• lipids
• Hyperlipidemia is a medical term that means your blood has too many lipids (fats) in it, i.e., cholesterol and triglycerides. (ahaevents.org)
• So all together, hyperlipidemia implies that you have an excess of lipids, particularly cholesterol, in your blood. (jimdo.com)
• Elevated blood lipids - called hyperlipidemia - in humans are major causes of cardiovascular diseases like atherosclerosis, insulin resistance, and hepatic lipidosis (fatty liver syndrome). (criticalcaredvm.com)
• Hyperlipidemia - How are lipids produced in the body? (criticalcaredvm.com)
• Hypolipidemic agents, or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high levels of fats (lipids), such as cholesterol, in the blood (hyperlipidemia). (wikipedia.org)
• The hydroxyl group on cholesterol interacts with the polar heads of the membrane phospholipids and sphingolipids, while the bulky steroid and the hydrocarbon chain are embedded in the membrane, alongside the nonpolar fatty-acid chain of the other lipids. (wikipedia.org)

• triglycerides
• Hyperlipidemia in Dogs & Cats - Why Worry about Cholesterol & Triglycerides? (criticalcaredvm.com)
• These enzymes interact with micelles to further break down triglycerides and cholesterol esters into monoglycerides, free cholesterol, and long chain fatty acids (LCFA), all forms that are easily absorbed by the small intestine. (criticalcaredvm.com)
• Once inside the cells of the small intestine, these components are converted back to triglycerides and cholesterol esters. (criticalcaredvm.com)
• A pattern compatible with hyperlipoproteinemia type IIa on the Fredrickson classification is typically found: raised level of total cholesterol, markedly raised level of low-density lipoprotein (LDL), normal level of high-density lipoprotein (HDL), and normal level of triglycerides. (wikipedia.org)

• fats
• Knowing which fats raise LDL cholesterol and which ones don't is the first step in lowering your risk of heart disease. (ahaevents.org)
• However, during the first seven hours after ingestion of cholesterol, as absorbed fats are being distributed around the body within extracellular water by the various lipoproteins (which transport all fats in the water outside cells), the concentrations increase. (wikipedia.org)

• obesity
• With rising rates of childhood obesity, more and more children are at risk for developing high cholesterol levels and cardiovascular disease. (medicinenet.com)
• Possible causes are raised cholesterol, hyperlipidaemia states, diabetes mellitus and obesity. (medhelp.org)
• His long-term research interests include cholesterol and atherosclerosis, obesity surgery, implantable devices, hyperlipidemias, and measurement of blood oxygen transport. (wikipedia.org)

• atherosclerosis
• Having high cholesterol can increase the risk of atherosclerosis, heart disease, stroke, circulatory diseases and an acidification of the body. (kobo.com)
• Accelerated deposition of cholesterol in the walls of arteries leads to atherosclerosis, the underlying cause of cardiovascular disease. (wikipedia.org)
• In 1913, a study by Nikolai Anitschkow showed that rabbits fed on cholesterol developed lesions in their arteries similar to atherosclerosis, suggesting a role for cholesterol in atherogenesis. (wikipedia.org)

• getting high
• You and your health care team should work together to ensure a healthy activity level and eating plan that can reduce your chances of getting high cholesterol, or lowering your cholesterol level if it is already elevated. (medicinenet.com)

• lipoprotein
• This combination of proteins and cholesterol is called a lipoprotein. (kobo.com)
• There are different types of cholesterol, based on what type of cholesterol the lipoprotein carries. (kobo.com)
• A distinction is made between Low-density lipoprotein (LDL) or "bad" cholesterol and High-density lipoprotein (HDL) or "good" cholesterol. (kobo.com)
• FH patients, characterized by extremely high levels of low-density lipoprotein cholesterol (LDL-C), above 400mg/dL in heterozygotes and 600 mg/dL in homozygotes, are prone to recurrent migratory polyarthritis typically involving large joints such as knees, elbows, and ankles. (psychiatryadvisor.com)
• One of the strategies is reducing dietary saturated fat intake to reduce blood low-density lipoprotein (LDL) which is considered as "bad" blood cholesterol. (wikipedia.org)
• Familial hypercholesterolemia (FH) is a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein (LDL, "bad cholesterol"), in the blood and early cardiovascular disease. (wikipedia.org)
• The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very-low-density lipoprotein (VLDL). (wikipedia.org)

