• This randomized Phase II trial will compare the efficacy and safety of laparoscopy-assisted D2 distal gastrectomy and open distal D2 gastrectomy after neoadjuvant chemotherapy for patients with macroscopically resectable serosa-positive gastric cancer. (nih.gov)
  • This trial will be able to appraise the use of the laparoscopic approach as a curative D2 distal gastrectomy after neoadjuvant chemotherapy for gastric cancer. (nih.gov)
  • The clear definition of the oligometastatic state, assessment of the response to neoadjuvant chemotherapy and realistic estimation of the R0 resectability will be useful for patient selection. (unige.ch)
  • Perioperative, neoadjuvant chemotherapy or chemoradiotherapy followed by surgery is appropriate. (medscape.com)
  • Neoadjuvant chemotherapy is a common treatment for patients with gastric cancer. (bjcancer.org)
  • Although its benefits have been demonstrated, neoadjuvant chemotherapy is underutilized in gastric cancer management, because of the lack of biomarkers for patient selection and a limited understanding of resistance mechanisms. (bjcancer.org)
  • Here, we performed whole-genome, whole-exome, and RNA sequencing on 84 clinical samples (including matched pre- and posttreatment tumors) from 35 patients whose responses to neoadjuvant chemotherapy were rigorously defined. (bjcancer.org)
  • Neoadjuvant chemotherapy also reshapes tumor-immune signaling and microenvironment. (bjcancer.org)
  • By enabling accurate staging, diagnostic laparoscopy permits patient selection for curative resection or neoadjuvant chemotherapy while avoiding nontherapeutic laparotomy, which is associated with a delay in the initiation of chemotherapy. (medscape.com)
  • We aimed to determine the predictive significance of Ki-67 and platelet lymphocyte ratio (PLR) in patients with gastric cancer (GC), who received fluorouracil, leucovorin, oxaliplatin, docetaxel (FLOT) as neoadjuvant chemotherapy (NAC). (jcpsp.pk)
  • Ki-67 and PLR have predictive significance in GC patients treated with neoadjuvant FLOT. (jcpsp.pk)
  • 1 Since, approximately 2/3 of the patients are in the locally advanced stage at the time of diagnosis, they are generally not suitable for surgical treatment, and neoadjuvant chemotherapy (NAC) is a more suitable treatment option for these patients. (jcpsp.pk)
  • In a Phase II study, MD Anderson researchers showed that a regimen of neoadjuvant and adjuvant treatment with checkpoint inhibitors nivolumab, a PD-1 inhibitor, and relatlimab, a LAG-3 inhibitor, was safe and effective in patients with resectable clinical stage III melanoma. (mdanderson.org)
  • Previous studies combining ipilimumab and nivolumab in the neoadjuvant setting for stage III melanoma have shown high pCR rates, which indicates the absence of actively growing cancer cells in tissue removed during surgery but led to high-grade toxicity in 30-40% of patients in the neoadjuvant setting. (mdanderson.org)
  • The old standard of care was that stage III melanoma patients get surgery first, but we've shown they can really benefit from a neoadjuvant approach," said Rodabe Amaria, M.D. , associate professor of Melanoma Medical Oncology , who will present the findings. (mdanderson.org)
  • Patients who underwent neoadjuvant chemotherapy (n=5) or adjuvant chemotherapy (n=3), patients with remnant gastric cancer (n=11), and a patient who underwent palliative resection (n=1) were excluded. (cancerdiagnosisprognosis.org)
  • The need to achieve no residual disease after surgery in order to optimize the prognosis of advanced-stage ovarian cancer introduced the idea of neoadjuvant chemotherapy followed by interval debulking surgery in an effort to reduce tumoural size in the case of non-operable advanced-staged ovarian cancer patients. (termedia.pl)
  • It is now evident that the strategy of neoadjuvant chemotherapy for stage IIIC and more has led to a significant positive impact among ovarian cancer patients. (termedia.pl)
  • However, because research is still leading to significant innovations, further amelioration of neoadjuvant chemotherapy by the addition of novel regimens such as anti-VEGF antibodies may also be achieved. (termedia.pl)
  • The present review aims to summarize state- of-the-art evidence regarding the efficacy and safety of neoadjuvant chemotherapy as well as novel insights regarding the use of modern therapeutic regimens in the context of neoadjuvant chemotherapy. (termedia.pl)
  • The last decade has been characterized by the breakthrough scientific evidence that neoadjuvant chemotherapy followed by interval debulking surgery for advanced-stage ovarian cancer may be comparable to primary debulking surgery. (termedia.pl)
  • There have been 3 major randomized controlled trials (RCTs) that indicated the effectiveness of neoadjuvant chemotherapy [ 3 - 5 ]. (termedia.pl)
  • Post-mastectomy radiation therapy and overall survival after neoadjuvant chemotherapy. (umassmed.edu)
  • Is Neoadjuvant Therapy Sufficient in Resected Pancreatic Cancer Patients? (umassmed.edu)
  • Patients were prognostically stratified according to the MPK score after gastrectomy for gastric cancer. (biomedcentral.com)
  • This retrospective study collected data from 914 patients who underwent gastrectomy for gastric cancer between January 2001 and December 2020 at the Nagasaki University Graduate School of Biomedical Science. (cancerdiagnosisprognosis.org)
  • The incidence and severity was highest in patients receiving trastuzumab with anthracycline-containing chemotherapy regimens. (rxlist.com)
