• lipids

• Having hyperlipidemia means there are too many lipids (fats) in your blood. (bidmc.org)
• Hyperlipidemia is a medical term that means your blood has too many lipids (fats) in it, i.e., cholesterol and triglycerides. (ahaevents.org)
• So all together, hyperlipidemia implies that you have an excess of lipids, particularly cholesterol, in your blood. (jimdo.com)
• Elevated blood lipids - called hyperlipidemia - in humans are major causes of cardiovascular diseases like atherosclerosis, insulin resistance, and hepatic lipidosis (fatty liver syndrome). (criticalcaredvm.com)
• Hyperlipidemia - How are lipids produced in the body? (criticalcaredvm.com)
• Hypolipidemic agents, or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high levels of fats (lipids), such as cholesterol, in the blood (hyperlipidemia). (wikipedia.org)

• atherosclerosis

• Having high cholesterol can increase the risk of atherosclerosis, heart disease, stroke, circulatory diseases and an acidification of the body. (kobo.com)
• His long-term research interests include cholesterol and atherosclerosis, obesity surgery, implantable devices, hyperlipidemias, and measurement of blood oxygen transport. (wikipedia.org)
• Accelerated deposition of cholesterol in the walls of arteries leads to atherosclerosis, the underlying cause of cardiovascular disease. (wikipedia.org)
• In 1913, a study by Nikolai Anitschkow showed that rabbits fed on cholesterol developed lesions in their arteries similar to atherosclerosis, suggesting a role for cholesterol in atherogenesis. (wikipedia.org)

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• fats

• You can also get cholesterol through animal food sources, though these are usually high in saturated and trans fats, which force your liver to make even more cholesterol than it would on its own. (bidmc.org)
• Knowing which fats raise LDL cholesterol and which ones don't is the first step in lowering your risk of heart disease. (ahaevents.org)
• (heart.org)
• They may also have modest effects on lowering triglycerides (blood fats) and raising HDL cholesterol. (heart.org)

• Lipid

• The CVI's Lipid and Cardiovascular Disease Prevention Clinic helps patients with high cholesterol assess and reduce their risk of cardiovascular disease. (bidmc.org)
• This condition should be suspected in any patient with xanthomas but a normal to only moderately elevated lipid profile as plant sterols are not measured as part of plasma cholesterol. (psychiatryadvisor.com)
• Hyperlipidemia - How is lipid absorbed from the diet? (criticalcaredvm.com)
• The first medication of this class, ezetimibe (Zetia®), was approved in 2002 for treating high cholesterol and certain inherited lipid abnormalities. (heart.org)
• Heterozygous FH is normally treated with statins, bile acid sequestrants, or other lipid lowering agents that lower cholesterol levels. (wikipedia.org)
• The lipid hypothesis is a medical theory postulating a link between blood cholesterol levels and occurrence of heart disease. (wikipedia.org)
• The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. (wikipedia.org)