• Hypertension
• 2 10 most costly medical conditions Condition Heart disease National Cost $90.9 B Cancer 71.4 Trauma-related 67.3 Mental disorders 59.9 Osteoarthritis 56.2 Hypertension 47.3 Diabetes 45.5 COPD, Asthma 44.5 Hyperlipidemia 38.5 Back problems 34.6 Soni, A. Top 10 Most Costly Conditions among Men and Women, 2008: Statistical Brief #331. (docplayer.net)
• however, many important cardiovascular risk factors are modifiable by lifestyle change, social change, drug treatment (for example prevention of hypertension, hyperlipidemia, and diabetes). (wikipedia.org)

• lipid
• This condition should be suspected in any patient with xanthomas but a normal to only moderately elevated lipid profile as plant sterols are not measured as part of plasma cholesterol. (psychiatryadvisor.com)
• Hyperlipidemia - How is lipid absorbed from the diet? (criticalcaredvm.com)
• Heterozygous FH is normally treated with statins, bile acid sequestrants, or other lipid lowering agents that lower cholesterol levels. (wikipedia.org)
• The lipid hypothesis is a medical theory postulating a link between blood cholesterol levels and occurrence of heart disease. (wikipedia.org)
• The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. (wikipedia.org)

• absorption
• Sitosterolemia is a particularly rare but interesting autosomal recessive disorder of childhood involving abnormal intestinal absorption of plant sterols leading to xanthomas in the setting of relatively normal serum cholesterol levels. (psychiatryadvisor.com)
• Early in his career, he discovered that the part of the small intestine called the ileum is the primary site for the absorption or cholesterol and bile acids (the primary end-products of cholesterol metabolism), and, that performing surgery-Buchwald's partial ileal bypass surgery-a procedure that bypasses part of the ileum, lowers cholesterol levels and dramatically improves the lives of those with familial hypercholesterolemia. (wikipedia.org)
• ezetimibe is a selective inhibitor of dietary cholesterol absorption. (wikipedia.org)
• Similar to ezetimibe, phytosterols reduce the absorption of cholesterol in the gut. (wikipedia.org)
• Dramatically Increased Intestinal Absorption of Cholesterol Following Hypophysectomy Is Normalized by Thyroid Hormone" (PDF). (wikipedia.org)
• The body also compensates for any absorption of additional cholesterol by reducing cholesterol synthesis. (wikipedia.org)

• diabetes
• As we generally do here on EndocrineWeb, we're going to separate that idea for you, and that is the reason we've set up together this current Patients' Guide to Treating High Cholesterol and Diabetes. (jimdo.com)
• Diabetic hyperlipidemia is, indeed, having elevated cholesterol when you have diabetes. (jimdo.com)
• Elevated cholesterol is hazardous for anybody, however as somebody with sort 2 diabetes, its especially imperative that you get treatment for elevated cholesterol. (jimdo.com)
• Cardiovascular muddlings are regular in individuals with sort 2 diabetes, and elevated cholesterol can likewise hurt your cardiovascular wellbeing. (jimdo.com)
• elevated cholesterol medicines when you have diabetes: There are solutions you can bring to help cut down your cholesterol numbers. (jimdo.com)
• eating admirably to oversee cholesterol and diabetes: This way of life change is important to the point that it got its own article. (jimdo.com)
• Eating admirably when you have elevated cholesterol and sort 2 diabetes is vital. (jimdo.com)
• Obviously, in case you're worried about your cholesterol levels and you have sort 2 diabetes, converse with your specialist. (jimdo.com)

• hyperglycemia
• The most common side effects of indinavir include: Gastrointestinal disturbances (abdominal pain, diarrhea, nausea, vomiting) General malaise and fatigue Nephrolithiasis/urolithiasis (the formation of kidney stones), which sometimes may lead to more severe condition including kidney failure Metabolic alterations including hyperlipidemia (cholesterol or triglyceride elevations) and hyperglycemia Alterations in body shape (lipodystrophy), colloquially known as "Crix belly" Indinavir inhibits urinary nitrous oxide production and may inhibit nitric oxide production. (wikipedia.org)

• metabolism
• Chylomicrons and VLDL are generally involved in triglyceride metabolism, while LDL and HDL involved with cholesterol metabolism. (criticalcaredvm.com)
• Others include defects in chylomicron metabolism, triglyceride metabolism, and metabolism of other cholesterol-containing particles, such as VLDL and IDL. (wikipedia.org)
• Thyroid hormone is useful in controlling cholesterol metabolism that has been affected by pituitary deletion. (wikipedia.org)