  • 1 Recent studies have shown that for patients with stage II-III disease, the use of fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT) therapy as NAC regimen is more effective than other chemotherapy regimens. (jcpsp.pk)
  • For chemotherapy, two-drug cytotoxic regimens that include a platinum agent are generally preferred for first-line therapy. (medscape.com)
  • Background/Aim: Japanese Gastric Cancer Treatment Guidelines do not recommend adjuvant chemotherapy after radical gastrectomy for pathological stage (p) T1N+ or pT2~3N0 gastric cancer. (cancerdiagnosisprognosis.org)
  • The Japanese Gastric Cancer Treatment Guidelines ( Tokyo, Kanehara & CO. Ltd. (2021)">6 ) recommend postoperative adjuvant chemotherapy after curative surgery for patients with pathological stage II or III gastric cancer ( Surgery 158(6) (2015)">7 , Lancet Oncol 14(12) (2013)">8 ). (cancerdiagnosisprognosis.org)
  • Can multimodal treatment with tumor resection and metastasectomy combined with perioperative chemotherapy, increase the chances of survival in oligometastatic patients? (unige.ch)
  • Despite recent advances in surgical techniques and in anticancer drugs, and the adoption of perioperative treatments mostly based on conventional chemotherapy, the prognosis of advanced and metastatic gastric cancer remains poor. (encyclopedia.pub)
  • In this study, we investigate the effects of the perioperative administration of flurbiprofen axetil on postoperative recurrence in patients with non-small cell lung cancer. (bmj.com)
  • This is the first study to evaluate the effect of the perioperative administration of non-steroidal anti-inflammatory drugs (NSAIDs) on postoperative recurrence in non-small cell lung cancer. (bmj.com)
  • A study by Fogh et al of induction chemoradiotherapy followed by surgery, a strategy that is widely used in treating esophageal cancer, found that perioperative morbidity and mortality with this approach was not significantly different in patients aged 70 years or older compared with younger patients. (medscape.com)
  • The perioperative complications were observed in four patients, including three patients of grade 1 and one patient of grade 2. (biomedcentral.com)
  • Perioperative chemotherapy is not associated with improved survival in high-grade truncal sarcoma. (umassmed.edu)
  • Gastric ultrasound assessment of the gastric antrum is a relatively new technology in anesthesia and can be used to assess the gastric antrum and provide information to anesthesia providers regarding the risk of aspiration in the perioperative period. (bepress.com)
  • One patient was excluded from the conventional care group because of a non-resectable tumor. (wjgnet.com)
  • Stage I, II, and III esophageal cancers are all potentially resectable. (medscape.com)
  • Of the 10-20% of patients who present with resectable tumors, the 5-year surviva rate is still only about 20%, with a median survival of around 23-43 months with adjuvant therapy ( 2 - 4 ). (iiarjournals.org)
  • For patients with resectable locoregional cancer, the guidelines recommend gastrectomy with a D1+ or a modified D2 lymph node dissection (performed by experienced surgeons in high-volume centers). (jnccn.org)
  • Objective: The objective of this study was to analyze whether patients undergoing esophageal atresia (EA) surgery benefit from a cross-disciplinary follow-up program, based on current clinical guidelines,implemented in our institution. (bvsalud.org)
  • 4 ] suggested that microsatellite instability could be used as a biomarker for PD-1 blockers in different tumors (colorectal, endometrial, cervical, esophageal, skin, and breast cancer) and that MSI plays a more significant role in precision medicine. (biomedcentral.com)
  • The clinical spectrum of esophageal cancer has changed dramatically over the past couple of decades. (jnccn.org)
  • An understanding of the factors that influence survival for patients with localized esophageal cancer has evolved concomitantly with these changes in epidemiology. (jnccn.org)
  • The treatment of localized esophageal cancer mandates a multidisciplinary approach, with treatment tailored to disease extent, location, histology, and an accurate assessment of pretreatment staging. (jnccn.org)
  • Diagnostic laparoscopy is useful for making a definitive clinical diagnosis whenever there is a diagnostic dilemma even after routine diagnostic workup, including patients with nonspecific abdominal pain, hemodynamically stable patients who have sustained blunt or penetrating trauma with suspected intra-abdominal injuries, and critically ill intensive care unit (ICU) patients with suspected intra-abdominal sepsis or pathologies. (medscape.com)
  • To further explore this topic, we retrospectively analyzed the impact of adjuvant chemotherapy on the clinical outcomes of 77 stage II and 117 stage III patients diagnosed between January 2008 and December 2012. (springeropen.com)
  • 2002 ). Fortunately, in the last decade, randomized, placebo-controlled, phase III clinical trials have proven the survival advantage conferred by adjuvant chemotherapy after D2 lymph node dissection (Noh et al. (springeropen.com)
  • There are clinical challenges related to adjuvant treatment in colorectal cancer (CRC) and novel molecular markers are needed for better risk stratification of patients. (frontiersin.org)
