• CONCLUSIONS: Second-line palliative chemotherapy with RP was shown to prolong the PFS and OS, especially among patients with ascites or peritoneal involvement, which warrants confirmation using larger sample studies. (bvsalud.org)
  • However, many patients are offered palliative chemotherapy (PC) instead, due to perceived morbidity of CRS and HIPEC. (medicinelakex1.com)
  • Patients treated with palliative chemotherapy suffer significant morbidity from disease progression that disrupts chemotherapy and results in significantly longer hospitalization. (medicinelakex1.com)
  • More common diseases, such as benign asbestos-related pleural disease and metastatic adenocarcinoma , can look radiographically identical to mesothelioma. (medscape.com)
  • CT is the imaging modality of choice to assess pleural disease and has shown sensitivity and specificity for identifying malignancy. (medscape.com)
  • Diffuse pleural thickening or extensive lobular pleural-based masses are seen in about 50% of cases. (medscape.com)
  • The most common mesothelioma finding on radiographs is unilateral, concentric, plaquelike, or nodular pleural thickening (as seen in the images below). (medscape.com)
  • Pleural effusions are common and may obscure the presence of the underlying pleural thickening. (medscape.com)
  • Cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy (HIPEC) provide prolonged survival in selected patients with colorectal (CLR) peritoneal carcinomatosis. (medicinelakex1.com)
  • Patients with low-grade appendiceal mucinous carcinomas (LAMNs) treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have a favorable prognosis. (rare-cancer.org)
  • The tumor frequently extends into the fissures, which become thickened and irregular in contour. (medscape.com)
  • Krukenberg tumor , also known as carcinoma mucocellulare , refers to the "signet ring" subtype of metastatic tumor to the ovary . (radiopaedia.org)
  • Although primary neoplasms arising in the mesentery are rare, the mesentery is a major avenue for the dissemination of tumours, which can spread through hematogenous, lymphatic, direct or peritoneal seeding. (sajr.org.za)
  • However, several mechanisms have been proposed, such as through lymphatic channels, blood vessels, and peritoneal cavity 9 . (radiopaedia.org)
  • The radiographic findings of mesothelioma are nonspecific and are observed in other diseases, including metastatic carcinoma, lymphoma, and benign asbestos disease. (medscape.com)
  • Differentiation between primary and metastatic ovarian carcinoma is of great importance with respect to treatment and prognosis but may be very difficult based on imaging findings solely. (radiopaedia.org)
  • We performed a retrospective review of a prospectively maintained database of 34 patients who underwent CRS and HIPEC and 21 patients who underwent PC for CLR peritoneal carcinomatosis, at the National Cancer Centre Singapore (NCCS), from Jan 2008 to Dec 2013. (medicinelakex1.com)
  • CRS and HIPEC confer prolonged survival compared to PC in patients with CLR peritoneal carcinomatosis. (medicinelakex1.com)
  • The role of serum procalcitonin (PCT) and C-reactive protein (CRP) levels in the diagnosis of spontaneous bacterial peritonitis (SBP) with decompensated chronic liver disease (CLD) has been a subject of debate. (bvsalud.org)
  • OS was calculated from the date of diagnosis of peritoneal metastases till death. (medicinelakex1.com)
  • CT plays an essential role in the diagnosis of mesenteric disease. (sajr.org.za)
  • Some mesenteric diseases present with distinctive imaging findings while others have similar findings, thereby complicating their differential diagnosis. (sajr.org.za)
  • This study compared the clinical outcome of a paclitaxel plus raltitrexed (RP) regimen as second-line treatment in metastatic gastric cancer (MGC) patients. (bvsalud.org)
  • METHODS: An open, randomized, multi-center phase II clinical trial was conducted involving 148 patients who were randomly assigned and treated with RP [raltitrexed (3 mg/m2 on day 1) and paclitaxel (135 mg/m2 on day 1 every 3 weeks)] or P [paclitaxel (135 mg/m2 on day 1 every 3 weeks)] as 2nd-line chemotherapy. (bvsalud.org)
  • Patients with a long history of recurrent abdominal pain and who on imaging were found to have a diffusely thickened gall bladder wall, with cholelithiasis, choledocholithiasis and submucosal hypoattenuated nodules were likely to have XGC while those with anorexia,weight loss,focal thickening of the gallbladder wall on imaging and dense local organ infiltration were more likely to have GBC. (medicinelakex1.com)
  • However, a subgroup of patients presents a clinically aggressive course with disease progression despite receiving treatment. (rare-cancer.org)
  • Subgroup analysis shows if MGC was combined with ascites or peritoneal involvement, the OS of the RP regimen was longer (P = 0.05). (bvsalud.org)
