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  • patients
  • There was no significant difference in the mortality from cardiovascular events between the two groups, nor was there any significant difference in the rate of myocardial infarction between the rofecoxib and naproxen treatment groups in patients without high cardiovascular risk. (wikipedia.org)
  • Patients with many different cardiovascular diseases have a higher likelihood of experiencing a blood clot or loss of blood flow in border-zone regions of the brain. (wikipedia.org)
  • Further studies performed in 2016 and presented at the British Cardiovascular Society Conference showed that patients admitted with a diagnosis of atrial fibrillation during the weekend had worse mortality and patients with heart failure discharged at the weekend also had a higher risk of death. (wikipedia.org)
  • citation needed] Gemfibrozil should not be given to these patients:[citation needed]Hepatic dysfunction Gemfibrozil should be used with caution in these higher risk categories:[citation needed]Biliary tract disease Renal dysfunction Pregnant women Obese patients Anticoagulants: Gemfibrozil potentiates the action of warfarin and indanedione anticoagulants. (wikipedia.org)
  • stroke
  • Talk with your doctor about having your cholesterol checked as well as your risk for heart disease and stroke. (bidmc.org)
  • The good news is, cholesterol can be lowered, reducing the risk of heart disease and stroke. (ahaevents.org)
  • On September 30, 2004, Merck withdrew rofecoxib from the market because of concerns about increased risk of heart attack and stroke associated with long-term, high-dosage use. (wikipedia.org)
  • Mitral stenosis poses a high risk of forming emboli which may travel to the brain and cause stroke. (wikipedia.org)
  • metabolism
  • While the most common problem related to calcium metabolism is undoubtedly bone loss from getting too little calcium, there can be problems when intake of this nutrient gets too high as well. (whfoods.com)
  • Others include defects in chylomicron metabolism, triglyceride metabolism, and metabolism of other cholesterol-containing particles, such as VLDL and IDL. (wikipedia.org)
  • bile
  • This class of LDL-lowering drugs, also known as bile acid sequestrants or bile acid-binding drugs, works in the intestines by promoting increased disposal of cholesterol. (heart.org)
  • Your body uses cholesterol to make bile, an acid used in the digestive process. (heart.org)
  • Bile acid sequestrants (resins, e.g. cholestyramine) are particularly effective for lowering LDL-C by sequestering the cholesterol-containing bile acids released into the intestine and preventing their reabsorption from the intestine. (wikipedia.org)
  • density
  • The high mineral density is attributed to the depth related pressure and the change in temperature from 20 °C+ at the surface to 8 °C at 600 meters depth generates the movement of this layer. (wikipedia.org)
  • Treatment
  • Knowing that you have a family history of high cholesterol can help with treatment. (bidmc.org)
  • Nandrolone esters have also more recently been proposed for the treatment of androgen deficiency in men due to favorable properties including their high ratio of anabolic to androgenic effect and consequent much lower risk of prostate enlargement, prostate cancer, and scalp hair loss relative to testosterone. (wikipedia.org)
  • In the United States, this is guided by the evidence-based guideline from the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATPIII). (wikipedia.org)
  • potassium
  • Potential side effects include poor kidney function, electrolyte imbalances especially low blood potassium and less commonly low blood sodium, gout, high blood sugar, and feeling faint initially upon standing up. (wikipedia.org)
  • risk
  • If you have high cholesterol, talk to your doctor about maintaining a healthy lifestyle to help reduce your risk of heart disease. (bidmc.org)
  • Knowing which fats raise LDL cholesterol and which ones don't is the first step in lowering your risk of heart disease. (ahaevents.org)
  • Taking certain cholesterol drugs with pravastatin can increase the risk of myopathy (muscle problems) or rhabdomyolysis (muscle breakdown). (healthline.com)
  • This risk is especially high for people who smoke or drink alcohol. (webmd.com)
  • deposits
  • Yellow deposits of cholesterol-rich fat may be seen in various places on the body such as around the eyelids (known as xanthelasma palpebrarum), the outer margin of the iris (known as arcus senilis corneae), and in the tendons of the hands, elbows, knees and feet, particularly the Achilles tendon (known as a tendon xanthoma). (wikipedia.org)
  • triglyceride
  • The most common side effects of indinavir include: Gastrointestinal disturbances (abdominal pain, diarrhea, nausea, vomiting) General malaise and fatigue Nephrolithiasis/urolithiasis (the formation of kidney stones), which sometimes may lead to more severe condition including kidney failure Metabolic alterations including hyperlipidemia (cholesterol or triglyceride elevations) and hyperglycemia Alterations in body shape (lipodystrophy), colloquially known as "Crix belly" Indinavir inhibits urinary nitrous oxide production and may inhibit nitric oxide production. (wikipedia.org)
  • bile
  • Early in his career, he discovered that the part of the small intestine called the ileum is the primary site for the absorption or cholesterol and bile acids (the primary end-products of cholesterol metabolism), and, that performing surgery-Buchwald's partial ileal bypass surgery-a procedure that bypasses part of the ileum, lowers cholesterol levels and dramatically improves the lives of those with familial hypercholesterolemia. (wikipedia.org)