• liver
• Cholesterol in the body is produced by the liver. (medicinenet.com)
• The liver produces cholesterol in the body. (medicinenet.com)
• Statins reduce the production of cholesterol by the liver by blocking an enzymatic reaction in the process of cholesterol synthesis. (medicinenet.com)
• Cholesterol is a waxy substance made in the liver and found in certain foods like dairy products, eggs and meat. (kobo.com)
• Conversely, HDL predominantly scavenges excess cholesterol from cells and delivers it to the liver. (criticalcaredvm.com)
• The primary function of LDL is to transport cholesterol to the liver and other tissues. (criticalcaredvm.com)
• They scavenge excess cholesterol from cells and return it to the liver for re-processing. (criticalcaredvm.com)
• Clinically, the choice of an agent will depend on the patient's cholesterol profile, cardiovascular risk, and the liver and kidney functions of the patient, evaluated against the balancing of risks and benefits of the medications. (wikipedia.org)

• deposition of cholesterol
• The term "plaque" refers to the deposition of cholesterol and other substances on the walls of blood vessels, eventually compromising circulation. (medicinenet.com)

• lowers
• A sedentary lifestyle lowers HDL cholesterol. (ahaevents.org)
• Smoking lowers HDL cholesterol. (ahaevents.org)
• PD slows gastric & intestinal motility leading to constipation Fiber adds bulk to stool to help for regular bowel movements Helps control blood sugars Lowers cholesterol How much do we need? (docplayer.net)

• Dietary
• Dietary sources (animal-derived foods) also contain cholesterol. (medicinenet.com)
• From a dietary standpoint, the best way to lower your cholesterol is reduce saturated fat and trans fat. (ahaevents.org)
• If dietary and life style management is ineffective, medication such as statin will be used to in conjunction to reduce blood cholesterol levels. (wikipedia.org)
• It examined the effect of adding monounsaturated fatty acid to dietary portfolio of cholesterol-lowering foods in hyperlipidemia. (wikipedia.org)
• Since individuals with FH underlying body biochemistry is slightly different, their high cholesterol levels are less responsive to the kinds of cholesterol control methods which are usually more effective in people without FH (such as dietary modification and statin tablets). (wikipedia.org)
• Typical daily cholesterol dietary intake for a man in the United States is 307 mg. (wikipedia.org)

• overweight
• Being overweight or obese tends to raise LDL cholesterol and lower HDL cholesterol. (ahaevents.org)
• Several risk factors, such as high blood pressure, high blood cholesterol, overweight or obese, smoking, have been identified to promote the cardiovascular diseases. (wikipedia.org)

• waxy substance
• Cholesterol is a fatty, waxy substance that is present in every cell of the body and is carried in the bloodstream. (medicinenet.com)

• Statins
• Medications that lower cholesterol are called statins. (medicinenet.com)
• HMG-CoA reductase inhibitors, commonly known as statins, are one class of drugs that lower blood cholesterol levels. (medicinenet.com)
• Controlling Cholesterol with Statins. (medicinenet.com)
• Statins are particularly well suited for lowering LDL, the cholesterol with the strongest links to vascular diseases. (wikipedia.org)

• Prevention
• Prevention and Treatment of High Cholesterol. (medicinenet.com)

• coronary heart d
• When a person with high cholesterol also smokes, their risk of coronary heart disease increases more than it otherwise would. (ahaevents.org)

• arteries
• The process of cholesterol buildup in arteries has been shown to begin during childhood. (medicinenet.com)
• Plaques" are cholesterol deposits in the blood vessels and arteries. (medicinenet.com)
• With less HDL to remove cholesterol from your arteries, your risk of plaque - and blockages - increases. (ahaevents.org)
• Less HDL cholesterol means there's less good cholesterol to remove LDL (bad) cholesterol from arteries. (ahaevents.org)
• Smokers can lower their cholesterol levels and help protect their arteries by quitting. (ahaevents.org)

• esters
• The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. (wikipedia.org)

• absorbed by the small intestine
• Components of bile, including bile salts and lecithin, interact with monoglycerides, free cholesterol, and LCFA to form micelles that are passively absorbed by the small intestine. (criticalcaredvm.com)