  • The integration of IFNG -rs1861494 in our previous clinical genetic multiparametric score of DFS improved the patients' risk stratification (Log-rank P = 0.0026 in the pooled population). (frontiersin.org)
  • The diagnosis of gastric cancer was confirmed pathologically with postoperative histological specimens, and clinical stage was determined as I or II according to the American Joint Committee on Cancer tumor-nodes-metastasis (TNM) staging system [ 15 ]. (biomedcentral.com)
  • As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
  • Several Phase II clinical trials conducted by researchers from The University of Texas MD Anderson Cancer Center show promising results for patients with melanoma, breast cancer, HER2-positive tumors and ovarian cancer. (mdanderson.org)
  • The results of these studies, which will be presented at the virtual 2021 American Society of Clinical Oncology (ASCO) Annual Meeting , highlight new advances in drug therapy research to improve patient outcomes. (mdanderson.org)
  • Clinical cancer research is mainly based on the use of cell line derived xenografts. (europdxworkshop.eu)
  • A randomized clinical trial REGATTA which aimed to evaluate whether the addition of gastrectomy to chemotherapy improves survival for advanced gastric cancer patients with a single non-curable factor was terminated ahead of time due to the negative results from the interim analysis [ 2 ]. (biomedcentral.com)
  • Ethics and dissemination The study protocol was approved by the Clinical Research Review Board of Saitama Medical University in September 2019 (No. 192002) and will be approved by each institutional review board of all participating institutions before patient enrolment. (bmj.com)
  • 4 5 However, surgery alone may not be a sufficient treatment because an observational study of 11 663 surgically treated patients with NSCLC showed that the 5-year overall survival (OS) rate in all patients was 69.6%, while the rates in patients with clinical stage IA, IB, IIA and IIB were 82.0%, 66.1%, 54.5% and 46.1%, respectively. (bmj.com)
  • Here we explore the epidemiology, aetiology and clinical aspects of this group of cancers. (omicsonline.org)
  • Data regarding demographics, clinical features, treatment and prognosis of IgG4-RD patients complicating malignancies were collected and compared to those of age- and sex-matched controls. (nature.com)
  • We sought to describe the incidence and clinical characteristics of malignancies in patients with IgG4-RD. Based on these results, significant factors were evaluated to determine whether they were related to malignancy. (nature.com)
  • This clinical and pre-clinical data supports the use of anti-angiogenic agents in the first and second line setting in patients with innate and acquired resistance to platinum therapy, respectively. (almacgroup.com)
  • 484 cases of cancer patients by phase clinical trial conducted research, confirmed by statistical analysis, the Senate combined with chemotherapy drugs for a capsule attenuated the synergism effect on the tumor Qi deficiency symptoms significantly improved clinical effect, can improve immune function and quality of life, weight gain, protection of white, non-toxic side effect is a safe and effective medicine for a class of drugs. (cancerlive.net)
  • 2) double-blind trial design should be emphasized, particularly in Phase clinical trial application process compared to the exact description of blind patients. (cancerlive.net)
  • D. Alderson, "Scottish Intercollegiate Guidelines Network (SIGN) 87-The Management of Oesophageal and Gastric Cancer," Clinical Oncology (Royal College of Radiologists), Vol. 20, No. 7, 2008, pp. 530-531. (scirp.org)
  • Can artificial intelligence be your angel to diagnose early gastric cancer in real clinical practice? (cdc.gov)
  • The NCCN Clinical Practice Guidelines in Oncology for Gastric Cancer provide evidence- and consensus-based recommendations for a multidisciplinary approach for the management of patients with gastric cancer. (jnccn.org)
  • The long-term clinical benefit persisted even after the initiation of second-line treatment - as indicated by the longer median PFS2** of 12.2 months with the combination therapy vs 10.4 months with chemotherapy alone (HR, 0.75, 95 percent CI, 0.67-0.84). (mims.com)
  • The gene expression and clinical data of patients with DLBCL were downloaded from the Gene Expression Omnibus database. (biomedcentral.com)
  • A nomogram containing the clinical information and prognostic scores of the patients was constructed using multivariate logistic regression and Cox proportional risk regression models. (biomedcentral.com)
  • The classic international prognostic index (IPI), which classifies patients into four risk groups, is widely used by clinicians as a valid prognostic tool in clinical practice [ 2 ]. (biomedcentral.com)
  • In addition, due to the high tumor heterogeneity, even patients in the same IPI risk category exhibit different clinical outcomes [ 6 ]. (biomedcentral.com)
  • Most clinical evidence supports the notion that neutrophils promote cancer progression in solid tumors [ 11 , 12 ]. (biomedcentral.com)
  • Find cutting edge cancer clinical trials near you using the new Victorian Cancer Trials Link. (cancervic.org.au)
  • Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
  • Breast cancer is a heterogeneous disease with a large variabil- survival after adjuvant polychemotherapy was 10% (from ity in clinical outcome. (lu.se)