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• blood

• The American Heart Association recommends that you have a blood test to check cholesterol every four to six years after age 20. (bidmc.org)
• Elevated blood cholesterol has been linked to serious health complications, but high cholesterol typically does not produce symptoms or signs. (medicinenet.com)
• Plaques" are cholesterol deposits in the blood vessels and arteries. (medicinenet.com)
• The term "plaque" refers to the deposition of cholesterol and other substances on the walls of blood vessels, eventually compromising circulation. (medicinenet.com)
• HMG-CoA reductase inhibitors, commonly known as statins, are one class of drugs that lower blood cholesterol levels. (medicinenet.com)
• Some people will also require prescription medications to lower blood cholesterol levels. (medicinenet.com)
• High Blood Cholesterol. (medicinenet.com)
• What Are the Signs and Symptoms of High Blood Cholesterol? (medicinenet.com)
• In hypercholesterolemia, there's too much LDL (bad) cholesterol in your blood. (ahaevents.org)
• A heart-healthy eating plan can help you manage your blood cholesterol level. (ahaevents.org)
• Just 40 minutes of aerobic exercise of moderate to vigorous intensity done three to four times a week is enough to lower both cholesterol and high blood pressure. (ahaevents.org)
• Dogs with hyperlipidemia, also called lipemia, have higher than normal amounts of triglycerides and/or cholesterol in their blood stream. (petmd.com)
• Therefore, the first thing a veterinarian will do when faced with a dog with hyperlipidemia is to repeat the testing on a sample of blood that was unquestionably taken after a 12 hour fast. (petmd.com)
• If hyperlipidemia persists despite fasting, my next step is to rule out other diseases that can cause fat levels in the blood to rise. (petmd.com)
• Dogs with hyperlipidemia are at higher than average risk for a very serious form of pancreatitis, so fat levels in the blood should be reduced even if the dog is currently asymptomatic. (petmd.com)
• Reduce blood fat, lower serum cholesterol. (tcmherbstore.com)
• Also called post-prandial hyperlipidemia, blood cholesterol and triglyceride levels increase following a meal. (criticalcaredvm.com)
• (healthline.com)
• Various medications are used to lower blood cholesterol levels. (heart.org)
• This reduces the amount of cholesterol circulating in the blood. (heart.org)
• Portfolio Diet is a therapeutic vegetarian diet created by Canadian researcher David Jenkins in 2003 to lower blood cholesterol. (wikipedia.org)
• Researches have found it has comparable blood cholesterol effect to statin treatment. (wikipedia.org)
• Several risk factors, such as high blood pressure, high blood cholesterol, overweight or obese, smoking, have been identified to promote the cardiovascular diseases. (wikipedia.org)
• One of the strategies is reducing dietary saturated fat intake to reduce blood low-density lipoprotein (LDL) which is considered as "bad" blood cholesterol. (wikipedia.org)
• If dietary and life style management is ineffective, medication such as statin will be used to in conjunction to reduce blood cholesterol levels. (wikipedia.org)
• 46 healthy individuals with high blood cholesterol levels were randomly assigned into one of three study groups: 1. (wikipedia.org)
• Familial hypercholesterolemia (FH) is a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein (LDL, "bad cholesterol"), in the blood and early cardiovascular disease. (wikipedia.org)
• Or, more concisely, "decreasing blood cholesterol. (wikipedia.org)
• however, a minority contends that the evidence does not support it, and that mechanisms independent of blood cholesterol levels are responsible. (wikipedia.org)
• After fifteen years follow-up, the study confirmed the results of larger studies that reported earlier on the predictive value for heart attack of several risk factors, blood pressure, blood cholesterol level, and cigarette smoking. (wikipedia.org)

• Obesity

• With rising rates of childhood obesity, more and more children are at risk for developing high cholesterol levels and cardiovascular disease. (medicinenet.com)

• lipoprotein

• This combination of proteins and cholesterol is called a lipoprotein. (kobo.com)
• There are different types of cholesterol, based on what type of cholesterol the lipoprotein carries. (kobo.com)
• A distinction is made between Low-density lipoprotein (LDL) or "bad" cholesterol and High-density lipoprotein (HDL) or "good" cholesterol. (kobo.com)
• FH patients, characterized by extremely high levels of low-density lipoprotein cholesterol (LDL-C), above 400mg/dL in heterozygotes and 600 mg/dL in homozygotes, are prone to recurrent migratory polyarthritis typically involving large joints such as knees, elbows, and ankles. (psychiatryadvisor.com)
• Early research shows that drinking tea containing yerba mate three times daily for 40 days can lower total cholesterol and low-density lipoprotein (LDL or "bad") cholesterol, and increase high-density lipoprotein (HDL or "bad") cholesterol, in people with high cholesterol. (webmd.com)
• A pattern compatible with hyperlipoproteinemia type IIa on the Fredrickson classification is typically found: raised level of total cholesterol, markedly raised level of low-density lipoprotein (LDL), normal level of high-density lipoprotein (HDL), and normal level of triglycerides. (wikipedia.org)
• The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very-low-density lipoprotein (VLDL). (wikipedia.org)