• hypercholesterolemia
• In hypercholesterolemia, there's too much LDL (bad) cholesterol in your blood. (ahaevents.org)
• This is true even if high cholesterol is due to genetics (familial hypercholesterolemia). (ahaevents.org)

• fatty
• Through the interaction with the phospholipid fatty-acid chains, cholesterol increases membrane packing, which both alters membrane fluidity and maintains membrane integrity so that animal cells do not need to build cell walls (like plants and most bacteria). (wikipedia.org)

• bile acids
• Bile acid sequestrants (resins, e.g. cholestyramine) are particularly effective for lowering LDL-C by sequestering the cholesterol-containing bile acids released into the intestine and preventing their reabsorption from the intestine. (wikipedia.org)

• intracellular
• Within the cell membrane, cholesterol also functions in intracellular transport, cell signaling and nerve conduction. (wikipedia.org)

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• levels
• Your doctor can advise you on how often your cholesterol levels should be tested. (medicinenet.com)
• Anyone of any age can have high cholesterol levels. (medicinenet.com)
• Both healthy lifestyle practices as well as medications can help prevent high cholesterol levels. (medicinenet.com)
• Some people will also require prescription medications to lower blood cholesterol levels. (medicinenet.com)
• (ahaevents.org)
• Rather than focus only your cholesterol levels, your doctor may discuss how they join other risk factors to affect your overall risk of heart disease. (ahaevents.org)
• These factors can all interact with high LDL cholesterol or low HDL cholesterol levels to affect your risk. (ahaevents.org)
• If lifestyle changes don't reduce your cholesterol levels enough, medication may be prescribed. (ahaevents.org)
• A diet high in fiber can help lower cholesterol levels by as much as 10 percent. (ahaevents.org)
• He or she will have the capacity to answer any inquiries you have, and in addition check your cholesterol levels and build up a treatment arrangement if vital. (jimdo.com)
• Also called post-prandial hyperlipidemia, blood cholesterol and triglyceride levels increase following a meal. (criticalcaredvm.com)
• 46 healthy individuals with high blood cholesterol levels were randomly assigned into one of three study groups: 1. (wikipedia.org)
• High cholesterol levels normally do not cause any symptoms. (wikipedia.org)
• Cholesterol levels may be determined as part of health screening for health insurance or occupational health, when the external physical signs such as xanthelasma, xanthoma, arcus are noticed, symptoms of cardiovascular disease develop, or a family member has been found to have FH. (wikipedia.org)
• Total cholesterol levels of 350-550 mg/dL are typical of heterozygous FH while total cholesterol levels of 650-1000 mg/dL are typical of homozygous FH. (wikipedia.org)
• Cholesterol levels can be drastically higher in people with FH who are also obese. (wikipedia.org)
• however, a minority contends that the evidence does not support it, and that mechanisms independent of blood cholesterol levels are responsible. (wikipedia.org)
• Keys' book Eat Well and Stay Well popularized the supplementary idea that reducing the amount of saturated fat in the diet would reduce cholesterol levels and the risks of serious diseases due to atheroma. (wikipedia.org)
• Keys was followed during the rest of the 20th century by an accumulation of work that repeatedly demonstrated associations between cholesterol levels (and other modifiable risk factors including smoking and exercise) and risks of heart disease. (wikipedia.org)

• deposits
• Xanthalesma / Xanthomas are deposits of fat/cholesterol in the eye lid. (medhelp.org)
• Yellow deposits of cholesterol-rich fat may be seen in various places on the body such as around the eyelids (known as xanthelasma palpebrarum), the outer margin of the iris (known as arcus senilis corneae), and in the tendons of the hands, elbows, knees and feet, particularly the Achilles tendon (known as a tendon xanthoma). (wikipedia.org)

• VLDL
• Chylomicrons, VLDL, and LDL are largely responsible for distrusting cholesterol and triglyceride to cells throughout the body. (criticalcaredvm.com)
• The triglyceride is then packaged with cholesterol in to VLDL and subsequently secreted into the bloodstream. (criticalcaredvm.com)
• If triglyceride is also removed from VLDL, then a cholesterol-rich particle called LDL remains. (criticalcaredvm.com)

• cell membrane
• The unprotonated form of tomatine forms complexes with sterols such as cholesterol, which may cause disruption of cell membrane and changes in membrane permeability. (wikipedia.org)
• The structure of the tetracyclic ring of cholesterol contributes to the fluidity of the cell membrane, as the molecule is in a trans conformation making all but the side chain of cholesterol rigid and planar. (wikipedia.org)

