• The World Trade Center (WTC) Health Program developed a new Medical Coverage Determination (MCD) for Chimeric Antigen Receptor T-cell (CAR-T) Therapy, outlining coverage details and criteria. (cdc.gov)
  • Chimeric antigen receptor-modified T cells with specificity for CD19 have shown promise in the treatment of chronic lymphocytic leukemia (CLL). (nih.gov)
  • It remains to be established whether chimeric antigen receptor T cells have clinical activity in acute lymphoblastic leukemia (ALL). (nih.gov)
  • Two children with relapsed and refractory pre-B-cell ALL received infusions of T cells transduced with anti-CD19 antibody and a T-cell signaling molecule (CTL019 chimeric antigen receptor T cells), at a dose of 1.4×10(6) to 1.2×10(7) CTL019 cells per kilogram of body weight. (nih.gov)
  • In addition, the chimeric antigen receptor T cells were observed in the cerebrospinal fluid (CSF), where they persisted at high levels for at least 6 months. (nih.gov)
  • cytokine blockade with etanercept and tocilizumab was effective in reversing the syndrome and did not prevent expansion of chimeric antigen receptor T cells or reduce antileukemic efficacy. (nih.gov)
  • Chimeric antigen receptor-modified T cells are capable of killing even aggressive, treatment-refractory acute leukemia cells in vivo. (nih.gov)
  • We designed a lentiviral vector expressing a chimeric antigen receptor with specificity for the B-cell antigen CD19, coupled with CD137 (a costimulatory receptor in T cells [4-1BB]) and CD3-zeta (a signal-transduction component of the T-cell antigen receptor) signaling domains. (nih.gov)
  • A low dose (approximately 1.5×10(5) cells per kilogram of body weight) of autologous chimeric antigen receptor-modified T cells reinfused into a patient with refractory chronic lymphocytic leukemia (CLL) expanded to a level that was more than 1000 times as high as the initial engraftment level in vivo, with delayed development of the tumor lysis syndrome and with complete remission. (nih.gov)
  • Apart from the tumor lysis syndrome, the only other grade 3/4 toxic effect related to chimeric antigen receptor T cells was lymphopenia. (nih.gov)
  • Engineered cells persisted at high levels for 6 months in the blood and bone marrow and continued to express the chimeric antigen receptor. (nih.gov)
  • Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
  • Chimeric antigen receptor (CAR) T-cell therapy is a rapidly growing treatment modality. (medscape.com)
  • This proposal seeks to develop for the first time in humans a novel CD5 knocked out (KO) anti-CD5 chimeric antigen receptor T cell (CART) product for patients with relapsed or refractory T-cell lymphomas. (lls.org)
  • The present project seeks to translate this discovery into a first-in-human clinical trial to evaluate the feasibility, toxicity, and efficacy of CD5-deleted anti-CD5 chimeric antigen receptor CART for T-cell lymphoma. (lls.org)
  • It's called Chimeric Antigen Receptor (CAR) T-Cell Therapy. (fundrazr.com)
  • Here, we demonstrate that NK cells (haNKs) engineered to express a PD-L1 chimeric antigen receptor (CAR) haNKs killed a panel of human and murine head and neck cancer cells at low effector-to-target ratios in a PD-L1-dependent fashion. (elifesciences.org)
  • Here, we describe the pre-clinical in vitro and in vivo study of irradiated haNK cells engineered to express a second-generation chimeric antigen receptor (CAR) targeting programmed death-ligand 1 (PD-L1). (elifesciences.org)
  • Characterization of dendritic cells generated in vivo by an E. coli derived chimeric dual receptor agonist. (medscimonit.com)
  • E. coli derived chimeric receptor agonists such as ProGP-4 may enable further investigations of immunotherapeutic approaches to the treatment of diseases such as cancer and autoimmunity. (medscimonit.com)
  • Ensure you have read ' Implementing chimeric antigen receptor T-cell therapy in practice ' before attempting to complete the module. (pharmaceutical-journal.com)
  • Tisagenlecleucel and axicabtagene ciloleucel are the two chimeric antigen receptor T-cell (CAR-T cell) treatments licensed in the UK. (pharmaceutical-journal.com)
  • One example is adoptive cell therapy with T cells that were genetically modified with gamma-retroviral and lentiviral (LV) delivery vectors to express a CD19-specific chimeric antigen receptor (CAR) for cancer treatment. (uni-wuerzburg.de)
  • Navai SA, Ahmed N. Broad Spectrum Chimeric Antigen Receptor T Cells to Target the Tumor Profile. (standuptocancer.org)
  • Chimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful immunotherapeutic tools for combating hematological diseases confronted with pressing medical needs. (nature.com)
  • CAR T cell therapy (or chimeric antigen receptor T cell therapy) is an example of cell-based gene therapy. (medlineplus.gov)
  • This gene provides instructions for making a protein, called the chimeric antigen receptor (CAR), that attaches to cancer cells. (medlineplus.gov)
  • Chimeric antigen receptors (CARs) are synthetic proteins expressed on the surface of T cells. (medscape.com)
  • BACKGROUND: Progenipoietin-4 (ProGP-4) is an E. coli derived chimeric growth factor that activates the human Flt3 and G-CSF receptors. (medscimonit.com)
  • A CD19/Fc fusion protein for detection of anti-CD19 chimeric antigen receptors. (escholarship.org)
  • Chimeric Antigen Receptors (CARs) consist of the antigen-recognition portion of a monoclonal antibody fused to an intracellular signaling domain capable of activating T-cells. (escholarship.org)
  • To this end we have used chimeric antigen receptors (CARs), a very promising approach recently used in several clinical trials to redirect primary human T cells against different tumours. (uninsubria.it)
  • One way to achieve this is to genetically modify immune cells, mainly T cells and recently also natural killer (NK) cells, to express chimeric antigen receptors (CARs). (nature.com)
  • Naive human pluripotent stem cells (hPSCs) can be used to generate mature human cells of all three germ layers in mouse-human chimeric embryos. (nature.com)
  • Transient inhibition of mTOR in human pluripotent stem cells enables robust formation of mouse-human chimeric embryos. (nature.com)
  • A chimeric monkey has been created using embryonic stem cells with two different sets of genes, a new study has demonstrated. (planer.com)
  • Previously engineered chimeric animals often exhibited low frequencies of the injected set of stem cells. (planer.com)
  • One example is adoptive cell therapy with T cells that were genetically modified with gamma-retroviral and lentiviral (LV) delivery vectors to express a CD19-specific chimeric The advances in genetic engineering have enabled us to confer T cells new desired functions or delete their specific undesired endogenous properties for improving their antitumor function. (uni-wuerzburg.de)
  • To test the RAS inhibitor's effectiveness, Satchell, Melnyk and colleagues grafted human breast and colon cancer cells onto mice and administered the chimeric toxin. (northwestern.edu)
  • Because mice don't respond to diphtheria toxin, the chimeric toxin trafficked directly to the human cancer cells and slowed tumor growth, demonstrating the effectiveness of the RAS inhibitor. (northwestern.edu)
  • If the binding subunit can be modified to traffic only to cancer cells, this chimeric toxin could be a seek and destroy weapon against cancer, Satchell said. (northwestern.edu)
  • The aim of this study was to test efficacy of ex-vivo created donor-recipient chimeric cells (DRCC) in reconstitution of bone marrow compartment following total body γ-irradiation (TBI). (aaps1921.org)
  • Chimeric monoclonal antibodies activate antigen-presenting cells (APCs) and T cells more effectively than murine monoclonal antibodies but can still induce production of human anti-chimeric antibodies. (msdmanuals.com)
  • This rat monoclonal chimeric antibody has been engineered from a RabMAb parent antibody ( ab237726 ). (abcam.com)
  • ab313596 is a mouse monoclonal chimeric antibody. (abcam.com)
  • Both inactivated and live-attenuated chimeric PCV1-2b vaccines induced a robust antibody responses, and significantly decreased microscopic lesion and lower viral loads in serum or superficial inguinal lymph nodes (SILN) compared with that in the nonvaccinated challenged group. (biomedcentral.com)
  • The Committee was informed of progress in research into chimeric chimpanzee/human monoclonal antibodies. (who.int)
  • DNA vaccine containing HEV ORF2 and ORF3 chimeric gene can successfully induce specific humoral and cellular immune response in mice. (wjgnet.com)
  • A mixture of all three anti-EBOV GP chimeric antibodies was protective against lethal challenge in a nonhuman primate study (Olinger et al. (anobase.org)
  • LETTERS additional studies will be required to elucidate whether New Chimeric Porcine the spectrum of potential hosts might include other farm or companion animals, and whether the virus might be Coronavirus in Swine Feces, able to infect humans. (cdc.gov)
  • Chimeric RNA, sometimes referred to as a fusion transcript, is composed of exons from two or more different genes that have the potential to encode novel proteins. (wikipedia.org)
