Children disease free survival. Medical search. Frequent questions

It improves the survival rate of children suffering from acute lymphoblastic leukemia relapse. (wikipedia.org)
however, because lymphoblastic lymphoma and acute lymphoblastic leukemia (ALL) are known to represent the same disease entity, the World Health Organization (WHO) classification has unified these entities as precursor B-cell and T-cell lymphoblastic leukemia/lymphoma. (medscape.com)
Hospitalization is necessary in patients with acute myeloid leukemia for managing chemotherapy and for treating complications related to the disease and its treatment, usually infections or febrile neutropenic episodes. (medscape.com)
June 3, 2011 (Chicago, Illinois) - A regimen of high-dose methotrexate appears to be superior to the standard protocol of escalating methotrexate in children and young adults with high-risk B-precursor acute lymphoblastic leukemia (ALL). (medscape.com)
With acute leukemias (ALL or AML), children who are free of the disease after 5 years are very likely to have been cured, because it's very rare for these cancers to return after this long. (cancer.org)
Results from the analysis showed a median overall survival (OS) of 26 months and demonstrated that responses remained durable in adults with relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL) with a consistent safety profile observed since the two-year analysis. (gilead.com)
Immunotherapy with blinatumomab leads to a strongly improved survival rate-from 66% to 93%-for children with an aggressive form of acute lymphoblastic leukemia (ALL). (medicalxpress.com)
Consuming a diet rich in vitamin A or its analogs may help prevent children and young adults with acute lymphoblastic leukemia (ALL) reduce their risk of developing painful pancreas inflammation during chemotherapy treatment. (medicalxpress.com)
Residing in border regions was linked with a higher risk of dying within five years among children with acute lymphoblastic leukemia, the most common type of pediatric cancer. (medicalxpress.com)
Acute' refers to the undifferentiated, immature state of the circulating lymphocytes ("blasts"), and to the rapid progression of disease, which can be fatal in weeks to months if left untreated. (medicalxpress.com)
The primary objectives of this study are: - To determine the proportion of children with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) related death, rehospitalization or major complications after infection with SARS-CoV-2 and/or Multisystem Inflammatory Syndrome in Children (MIS-C), and - To determine immunologic mechanisms and immune signatures associated with disease spectrum and subsequent clinical course during the year of follow-up. (stanford.edu)
Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. (medscape.com)
See the Childhood Acute Lymphoblastic Leukemia: Diagnosis, Management, and Complications slideshow to help recognize and treat this disease and its associated complications. (medscape.com)
Acute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children, representing more than a quarter of all pediatric cancers. (medscape.com)
The image below depicts bone marrow aspirate from a child with T-cell acute lymphoblastic leukemia. (medscape.com)
Children with acute lymphoblastic leukemia (ALL) often present with signs and symptoms that reflect bone marrow infiltration and/or extramedullary disease. (medscape.com)
The impact of dexamethasone and prednisone on sleep in children with acute lymphoblastic leukemia. (chop.edu)
The secondary objectives are to evaluate the relapse-free and overall survival after hematopoietic stem cell transplant as well as to evaluate the incidence of acute and chronic graft-versus-host disease after this preparative regimen. (mycancergenome.org)
Pediatric acute liver failure is a rare process that results from many different diseases including toxin ingestion and drug overdose, infections, metabolic and genetic disorders, immune-mediated diseases, and ischemia. (bvsalud.org)
Up to 50% of children with acute liver failure will never have an underlying cause found. (bvsalud.org)
Opportunities for improvement in the care of children with acute liver failure still exist. (bvsalud.org)

Millions continue to die from preventable diseases like HIV/AIDS, tuberculosis, malaria and respiratory infections. (who.int)
The WHO Eastern Mediterranean Region has experienced significant success in reducing morbidity and mortality due to vaccine‐preventable diseases. (who.int)
Moreover, the majority of the vaccine‐preventable disease‐related deaths are due to pneumococcal disease and rotavirus diarrhoea, some of which can be prevented through vaccination with newly-available vaccines. (who.int)
This event can be leveraged to bridge immunization gaps, introduce and expand the use of new vaccines, prevent and respond to vaccine‐preventable diseases in outbreaks and humanitarian crises, and achieve regional and national goals for accelerated disease control, elimination and eradication. (who.int)
The successes are mainly attributed to efforts of Ministry of Health (MOH) and its partners in the areas of malaria control, control of vaccine preventable diseases and improvement in prevention and case management of the main childhood killer diseases. (who.int)
Although mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) is preventable through antiretroviral treatment (ART) during pregnancy and postpartum, the Joint United Nations Programme on HIV/AIDS (UNAIDS) estimates that 160,000 new HIV infections occurred among children in 2018 (1). (cdc.gov)

