• CHOP
  • However, despite that difference they both are approached in the standard fashion and still the standard of care is CHOP chemotherapy. (lymphoma.org)
  • Unfortunately for T-cell lymphomas, we do not have the supplemental biologic therapies, such as Rituxan, that are now the standard of care for the B-cell lymphomas, so CHOP alone given on a 21-day basis for six to eight cycles, is still the standard of care. (lymphoma.org)
  • To develop a molecular predictor of outcome of R-CHOP and DA-EPOCH-R chemotherapy using molecular profiling. (clinicaltrials.gov)
  • lymphocytes
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (wikipedia.org)
  • Lymphocyte-variant hypereosinophila, also termed lymphocyte variant eosinophilia, is a rare disorder in which eosinophilia or hypereosinophilia (i.e. a large or extremely large increase in the number of eosinophils in the blood circulation) is caused by aberrant population of lymphocytes. (wikipedia.org)
  • These aberrant lymphocytes function abnormally by stimulating the proliferation and maturation of bone marrow eosinophil-precursor cells termed colony forming unit-Eosinophils or CFU-Eos. (wikipedia.org)
  • numerous tyrosine kinase cell signaling proteins are responsible for the growth and proliferation of eosinophils {see clonal eosinophilia}), methotrexate and Hydroxycarbamide (both are chemotherapy and immunosuppressant drugs), and Alemtuzumab (a antibody that binds to the CD52 antigen on mature lymphocytes thereby marking them for destruction by the body). (wikipedia.org)
  • Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell). (wikipedia.org)
  • The main classes are malignant neoplasms (that is, cancers) of the lymphocytes, a type of white blood cell that belongs to both the lymph and the blood and pervades both. (wikipedia.org)
  • Most cases of DLBCL are centroblastic, having the appearance of medium-to-large-sized lymphocytes with scanty cytoplasm. (wikipedia.org)
  • phases of chemotherapy
  • This includes several phases of chemotherapy that can take two years to complete, beginning with a four-week "induction," given by IV infusion, designed to destroy as many cancer cells as possible. (nyulangone.org)
  • It is given as 3 phases of chemotherapy (induction, consolidation, and maintenance) using many drugs, and it lasts for about 2 years. (cancer.org)
  • Tumors
  • It is expressed in embryonal carcinoma but not in seminoma and is thus a useful marker in distinguishing between these germ cell tumors. (wikipedia.org)
  • In these cases, the tumors should be classified as combined small cell lung carcinoma (c-SCLC), and are (usually) treated like "pure" SCLC. (wikipedia.org)
  • These tumors are believed to start in the cells covering the ovaries, though some may form at the Fallopian tubes. (wikipedia.org)
  • Less common types of ovarian cancer include germ cell tumors and sex cord stromal tumors. (wikipedia.org)
  • variants
  • All types can occur in unusual histologic variants and as mixed cell-type combinations. (wikipedia.org)
  • citation needed] Within cellular morphology, three variants are most commonly seen: centroblastic, immunoblastic, and anaplastic. (wikipedia.org)
  • remission
  • The goal is to achieve remission, in which no cancer cells can be detected through laboratory tests. (nyulangone.org)
  • After a child achieves remission, doctors recommend maintenance chemotherapy, given both by mouth and through an IV infusion, to help prevent the cancer from returning. (nyulangone.org)
  • Consolidation chemotherapy is given after remission in order to prolong the overall disease-free time and improve overall survival. (wikipedia.org)
  • Maintenance chemotherapy is a repeated low-dose treatment to prolong remission. (wikipedia.org)
  • gene
  • The t(2;5)(p23;35) fuses the anaplastic lymphoma kinase ( ALK ) gene on chromosome 2 with the nucleophosmin ( NPM ) gene on chromosome 5, resulting in a fusion gene that encodes for an 80-kDa NPM-ALK chimeric protein with constitutive tyrosine kinase activity. (bloodjournal.org)
  • pediatric
  • T-cell alloreactivity dominates NK-cell alloreactivity in minimally T-cell depleted HLA-nonidentical pediatric bone marrow transplantation. (chkd.org)
  • malignant cells
  • This is most often the case when a pathologist examines a small amount of malignant cells or tissue in a cytology or biopsy specimen. (wikipedia.org)
  • Intravascular lymphomas have a large cell morphology, i.e. the malignant cells are two or more times the size of a normal lymphocyte, and typically have a prominent nucleolus. (wikipedia.org)
  • protein
  • RAS guanyl-releasing protein 1 (RASGRP1) deficiency has recently been shown to cause a primary immunodeficiency (PID) characterized by CD4 + T cell lymphopenia and Epstein-Barr virus (EBV)-associated B cell lymphoma. (springer.com)
  • These lymphomas show immunopositivity for ALK protein in 70% of cases. (wikipedia.org)
  • In some non-Hodgkin lymphomas, an increased amount of protein produced by the lymphoma cells causes the blood to become so thick that plasmapheresis is performed to remove the protein. (wikipedia.org)
  • antibody
  • The company, headquartered in Bothell, Washington (a suburb of Seattle), is the industry leader in antibody-drug conjugates or ADCs, a technology designed to harness the targeting ability of monoclonal antibodies to deliver cell-killing agents directly to cancer cells. (wikipedia.org)
  • Antibody-drug Conjugates are intended to spare non-targeted cells and thus reduce many of the toxic effects of traditional chemotherapy, while potentially enhancing antitumor activity. (wikipedia.org)
  • The peptide-based linker bonds the antibody to the cytotoxic compound in a stable manner so the drug is not easily released from the antibody under physiologic conditions to help prevent toxicity to healthy cells and ensure dosage efficiency. (wikipedia.org)
  • The peptide antibody-drug bond facilitates rapid and efficient drug cleavage inside target tumor cell. (wikipedia.org)
  • abnormal
  • P2 and P3 showed decreased mitogen-induced lymphocyte proliferation, reduced T cell receptor excision circles, abnormal T cell receptor (TCR) Vβ repertoires, and increased frequencies of TCRγδ cells. (springer.com)
  • It results in abnormal cells that have the ability to invade or spread to other parts of the body. (wikipedia.org)
  • multiagent
  • Multiagent chemotherapy is given, and can result in long term success, particularly in childhood but prognosis is generally poor, particularly in higher stage disease. (wikipedia.org)
  • PTCL
  • PTCL specifically affects T-cells, and results when T-cells develop and grow abnormally. (wikipedia.org)
  • Currently PTCL is treated similarly to B-cell lymphomas. (wikipedia.org)
  • However, in recent years, scientists have developed techniques to better recognize the different types of lymphomas, such as PTCL. (wikipedia.org)
  • electronic version] Retrieved May 19, 2009, from http://www.lymphoma.org/atf/cf/%7B0363CDD6-51B5-427B-BE48-E6AF871ACEC9%7D/PTCL.PDF Stein H, Bonk A, Tolksdorf G, Lennert K, Rodt H, Gerdes J (August 1980). (wikipedia.org)