• absorption

• Sitosterolemia is a particularly rare but interesting autosomal recessive disorder of childhood involving abnormal intestinal absorption of plant sterols leading to xanthomas in the setting of relatively normal serum cholesterol levels. (psychiatryadvisor.com)
• Selective cholesterol absorption inhibitors are most effective at lowering LDL cholesterol. (heart.org)
• Early in his career, he discovered that the part of the small intestine called the ileum is the primary site for the absorption or cholesterol and bile acids (the primary end-products of cholesterol metabolism), and, that performing surgery-Buchwald's partial ileal bypass surgery-a procedure that bypasses part of the ileum, lowers cholesterol levels and dramatically improves the lives of those with familial hypercholesterolemia. (wikipedia.org)
• ezetimibe is a selective inhibitor of dietary cholesterol absorption. (wikipedia.org)
• Similar to ezetimibe, phytosterols reduce the absorption of cholesterol in the gut. (wikipedia.org)
• Dramatically Increased Intestinal Absorption of Cholesterol Following Hypophysectomy Is Normalized by Thyroid Hormone" (PDF). (wikipedia.org)

• Dietary

• Dietary sources (animal-derived foods) also contain cholesterol. (medicinenet.com)
• From a dietary standpoint, the best way to lower your cholesterol is reduce saturated fat and trans fat. (ahaevents.org)
• Dietary changes are at the center of treating idiopathic hyperlipidemia. (petmd.com)
• It examined the effect of adding monounsaturated fatty acid to dietary portfolio of cholesterol-lowering foods in hyperlipidemia. (wikipedia.org)
• Since individuals with FH underlying body biochemistry is slightly different, their high cholesterol levels are less responsive to the kinds of cholesterol control methods which are usually more effective in people without FH (such as dietary modification and statin tablets). (wikipedia.org)

• liver

• Your body needs cholesterol to build cells, and your liver makes enough cholesterol to do that. (bidmc.org)
• Cholesterol in the body is produced by the liver. (medicinenet.com)
• The liver produces cholesterol in the body. (medicinenet.com)
• Statins reduce the production of cholesterol by the liver by blocking an enzymatic reaction in the process of cholesterol synthesis. (medicinenet.com)
• Cholesterol is a waxy substance made in the liver and found in certain foods like dairy products, eggs and meat. (kobo.com)
• Conversely, HDL predominantly scavenges excess cholesterol from cells and delivers it to the liver. (criticalcaredvm.com)
• The primary function of LDL is to transport cholesterol to the liver and other tissues. (criticalcaredvm.com)
• They scavenge excess cholesterol from cells and return it to the liver for re-processing. (criticalcaredvm.com)
• This class of drugs, also known as HMG CoA reductase inhibitors, works in the liver to prevent cholesterol from forming. (heart.org)
• PCSK9 inhibitors bind to and inactivate a protein in liver in order to lower LDL (bad) cholesterol. (heart.org)
• Clinically, the choice of an agent will depend on the patient's cholesterol profile, cardiovascular risk, and the liver and kidney functions of the patient, evaluated against the balancing of risks and benefits of the medications. (wikipedia.org)

• hyperglycemia

• The most common side effects of indinavir include: Gastrointestinal disturbances (abdominal pain, diarrhea, nausea, vomiting) General malaise and fatigue Nephrolithiasis/urolithiasis (the formation of kidney stones), which sometimes may lead to more severe condition including kidney failure Metabolic alterations including hyperlipidemia (cholesterol or triglyceride elevations) and hyperglycemia Alterations in body shape (lipodystrophy), colloquially known as "Crix belly" Indinavir inhibits urinary nitrous oxide production and may inhibit nitric oxide production. (wikipedia.org)

• coronary heart d

• When a person with high cholesterol also smokes, their risk of coronary heart disease increases more than it otherwise would. (ahaevents.org)

• Statins

• Medications that lower cholesterol are called statins. (medicinenet.com)
• Controlling Cholesterol with Statins. (medicinenet.com)
• Statins block an enzyme known as HMG Co-A reductase to help lower cholesterol levels. (healthline.com)
• Statins are the only cholesterol-lowering drug class that has been directly associated with a reduction in the risk of heart attack or stroke. (heart.org)
• Statins are most effective at lowering LDL (bad) cholesterol. (heart.org)
• Statins are particularly well suited for lowering LDL, the cholesterol with the strongest links to vascular diseases. (wikipedia.org)

• metabolism

• Chylomicrons and VLDL are generally involved in triglyceride metabolism, while LDL and HDL involved with cholesterol metabolism. (criticalcaredvm.com)
• Others include defects in chylomicron metabolism, triglyceride metabolism, and metabolism of other cholesterol-containing particles, such as VLDL and IDL. (wikipedia.org)
• Thyroid hormone is useful in controlling cholesterol metabolism that has been affected by pituitary deletion. (wikipedia.org)

