• proliferation
  • It is the first-in-class of a kind of drug called a "HER dimerization inhibitor" - it inhibits the dimerization of HER2 with other HER receptors, which prevents them from signalling in ways that promote cell growth and proliferation. (wikipedia.org)
  • resistance
  • Zeocin and other related chemicals in the bleomycin family of compounds are primarily used in molecular biology as an antibiotic, especially for the selection of eukaryotic cell lines when used in conjunction with vectors containing a selectable marker for zeocin resistance. (wikipedia.org)
  • Multiple independent complementation groups of Chinese hamster ovary (CHO) cells have been isolated, and this gene restored UV resistance to cells of complementation group 4. (wikipedia.org)
  • human
  • Moving to the University of Texas Health Science Center in Dallas, now the UT Southwestern Medical Center, Brown and colleague Joseph L. Goldstein researched cholesterol metabolism and discovered that human cells have low-density lipoprotein (LDL) receptors that extract cholesterol from the bloodstream. (wikipedia.org)
  • gene
  • Gene regulation gives the cell control over structure and function, and is the basis for cellular differentiation, morphogenesis and the versatility and adaptability of any organism. (wikipedia.org)
  • Gene regulation may also serve as a substrate for evolutionary change, since control of the timing, location, and amount of gene expression can have a profound effect on the functions (actions) of the gene in a cell or in a multicellular organism. (wikipedia.org)
  • receptor
  • Activation of the kisspeptin receptor is linked to the phospholipase C and inositol trisphosphate second messenger cascades inside the cell. (wikipedia.org)
  • In addition to explaining the underlying pathology of this disease, their work uncovered a fundamental aspect of cell biology - Receptor-mediated endocytosis. (wikipedia.org)
  • protein
  • Cells were harvested for RNA isolation from Day 4, and for total cellular protein extraction from Day 7. (sigmaaldrich.com)
  • Bves is a highly conserved, transmembrane protein that is involved in cell adhesion, cell motility, and most recently has been shown to play a role in vesicular transport. (wikipedia.org)
  • Bves interacts with GEFT, a protein that modulates Rho GTPases, Rac1 and Cdc42, which are important for cell motility through modulation of the actin cytoskeleton. (wikipedia.org)
  • In cholesterol-depleted cells, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi apparatus. (wikipedia.org)
  • cascades
  • Taken together, these data demonstrate that Bves modulates Rho GTPase signaling cascades through interaction with GEFT to affect cell movement and morphology. (wikipedia.org)
  • biology
  • To give you confidence in the health of your cells every step of the way, we've highlighted the technologies and products within cell biology that are critical to maintaining optimal cell health. (thermofisher.com)
  • adhesion
  • Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation. (wikipedia.org)
  • Grossly, cell motility and cell adhesion are impaired. (wikipedia.org)
  • migration
  • VAMP3 is important for recycling of integrins during cell migration and is also necessary for exocytosis of transferrin. (wikipedia.org)
  • Thus, Bves is important for VAMP3-mediated vesicular transport underlying cell migration and transferrin recycling. (wikipedia.org)
  • Type
  • Glycogen storage disease type II, also called Pompe disease, is an autosomal recessive metabolic disorder which damages muscle and nerve cells throughout the body. (wikipedia.org)
  • cellular
  • The results show that only the hydroxylated derivatives (NMHE and 9-hydroxyellipticinium), which covalently bind to nucleic acids, increase the cellular sensitivity to ionizing radiations, whereas the non-hydroxylated derivative, 2N-methyl-ellipticinium, has no influence on cell radiosensitivity. (biomedsearch.com)
  • cholesterol
  • Since 1993, Drs. Brown, Goldstein, and their colleagues have described the unexpectedly complex machinery by which cells maintain the necessary levels of fats and cholesterol in the face of varying environmental circumstances. (wikipedia.org)
  • results
  • Maintaining healthy cells is the key to experimental success and reproducible research results. (thermofisher.com)
  • The results support the approach of Mgat1 and Mgat4 co-overexpression to create host cell lines for biopharmaceutical production with increased sialylation. (sigmaaldrich.com)
  • sensitive
  • The main effect is observed in the case of exponentially growing cells which are also more sensitive to the drug alone than plateau phase cells. (biomedsearch.com)
  • Thermal radiosensitization in heat- and radiation-sensitive mutants of CHO cells. (biomedsearch.com)
  • Cells with disabling mutations in ERCC4 are more sensitive than normal to particular DNA damaging agents, including ultraviolet radiation and to chemicals that cause crosslinking between DNA strands. (wikipedia.org)