Despite the generally excellent prognosis of children and adolescents with Hodgkin's lymphoma (HL), approximately 15% of patients relapse. (nih.gov)
Survival rates are often used by doctors as a standard way of discussing a child's prognosis (outlook). (cancer.org)
Children with intraocular retinoblastoma who have access to modern medical care have a very good prognosis for survival (>95% in industrialized countries). (aao.org)
Historically, children with extraocular retinoblastoma had a very poor prognosis for survival. (aao.org)
Prognostic evidence arises from prognosis studies, which aim to examine and predict future outcomes (such as death, disease progression, side effects or medical complications like pre-eclampsia) in people with a particular health condition or start point (such as those developing a certain disease, undergoing surgery, or women who are pregnant). (bmj.com)
Diffuse brainstem glioma is a devastating disease with very poor prognosis. (cochrane.org)
In general, mediastinal soft tissue sarcomas have a poor prognosis with a mean survival ranging from 4 to 34 months [ 2 , 5 - 9 ]. (allenpress.com)
Children with high risk disease have poor prognosis with only 30% showing 5-year event-free survival. (elifesciences.org)
The 2016 World Health Organization (WHO) classification of lymphoid neoplasms incorporates genetic data, clinical features, cell morphology, and immunophenotype, all of which have important implications for disease prognosis and management. (msdmanuals.com)

Massive choroidal invasion (≥3 mm of invasion), extrascleral extension, or postlaminar optic nerve disease increase the risk that metastatic disease could develop. (aao.org)
20-30% present with metastatic disease. (standardofcare.com)
For children with metastatic disease or disease in certain places of the brain, the survival drops to about 50 percent. (fredhutch.org)

time from diagnosis, study entry, or treatment to disease progression, disease relapse, a second tumour, or death), radiological response (a reduction in tumour size of more than 50%), and toxicities (damage to the body due to radiotherapy). (cochrane.org)
The 5-year progression-free survival and overall survival were 30% and 93.3%, respectively. (dtrf.org)
The phase III COSMIC-312 study has met its primary endpoint, showing a significant improvement in progression-free survival with cabozantinib plus atezolizumab compared with sorafenib in treatment-naive hepatocellular carcinoma (HCC), investigators reported at a European Society for Medical Oncology (ESMO) Virtual Plenary Session in November 2021. (ascopost.com)
Dr. Kelley presented the final primary progression-free survival analysis and the interim analyses for overall survival, as well as the interim analysis of progression-free survival for the comparison of cabozantinib and sorafenib as single agents. (ascopost.com)
She explained the rationale for combining cabozantinib and atezolizumab: cabozantinib is a standard of care after first-line sorafenib, having been shown to improve overall survival and progression-free survival vs placebo in that setting. (ascopost.com)
Dual primary endpoints were progression-free survival by blinded independent review for the combination vs sorafenib in the first 372 patients randomly assigned to these two arms (ITT [intention-to-treat] analysis) and overall survival for the combination vs sorafenib in all randomly assigned patients (ITT analysis). (ascopost.com)
The key secondary endpoint was progression-free survival for the single agents cabozantinib vs sorafenib. (ascopost.com)
Prespecified interim analyses of overall survival for cabozantinib/atezolizumab vs sorafenib and progression-free survival for cabozantinib vs sorafenib were performed at the primary progression-free survival analysis. (ascopost.com)
The risk of disease progression was reduced significantly by 37%, but no significant differences were observed for the primary overall survival endpoint in the ITT population. (ascopost.com)
The combination's advantage was clear in key subgroups, with the greatest benefits in progression-free survival seen in patients from Asia (HR = 0.56), those with HBV (HR = 0.46), and those with extrahepatic spread/macrovascular invasion (HR = 0.57). (ascopost.com)
For these subsets, overall survival mirrored the progression-free survival findings, with impressive hazard ratios. (ascopost.com)

Lymphoblastic lymphoma is associated with exposure to radiation or pesticides and congenital or acquired immunosuppression and is more common in children and young adults. (medscape.com)
High-dose methotrexate will be incorporated in current and future Children's Oncology Group trials for children and young adults. (medscape.com)
Although event-free survival continues to improve for children and young adults with high-risk ALL, CNS disease has become an increasing site of treatment failure, the authors note. (medscape.com)
While 80% of ALL occurs in children, it represents a devastating disease in adults. (gilead.com)
To assess the effects of conventional radiotherapy (with or without chemotherapy) versus other therapies (including different radiotherapy techniques) for newly diagnosed diffuse brainstem gliomas in children and young adults aged 0 to 21 years. (cochrane.org)
So far, there is no analysis or review available that assessed the benefits or harms of radiation for newly diagnosed diffuse brainstem glioma in children and young adults aged 0 to 21 years. (cochrane.org)
Further research is needed to establish the role of radiotherapy in the management of newly diagnosed diffuse brainstem glioma in children and young adults. (cochrane.org)
All randomised controlled trials (RCTs), quasi-randomised trials (QRCTs), or controlled clinical trials (CCTs) that compared conventional fractionated radiotherapy (with or without chemotherapy) versus other therapies (including different radiotherapy techniques) for newly diagnosed diffuse brainstem glioma in children and young adults aged 0 to 21 years. (cochrane.org)
In Europe, Myozyme is indicated for infants, children and adults with Pompe disease. (businesswire.com)
The overall cure rate in children is 85%, and about 50% of adults have long-term disease-free survival. (medicalxpress.com)
Extraosseous Ewing sarcoma occurs much more frequently in adults and children. (standardofcare.com)
Although recent trials of TB treatment-shortening in adults with sputum-positivity have not been successful, the question has never been addressed in children, who have mainly paucibacillary, non-severe smear-negative disease. (biomedcentral.com)
These adults are often parents of young children, increasing the exposure of children to TB. (biomedcentral.com)
Historically, studies of anti-tuberculosis treatment in children have lagged substantially behind adult studies and data regarding TB treatment extrapolated from adults. (biomedcentral.com)
The approaches used to treat childhood TB have relied on extrapolation to children of the evidence from clinical trials in adults who have a different spectrum of TB disease and lower bacillary burden [ 8 ]. (biomedcentral.com)
In another paper, the cumulative survival in 150 adults was followed from 2003 to 2016 and patients were screened for heart, lung, and kidney disease. (nih.gov)
In 1999 there were 2 major obstacles for curing adults with sickle cell disease. (nih.gov)
The first step was to provide a curative option for the majority of adults with SCD that are not eligible for the standard transplant because of age and co-morbidities including heart, lung, and kidney disease. (nih.gov)
In addition, the benefits of immunization are increasingly being extended to adolescents and adults, providing protection against life‐threatening diseases, such as influenza, meningitis and cancers that occur in adulthood. (who.int)