• high cholesterol levels

• Anyone of any age can have high cholesterol levels. (medicinenet.com)
• Both healthy lifestyle practices as well as medications can help prevent high cholesterol levels. (medicinenet.com)
• High cholesterol levels normally do not cause any symptoms. (wikipedia.org)

• hypertension

• however, many important cardiovascular risk factors are modifiable by lifestyle change, social change, drug treatment (for example prevention of hypertension, hyperlipidemia, and diabetes). (wikipedia.org)

• medications

• These may include bile acid resins or other cholesterol-lowering medications. (healthline.com)
• Some cholesterol-lowering medications may interact with grapefruit, grapefruit juice, pomegranate and pomegranate juice. (heart.org)
• This relatively new class of cholesterol-lowering medications works by preventing cholesterol from being absorbed in the intestine. (heart.org)

• unhealthy cholesterol

• In many cases, this can cause you to develop an unhealthy cholesterol level. (bidmc.org)
• For some people, lifestyle changes, like a better diet and more exercise, may prevent or treat unhealthy cholesterol levels. (heart.org)

• overweight

• Being overweight or obese tends to raise LDL cholesterol and lower HDL cholesterol. (ahaevents.org)

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• levels

• Your doctor can advise you on how often your cholesterol levels should be tested. (medicinenet.com)
• (ahaevents.org)
• Rather than focus only your cholesterol levels, your doctor may discuss how they join other risk factors to affect your overall risk of heart disease. (ahaevents.org)
• These factors can all interact with high LDL cholesterol or low HDL cholesterol levels to affect your risk. (ahaevents.org)
• If lifestyle changes don't reduce your cholesterol levels enough, medication may be prescribed. (ahaevents.org)
• A diet high in fiber can help lower cholesterol levels by as much as 10 percent. (ahaevents.org)
• Smokers can lower their cholesterol levels and help protect their arteries by quitting. (ahaevents.org)
• Hyperlipidemia can have several causes, the most common of which is a normal physiological response that occurs after a dog has eaten a meal containing moderate to high levels of fat. (petmd.com)
• Obviously, in case you're worried about your cholesterol levels and you have sort 2 diabetes, converse with your specialist. (jimdo.com)
• He or she will have the capacity to answer any inquiries you have, and in addition check your cholesterol levels and build up a treatment arrangement if vital. (jimdo.com)
• By improving cholesterol levels, this drug can help slow the development of heart disease . (healthline.com)
• The simple cooking tips below will help you prepare tasty, heart-healthy meals that could help improve your cholesterol levels by reducing excess saturated fat and trans fat. (heart.org)
• Cholesterol levels may be determined as part of health screening for health insurance or occupational health, when the external physical signs such as xanthelasma, xanthoma, arcus are noticed, symptoms of cardiovascular disease develop, or a family member has been found to have FH. (wikipedia.org)
• Total cholesterol levels of 350-550 mg/dL are typical of heterozygous FH while total cholesterol levels of 650-1000 mg/dL are typical of homozygous FH. (wikipedia.org)
• Cholesterol levels can be drastically higher in people with FH who are also obese. (wikipedia.org)
• Keys' book Eat Well and Stay Well popularized the supplementary idea that reducing the amount of saturated fat in the diet would reduce cholesterol levels and the risks of serious diseases due to atheroma. (wikipedia.org)
• Keys was followed during the rest of the 20th century by an accumulation of work that repeatedly demonstrated associations between cholesterol levels (and other modifiable risk factors including smoking and exercise) and risks of heart disease. (wikipedia.org)

• symptoms

• Many people do not know they have high cholesterol, as it often has no obvious symptoms. (bidmc.org)

• waxy substance

• Cholesterol is a fatty, waxy substance that is present in every cell of the body and is carried in the bloodstream. (medicinenet.com)

• intestine

• These enzymes interact with micelles to further break down triglycerides and cholesterol esters into monoglycerides, free cholesterol, and long chain fatty acids (LCFA), all forms that are easily absorbed by the small intestine. (criticalcaredvm.com)
• Components of bile, including bile salts and lecithin, interact with monoglycerides, free cholesterol, and LCFA to form micelles that are passively absorbed by the small intestine. (criticalcaredvm.com)
• Once inside the cells of the small intestine, these components are converted back to triglycerides and cholesterol esters. (criticalcaredvm.com)
• Bile acid sequestrants (resins, e.g. cholestyramine) are particularly effective for lowering LDL-C by sequestering the cholesterol-containing bile acids released into the intestine and preventing their reabsorption from the intestine. (wikipedia.org)