  • If the chest is to be studied, images are obtained in the arterial phase of contrast enhancement, followed by a pause sufficiently long to image the abdomen and pelvis in the late arterial or early portal venous phase. (radiologykey.com)
  • They demonstrate various contrast enhancement patterns including early peripheral enhancement because of vascular tissue ( Figure 1 ), delayed central enhancement of the fibrotic components, heterogenous, homogenous and absent enhancement. (sajr.org.za)
  • Strong contrast enhancement is usually seen in the solid component or the wall of the intratumoral cyst 5 . (radiopaedia.org)
  • Secondary outcomes of frequency of chemotherapy disruptions, need for invasive interventions, and duration of hospitalization for complications of peritoneal disease were evaluated. (medicinelakex1.com)
  • therefore, disease extent is frequently underestimated in radiographs. (medscape.com)
  • It is a stage IV disease, and median overall survival is of the order of approximately 16 months 7,8 . (radiopaedia.org)
  • The most common category of nonmesotheliomatous cancer to involve the pleura is represented by extrapleural primary malignancies that secondarily involve the pleura via metastatic spread. (medscape.com)
  • There are a variety of metastatic carcinomas to the ovary that can mimic primary ovarian tumors 4 . (radiopaedia.org)
  • OBJECTIVE: Paclitaxel (P) is a standard second-line chemotherapy in the treatment of advanced gastric cancer. (bvsalud.org)
  • the treatment is usually surgical, although other treatment options such as chemotherapy and radiotherapy are used. (medscape.com)
  • However, malignant SFTs, which comprise 10%-15% of SFTs, not only aggressively infiltrate adjacent structures but are also capable of metastatic spread. (medscape.com)
  • Evaluation of the mesentery is often neglected during routine ultrasound (US) because of inadequate training and unfamiliarity with the common US features encountered with mesenteric disease. (sajr.org.za)
  • Tuberculous pericarditis is a common disease among the African and Asian populations because of the high prevalence of tuberculous infections. (sajr.org.za)
  • 60.0% due to complications of peritoneal disease, most commonly intestinal obstruction (I/O). 14.3% required emergency surgery for I/O and 23.8% required abdominal cope loop and ureteric stent insertion. (medicinelakex1.com)
  • Peritoneal carcinomas are divided into primary and secondary peritoneal tumors. (medscape.com)
  • Standard imaging tests, including ultrasonography and helical CT scans, are notably insensitive for the detection of peritoneal tumors. (medscape.com)
  • Ovarian-related peritoneal carcinomatosis typically manifests as discrete nodules or coalescent plaques on peritoneal surfaces in association with ascites (Figure 2). (medscape.com)
  • Primary peritoneal carcinoma usually manifests as abdominal distention and diffuse nonspecific abdominal pain secondary to ascites. (medscape.com)
  • CT findings in patients with malignant peritoneal mesotheliomas range from peritoneum-based masses (a so-called "dry" appearance) to ascites, irregular or nodular peritoneal thickening, and an omental mass (a so-called "wet" appearance). (medscape.com)
  • [ 39 ] owing to the thickened tumor-implanted omentum floating in ascites. (medscape.com)
  • [ 10 ] Gastrointestinal and ureteral obstruction are the most common complications associated with peritoneal carcinomatosis, and may arise from distinct focal lesions or diffuse, microscopic infiltration. (medscape.com)
  • Diffuse pleural thickening or extensive lobular pleural-based masses are seen in about 50% of cases. (medscape.com)
  • Is there any advantage to combined trastuzumab and chemotherapy in perioperative setting her 2neu positive localized gastric adenocarcinoma? (biomedcentral.com)
  • We report here a 44-year-old Moroccan man with resectable gastric adenocarcinoma with overexpression of human epidermal growth factor receptor 2 (HER2) by immunohistochemistry who was treated with trastuzumab in combination with chemotherapy in perioperative setting. (biomedcentral.com)
  • Further research to evaluate trastuzumab in combination with chemotherapy regimens in the perioperative and adjuvant setting is urgently needed. (biomedcentral.com)
  • It was centrally hypodense with peripheral enhancement in the arterial phase suggesting an angiomatose lesions or secondary localizations. (biomedcentral.com)
  • In front of this doubt about hepatic lesions, endoscopic ultrasound was not retained and platinum based chemotherapy regimen including Capecitabine (2000 mg/m 2 /j) po bid on day 1 to day 14 plus oxaliplatin (130 mg/m 2 /j) on day 1 were given every 3 weeks. (biomedcentral.com)