Centers for Disease Control and Prevention. (cdc.gov)
An expert authority on vaccine programs and global health, author William H. Foege, former director of the US Centers for Disease Control and Prevention, was the lead architect of the Task Force. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
In total, 1433 children (57% male) from 67 centers in 29 countries were included. (bvsalud.org)
In the area of non-communicable diseases, although lots remain to be done, the Ministry of Health is exerting its efforts in the provision of care to patients, with the establishment of dedicated NCD services including NCD corners in all health facilities & NCD clinics in health centers and above levels in all Zones. (who.int)
This program is cosponsored by the Centers for Disease Control and Prevention (CDC) and the Association of Public Health Laboratories (APHL). (cdc.gov)

The researchers' goal was to determine whether marital status was a positive prognostic factor in the rare asbestos-related disease in the same way that it is for other malignancies, including pancreatic cancer, breast cancer, lung cancer, melanoma, and prostate cancer. (mesothelioma.net)
However, they are also important for summarising other evidence, such as the accuracy of screening and diagnostic tests, 1 the causal association of risk factors for disease onset, and the prognostic ability of bespoke factors and biomarkers. (bmj.com)
For example, in many cancers, tumour grade at the time of histological examination is a prognostic factor because it is associated with time to disease recurrence or death. (bmj.com)
Understanding the variants that are specific to a certain kind of tumor and a patient's genetics may provide a more specific diagnosis of tumor type or subtype, additional prognostic information to help predict survival for a child diagnosed with cancer, and allow physicians to explore personalized treatment approaches that may be most effective for that patient. (childrensmercy.org)
BACKGROUND: This study aimed to assess the outcome of stem cell transplantation (SCT), including overall survival (OS), failure-free survival (FFS) and graft-versus-host disease (GvHD)-free/failure-free survival (GFFS), and to analyze prognostic. (koreamed.org)
CD4+ T-lymphocyte levels also are used as prognostic indicators in patients who have HIV disease (17,18) and recently have been included as one of the criteria for initiating prophylaxis for several opportunistic infections that are sequelae of HIV infection (19,20). (cdc.gov)

however, a combination of docetaxel and prednisone improves survival rates and lengthens the disease-free period. (wikipedia.org)
Nandivada P, Tirabassi M. Invited Commentary: Persistence Pays Off- Pursuing NED Status in Hepatoblastoma Improves Survival: An Observational Study by Fleming A, et?al. (umassmed.edu)

Notably, though some had hypothesized that married patients sought diagnosis earlier, the analysis revealed more early-stage disease among the unmarried group. (mesothelioma.net)
If your child has symptoms of leukemia, your doctor will order various tests to confirm a diagnosis. (hopkinsmedicine.org)
Short-term survival is also high: fewer than 10% of children die within a year of diagnosis and only 2% die within 30 days. (parliament.uk)
In combination with the challenges in confirming a TB diagnosis in children and the resource constraints, the focus has been on adult trials. (biomedcentral.com)
Exome sequencing allows researchers to find a molecular diagnosis in families with children who have a genetic basis for their disease. (childrensmercy.org)
We are planning to use this test for every patient at Children's Mercy who receives a new leukemia or solid tumor diagnosis as well as for those children whose cancer has relapsed. (childrensmercy.org)
APPROACH AND RESULTS: This was a multicenter retrospective study of children with a clinically and/or genetically confirmed ALGS diagnosis, born between January 1997 and August 2019. (bvsalud.org)
Event-free survival (EFS) [Time Frame: the date of Wilms tumor diagnosis to the first treatment failure or date of last follow-up. (who.int)

According to the Joint United Nations Programme on HIV/AIDS (UNAIDS), the estimated number of new cases of HIV among children in 2019 (150,000) was nearly eight times the 2020 global target. (cdc.gov)
In 2019, through PEPFAR, CDC supported treatment for 482,000 HIV-positive pregnant women to reduce the risk of mother-to-child transmission. (cdc.gov)