• Prevention

• Prevention and Treatment of High Cholesterol. (medicinenet.com)

• patients

• Thus, the treatment of hyperlipidemia plays a crucial role in the management of patients with CAD or those at increased risk of CAD all around the world. (hindawi.com)
• As we generally do here on EndocrineWeb, we're going to separate that idea for you, and that is the reason we've set up together this current Patients' Guide to Treating High Cholesterol and Diabetes. (jimdo.com)

• arteries

• The process of cholesterol buildup in arteries has been shown to begin during childhood. (medicinenet.com)
• With less HDL to remove cholesterol from your arteries, your risk of plaque - and blockages - increases. (ahaevents.org)
• Less HDL cholesterol means there's less good cholesterol to remove LDL (bad) cholesterol from arteries. (ahaevents.org)

• medication

• Your doctor can also prescribe medication to help lower your cholesterol if needed. (bidmc.org)
• If you have high cholesterol, are taking a cholesterol medication or have a history of heart disease, you may qualify for this study. (drugs.com)
• For others with high cholesterol, medication may also be needed. (heart.org)

• esters

• The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. (wikipedia.org)

• primary

• Diabetes mellitus, Cushing's disease, pancreatitis, hypothyroidism, and a type of kidney disease that causes protein to be lost into the urine are the most common primary diseases that can result in hyperlipidemia. (petmd.com)
• Adequately controlling the primary problem in these cases will usually take care of the hyperlipidemia as well. (petmd.com)

• diabetes

• Diabetic hyperlipidemia is, indeed, having elevated cholesterol when you have diabetes. (jimdo.com)
• Elevated cholesterol is hazardous for anybody, however as somebody with sort 2 diabetes, its especially imperative that you get treatment for elevated cholesterol. (jimdo.com)
• Cardiovascular muddlings are regular in individuals with sort 2 diabetes, and elevated cholesterol can likewise hurt your cardiovascular wellbeing. (jimdo.com)
• elevated cholesterol medicines when you have diabetes: There are solutions you can bring to help cut down your cholesterol numbers. (jimdo.com)
• eating admirably to oversee cholesterol and diabetes: This way of life change is important to the point that it got its own article. (jimdo.com)
• Eating admirably when you have elevated cholesterol and sort 2 diabetes is vital. (jimdo.com)

• hypercholesterolemia

• Sometimes people inherit high cholesterol from parents or grandparents, called familial hypercholesterolemia (FH). (bidmc.org)
• This is true even if high cholesterol is due to genetics (familial hypercholesterolemia). (ahaevents.org)

• diseases

• Retesting a fasted serum sample and a thorough health work-up to rule out other diseases will eliminate most cases of hyperlipidemia … unless the dog in question in a schnauzer. (petmd.com)

• lowers

• A sedentary lifestyle lowers HDL cholesterol. (ahaevents.org)
• Smoking lowers HDL cholesterol. (ahaevents.org)

• VLDL

• Chylomicrons, VLDL, and LDL are largely responsible for distrusting cholesterol and triglyceride to cells throughout the body. (criticalcaredvm.com)
• The triglyceride is then packaged with cholesterol in to VLDL and subsequently secreted into the bloodstream. (criticalcaredvm.com)
• If triglyceride is also removed from VLDL, then a cholesterol-rich particle called LDL remains. (criticalcaredvm.com)

• risks

• If you're diagnosed with hyperlipidemia, your overall health and risks will help guide treatment. (ahaevents.org)

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• types of cholesterol

• (bidmc.org)

• Dogs

• Some dogs with hyperlipidemia have no clinical signs while others become quite sick. (petmd.com)
• Hyperlipidemia in Dogs & Cats - Why Worry about Cholesterol & Triglycerides? (criticalcaredvm.com)

• heart disease and stroke

• Talk with your doctor about having your cholesterol checked as well as your risk for heart disease and stroke. (bidmc.org)
• The good news is, cholesterol can be lowered, reducing the risk of heart disease and stroke. (ahaevents.org)