  • Adjuvant polychemotherapy (e.g. with 58% to 68%) for patients under the age of 50.1 Besides an cyclophosphamide, methotrexate and 5-fluorouracil (CMF)) or improvement in clinical outcome, these figures indicate that anthracycline-containing regimes, produce substantial reduc- a large proportion of the patients will never recur after the tion in recurrence and mortality. (lu.se)
  • The influence of adjuvant chemotherapy on the survival of gastric adenocarcinoma patients in a stage-specific manner is controversial. (springeropen.com)
  • Current study aimed to develop and validate prognostic nomograms for patients with metastatic gastric adenocarcinoma treated with palliative gastrectomy. (biomedcentral.com)
  • The development dataset comprised 1186 patients from the Surveillance, Epidemiology, and End Results Program who were diagnosed with metastatic gastric adenocarcinoma in 2004-2011, while the validation dataset included 407 patients diagnosed in 2012-2015. (biomedcentral.com)
  • Our survival nomograms for patients with metastatic gastric adenocarcinoma undergoing palliative gastrectomy can assist surgeons in treatment decision-making and prognostication. (biomedcentral.com)
  • Adenocarcinoma accounts for the majority of gastric cancer diagnoses, and patients with gastric adenocarcinoma often experience relatively short survival times. (biomedcentral.com)
  • Oesophageal cancer is group comprising several histological types, chiefly squamous cell (SCC), adenocarcinoma, leiomyosarcoma and other rarer types. (omicsonline.org)
  • Clinicopathologic behavior of gastric adenocarcinoma in Hispanic patients: analysis of a single institution's experience over 15 years. (umassmed.edu)
  • Is there a role for surgery with adequate nodal evaluation alone in gastric adenocarcinoma? (umassmed.edu)
  • The impact of ethnicity on the presentation and prognosis of patients with gastric adenocarcinoma. (umassmed.edu)
  • Racial differences in cancer specialist consultation, treatment, and outcomes for locoregional pancreatic adenocarcinoma. (umassmed.edu)
  • Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma. (umassmed.edu)
  • Patients with oligometastatic gastric and esophagogastric junction cancer are randomized after chemotherapy to either undergo resection followed by adjuvant chemotherapy or to undergo definitive chemotherapy. (unige.ch)
  • Gastric cancer (GC) is one of the most severe digestive tract tumors globally, with many new cases added each year [ 1 , 2 ]. (biomedcentral.com)
  • However, due to the heterogeneity of tumors [ 3 ], some patients are prone to recurrence or metastasis after surgery. (biomedcentral.com)
  • Antibody-drug conjugates (ADCs) are revolutionizing care for patients with certain advanced solid tumors. (medscape.com)
  • Postoperative chemoradiation is the preferred option after complete gastric resection for patients with T3-T4 tumors and node-positive T1-T2 tumors. (jnccn.org)
  • Higher overall survival from adjuvant chemotherapy in stage II patients with node involvement did not reach the level of statistical significance ( P = 0.102). (springeropen.com)
  • 75 years were included in a subgroup analysis in which the benefit of adjuvant chemotherapy on relapse-free survival and overall survival were demonstrated for patients with stage III disease. (springeropen.com)
  • Adjuvant chemotherapy prolongs relapse-free and overall survival for patients with stage III gastric cancer in a real-world situation. (springeropen.com)
  • 9 ] used the preoperative inflammatory, nutritional, and tumor marker index to develop a model that can predict the overall survival of GC patients and obtain good discrimination. (biomedcentral.com)
  • A previous systematic review and meta-analysis of 14 studies comprising 3003 patients with incurable advanced gastric cancer revealed that palliative gastrectomy significantly improved overall survival [ 9 ]. (biomedcentral.com)
  • Pathological stage (p)T1N0 gastric cancers are classified as Stage IA according to the Japanese Classification of Gastric Carcinoma ( Tokyo, Kanehara & CO. Ltd. (2017)">4 ) and show a very good prognosis with a 5-year overall-survival rate of 99.0% ( Gastric Cancer 21(1) (2018)">5 ). (cancerdiagnosisprognosis.org)
  • reported a 5-year overall-survival (OS) rate of 93.2% for Stage IB, 79.9% for Stage II, and 41.2% for Stage IIIB ( Gastric Cancer 21(1) (2018)">5 ). (cancerdiagnosisprognosis.org)
  • Kaplan Meier plotters were used to evaluate overall survival (OS) and progression-free survival (PFS) in ovarian cancer patients and GEPIA for the differential expression of ESR2 levels in ovarian cancer and adjacent normal tissues. (cancerindex.org)
  • However, the improvement of overall survival achieved by postoperative adjuvant chemotherapy may be insufficient in consideration of the deterioration of quality of life (QOL). (bmj.com)
  • Univariate Cox regression analysis was used to identify overall survival (OS)-related NETs, and the least absolute shrinkage and selection operator was used to evaluate the predictive efficacy of the NRGs. (biomedcentral.com)
  • We identified 36 NRGs that significantly affected patient overall survival (OS). (biomedcentral.com)
  • Nivolumab plus chemotherapy versus placebo plus chemotherapy in patients with HER2-negative, untreated, unresectable advanced or recurrent gastric or gastro-oesophageal junction cancer (ATTRACTION-4): a randomised, multicentre, double-blind, placebo-controlled, phase 3 trial. (nih.gov)
  • The standard treatment approach was EBRT plus chemotherapy for recurrent carcinoma after surgery or metastasis in the retroperitoneal region. (biomedcentral.com)