A chronological account of the Task Force is the first aim of the book, which will be fascinating reading for those training or already working in global health, public health, infectious diseases, or immunization programs. (cdc.gov)
While the prospects for using human genome-based testing in clinical care and prevention are exciting, the emergence of powerful sequencing and bioinformatics tools has completely changed the landscape in the public health fight against infectious diseases. (cdc.gov)
In 2013 CDC launched the Advanced Molecular Detection (AMD) Initiative, which aims to build critical molecular sequencing and bioinformatics capacities at national and state levels to support public health efforts to control infectious diseases. (cdc.gov)
The most immediate causes of these poor health outcomes are infectious diseases and undernutrition, while more remote factors, such as resources available to parents, are also known to play a role in child health. (lu.se)

For many years, most children in the United States were treated with chemotherapy protocols developed by the Children's Cancer Group and the Pediatric Oncology Group. (medscape.com)
A pediatric oncologist (a doctor who specializes in childhood cancer) will lead the medical team caring for a child with Hodgkin lymphoma. (rchsd.org)
Thanks to the innovative treatments we offer, our five-year survival rates for many types of pediatric leukemia are 93 percent or greater. (hopkinsmedicine.org)
His clinical and research interests include transplantation in infants and small children, neonatal surgery, congenital anomalies and pediatric tumors. (seattlechildrens.org)
The incidence of adrenocortical tumors in children is extremely low (only 0.2% of pediatric cancers). (oncolink.org)
Clinical and outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry. (oncolink.org)
Factors associated with survival in pediatric adrenocortical carcinoma: An analysis of the National Cancer Data Base (NCDB). (oncolink.org)
For other discussions of HIV infection, see HIV Disease, Pediatric HIV Infection, and Antiretroviral Therapy for HIV Infection. (medscape.com)

Median (95% CI) relapse-free survival (RFS) censored and not censored at subsequent alloSCT were both 11.6 (2.7-20.5) and 11.7 months (2.8-20.5), respectively. (gilead.com)
Duration of remission and relapse-free survival, overall survival, minimal residual disease (MRD) negativity rate, and alloSCT rate were assessed as secondary endpoints. (gilead.com)

A recent study published in the May 15, 2020 edition of CDC's Morbidity and Mortality Weekly Report (MMWR) pdf icon found that when mothers were diagnosed with HIV and started antiretroviral treatment (ART) before they became pregnant, their babies were more likely to remain HIV-free. (cdc.gov)
Mortality rate of adrenocortical tumors in children under 15 years of age in Curitiba, Brazil. (oncolink.org)
Although child health in sub-Saharan Africa has been improving for the past few decades, the region still has the highest mortality rate for children under five as well as high levels of child morbidity. (lu.se)

Children who survive bilateral retinoblastoma have an increased incidence of a second-primary nonocular malignancy later in life. (aao.org)
In children, 25 new cases are expected to occur annually in the United States, for an estimated annual incidence of 0.2 to 0.3 cases per 1 million individuals. (oncolink.org)
Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995. (oncolink.org)
In the non-Brazilian cases, relatives of children with adrenocortical tumors often, although not invariably, have a high incidence of nonadrenal cancers (Li-Fraumeni syndrome). (oncolink.org)
A 42-month prospective study by Smith et al in 912 HIV-1-infected patients found that condylomata acuminata and verrucae are observed early, and their frequency does not increase as the disease progresses, whereas the incidence of HSV infections, MC, and oral hairy leukoplakia increases as the disease advances. (medscape.com)

The event-free rate of cardiovascular events in patients with the distal-dominant form was significantly worse (log-rank P=0.012) than that in patients with the pure-apical form (follow-up period: asymptotically approximately 5 years). (nih.gov)
Genzyme's commitment to innovation continues today with a substantial development program focused on these fields, as well as cardiovascular disease, neurodegenerative diseases, and other areas of unmet medical need. (businesswire.com)
Medical providers use risk calculators in a number of ways, for example, to predict an individual patient's risk of cardiovascular disease, risk of having a child with Down syndrome, likelihood of survival from an intensive care unit, and likelihood of experiencing other medical conditions. (aao.org)

However, in a recent COG report, the authors demonstrated that intensive multimodal therapies-including high-dose chemotherapy, radiation, and bone marrow transplantation-have enabled improved efficacy for curing patients with regional extraocular retinoblastoma (87% event-free survival [EFS] at 36 months) and metastatic retinoblastoma not involving the CNS (79% EFS at 36 months), while rates for patients with CNS disease continue to be dismal (8% EFS at 36 months). (aao.org)
ZUMA-3 is an ongoing international multicenter (US, Canada, Europe), single arm, open label, registrational Phase 1/2 study of Tecartus in adult patients (≥18 years old) with ALL whose disease is refractory to or has relapsed following standard systemic therapy or hematopoietic stem cell transplantation. (gilead.com)
Solid organ transplantation is an important therapeutic option for children with a variety of end stage diseases. (stanford.edu)
Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative therapy for sickle cell disease (SCD). (haematologica.org)
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a well-established treatment modality for a variety of diseases. (koreamed.org)
PURPOSE: To identify the symptoms and signs of patients with dry eye disease (DED) after allogenic hematopoietic stem cell transplantation (HSCT) and analyze the correlations between these signs and symptoms. (koreamed.org)
For some children liver transplantation is needed for survival, but many children will recover with appropriate therapy, without the need for transplantation. (bvsalud.org)
Nonetheless, overall survival is approximately 50% without liver transplantation. (bvsalud.org)

