• density
  • The high mineral density is attributed to the depth related pressure and the change in temperature from 20 °C+ at the surface to 8 °C at 600 meters depth generates the movement of this layer. (wikipedia.org)
  • fatty substances
  • These three vascular disease conditions (heart attack, stroke, and peripheral vascular disease) can be associated with the same cause, atherosclerosis (a build-up of plaque, which is a deposit of fatty substances, cholesterol, cellular waste products, calcium, and fibrin in the inner lining of an artery), and are all linked to the same risk factors. (nyhq.org)
  • Statins
  • Statins are one kind of drug that lowers cholesterol and has been proven to reduce the chance of heart disease. (medlineplus.gov)
  • Medications that lower cholesterol are called statins. (medicinenet.com)
  • HMG-CoA reductase inhibitors, commonly known as statins, are one class of drugs that lower blood cholesterol levels. (medicinenet.com)
  • Statins reduce the production of cholesterol by the liver by blocking an enzymatic reaction in the process of cholesterol synthesis. (medicinenet.com)
  • Controlling Cholesterol with Statins. (medicinenet.com)
  • Statins are particularly well suited for lowering LDL, the cholesterol with the strongest links to vascular diseases. (wikipedia.org)
  • Heterozygous FH is normally treated with statins, bile acid sequestrants, or other lipid lowering agents that lower cholesterol levels. (wikipedia.org)
  • Further research has suggested the role of cholesterol and possibly statins improving the mortality in patients suffering from breast cancer, lung cancer, prostate cancer and bowel cancer. (wikipedia.org)
  • Further research presented in 2016 showed the role of high cholesterol and possibly the role of statins improving the mortality and survival of patients with breast cancer, lung cancer, bowel cancer and prostate cancer and strengthening calls for a clinical trial of statins in cancer. (wikipedia.org)
  • Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body. (wikipedia.org)
  • Fibrates
  • Since fibrates increase the cholesterol content of bile, they increase the risk for gallstones. (wikipedia.org)
  • However, It is not recommended to combine statin medication treatment with certain other cholesterol-lowering medications, particularly fibrates, because this may increase the risk of myopathy-related adverse effects. (wikipedia.org)
  • liver
  • Low levels of protein in the blood stimulate the synthesis of protein in the liver, leading to increased production of lipoproteins. (news-medical.net)
  • Cholesterol in the body is produced by the liver. (medicinenet.com)
  • The liver produces cholesterol in the body. (medicinenet.com)
  • In this study we compared the effects of rosuvastatin 10 mg/fenofibrate 160 mg combination and rosuvastatin 10 mg monotherapy on muscle and liver enzyme, homocysteine levels, kidney, blood glucose control, and blood cell counts. (clinicaltrials.gov)
  • Hepatic impairment: In patients with chronic alcoholic liver disease, levels of atorvastatin may be significantly increased depending upon the extent of liver disease. (wikipedia.org)
  • Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. (wikipedia.org)
  • However, LXRα knockout mice develop enlarged fatty livers, degeneration of liver cells, high cholesterol levels in liver, and impaired liver function when fed a high-cholesterol diet. (wikipedia.org)
  • Treatment with LXR agonists (hypocholamide, T0901317, GW3965, or N,N-dimethyl-3beta-hydroxy-cholenamide (DMHCA)) lowers the cholesterol level in serum and liver and inhibits the development of atherosclerosis in murine disease models. (wikipedia.org)
  • SCD-1 expression is significantly increased in liver tissue and heart in response to a high-carbohydrate diet, whereas SCD-2 expression is observed in brain tissue and induced during the neonatal myelination. (wikipedia.org)
  • Mice that were fed a high-carbohydrate diet had an induced expression of the liver SCD-1 gene and other lipogenic genes through an insulin-mediated SREBP-1c-dependent mechanism. (wikipedia.org)
  • stroke
  • Too much bad cholesterol can increase your chance of getting heart disease, stroke, and other problems. (medlineplus.gov)
  • On September 30, 2004, Merck withdrew rofecoxib from the market because of concerns about increased risk of heart attack and stroke associated with long-term, high-dosage use. (wikipedia.org)
  • Mitral stenosis poses a high risk of forming emboli which may travel to the brain and cause stroke. (wikipedia.org)
  • Myocardial infarction and stroke prophylaxis in patients with type II diabetes There have been recent studies suggesting that high-dose statin therapy plays a plaque-stabilizing role in people suffering from acute coronary syndrome and thrombotic stroke. (wikipedia.org)
  • treatment
  • You should should continue to follow a cholesterol-lowering diet during treatment with this medicine. (netdoctor.co.uk)