  • Upfront treatment with nivolumab plus chemotherapy continues to yield significant survival benefit compared with chemotherapy alone in patients with advanced GC /GEJC/EAC* after 24 months, regardless of their PD-L1 combined positive score (CPS), according to long-term data from the CheckMate-649 trial presented at GICS 2022. (mims.com)
  • In addition,] patients with tumours with high microsatellite instability showed remarkable benefit with nivolumab plus chemotherapy, but efficacy was also clearly observed when these patients were excluded from the analysis," he reported. (mims.com)
  • However, this guideline does not recommend postoperative adjuvant chemotherapy for pT1N+ or pT2~3N0 gastric cancer, despite the risk of recurrence. (cancerdiagnosisprognosis.org)
  • Introduction In patients with non-small cell lung cancer, surgical treatment with postoperative adjuvant chemotherapy is performed. (bmj.com)
  • Surgery provides a curative opportunity for a number of patients and is considered the foundation of multimodal management of gastric cancer. (biomedcentral.com)
  • Based on such backgrounds, no standard first-line chemotherapy has been established and an unmet need exists for prolongation the survival time in AGC patients with SPM. (biomedcentral.com)
  • The Dutch D1/D2 trial reported an increased median survival for a subgroup of patients with single metastasis who underwent resection. (unige.ch)
  • Multimodal treatment with resection doubled the median survival of oligometastatic patients in the German AIO-FLOT 3 study and as a consequence, the AIO-FLOT 5 (RENAISSANCE) trial was designed. (unige.ch)
  • Before 2000, there was no large-scaled randomized phase III trial to evaluate the benefit of adjuvant chemotherapy on the survival of patients with gastric cancer after operation. (springeropen.com)
  • Although some meta-analyses suggested a positive effect of adjuvant chemotherapy on survival of patients with gastric cancer (Hejna et al. (springeropen.com)
  • Immunohistochemistry indicators are increasingly being used to predict the survival prognosis of cancer patients after surgery. (biomedcentral.com)
  • Many phase III trials failed to demonstrate a survival benefit from the addition of molecular therapy to conventional chemotherapy for advanced and metastatic gastric cancer, and only three agents were approved by the FDA. (encyclopedia.pub)
  • The survival benefits of molecular therapies available to date for advanced and metastatic gastric cancer are rather unclear, mostly due to inaccurate patient selection, particularly concerning oncogene amplification and copy number. (encyclopedia.pub)
  • We aimed to determine whether the combination of NLR and PLR (NLR-PLR) could better predict survival of patients after curative resection for stage I-II gastric cancer. (biomedcentral.com)
  • The preoperative NLR-PLR score is a useful predictor of postoperative survival in the patients with stage I-II gastric cancer and may help identify high-risk patients for rational therapy and timely follow-up. (biomedcentral.com)
  • Therefore, a preoperative predictor of postoperative survival in the patients with stage I-II gastric cancer would be useful. (biomedcentral.com)
  • To test our hypothesis that an integrated indicator may better reflect the balance of host inflammation, we determined the prognostic value of NLR-PLR in predicting postoperative survival of the patients with stage I-II gastric cancer. (biomedcentral.com)
  • Recently, evidence has emerged that palliative gastrectomy in patients with stage IV gastric cancer may offer some survival benefits. (biomedcentral.com)
  • Moreover, a recent study based on the Surveillance, Epidemiology, and End Results Program (SEER) data demonstrated a survival benefit for palliative gastrectomy in gastric cancer patients with stage IV disease after balancing baseline characteristics using propensity score matching analysis [ 10 ]. (biomedcentral.com)
  • The onset of RCC is hidden, and 16% of patients have metastasized at first diagnosis with a 5-year survival of 9-12%[ 3 ]. (medsci.org)
  • Recently, with the advent of immunotherapy and anti-angiogenesis therapy, the survival of RCC patients has been improved[ 4 ]. (medsci.org)
  • Survival figures remain relatively poor, partially due to the fact that significant proportion of patients present with advanced disease. (omicsonline.org)
  • While incidence is increasing overall 5-year survival remains poor making this relatively rare cancer the 6th leading cause of cancer related death world-wide [ 1 - 3 ]. (omicsonline.org)
  • For example, in breast cancer, meta-analyses have unequivocally shown improved survival follows improvements in locoregional control ( 5 ). (iiarjournals.org)
  • Keeping it in the family: the impact of marital status and next of kin on cancer treatment and survival. (umassmed.edu)
  • Presentation and Survival of Gastric Cancer Patients at an Urban Academic Safety-Net Hospital. (umassmed.edu)
  • Augmented Features Synergize Radiomics in Post-Operative Survival Prediction and Adjuvant Therapy Recommendation for Non-Small Cell Lung Cancer. (cdc.gov)
  • Data Mining and Machine Learning in Cancer Survival Research: An Overview and Future Recommendations. (cdc.gov)
  • Despite these improvements in the staging and use of multimodality therapy, only modest improvements in patient survival have been observed. (jnccn.org)