Biology, clinical characteristics, and management of adrenocortical tumors in children. (oncolink.org)
Physicians and their clinical team members need to educate patients regarding their disease, including potential preventive measures, treatments, and outcomes. (aao.org)
As an example, one of the drugs that showed promise in this manner will be tested in a national clinical trial for children with brain tumors beginning next year. (fredhutch.org)
Clinical disease: physical signs and symptoms resulting from a sufficiently absorbed toxicant dose. (cdc.gov)

This means that people in need of medical help for illnesses other than Ebola are being turned away, even when they have potentially life threatening conditions such as malaria or complications during child birth. (huffpost.com)
These diseases and their related complications generate a real and significant threat globally and to Eritrea. (who.int)

Our hope is that these results, along with our commitment to long-term research of Tecartus, will continue to provide clarity to physicians on optimal treatment methods for these patients living with this rare disease who have suffered historically poor outcomes. (gilead.com)

This means that they're in permanent remission and will have long-term cancer-free survival. (rchsd.org)
Low dose chemotherapy achieved stable disease and even remission of the lesions with low toxicity. (dtrf.org)

Your child's doctor can probably tell you how these numbers apply to your child. (cancer.org)
For this analysis, HIV-free survival was defined as the child being alive and HIV-negative at the time of the survey, as determined by either the HIV testing conducted during the survey or the maternal report of the child's HIV status. (cdc.gov)
The test - available free of charge to Children's Mercy (CM) patients thanks to generous philanthropic contributions from the community - allows researchers and physicians to better understand treatment options for a child's cancer, their chance of survival, and hereditary cancer risk factors for the patient and their family. (childrensmercy.org)
Newborn screening identifies more than 30 conditions that can affect a child's long-term health or survival. (cdc.gov)

Data suggest that young patients with recurring disease following autologous HSCT, as well as some patients with multiple relapses and selected patients with refractory lymphoma, might benefit from allogeneic HSCT, but relapse remains the major challenge. (nih.gov)
Lymphoblastic lymphoma is aggressive and progresses rapidly, presenting as stage IV disease in more than 70% of patients (see Staging). (medscape.com)
The researchers also suggested that spouses and children of married patients impacted compliance with doctors' advice and encouraged active treatment. (mesothelioma.net)
In a planned interim analysis, 5-year event-free survival for patients who received the high-dose regimen was 82%, compared with 75% for those receiving the escalation protocol. (medscape.com)
Enrollment was stopped early because the survival difference crossed a predefined boundary, explained Dr. Larsen, and patients receiving the escalating-dose regimen were permitted to cross over to the high-dose regimen when feasible. (medscape.com)
The continued durable response and significant improvement in survival indicated by these new data can potentially establish a new standard of care for adult patients living with this aggressive form of leukemia. (gilead.com)
We offer advanced treatments like CAR T-cell therapy that result in excellent survival rates for our patients, and our program is recognized as a Top 50 Children's Cancer Program by U.S. News & World Report for 2023-2024. (hopkinsmedicine.org)
Patients who cannot undergo complete resection or have an unresectable disease have poor prognoses [ 2 ]. (allenpress.com)
Eligible patients had HCC not amenable to curative treatment or locoregional therapy, Child-Pugh class A, an Eastern Cooperative Oncology Group performance status ≤ 1, and no prior systemic therapy. (ascopost.com)
Asian patients accounted for 29% of the population, and 69% of patients had extrahepatic disease or macrovascular invasion. (ascopost.com)
Genzyme is also continuing its 160 L production in the U.S. for patients with infantile-onset Pompe disease. (businesswire.com)
approximately 1,400 Pompe patients are currently treated with either Myozyme or Lumizyme, which are the only treatments approved for the disease. (businesswire.com)
In the US, Lumizyme is indicated for patients 8 years and older with late (non-infantile) onset Pompe disease (GAA deficiency) who do not have evidence of cardiac hypertrophy. (businesswire.com)
In the US, Myozyme (alglucosidase alfa) is indicated for use in patients with Pompe disease (GAA deficiency). (businesswire.com)
Myozyme has been shown to improve ventilator-free survival in patients with infantile-onset Pompe disease as compared to an untreated historical control, whereas use of Myozyme in patients with other forms of Pompe disease has not been adequately studied to assure safety and efficacy. (businesswire.com)
[1] With five-year disease-free survival rates now surpassing 80% for young people, [2] health care providers need to provide information about the risks of infertility to patients with cancer. (cancer.org.au)
In order to discuss fertility with patients, it is important to understand the impact of cancer treatment on fertility and the chance of conceiving a child naturally. (cancer.org.au)
In a publication on 225 patients, primarily with Hb SS disease, data shows that even though 60% of patients were taking hydroxyurea, the median survival age was only 48 years. (nih.gov)
Five of eight patients engrafted and only two remain free of SCD. (nih.gov)
Ten of twelve patients engrafted, but only six remain free of SCD. (nih.gov)
It's incredibly gratifying to see my weight loss surgery patients reduce or eliminate their need for prescription medications and become free from conditions like back pain, diabetes, high blood pressure, and acid reflux" says Dr. Spiegel. (memorialhermann.org)
An elevated arterial or free venous serum ammonia level is the classic laboratory abnormality reported in patients with hepatic encephalopathy. (medscape.com)