• intestine
• Typically, about 50% of the excreted cholesterol is reabsorbed by the small intestine back into the bloodstream. (wikipedia.org)

• synthesis
• At first it was thought that the synthesis of steroidal alkaloids only involved multiple steps of hydroxylation, oxidation and amination of cholesterol with arginine as the source of the incorporated nitrogen. (wikipedia.org)

• phytosterols
• Plants manufacture phytosterols (substances chemically similar to cholesterol), which can compete with cholesterol for reabsorption in the intestinal tract, thus potentially reducing cholesterol reabsorption. (wikipedia.org)
• When intestinal lining cells absorb phytosterols, in place of cholesterol, they usually excrete the phytosterol molecules back into the GI tract, an important protective mechanism. (wikipedia.org)

• derivative
• These compounds consist of an aglycon, which is a cholesterol derivative, and a carbohydrate chain, which in the case of α-tomatine consists of two d-glucose units, a d-galactose unit, and a d-xylose unit. (wikipedia.org)

• typically
• Elevated blood cholesterol has been linked to serious health complications, but high cholesterol typically does not produce symptoms or signs. (medicinenet.com)

• enzymes
• This hormone stimulates the pancreas to secrete digestive enzymes like lipases and cholesterol esterase. (criticalcaredvm.com)

• plant sterols
• Soy protein, nuts, viscous fibre, and plant sterols have been found to have cholesterol lowering effect. (wikipedia.org)

• risks
• If you're diagnosed with hyperlipidemia, your overall health and risks will help guide treatment. (ahaevents.org)

• Treatment
• Dr. Melissa Stiles interviews Dr. Patrick McBride about the NCEP Adult Treatment Panel III Cholesterol Guidelines. (blogspot.gr)
• ASOs have been approved for use by the U.S. Food and Drug Administration for the treatment of conditions with other genetic causes-such as elevated cholesterol and hyperlipidemia. (wikipedia.org)
• Researches have found it has comparable blood cholesterol effect to statin treatment. (wikipedia.org)
• It concluded that diet portfolio has comparable cholesterol-lowering effect to statin treatment. (wikipedia.org)
• In the United States, this is guided by the evidence-based guideline from the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATPIII). (wikipedia.org)

• plasma
• In this structural role, cholesterol also reduces the permeability of the plasma membrane to neutral solutes, hydrogen ions, and sodium ions. (wikipedia.org)

• diet
• Portfolio Diet is a therapeutic vegetarian diet created by Canadian researcher David Jenkins in 2003 to lower blood cholesterol. (wikipedia.org)
• This diet emphasizes using a portfolio of foods or food components that have found to associate with cholesterol lowering to enhance this effect. (wikipedia.org)
• David Jenkins believes including all of these foods in the diet is able to achieve better cholesterol lowering results. (wikipedia.org)
• The study compared the effect of cholesterol lowering effect using the portfolio diet versus Lovastatin. (wikipedia.org)

• Lipoproteins
• Triglyceride and cholesterol chiefly circulate throughout the body with lipoproteins. (criticalcaredvm.com)

• lower
• Just 40 minutes of aerobic exercise of moderate to vigorous intensity done three to four times a week is enough to lower both cholesterol and high blood pressure. (ahaevents.org)

• nuts
• cholesterol nuts and bolts: What is it? (jimdo.com)

• body
• Cholesterol plays a number of roles in maintaining vital body functions including hormone production and digestion. (medicinenet.com)
• citation needed] Cholesterol is recycled in the body. (wikipedia.org)

• amounts
• citation needed] Plants make cholesterol in very small amounts. (wikipedia.org)

• closely
• The starting point for treating high cholesterol is working closely with your doctor or healthcare provider. (ahaevents.org)

• good
• The good news is, cholesterol can be lowered, reducing the risk of heart disease and stroke. (ahaevents.org)
• Level of the good cholesterol HDL is also increased. (wikipedia.org)

• risk
• After fifteen years follow-up, the study confirmed the results of larger studies that reported earlier on the predictive value for heart attack of several risk factors, blood pressure, blood cholesterol level, and cigarette smoking. (wikipedia.org)

• often
• Hyperlipidemia can often be improved by lifestyle changes. (ahaevents.org)