  • We have developed a novel method for co-expressing multiple chimeric fluorescent fusion proteins in plants to overcome the difficulties of conventional methods. (jove.com)
  • Here, we describe a protocol for generating mouse-human chimeric embryos by injecting naive hPSCs converted from the primed state. (nature.com)
  • Fig. 7: NGS quantification of human DNA in mouse-human chimeric embryos. (nature.com)
  • This chimeric RNA can then be translated into a fusion protein. (wikipedia.org)
  • Human-murine chimeric autoantibodies with high affinity and specificity for systemic sclerosis. (bvsalud.org)
  • A murine / human chimeric IgG produced in N. benthamiana and is reactive to EBOV GP. (anobase.org)
  • To construct the plasmid pcHEV23 containing fragments of HEV ORF2 and ORF3 chimeric gene and to assess its ability to elicit specific immunologic response in mice. (wjgnet.com)
  • Chimeras are useful for studying embryo development but previous efforts to engineer chimeric animals have only been successful in mice and rats, this study is the first to demonstrate significant chimerism in primates. (planer.com)
  • In the present study, we investigated whether these metabolites could be generated in humanized chimeric mice produced from TK-NOG mice. (aspetjournals.org)
  • Overall, humanized TK-NOG chimeric mice were considered to be a functional tool for the study of drug metabolism of diclofenac in humans. (aspetjournals.org)
  • In this study, the efficacy of inactivated and live-attenuated (2 × 10 3.5 or 2 × 10 4.0 50 % tissue culture infective dose [TCID 50 ] dose) chimeric PCV1-2b vaccines was compared side-by-side in conventional pigs. (biomedcentral.com)
  • A chimeric toxin slowed tumor growth in mouse models of human breast and colon cancer, according to a Northwestern Medicine study published in Proceedings of the National Academy of the Sciences (PNAS). (northwestern.edu)
  • This chimeric virus presumably resulted from a ribosome entry and implications for genome organization. (cdc.gov)
  • Our study aims to characterize a small-animal infection model using a chimeric MmuPV1 genome with HPV-16 E6 and E7 in place of mouse E6 and E7 (MmuPV1-16E6E7). (iupui.edu)
  • The results demonstrated that both inactivated and live-attenuated chimeric PCV1-2b vaccines were effective to induce protective immunity against PCV2b infection. (biomedcentral.com)
  • However, occasionally gene products or pre-mRNA transcripts are spliced together so that exons from different transcripts are mixed together in a fusion product known as chimeric RNA. (wikipedia.org)
  • L1s generate hundreds of developmentally regulated and cell type-specific transcripts, many that are co-opted as chimeric transcripts or regulatory RNAs. (lu.se)
  • If the mouse gene for the whole variable region is spliced next to the human constant region, the product is termed "chimeric. (msdmanuals.com)
  • One of the first studies to investigate the generation of chimeric RNA examined the fusion of the first three exons of a gene known as JAZF1 to the last 15 exons of a gene known as JJAZ1. (wikipedia.org)
  • Chimeric Therapeutics expects a phase-1B clinical trial into its "natural killer" cell therapy for newly-diagnosed patients with acute myeloid leukemia to be open for new enrolments before the end of the year. (businessnews.com.au)
  • Chimeric says the trial showed positive results, particularly in blood cancers, where all patients achieved disease control. (businessnews.com.au)
  • Preference for normal, reversed or chimeric self-faces with neutral emotional expression in patients with schizophrenia and control subjects. (nel.edu)
  • Chimeric RNA often incorporates exons from highly expressed genes, but the chimeric transcript itself is usually expressed at low levels. (wikipedia.org)
  • Previous studies have demonstrated effectiveness of chimeric PCV1-2 vaccines against PCV2b challenge. (biomedcentral.com)
  • crRNA and tracrRNA duplexes can also be fused to generate a chimeric sgRNA 12 that mimics the natural crRNA-tracrRNA hybrid. (cdc.gov)
  • The researchers hope that developing a chimeric monkey model will facilitate research on neurological conditions such a motor neurone disease, but the chimeric macaque was euthanised after ten days due to respiratory issues coupled with hypothermia. (planer.com)
  • Through her multi-year project, ChimaTEK: Virtual Chimeric Space (2015-16), New York-based artist Saya Woolfalk invites viewers to imagine a new reality. (seattleartmuseum.org)