Joint contracture in chronic graft-versus-host disease (cGVHD) is refractory to treatment, and tends to deteriorate gradually over time. (koreamed.org)
Their relevance in terms of graft-versus-host disease (GVHD). (koreamed.org)

Adrenocortical tumors encompass a spectrum of diseases with often seamless transition from benign (adenoma) to malignant (carcinoma) behavior. (oncolink.org)
Rodriguez-Galindo C: Adrenocortical tumors in children. (oncolink.org)
In: Schneider DT, Brecht IB, Olson TA: Rare Tumors in Children and Adolescents. (oncolink.org)
According to Olson, current treatment options of surgery, radiation and chemotherapy are better today, yet a number of children still die from these tumors and often the therapy permanently damages many of those who survive. (fredhutch.org)

Native liver survival (NLS) and event-free survival rates were assessed. (bvsalud.org)

Spinal muscular atrophy is a devastating, monogenic neurodegenerative disease that in its most severe form, SMA Type 1 (SMA1), afflicted children never sit unassisted, roll over or maintain head control. (neurology.org)
We now know that a number of other children have also developed severe neurological side effects and the Milan protocol was quickly withdrawn from use in the UK. (parliament.uk)
Tuberculosis (TB) in children is frequently paucibacillary and non-severe forms of pulmonary TB are common. (biomedcentral.com)
We aim to recruit 1200 African and Indian children aged below 16 years with non-severe TB, with or without HIV infection. (biomedcentral.com)
Background: Since October 2021, there have been more than 500 cases of severe hepatitis of unknown origin in children reported worldwide, including 180 cases in the U.S. The most frequently detected potential pathogen to date has been adenovirus, typically serotype 41. (bvsalud.org)
Many associated skin diseases are more severe in this group. (medscape.com)
Other individuals have a multitude of the most severe symptoms of end-stage liver disease and a limited chance for survival. (medscape.com)

The primary efficacy and safety endpoints are TB disease-free survival 72 weeks post randomisation and grade 3 or 4 adverse events. (biomedcentral.com)

Accurate survival rates for less common forms of childhood leukemia are harder to find. (cancer.org)
However, we should not allow these headline statistics, encouraging though they are, to blind us to the fact that, rare though childhood cancer is, it remains the leading cause of death in children and teenagers in the United Kingdom. (parliament.uk)
Her labour ensures the survival and well-being of her family but robs her not only of her childhood but also of her right to be free of hunger, ignorance, disease and poverty. (whale.to)

If a child is over age three and has a complete surgical resection followed by radiation and chemotherapy, the likelihood of three-year cancer-free survival is about seventy percent. (fredhutch.org)

The company's products and services are focused on rare inherited disorders, kidney disease, orthopaedics, cancer, transplant and immune disease. (businesswire.com)
First, we are interested in Epstein Barr Virus-mediated mechanisms of immune evasion with particular emphasis on pathways that promote survival and proliferation of EBV B cell lymphomas, the characterization of the human T cell and NK cell response to EBV and the identification of novel therapeutics for treatment of EBV B cell lymphomas. (stanford.edu)
When vaccines are combined with other health interventions, such as vitamin A supplementation to boost children's immune systems, provision of deworming medicine, growth‐monitoring, and distribution of insecticide‐treated nets to prevent malaria, immunization becomes a major force for child survival. (who.int)
For patient education information, see the Immune System Center, Sexually Transmitted Diseases Center, Teeth and Mouth Center, and Yeast and Fungal Infections Center, as well as HIV/AIDS, Canker Sores, Candidiasis (Yeast Infection), and Syphilis. (medscape.com)
Verrucous herpes infection, leprosy, condylomalike molluscum contagiosum, and AIDS-associated pigmented or nonpigmented erythroderma may be seen in early HIV disease or as part of immune restoration syndrome after the initiation of antiretroviral therapy. (medscape.com)
10, 11, 12] Diffuse or disseminated leishmaniasis may occur with HIV disease,[13, 14] including in association with the immune reconstitution inflammatory syndrome. (medscape.com)

Short time to relapse and refractory disease at the time of autologous HSCT remain the most important risk factors. (nih.gov)

For children under age three, the outcome remains about 30 percent even after highly aggressive therapy that sometimes includes multiple rounds of chemotherapy combined with infusions hematopoetic stem cells. (fredhutch.org)

Mother-to-child transmission of HIV can occur during pregnancy, delivery, or breastfeeding. (cdc.gov)
Of the estimated 10.4 million new tuberculosis (TB) cases globally per annum, approximately one million occur in children in Africa and South East Asia [ 1 ]. (biomedcentral.com)
Steps that must occur for an environmental toxicant to cause disease. (cdc.gov)
Exposure: For a toxicant to cause disease, exposure must occur. (cdc.gov)

But more needs to be done to reach the global goals for the elimination of new HIV infections among children. (cdc.gov)
In the later stages of HIV disease, chronic herpes simplex virus (HSV), molluscum contagiosum (MC), and cytomegalovirus (CMV) infections appear. (medscape.com)
The most common cutaneous infections in children with HIV disease are impetigo and cellulitis caused by Staphylococcus aureus. (medscape.com)