• good

• Level of the good cholesterol HDL is also increased. (wikipedia.org)

• derivative

• These compounds consist of an aglycon, which is a cholesterol derivative, and a carbohydrate chain, which in the case of α-tomatine consists of two d-glucose units, a d-galactose unit, and a d-xylose unit. (wikipedia.org)

• Treatment

• Knowing that you have a family history of high cholesterol can help with treatment. (bidmc.org)
• Dr. Melissa Stiles interviews Dr. Patrick McBride about the NCEP Adult Treatment Panel III Cholesterol Guidelines. (blogspot.gr)
• ASOs have been approved for use by the U.S. Food and Drug Administration for the treatment of conditions with other genetic causes-such as elevated cholesterol and hyperlipidemia. (wikipedia.org)
• It concluded that diet portfolio has comparable cholesterol-lowering effect to statin treatment. (wikipedia.org)
• In the United States, this is guided by the evidence-based guideline from the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATPIII). (wikipedia.org)

• acid

• This class of LDL-lowering drugs, also known as bile acid sequestrants or bile acid-binding drugs, works in the intestines by promoting increased disposal of cholesterol. (heart.org)
• Your body uses cholesterol to make bile, an acid used in the digestive process. (heart.org)

• Health

• You and your health care team should work together to ensure a healthy activity level and eating plan that can reduce your chances of getting high cholesterol, or lowering your cholesterol level if it is already elevated. (medicinenet.com)

• enzymes

• This hormone stimulates the pancreas to secrete digestive enzymes like lipases and cholesterol esterase. (criticalcaredvm.com)

• plant sterols

• Soy protein, nuts, viscous fibre, and plant sterols have been found to have cholesterol lowering effect. (wikipedia.org)

• reduce

• If you have high cholesterol, talk to your doctor about maintaining a healthy lifestyle to help reduce your risk of heart disease. (bidmc.org)

• deposits

• Yellow deposits of cholesterol-rich fat may be seen in various places on the body such as around the eyelids (known as xanthelasma palpebrarum), the outer margin of the iris (known as arcus senilis corneae), and in the tendons of the hands, elbows, knees and feet, particularly the Achilles tendon (known as a tendon xanthoma). (wikipedia.org)

• diet

• High cholesterol can usually be successfully improved and managed through healthy diet and lifestyle changes. (bidmc.org)
• This diet emphasizes using a portfolio of foods or food components that have found to associate with cholesterol lowering to enhance this effect. (wikipedia.org)
• David Jenkins believes including all of these foods in the diet is able to achieve better cholesterol lowering results. (wikipedia.org)
• The study compared the effect of cholesterol lowering effect using the portfolio diet versus Lovastatin. (wikipedia.org)

• people

• Therefore, many people are unaware that their cholesterol level is high. (medicinenet.com)

• Triglycerides

• Dyslipidemia is an abnormal amount of lipids (e.g. triglycerides, cholesterol and/or fat phospholipids) in the blood. (wikipedia.org)
• It is used in addition to diet to reduce elevated low-density lipoprotein cholesterol (LDL), total cholesterol, triglycerides (TG), and apolipoprotein B (apo B), and to increase high-density lipoprotein cholesterol (HDL) in adults with primary hypercholesterolemia or mixed dyslipidemia. (wikipedia.org)
• Fibrates effectively lower serum triglycerides and raises serum HDL-cholesterol levels. (wikipedia.org)
• Offspring of mothers who ate badly had higher levels of cholesterol and triglycerides in their bloodstream and higher risk of heart disease. (wikipedia.org)
• They were originally indicated for cholesterol disorders and more recently for disorders that feature high triglycerides. (wikipedia.org)

• triglyceride

• The most common side effects of indinavir include: Gastrointestinal disturbances (abdominal pain, diarrhea, nausea, vomiting) General malaise and fatigue Nephrolithiasis/urolithiasis (the formation of kidney stones), which sometimes may lead to more severe condition including kidney failure Metabolic alterations including hyperlipidemia (cholesterol or triglyceride elevations) and hyperglycemia Alterations in body shape (lipodystrophy), colloquially known as "Crix belly" Indinavir inhibits urinary nitrous oxide production and may inhibit nitric oxide production. (wikipedia.org)