  • This analysis confirms the previous data by showing clinically meaningful long-term OS and progression-free survival [PFS] benefits, with sustained separation of the survival curves for patients with tumours expressing PDL-1 CPS ≥5," highlighted invited discussant Dr Stefano Cascinu of the Vita-Salute San Raffaele University in Milan, Italy. (mims.com)
  • Currently, the 5-year survival rate for first-line treatment, as represented by R-CHOP, is 60-70%, with up to 50% of patients presenting as chemo-refractory or relapsing after treatment [ 7 ]. (biomedcentral.com)
  • Patients and Methods: We conducted a retrospective study of 63 patients diagnosed from 2004-2013 with histopathologically-confirmed stage I/II pancreatic cancer treated with a surgical resection followed by adjuvant concurrent chemoradiation to at least 45 Gy using 3D planning and capecitabine at 1,600 mg/m 2 /day (Monday-Friday) for 6 weeks. (iiarjournals.org)
  • Conclusion: Concurrent chemoradiation using capecitabine as a radiosensitizer in the adjuvant setting for pancreatic cancer was completed by the vast majority of patients in this series. (iiarjournals.org)
  • Pancreatic cancer remains one of the deadliest cancer diagnoses. (iiarjournals.org)
  • There will be approximately 48,960 new cases for pancreatic cancer (24,840 men and 24,120 women) diagnosed in USA in 2015 and unfortunately 40,560 deaths from pancreatic cancer (20,710 men and 19,850 women) are expected ( 1 ). (iiarjournals.org)
  • Outcomes following resection of pancreatic cancer. (umassmed.edu)
  • Gene therapy for pancreatic cancer. (umassmed.edu)
  • Redefining mortality after pancreatic cancer resection. (umassmed.edu)
  • A Tale of Two Cities: Reconsidering Adjuvant Radiation in Pancreatic Cancer Care. (umassmed.edu)
  • Evolution and impact of lymph node dissection during pancreaticoduodenectomy for?pancreatic cancer. (umassmed.edu)
  • Potential benefit of resection for stage IV gastric cancer: a national survey. (umassmed.edu)
  • Qureshi YA, Rohatgi A (2013) Gastro-Oesophageal Cancer. (omicsonline.org)
  • Gastro-oesophageal cancer remains a devastating diagnosis for the patient and a challenge for the clinician. (omicsonline.org)
  • The incidence of gastro-oesophageal cancer has striking geographical variation as does the gold standard treatment. (omicsonline.org)
  • A microsite designed for patients and families preparing for oesophageal or gastric cancer surgery offers video guides explaining chemotherapy services and surgery pathways in detail. (htn.co.uk)
  • Traditional chemotherapy and radiotherapy have limited effect in RCC, and molecular biomarkers are more targetable to guide treatment decisions. (medsci.org)
  • We enrolled 15 patients with 17 retroperitoneal recurrent carcinomas after external beam radiotherapy (EBRT). (biomedcentral.com)
  • Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)
  • SEE NAMCS PATIENT DATASET NAMES FOR DSN ABSTRACT General Information This material provides documentation for users of the Micro-Data tapes of the National Ambulatory Medical Care Survey (NAMCS) conducted by the National Center for Health Statistics. (cdc.gov)
  • Evaluation of the epidemiological and prognosis significance of ESR2 rs3020450 polymorphism in ovarian cancer. (cancerindex.org)
  • To investigate the correlation between the polymorphism of estrogen receptor β gene (ESR2) rs3020450 and cancer susceptibility, and explore the epidemiological significance and the effect of ESR2 expression levels on the prognosis of ovarian cancer. (cancerindex.org)
  • Based on meta-analysis the association between ESR2 rs3020450 polymorphism and cancer susceptibility was estimated and a case-control design was used to verify this result in ovarian cancer. (cancerindex.org)
  • In the stratified analysis by cancer types, significantly decreased risk was found in ovarian cancer (AG vs GG: OR = 0.73, 95%CI: 0.53-0.97, P = 0.03). (cancerindex.org)
  • Based on meta-analysis and case-control pooled results, ARP and PARP were evaluated respectively in allele (21.95% and7.97%), heterozygote (36.99% and 12.11%) and dominant model (36.84% and 12.97%) of rs3020450 polymorphism in ovarian cancer. (cancerindex.org)
  • Currently, the FDA has approved six ADCs to treat various solid cancers, including breast, gastric, cervical, and platinum-resistant ovarian cancer , as well as another handful to treat a range of hematologic malignancies, including lymphoma . (medscape.com)
  • Ovarian cancer represents the fifth cause of cancer death among women, carrying one of the worst prognoses among gynaecological malignancies [ 1 ]. (termedia.pl)
  • Standard methods of treatment for advanced-stage ovarian cancer enrol both cytoreduction surgery, also called optimal debulking, as well as platinum-based chemotherapy [ 2 ]. (termedia.pl)
  • In this study, the authors randomly assigned 670 patients with stage IIIC or IV ovarian cancer [ 4 ]. (termedia.pl)
  • Tailoring therapy based on different characteristics for patients with stage II gastric cancer may produce better outcomes. (springeropen.com)
  • Amaria and other researchers are continuing to follow patient outcomes and will be conducting further translational studies to discern the mechanisms of response and resistance to this combination. (mdanderson.org)
  • Transperineally ultrasound (US)-guided 125I RSI-BT was a standard modality for prostate cancer because of the excellent outcomes and minimally invasive procedure compared with surgery or EBRT [ 15 , 16 ]. (biomedcentral.com)