Dr. Keith Hoots, the Division Director at the Division of Blood Diseases and Resources (DBDR) opened the meeting by greeting the Sickle Cell Disease Advisory committee (SCDAC) members. (nih.gov)

In the third National Wilms Tumor Study (NWTS), the survival rate ranged from 95% for stage I to almost 80% for stage IV. (medscape.com)

To test whether marital status has an impact on malignant pleural mesothelioma survival , the scientists relied on the research data collected by the Surveillance, Epidemiology, and End Results (SEER) program, which includes 18 different cancer registries' research data and covers 30% of the U.S. population. (mesothelioma.net)

The International Berlin-Frankfurt-Münster (BFM) Study Group reported that children with relapsed AML who received liposomal daunorubicin (DNX) in conjunction with the FLAG regimen (fludarabine, cytarabine, and granulocyte colony-stimulating factor [G-CSF]) had improved early treatment response. (medscape.com)
Even though methotrexate has been used for more than 5 decades and is an essential part of the treatment regimen for children with ALL, the optimal dose and schedule have not been fully established. (medscape.com)
Improvements in treatment since then might result in a better outlook for children now being diagnosed. (cancer.org)
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease. (umassmed.edu)
Favourable opinion for reimbursement in the treatment of pre-symptomatic infants and children with genetically diagnosed 5q spinal muscular atrophy with 2 to 3 copies of the SMN2 gene. (has-sante.fr)
Therapeutic improvement in the treatment of pre-symptomatic infants and children with genetically diagnosed 5q spinal muscular atrophy with 2 to 3 copies of the SMN2 gene. (has-sante.fr)
Due to the complexity of the management of this rare disease, the Committee reiterates that it recommends that decisions to initiate or discontinue treatment with SPINRAZA (nusinersen) be taken at multidisciplinary review meetings in neuromuscular diseases reference and expertise centres. (has-sante.fr)
This study clearly shows the earlier we reach HIV-positive women with treatment, the better the chances are for their children to survive and stay HIV-free," says Sasi Jonnalagadda from DGHT's Epidemiology and Surveillance Branch, who led this analysis. (cdc.gov)
Given the patient's extended survival, we present the oncologic rationale for treatment and considerations of late toxicity. (allenpress.com)
Systemic treatment of adrenocortical carcinoma in children: data from the German GPOH-MET 97 trial. (oncolink.org)
They have set up Blue Skye Thinking, a charity that supports research so that all children diagnosed with brain tumours will have a better chance of survival and a better quality of life post-treatment. (parliament.uk)
Evidence for tuberculosis treatment in children is largely extrapolated from adult studies. (biomedcentral.com)
SHINE should inform whether treatment-shortening of drug-susceptible TB in children, regardless of HIV status, is efficacious and safe. (biomedcentral.com)
A positive result from this trial could simplify and shorten treatment, improve adherence and be cost-saving for many children with TB. (biomedcentral.com)
The treatment of cancer in pre-menopausal women of child bearing age is associated with decreased pregnancy and live birth rates. (cancer.org.au)
It is recommended that health professionals inform all people diagnosed with cancer (or their parents in the case of children) that there is potential for cancer treatment to impact their fertility. (cancer.org.au)
Treatment failure included abandonment of treatment, death, and progressive or relapsed disease. (who.int)
Figure 1), observing that "Poverty, the use of impure water, availability and treatment of drinking water, few barriers constipation, overwork, bad alimentation, the total absence were in place to stop the rapid spread of cholera, especially of hygiene, and meteorologic conditions" were the causes in a population that had not previously been exposed to of "this disease that is making so many victims. (cdc.gov)

These numbers tell you what portion of children in a similar situation (such as with the same type and subtype of leukemia) are still alive a certain amount of time after they were diagnosed. (cancer.org)
The 5-year survival rate refers to the percentage of children who live at least 5 years after their leukemia is diagnosed. (cancer.org)
Leukemia is the most common cancer in children. (hopkinsmedicine.org)
Having a child diagnosed with leukemia is an overwhelming moment for a family. (hopkinsmedicine.org)
Our blood cancer specialists see several hundred children with leukemia every year. (hopkinsmedicine.org)
Without enough healthy white blood cells, children with leukemia are less able to fight off infection. (hopkinsmedicine.org)
What Causes Leukemia in Children? (hopkinsmedicine.org)
What Are the Early Symptoms of Leukemia in Children? (hopkinsmedicine.org)
Does living along the US-Mexico border affect the chances of survival among children with leukemia? (medicalxpress.com)
ALL is the most common type of cancer and leukemia in children in the United States. (medscape.com)

Current 5-year survival rates are based on children first diagnosed and treated more than 5 years ago. (cancer.org)
Children who are disease-free for five years are very likely cured. (hopkinsmedicine.org)
By comparison, those children whose mothers did not receive ART at any stage of pregnancy had only a 53 percent chance of HIV-free survival beyond three years. (cdc.gov)
Eight in 10 children with cancer survive five years or more, compared with just three in 10 in the 1960s. (parliament.uk)
By 10 and 18 years, 51.5% and 66.0% of children with ALGS experienced ≥1 adverse liver-related event (CEPH, transplant, or death). (bvsalud.org)
In the early asymptomatic stage of HIV disease, which may last from a few years to a decade or longer, no signs of infection other than lymphadenopathy are present. (medscape.com)
This new level is based on the U.S. population of children ages 1-5 years who represent the top 2.5% of children with the highest blood lead levels. (cdc.gov)

