• Tumors
  • It is expressed in embryonal carcinoma but not in seminoma and is thus a useful marker in distinguishing between these germ cell tumors. (wikipedia.org)
  • In these cases, the tumors should be classified as combined small cell lung carcinoma (c-SCLC), and are (usually) treated like "pure" SCLC. (wikipedia.org)
  • Lymphomas and leukemias are a part of the broader group of tumors of the hematopoietic and lymphoid tissues. (wikipedia.org)
  • Thus, lymphomas and leukemias are both tumors of the hematopoietic and lymphoid tissues, and as lymphoproliferative disorders, lymphomas and lymphoid leukemias are closely related, to the point that some of them are unitary disease entities that can be called by either name (for example, adult T-cell leukemia/lymphoma). (wikipedia.org)
  • clinical
  • To learn more about available lymphoma clinical trials, contact us at cancer@cchmc.org or 513-636-2799. (cincinnatichildrens.org)
  • Within the Children's Oncology Group, Dr. Lowe is a member of the non-Hodgkin lymphoma steering committee and is currently the study chair for an ongoing international clinical trial. (chkd.org)
  • Our report of three novel patients widens the scope of RASGRP1 deficiency by providing new clinical and immunological insights on autoimmunity, immune cell development, and predisposition to lymphoproliferative disease. (springer.com)
  • In many clinical settings, however, studies on the T cell receptor and IL-5 are not available and therefore not routine parts of the diagnostic work-up or criteria for the disease. (wikipedia.org)
  • subtypes
  • These 2 subtypes usually associate with weight loss, fevers and night sweats, and can be lethal if left untreated without chemotherapy. (wikipedia.org)
  • Peripheral T-cell lymphoma (PTCL) is defined as a diverse group of aggressive lymphomas that develop from mature-stage white blood cells called T-cells and natural killer cells (NK cells) (see figure for an overview of PTCL subtypes). (wikipedia.org)
  • The World Health Organization (WHO) classification system defines more than a dozen subtypes, each of which can be differentiated based on the location of the tumor, the presence of other cells within the tumor (such as T cells), and whether the patient has certain other illnesses related to DLBCL. (wikipedia.org)
  • There are dozens of subtypes of lymphomas. (wikipedia.org)
  • subtype
  • Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS), is a subtype of peripheral T-cell lymphoma. (wikipedia.org)
  • Subcutaneous panniculitis-like T-cell lymphoma, is a subtype of Peripheral T-cell lymphoma. (wikipedia.org)
  • Currently Subcutaneous Panniculitis-like T-cell Lymphoma, being a PTCL subtype, is treated similarly to B-cell lymphomas. (wikipedia.org)
  • The symptom of episodic angioedema in lymphocyte-variant hypereosinophilia resembles that occurring in Gleich's syndrome, a rare disease that is accompanied by secondary hypereosinophilia plus a sub-population of CD3(-), CD4(+) T cells and therefore proposed, at least in many patients, a subtype of lymphocyte-variant hypereosiophilia. (wikipedia.org)
  • pediatric
  • T-cell alloreactivity dominates NK-cell alloreactivity in minimally T-cell depleted HLA-nonidentical pediatric bone marrow transplantation. (chkd.org)
  • monoclonal
  • They may also include monoclonal antibodies, which are manmade molecules designed to attach to surface proteins on cancer cells to help the body fight cancer. (nyulangone.org)
  • The company, headquartered in Bothell, Washington (a suburb of Seattle), is the industry leader in antibody-drug conjugates or ADCs, a technology designed to harness the targeting ability of monoclonal antibodies to deliver cell-killing agents directly to cancer cells. (wikipedia.org)
  • a humanized IgG1 monoclonal antibody conjugated via a non-cleavable maleimidocaproyl (mc) linker with monomethyl auristatin F (MMAF), used in Phase I trial of relapsed or refractory renal cell carcinoma patients or non-Hodgkin lymphoma patients. (wikipedia.org)
  • variants
  • All types can occur in unusual histologic variants and as mixed cell-type combinations. (wikipedia.org)
  • citation needed] Within cellular morphology, three variants are most commonly seen: centroblastic, immunoblastic, and anaplastic. (wikipedia.org)
  • Diagnosis
  • Early diagnosis is critical and hematopoietic stem cell transplantation might be considered as curative treatment. (springer.com)
  • LCLC's have typically comprised around 10% of all NSCLC in the past, although newer diagnostic techniques seem to be reducing the incidence of diagnosis of "classic" LCLC in favor of more poorly differentiated squamous cell carcinomas and adenocarcinomas. (wikipedia.org)
  • The finding of T cells bearing abnormal immunophenotype cluster of differentiation markers is critical to making the diagnosis. (wikipedia.org)