  • At the time of diagnosis of gastric cancer approximately one third of patients already have metastases. (unige.ch)
  • Unfortunately, these approaches were often associated with prolonged hospital stays, higher numbers of radiologic imaging studies and laparotomies with negative findings, and patient dissatisfaction if the diagnosis could not be established. (medscape.com)
  • Regarding the utility of exploratory laparoscopy for patients with NSAP, a meta-analysis of four randomized control trials (N = 811) comparing exploratory laparoscopy with active observation concluded that early diagnostic laparoscopy was associated with a decreased number of patients discharged without a final diagnosis. (medscape.com)
  • However, a substantial proportion of gastric adenocarcinomas are advanced or metastatic disease at the time of diagnosis. (biomedcentral.com)
  • The use of serum prostate-specific antigen (PSA) levels has been recognised as a huge step forward in the diagnosis and treatment of prostate cancer, however since its implementation as a biomarker it has become apparent that the numbers of deaths from prostate cancer has only decreased slightly. (almacgroup.com)
  • Machine Learning and Deep Learning Applications in Multiple Myeloma Diagnosis, Prognosis, and Treatment Selection. (cdc.gov)
  • Selection of diagnosis with oncologic relevance information from histopathology free text reports: A machine learning approach. (cdc.gov)
  • When R0/R1 surgery is achieved, patients receive S-1 chemotherapy for 1-year post-operatively. (nih.gov)
  • Endoscopic mucosal resection or surgery is primary treatment for early-stage gastric cancer. (medscape.com)
  • Materials and methods: An observational, analytical, retrospectivestudy of patients undergoing EA surgery from 2012 to 2022 was carriedout. (bvsalud.org)
  • The results of a joint pediatric surgery and gastroenterology consultation program which was implemented in 2018 and applies a protocolbased on the new ESPGHAN-NASPGHAN guidelines were analyzed.Patients were divided according to whether they had been treated before or after 2018. (bvsalud.org)
  • We used 245 patients who underwent surgery at one center as the training cohort and 111 patients from another center as the validation cohort. (biomedcentral.com)
  • Most patients can achieve a good prognosis under our comprehensive treatment model based on surgery and adjuvant chemotherapy. (biomedcentral.com)
  • Thirty patients were enrolled in the study and received two doses of nivolumab with relatlimab before surgery, followed by up to 10 additional doses of the combination therapy after surgery. (mdanderson.org)
  • The study enrolled 61 patients with stage I-III breast cancer and a germline BRCA mutation who were treated with talazoparib for 24 weeks prior to surgery. (mdanderson.org)
  • Primary tumor material (P) derived from patients undergoing surgery for head and neck squamous cell carcinoma (HNSCC) or glioblastoma multiforme (GBM) was transplanted subcutaneously into NMRI Foxn1 nu/nu mice. (europdxworkshop.eu)
  • Surgery is generally not a priority recommendation in such circumstances, except for patients with potentially life-threatening complications such as gastrointestinal bleeding, perforation, or obstruction. (biomedcentral.com)
  • In Japan, mortality from gastric cancer has decreased significantly over the past 20 years because of advances in various treatment methods such as surgery and chemotherapy ( World J Gastrointest Oncol 6(10) (2014)">3 ). (cancerdiagnosisprognosis.org)
  • 3 Although there have been no randomised controlled trials to compare surgery with radiation therapy or chemotherapy, observational studies have suggested that surgery is the most curative treatment for lung cancer. (bmj.com)
  • Bradford Teaching Hospitals has shared updates from its Virtual Royal Infirmary (VRI) Programme, which focuses on delivering digital patient education tools across a range of specialties including paediatric surgery and fracture care. (htn.co.uk)
  • For early and some locoregional cancers, surgery is the primary treatment. (medscape.com)
  • Conclusions: Digestive-surgical cross-disciplinary follow-up of EApatients has a positive impact on patient progression. (bvsalud.org)
  • Surgical resection is one of the best treatment methods for GC patients that can be curatively resected. (biomedcentral.com)
  • We collected data from the medical records of patients with stage I-II gastric cancer undergoing curative resection between December 2000 and November 2012 at the Sun Yat-sen Cancer Center. (biomedcentral.com)
  • Postoperative chemotherapy is included as an option after a modified D2 lymph node dissection for this group of patients. (jnccn.org)
  • This retrospective study involved patients at six Japanese academic hospitals between 2010 and 2016. (biomedcentral.com)
  • In 2016, the Cochrane Collaborative Group published a systematic review with the aim of assessing the efficacy and safety of MTs available for the treatment of advanced and metastatic gastric cancer [ 16 ] . (encyclopedia.pub)
  • Gastric cancer is a common digestive malignant disease and one of the leading causes of cancer mortality ( CA Cancer J Clin 68(6) (2018)">1 , Lancet 388(10060) (2016)">2 ). (cancerdiagnosisprognosis.org)
  • Therefore, it is essential to identify new additional predictive markers, and there is an urgent need for scoring systems that can discriminate postoperative patients by which high-risk patients can be identified, to improve prognostic prediction and provide appropriate treatment. (biomedcentral.com)