  • Direct visualization of the peritoneal surfaces along with palpation of the abdominal contents is by far the most sensitive modality for detecting peritoneal cancer. (medscape.com)
  • CT is the imaging modality of choice to assess pleural disease and has shown sensitivity and specificity for identifying malignancy. (medscape.com)
  • The distribution of metastases within the peritoneal cavity is not random, but is modulated by the anatomical attachments and pathophysiological properties of the peritoneal surfaces. (medscape.com)
  • The sensitivity of the test results depends on the ability to completely lavage all regions of the peritoneal cavity and to detect cancer cells being shed into the peritoneal cavity by the tumor. (medscape.com)
  • Open abdominal exploration and palpation are extremely sensitive for 1- to 2-mm peritoneal nodules. (medscape.com)
  • Patients with low-grade appendiceal mucinous carcinomas (LAMNs) treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have a favorable prognosis. (rare-cancer.org)
  • [ 8 , 9 ] Substitution of normal omental or mesenteric fat by the tumor results in the appearance of so-called 'omental cake' (a thickened appearance of the greater omentum). (medscape.com)
  • coronal reformated contrast-enhanced computed tomography images show abnormal thickening of the supramesocolic greater omentum, which appears as omental cake (arrow). (medscape.com)
  • More common diseases, such as benign asbestos-related pleural disease and metastatic adenocarcinoma , can look radiographically identical to mesothelioma. (medscape.com)
  • Staging workups, including computed tomography (CT) scan of chest, abdomen and pelvis showed a circumferential and irregular thickening fundic area arriving in contact with body pancreas without infiltration sign without loco regional lymph node. (biomedcentral.com)
  • Invasion of the diaphragm and omentum is thought to occur mainly by migration through the lymphatic system, since these surfaces are the primary sites of peritoneal fluid reabsorption. (medscape.com)
  • For patients with unresectable or recurrent malignant mesothelioma, palliative systemic chemotherapy should be considered. (medscape.com)
  • As such, GBC remains a highly lethal disease, with only 10% of all patients presenting at a stage amenable to surgical resection. (hindawi.com)
  • However, a subgroup of patients presents a clinically aggressive course with disease progression despite receiving treatment. (rare-cancer.org)
  • Patients with chiasma tic-hypothalamic low-grade glioma (CHLGG) have frequent MRI s with gadolinium -based contrast agent s (GBCA) for disease monitoring . (neurosurgery.directory)
  • MRI without GBCA effectively identifies patients with progressive disease. (neurosurgery.directory)
  • Peritoneal carcinomatosis in a 48-year-old female with ovarian cancer. (medscape.com)
  • Cite this: Imaging Ovarian Cancer and Peritoneal Metastases-Current and Emerging Techniques - Medscape - Jul 01, 2010. (medscape.com)
  • Women with higher risk of ovarian cancer also have increased risk of peritoneal cancer. (medscape.com)
  • Epithelial cancers of ovarian, fallopian tube, and peritoneal origin are known as epithelial ovarian cancer in clinical practice. (medscape.com)
  • Secondary peritoneal carcinomas usually invade locally or metastasize into the peritoneum from adjacent or remote organs. (medscape.com)
  • Myasthenia gravis accounts for 25-30% of the secondary cases.10,20,21 In some cases of myasthenia gravis, regurgitation and weight loss may be the only presenting signs of the disease, whereas in most other cases of acquired secondary megaesophagus regurgitation is but one of many clinical signs including peripheral muscle weakness. (canine-megaesophagus.com)
  • A study by Perez et al found US-guided percutaneous biopsy to be safe and effective for diagnosing omental disease. (medscape.com)
  • The addition of contrast agents provides differential enhancement of tumor and normal soft tissues, thus further improving the delineation of hepatic and extrahepatic tumor (Figure 2). (cancernetwork.com)
  • Most cancers are asymptomatic until the disease is advanced. (medscape.com)
  • [ 3 , 4 ] Following the hydrodynamics of peritoneal fluid, cancer cells sloughed from the ovarian surface initially reach the rectouterine and lateral paravesical recesses by way of gravity, and then flow cranially, mainly via the right paracolic gutter into the right subdiaphragmatic space. (medscape.com)
  • In most cases of scrotal disease, the combination of clinical history, physical examination, and information obtained with ultrasonography is sufficient for diagnostic decision-making. (e-ultrasonography.org)
  • Laparoscopy is minimally invasive and allows for safe, directed peritoneal lavage. (medscape.com)
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