  • Prevention and Treatment of High Cholesterol. (medicinenet.com)
  • Nandrolone esters have also more recently been proposed for the treatment of androgen deficiency in men due to favorable properties including their high ratio of anabolic to androgenic effect and consequent much lower risk of prostate enlargement, prostate cancer, and scalp hair loss relative to testosterone. (wikipedia.org)
  • In the United States, this is guided by the evidence-based guideline from the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATPIII). (wikipedia.org)
  • For high blood pressure it is often recommended as a first line treatment. (wikipedia.org)
  • Nevertheless, treatment (including higher statin doses) is usually effective. (wikipedia.org)
  • Researches have found it has comparable blood cholesterol effect to statin treatment. (wikipedia.org)
  • It concluded that diet portfolio has comparable cholesterol-lowering effect to statin treatment. (wikipedia.org)
  • statin
  • It was discovered at that point that I had inherited a familial tendency for a type of cholesterol that is hard to control and I had to be on a statin to get it under control, that diet was not enough. (healingwell.com)
  • Although the combination of statin and fenofibrate is one of the options for patients with combined hyperlipidemia, non-lipid effects of it has not been completely understood yet. (clinicaltrials.gov)
  • LDL level was reduced significantly in both the statin group and the diet portfolio group. (wikipedia.org)
  • patients
  • citation needed] Gemfibrozil should not be given to these patients:[citation needed]Hepatic dysfunction Gemfibrozil should be used with caution in these higher risk categories:[citation needed]Biliary tract disease Renal dysfunction Pregnant women Obese patients Anticoagulants: Gemfibrozil potentiates the action of warfarin and indanedione anticoagulants. (wikipedia.org)
  • Due to a rare paradoxical decrease in HDL-C seen in some patients on fenofibrate, as per US FDA label change, it is recommended that the HDL-C levels be checked within the first few months after initiation of fibrate therapy. (wikipedia.org)
  • Geriatric: Plasma concentrations of atorvastatin in healthy elderly subjects are higher than those in young adults, and clinical data suggests a greater degree of LDL-lowering at any dose for patients in the population as compared to young adults. (wikipedia.org)
  • kidney
  • Lipantil micro 200 and Lipantil micro 267 are not suitable for children, or people with decreased kidney function, as they contain too high a dose of the medicine for these groups of people. (netdoctor.co.uk)
  • Adults with a history of elevated cholesterol, diabetes, kidney problems, heart disease, and other conditions require more frequent testing. (medlineplus.gov)
  • Other uses include diabetes insipidus, renal tubular acidosis, and to decrease the risk of kidney stones in those with high calcium level in the urine. (wikipedia.org)
  • Potential side effects include poor kidney function, electrolyte imbalances especially low blood potassium and less commonly low blood sodium, gout, high blood sugar, and feeling faint initially upon standing up. (wikipedia.org)
  • It is also used for the prevention of kidney stones in those who have high levels of calcium in their urine. (wikipedia.org)
  • markedly
  • Markedly elevated CPK levels or if a myopathy is suspected or diagnosed after dosing of atorvastatin has begun. (wikipedia.org)
  • phospholipids
  • Lp(a) carries cholesterol and binds atherogenic proinflammatory oxidized phospholipids as a preferential carrier of oxidized phospholipids in human plasma, which attract inflammatory cells to vessel walls and leads to smooth muscle cell proliferation. (wikipedia.org)
  • Oleate and palmitoleate are major components of membrane phospholipids, cholesterol esters and alkyl-diacylglycerol. (wikipedia.org)
  • acid sequestrants
  • Bile acid sequestrants (resins, e.g. cholestyramine) are particularly effective for lowering LDL-C by sequestering the cholesterol-containing bile acids released into the intestine and preventing their reabsorption from the intestine. (wikipedia.org)
  • Atorvastatin may be used in combination with bile acid sequestrants and ezetimibe to increase the reduction in cholesterol levels. (wikipedia.org)
  • deposits
  • Yellow deposits of cholesterol-rich fat may be seen in various places on the body such as around the eyelids (known as xanthelasma palpebrarum), the outer margin of the iris (known as arcus senilis corneae), and in the tendons of the hands, elbows, knees and feet, particularly the Achilles tendon (known as a tendon xanthoma). (wikipedia.org)
  • risk
  • What puts me at a higher risk to have a cerebrovascular accident? (drugs.com)
  • Other research focusing on young South Asians has shown that they have a higher risk of Diabetes and associated heart disease compared to other ethnic groups. (wikipedia.org)