  • However, studies have shown that HDL-lacking mice still have the ability to transport cholesterol to bile, suggesting that there are alternative mechanisms for cholesterol removal. (wikipedia.org)
  • After being transported to the liver by HDL, cholesterol is delivered to the intestines via bile production. (wikipedia.org)
  • obese
  • It is well recognized that obese women are at increased risk of preeclampsia and that women who have never been pregnant are at higher risk of preeclampsia than women who have had children in the past. (wikipedia.org)
  • For mothers, impaired glucose tolerance and hyperlipidemia are more common among obese mothers. (wikipedia.org)
  • statins
  • Statins remain the first line for treatment of blood cholesterol. (wikipedia.org)
  • Further research has suggested the role of cholesterol and possibly statins improving the mortality in patients suffering from breast cancer, lung cancer, prostate cancer and bowel cancer. (wikipedia.org)
  • Further research presented in 2016 showed the role of high cholesterol and possibly the role of statins improving the mortality and survival of patients with breast cancer, lung cancer, bowel cancer and prostate cancer and strengthening calls for a clinical trial of statins in cancer. (wikipedia.org)
  • uptake
  • HDL is removed by HDL receptors such as scavenger receptor BI (SR-BI), which mediate the selective uptake of cholesterol from HDL. (wikipedia.org)
  • internally
  • the complexes are capable of picking up cholesterol, carried internally, from cells by interaction with the ATP-binding cassette transporter A1 (ABCA1). (wikipedia.org)
  • stroke
  • ACCELERATE studied evacetrapib in participants with high-risk vascular disease (previous myocardial infarction, stroke or peripheral vascular disease, or several cardiovascular risk factors). (wikipedia.org)
  • On September 30, 2004, Merck withdrew rofecoxib from the market because of concerns about increased risk of heart attack and stroke associated with long-term, high-dosage use. (wikipedia.org)
  • lipid
  • Low and high throughput gene expression analysis have allowed the creation of comprehensive maps illustrating the role of PPAR-alpha as master regulator of lipid metabolism via regulation of numerous genes involved in various aspects of lipid metabolism. (wikipedia.org)
  • In lipid digestion, cholesterol is packed into Chylomicrons in the small intestine, which are delivered to the Portal vein and Lymph. (wikipedia.org)
  • dosages
  • Prior to gender confirmation surgery, dosages of estrogen for transgender people are often higher than replacement dosages used for cisgender women. (wikipedia.org)
  • Cardiovascular Disease
  • EBBINGHAUS ( E valuating PCSK9 B inding anti B ody I nfluence o N co G nitive H e A lth in high cardiovasc U lar risk S ubjects) is a double-blind, placebo-controlled randomized non-inferiority trial involving of 1,974 patients with clinically evident atherosclerotic cardiovascular disease enrolled in the Repatha cardiovascular outcomes trial (FOURIER). (amgen.com)
  • It is mainly used to reduce cholesterol levels in people at risk of cardiovascular disease. (wikipedia.org)
  • tissues
  • Human PPAR-alpha seems to be expressed more equally among various tissues, with high expression in liver, intestine, heart, and kidney. (wikipedia.org)
  • treatment
  • If the person has a family history of high cholesterol or a medical condition that increases the risk, a treatment plan can be suggested. (allhealth.com.au)
  • Anyone with high cholesterol should discuss treatment options with a healthcare professional. (allhealth.com.au)
  • Evacetrapib evaluation for treatment of high-risk vascular disease was discontinued due to lack of efficacy, as had already happened in the past with two other CETP inhibitors (torcetrapib and dalcetrapib) due to increased deaths and little identifiable cardiovascular benefit (despite substantial increases in HDL). (wikipedia.org)
  • There was no significant difference in the mortality from cardiovascular events between the two groups, nor was there any significant difference in the rate of myocardial infarction between the rofecoxib and naproxen treatment groups in patients without high cardiovascular risk. (wikipedia.org)
  • include
  • Synthetic ligands include the fibrate drugs, which are used to treat hyperlipidemia, and a diverse set of insecticides, herbicides, plasticizers, and organic solvents collectively referred to as peroxisome proliferators. (wikipedia.org)
  • patients
  • Further studies performed in 2016 and presented at the British Cardiovascular Society Conference showed that patients admitted with a diagnosis of atrial fibrillation during the weekend had worse mortality and patients with heart failure discharged at the weekend also had a higher risk of death. (wikipedia.org)
  • 2013 Merck Sharp & Dohme Corp. Ezetimibe and Atorvastatin vs. Atorvastatin in Patients Age 65 and Older at High Risk for Coronary Heart Disease (CHD). (wikipedia.org)
  • clinical
  • Some cardiologists opposed the approval, because the combination reduced LDL cholesterol in a clinical trial, but it did not reduce heart disease. (wikipedia.org)
  • result
  • This C30 triterpene, whose biosynthesis is described in Section B, is named after the dogfish Squalus in whose liver it accumulates as a result of blockage in oxidation to cholesterol. (how-to-tradeforex.com)
  • As a result my cholesterol level test comes out normal. (buymedseasily.com)
  • One chemical ingredient in the extract is the steroid guggulsterone, which acts as an antagonist of the farnesoid X receptor, once believed to result in decreased cholesterol synthesis in the liver. (wikipedia.org)