  • lymphocytes
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (wikipedia.org)
  • Most cases of DLBCL are centroblastic, having the appearance of medium-to-large-sized lymphocytes with scanty cytoplasm. (wikipedia.org)
  • Lymphocyte-variant hypereosinophila, also termed lymphocyte variant eosinophilia, is a rare disorder in which eosinophilia or hypereosinophilia (i.e. a large or extremely large increase in the number of eosinophils in the blood circulation) is caused by aberrant population of lymphocytes. (wikipedia.org)
  • These aberrant lymphocytes function abnormally by stimulating the proliferation and maturation of bone marrow eosinophil-precursor cells termed colony forming unit-Eosinophils or CFU-Eos. (wikipedia.org)
  • Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell). (wikipedia.org)
  • The main classes are malignant neoplasms (that is, cancers) of the lymphocytes, a type of white blood cell that belongs to both the lymph and the blood and pervades both. (wikipedia.org)
  • malignant cells
  • This is most often the case when a pathologist examines a small amount of malignant cells or tissue in a cytology or biopsy specimen. (wikipedia.org)
  • Intravascular lymphomas have a large cell morphology, i.e. the malignant cells are two or more times the size of a normal lymphocyte, and typically have a prominent nucleolus. (wikipedia.org)
  • antibody
  • Antibody-drug Conjugates are intended to spare non-targeted cells and thus reduce many of the toxic effects of traditional chemotherapy, while potentially enhancing antitumor activity. (wikipedia.org)
  • The peptide-based linker bonds the antibody to the cytotoxic compound in a stable manner so the drug is not easily released from the antibody under physiologic conditions to help prevent toxicity to healthy cells and ensure dosage efficiency. (wikipedia.org)
  • The peptide antibody-drug bond facilitates rapid and efficient drug cleavage inside target tumor cell. (wikipedia.org)
  • multiagent
  • Multiagent chemotherapy is given, and can result in long term success, particularly in childhood but prognosis is generally poor, particularly in higher stage disease. (wikipedia.org)
  • PTCL
  • PTCL specifically affects T-cells, and results when T-cells develop and grow abnormally. (wikipedia.org)
  • Currently PTCL is treated similarly to B-cell lymphomas. (wikipedia.org)
  • However, in recent years, scientists have developed techniques to better recognize the different types of lymphomas, such as PTCL. (wikipedia.org)
  • electronic version] Retrieved May 19, 2009, from http://www.lymphoma.org/atf/cf/%7B0363CDD6-51B5-427B-BE48-E6AF871ACEC9%7D/PTCL.PDF Stein H, Bonk A, Tolksdorf G, Lennert K, Rodt H, Gerdes J (August 1980). (wikipedia.org)
  • Cytologic findings of peripheral T-cell lymphoma (PTCL) with high epitheloid cell content (Lennert's lymphoma) in imprint smear. (wikipedia.org)
  • Patients
  • All three patients had CD4 + T cell lymphopenia. (springer.com)
  • Also, clonal T cell populations (as well as clonal B cell populations) are sometimes present in the lymph nodes or peripheral blood of patients with rheumatologic or infectious conditions. (oncologynurseadvisor.com)
  • Otherwise healthy patients over the age of 60 can also sometimes have benign clonal T cell populations in the peripheral blood. (oncologynurseadvisor.com)
  • Some patients may receive a stem cell transplant. (wikipedia.org)
  • Additionally, a phase 2 trial, PROFILE 1005, studies patients meeting similar criteria who have received more than one line of prior chemotherapy. (wikipedia.org)
  • Taxotere
  • Sanofi-Aventis is opposing certification of a Taxotere class action lawsuit seeking to represent all women in Louisiana who suffered long-term or permanent hair loss after using the chemotherapy drug. (aboutlawsuits.com)
  • More than 1,100 Taxotere lawsuits have been filed by women nationwide who say they suffered permanent hair loss due to the side effects of the chemotherapy drug. (aboutlawsuits.com)
  • A Science Day for Taxotere litigation is scheduled for May 3, at which point the court will hear presentations on Taxotere chemotherapy and its links to permanent hair loss. (aboutlawsuits.com)
  • abnormal
  • P2 and P3 showed decreased mitogen-induced lymphocyte proliferation, reduced T cell receptor excision circles, abnormal T cell receptor (TCR) Vβ repertoires, and increased frequencies of TCRγδ cells. (springer.com)
  • small cell lung
  • Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). (wikipedia.org)
  • LCLC is differentiated from small cell lung carcinoma (SCLC) primarily by the larger size of the anaplastic cells, a higher cytoplasmic-to-nuclear size ratio, and a lack of "salt-and-pepper" chromatin. (wikipedia.org)
  • The two main types are small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC). (wikipedia.org)