nasal tip. (newfaceny.com)
External1
- Anatomy and Structure of the Nasal Tip The nasal architecture is complex, and assessing its external appearance requires critical understanding of the underlying structure. (newfaceny.com)
Year1
- In the second half of the first year of life, the septum progressively ossifies in posterior-anterior direction by a process of endochondral ossification. (wikipedia.org)
Technique2
- Augmentation of Nasal Tip Projection Using the Inferior Turbinate: Review of Technique and Evaluation of Long Term Success. (newfaceny.com)
- This paper was a review of a technique for using inferior turbinate bone as a structural nasal tip supporting graft. (newfaceny.com)