Although these treatments prolonged pancytopenia, they decreased induction failures and substantially improved disease-free survival. (medscape.com)
Undernutrition is responsible for one third of all child deaths and contributes substantially to the global burden of disease. (who.int)

Pompe disease is a progressive, debilitating and often fatal neuromuscular disease caused by a genetic deficiency or dysfunction of the lysosomal enzyme acid alpha-glucosidase (GAA). (businesswire.com)

Some people find survival rates helpful, but some people might not. (cancer.org)
Even when taking these other factors into account, survival rates are at best rough estimates. (cancer.org)
However, survival rates vary depending on the subtype of AML and other factors. (cancer.org)
For JMML, 5-year survival rates of about 50% have been reported. (cancer.org)
Ministers have demonstrated a clear commitment to fighting cancer and the work and money that has been put into the system to improve cancer survival rates are bearing fruit and proving that the money is being well spent. (parliament.uk)
Child survival and HIV-free survival rates* are standard measures of progress toward eliminating MTCT(dagger) (2). (cdc.gov)

Nested pharmacokinetic studies will evaluate anti-tuberculosis drug concentrations, providing model-based predictions for optimal dosing, and measure antiretroviral exposures in order to describe the drug-drug interactions in a subset of HIV-infected children. (biomedcentral.com)

Specific medical therapies may be applied to many liver diseases in an effort to diminish symptoms and to prevent or forestall the development of cirrhosis. (medscape.com)

Because of this, Dr. Healey has unique expertise in the surgery of the liver and biliary tract in children. (seattlechildrens.org)
A patient may become disease-free if treated with the complete removal of the tumor or a liver transplant if the cancer has not spread outside the liver. (thebarberlawfirm.com)
This study aimed to elucidate the natural history of liver disease in a contemporary, international cohort of children with ALGS. (bvsalud.org)
CONCLUSIONS: In this large international cohort of ALGS, only 40.3% of children reach adulthood with their native liver. (bvsalud.org)

Accounts for about 2% of cancers in children. (standardofcare.com)

The response rate to chemotherapy was 54%, and up to 81% if stable disease cases were included. (dtrf.org)

For more information on how the team in the Cancer and Blood Disorders Institute at Johns Hopkins All Children's Hospital can help your child, please give us a call. (hopkinsmedicine.org)

and ensure the long-term health of mothers and children. (nih.gov)
Long-term survival and state of health after paediatric intensive care. (bmj.com)
Early tumor detection has improved the long-term disease-free survival of children with WAGR syndrome. (medscape.com)
CAMBRIDGE, Mass.--( BUSINESS WIRE )-- Genzyme Corp. (NASDAQ: GENZ) today announced that it will build an additional manufacturing plant in Geel, Belgium, to support the long-term growth of Myozyme ® and Lumizyme ® for Pompe disease. (businesswire.com)

Consequently, despite the large number with health impairment before admission, cumulative one year survival was favourable and health status in three quarters of the population was preserved. (bmj.com)

And children who have Down syndrome or Li-Fraumeni syndrome are also at a higher risk for the disease. (hopkinsmedicine.org)
PAX6 plays a role in CNS development as well and may be responsible for the mental retardation seen in a reported 75% of children with WAGR syndrome. (medscape.com)

The study looked at 33,863 births and found that children born to mothers living with HIV were less likely to *survive until the age of 3 compared to mothers without HIV. (cdc.gov)
We have heard many stories of people who survive the disease but are not allowed back or are stigmatized. (huffpost.com)

12 months after completion of therapy) may be cured with conventional therapy, those with progressive disease or early relapse (3-12 months) are considered candidates for autologous HSCT. (nih.gov)
Data on allogeneic HSCT in children with HL are scarce. (nih.gov)

Anatomy5

Organisms2

Diseases61

Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment80

Psychiatry and Psychology17

Phenomena and Processes25

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena15

Humanities1

Information Science9

Named Groups9

Health Care52

Geographicals4

Acute21

Preventable6

Prognosis9

Metastatic disease3

Progression11

Adults19

Centers6

Prognostic6

Improves survival2

Diagnosis8

20192

Infectious diseases4

Pediatric8

Relapse-free2

Mortality3

Incidence5

Cardiovascular3

Transplantation8

Clinical4

Complications2

Outcomes1

Remission2

Child's4

Patients22

Graft versus2

Tumors4

Event-free1

Severe7

Endpoints1

Childhood3

Cancer-free survival1

Immune6

Refractory1

Outcome1

Occur4

Infections3

Sickle cell di1

Wilms Tumor1

Malignant1

Treatment18

Leukemia10

Years7

Substantially2

Neuromuscular1

Rates6

Tuberculosis1

Symptoms1

Liver4

Cancers1

Chemotherapy1

Children's Hospital1

Long-term4

Favourable1

Syndrome2

Survive2

HSCT2