• Cardiovascular Diseases

• Those with higher levels of HDL-C tend to have fewer problems with cardiovascular diseases, while those with low HDL-C cholesterol levels (especially less than 40 mg/dL or about 1 mmol/L) have increased rates for heart disease. (wikipedia.org)

• total cholesterol

• Liptruzet has also been approved to reduce elevated total cholesterol and elevated LDL in patients diagnosed with homozygous familial hypercholesterolemia as an adjunctive treatment to other hyperlipidemia treatments. (wikipedia.org)

• chronic

• Tendon xanthomas are associated with type II hyperlipidemia, chronic biliary tract obstruction, and primary biliary cirrhosis. (wikipedia.org)

• serum

• The remainder of the serum cholesterol after subtracting the HDL is the non-HDL cholesterol. (wikipedia.org)

• bile

• Early in his career, he discovered that the part of the small intestine called the ileum is the primary site for the absorption or cholesterol and bile acids (the primary end-products of cholesterol metabolism), and, that performing surgery-Buchwald's partial ileal bypass surgery-a procedure that bypasses part of the ileum, lowers cholesterol levels and dramatically improves the lives of those with familial hypercholesterolemia. (wikipedia.org)
• However, studies have shown that HDL-lacking mice still have the ability to transport cholesterol to bile, suggesting that there are alternative mechanisms for cholesterol removal. (wikipedia.org)

• statins

• However, due to lack of cardiovascular benefit in several large trials and the risk of side effects such as muscle damage, the FDA withdrew approval for the use in high cholesterol treatment in combination with statins. (wikipedia.org)
• Statins remain the first line for treatment of blood cholesterol. (wikipedia.org)
• Further research has suggested the role of cholesterol and possibly statins improving the mortality in patients suffering from breast cancer, lung cancer, prostate cancer and bowel cancer. (wikipedia.org)
• Further research presented in 2016 showed the role of high cholesterol and possibly the role of statins improving the mortality and survival of patients with breast cancer, lung cancer, bowel cancer and prostate cancer and strengthening calls for a clinical trial of statins in cancer. (wikipedia.org)

• uptake

• HDL is removed by HDL receptors such as scavenger receptor BI (SR-BI), which mediate the selective uptake of cholesterol from HDL. (wikipedia.org)

• bloodstream

• HDL particles increase in size as they circulate through the bloodstream and incorporate more cholesterol and phospholipid molecules from cells and other lipoproteins, for example by the interaction with the ABCG1 transporter and the phospholipid transport protein (PLTP). (wikipedia.org)

• ABCA1

• the complexes are capable of picking up cholesterol, carried internally, from cells by interaction with the ATP-binding cassette transporter A1 (ABCA1). (wikipedia.org)
• Here they act by increasing the expression of ABCA1, which transports extra-hepatic cholesterol into HDL. (wikipedia.org)

• high

• His work has shown for the first time a link between high cholesterol and breast cancer. (wikipedia.org)
• Potluri and the ACALM Study Unit showed for the first time in humans, a possible association between high cholesterol and breast cancer. (wikipedia.org)

• fibrate

• Synthetic ligands include the fibrate drugs, which are used to treat hyperlipidemia, and a diverse set of insecticides, herbicides, plasticizers, and organic solvents collectively referred to as peroxisome proliferators. (wikipedia.org)

• clinical

• Some cardiologists opposed the approval, because the combination reduced LDL cholesterol in a clinical trial, but it did not reduce heart disease. (wikipedia.org)

• disease

• A xanthoma (pl. xanthomas or xanthomata) (condition: xanthomatosis), from Greek ξανθος (xanthos), meaning 'yellow', is a deposition of yellowish cholesterol-rich material that can appear anywhere in the body in various disease states. (wikipedia.org)

• Drug

• Ezetimibe/atorvastatin (brand name Liptruzet) is a cholesterol lowering combination drug. (wikipedia.org)
• Drug to Cut Cholesterol Is Approved by the F.D.A. By KATIE THOMAS, New York Times, May 3, 2013 Liptruzet [package insert]. (wikipedia.org)

• Type

• Palmar xanthomata and tuboeruptive xanthomata (over knees and elbows) occur in type III hyperlipidemia. (wikipedia.org)

• News

• Indian herb can reduce cholesterol, BBC NEWS, 2 May 2002 Murray (2012). (wikipedia.org)