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  • chromosome
  • Patients are more likely to be cured if their leukemia cells have more than 50 chromosomes (called hyperdiploidy ), especially if there is an extra chromosome 4, 10, or 17. (cancer.org)
  • radiation
  • X-rays or CT scans done before birth or during childhood use much lower levels of radiation than those used for treatment. (cancer.org)
  • High radiation exposure can cause leukemia, as can genetic risk factors like Down Syndrome, and there may be other risk factors we do not know about, he said. (reuters.com)
  • Other serious side effects may include allergic reactions such as anaphylaxis, heart damage, tissue damage at the site of injection, radiation recall, and treatment-related leukemia. (wikipedia.org)
  • Ionizing radiation is another exposure conclusively linked with childhood leukemia. (wikipedia.org)
  • cases
  • Doctors have found that if the spinal tap isn't performed expertly and some blood leaks into the CSF, in some cases leukemia cells may get into the fluid and grow there. (cancer.org)
  • Childhood leukemia is a very rare disease, so it is hard to have enough cases in one study to determine which risk factors play a role, but according to this and other large surveys, the evidence seems to be pointing toward an association between traffic emissions and childhood leukemia, said coauthor Denis Hemon of the Institute National de la Santé et de la Recherché Medical (INSERM) based in Paris. (reuters.com)
  • Though benzene levels have sharply decreased in Europe in recent years, and the levels in the current study are largely well below European regulations, childhood leukemia cases have not decreased, Vinceti said. (reuters.com)
  • The exact cause of most cases of childhood leukemia is not known. (wikipedia.org)
  • pediatric
  • After introductory chapters on the epidemiology and biology of pediatric leukemia, treatment considerations are extensively reviewed, with emphasis on the use of risk-adjusted treatment approaches. (springer.com)
  • This handbook has far-reaching applicability to the clinical diagnosis and management of pediatric leukemia and will prove invaluable to specialists, generalists, and trainees alike. (springer.com)
  • epidemiology
  • The new findings, published in the October 2010 issue of the International Journal of Epidemiology, come from the Northern California Childhood Leukemia Study, a population-based case-control study that includes 35 counties in the northern and central regions of the state. (innovations-report.com)
  • disease
  • Even though these findings may make a doctor suspect that a child has leukemia, usually the disease can't be diagnosed for sure without looking at a sample of bone marrow cells. (cancer.org)
  • New testing techniques, such as flow cytometry or polymerase chain reaction (PCR), can accurately measure leukemia cells in the bone marrow after treatment, or minimal residual disease (MRD). (cancer.ca)
  • The late effects of leukemia and its therapy are then considered in depth, with due attention to management of the psychosocial impact of the disease. (springer.com)
  • This so-called "priming" of the immune system may explain why 99 out of every 100 kids who are genetically predisposed to childhood leukemia don't actually contract the disease-and why rates of ALL are higher in technologically advanced developed countries compared to undeveloped countries, which tend to have less effective sanitation systems and therefore a higher (and arguably healthier) rate of microbial exposure. (organicconsumers.org)
  • Other branch of medicine that is of great interest to him is childhood ITP, where he feels qualms about the early treatment of this disease with the help of immunoglobulin. (wikipedia.org)
  • exposure
  • Evidence is starting to mount that exposure to traffic emissions early in life is tied to childhood leukemia, either only to AML or just more strongly to this than to other forms of leukemia, said professor Marco Vinceti of the Universita di Modena e Reggio Emilia in Italy, who has studied this question but was not part of the French paper. (reuters.com)
  • The study found an increased risk from X-rays for ALL, but not for AML or T-cell leukemia, and there was no association with age at first exposure. (innovations-report.com)
  • There also appears to be some evidence linking childhood leukemia to x-ray exposure. (wikipedia.org)
  • researchers
  • A 300 meter increase in major road length within 150 meters of the home appeared to increase the risk of AML by 20 percent, but did not affect the risk of ALL, when the researchers compared the leukemia groups and the comparison group. (reuters.com)
  • Diagnostic X-rays may increase the risk of developing childhood leukemia, according to a new study by researchers at the University of California, Berkeley's School of Public Health. (innovations-report.com)
  • http://www.iflscience.com/health-and-medicine/researchers-kill-drug-resistant-leukemia-cells-using-dna-trojan-horse-attack Daunorubicin should only be administered in a rapid intravenous infusion. (wikipedia.org)
  • cells
  • The antibody acts like a homing signal, bringing the chemo drug to the leukemia cells, where it enters the cells and kills them when they try to divide into new cells. (cancer.org)
  • Standard lab tests, such as microscopy, may not find these leukemia cells. (cancer.ca)
  • But more sensitive tests, such as flow cytometry or polymerase chain reaction (PCR), find these leukemia cells. (cancer.ca)
  • This leukemia typically progresses rapidly and is characterized by the development of leukemic white blood cells called lymphoblasts, which accumulate and crowd out healthy cells. (emaxhealth.com)
  • Among concerns, sometimes leukemia can develop resistance, and sometimes patients worsen while waiting for their new cells, said Sekeres, who directs the Cleveland Clinic's leukemia program and wasn't involved with CAR-T testing. (foxbusiness.com)
  • When a child has leukemia, the cells do not respond to the signals telling them when to stop and when to produce cells, regardless of the available space. (wikipedia.org)
  • diagnosis
  • Interviews were conducted with mothers within four months of the diagnosis of leukemia, and the mothers were asked to report on the number of X-rays received by the child at least 12 months or more before the leukemia diagnosis. (innovations-report.com)
  • child
  • If your child has signs and symptoms that might suggest leukemia, the doctor will want to get a thorough medical history to learn about the symptoms and how long your child has had them. (cancer.org)
  • The healthcare team will create a treatment plan just for your child with leukemia. (cancer.ca)
  • They help doctors decide whether a child with leukemia should receive standard treatment or more intensive treatment. (cancer.org)
  • acute lymphobl
  • Langhorne, PA and Oxford, UK - 18 November 2011 - EUSA Pharma, a transatlantic specialty pharmaceutical company focused on oncology, oncology supportive care and critical care, today announced that the US Food and Drug Administration (FDA) has approved its orphan drug ERWINAZE™ (asparaginase Erwinia chrysanthemi) for the treatment of acute lymphoblastic leukemia (ALL) in patients with hypersensitivity to E. coli-derived asparaginase. (adventls.com)
  • Treatment with asparaginase is a vital and life-saving therapy for thousands of patients, mostly children, with acute lymphoblastic leukemia each year. (adventls.com)
  • Asparagine is essential for cell growth, and its removal from the blood inhibits the growth of cells associated with acute lymphoblastic leukemia. (adventls.com)
  • Background: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. (ijbc.ir)
  • Ale Ahmad A, Saburi E, Rajaei T, Mortazavi Y. Taq1 Polymorphism (rs731236) of Vitamin D Receptor Gene in Children with Acute Lymphoblastic Leukemia. (ijbc.ir)
  • As a result, it has been implicated in cancers such as childhood acute lymphoblastic leukemia (ALL) and glioblastoma multiforme (GBM). (wikipedia.org)
  • studies
  • While the support from individual studies is weak, the epidemiological studies demonstrate, for some methods of measuring exposure, a fairly consistent pattern of a small, increased risk with increasing exposure that is somewhat weaker for chronic lymphocytic leukemia than for childhood leukemia. (arthurhu.com)