  • Ki-67 is an independent prognostic marker for OS in gastric cancer. (jcpsp.pk)
  • Identifying prognostic factors of OS may help identify patients at high risk for close follow-up and guide treatment for selected patients. (biomedcentral.com)
  • In prespecified subgroup analyses, OS benefit favouring the combination therapy persisted across key subgroups, including patients with poor prognostic factors such as those with high tumour burden, liver metastases, or low albumin, noted presenting author Dr Kohei Shitara of National Cancer Center Hospital East in Kashiwa, Japan. (mims.com)
  • The study population included a total of 270 stage II-III CRC patients treated with adjuvant FL with (FL + OXA, n = 119) or without oxaliplatin (FL, n = 151). (frontiersin.org)
  • Deep learning in image-based breast and cervical cancer detection: a systematic review and meta-analysis. (cdc.gov)
  • Can we increase the cervical cancer screening interval with an HPV test for women living with HIV? (who.int)
  • Cervical cancer prevention in countries with the highest HIV prevalence: a review of policies. (who.int)
  • Screening technologies for cervical cancer: Overview. (who.int)
  • Herzuma (trastuzumab-pkrb) is a HER2 /neu receptor antagonist indicated for the treatment of HER2-overexpressing breast cancer . (rxlist.com)
  • Select patients for therapy based on an FDA-approved companion diagnostic for a trastuzumab product [see DOSAGE AND ADMINISTRATION ]. (rxlist.com)
  • Patients who receive trastuzumab deruxtecan, for instance, may develop interstitial lung disease , which can be fatal. (medscape.com)
  • Trastuzumab with chemotherapy is recommended as first-line therapy for patients with HER2-positive advanced or metastatic cancer, confirmed by immunohistochemistry and, if needed, by fluorescence in situ hybridization for IHC 2+. (jnccn.org)
  • There is no standard first-line chemotherapy for advanced gastric cancer with severe peritoneal metastasis. (biomedcentral.com)
  • Patients with advanced gastric cancer and severe peritoneal metastasis were included if they had massive ascites and/or inadequate oral intake requiring intravenous nutritional support. (biomedcentral.com)
  • Combination therapy with fluoropyrimidine and platinum might be more effective than monotherapy with fluoropyrimidine and was tolerable for patients with advanced gastric cancer and severe peritoneal metastasis. (biomedcentral.com)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • METHODS: Male colorectal cancer (CRC) screenees were recruited to undergo upper endoscopy, identifying newly diagnosed cases of Barrett's esophagus. (who.int)
  • Further randomized trials investigate the benefit of antibodies and immune checkpoint inhibitors in locoregional and advanced metastatic gastric cancer with promising results. (unige.ch)
  • After a minimum follow-up of 24 months, the nivolumab + chemotherapy group saw sustained improvements in OS (HR, 0.79, 95 percent confidence interval [CI], 0.71-0.88) and PFS (HR, 0.79, 95 percent CI, 0.70-0.89) - which the investigators described as "clinically meaningful" compared with the chemotherapy alone group. (mims.com)
  • When the analyses were stratified by CPS for PD-L1, both OS and objective response rate (ORR) were higher in the nivolumab + chemotherapy group than the chemotherapy group alone, regardless of CPS. (mims.com)
  • These data further support the use of nivolumab + chemotherapy as standard first-line treatment in patients with advanced oesophagogastric cancer," he concluded. (mims.com)
  • Gastric cancer (GC) has high incidence and mortality and is among the most common malignancies: in 2012 it was the second-leading cause of cancer-related deaths worldwide [ 1 ]. (oncotarget.com)
  • A simple risk score to predict in-hospital mortality after pancreatic resection for cancer. (umassmed.edu)
  • The TNM staging system has been widely used to predict GC prediction, but the staging is for patients receiving different treatments, and even at the same stage, the prognosis of patients may be completely different [ 8 ]. (biomedcentral.com)
  • We developed a genetic risk model based on NRGs to predict the prognosis of patients with DLBCL, which may assist in the selection of treatment drugs for these patients. (biomedcentral.com)
  • Patients and Methods: The study included 157 patients with diagnosed pT1N+ or pT2-3N0 gastric cancer who underwent radical gastrectomy at our institution between January 2001 and December 2020. (cancerdiagnosisprognosis.org)
  • Machine learning methods to predict presence of residual cancer following hysterectomy. (cdc.gov)
  • Patients and methods proportion of the patients will recur despite treatment with adjuvant polychemotherapy. (lu.se)
  • Of the 63 patients reviewed, 61 patients (97%) completed concurrent chemoradiotherapy. (iiarjournals.org)
  • The stomach, duodenum, or esophagus is clinically involved only rarely, although microscopic evidence of disease is often detectable in the gastric antrum, especially in younger patients. (msdmanuals.com)
  • Liquid biopsy: The genomic alterations of solid cancers can be identified by evaluating circulating tumor DNA (ctDNA) in the blood This procedure is used more in patients who cannot undergo traditional biopsy, but can also be performed in other patients to gather more evidence for management. (medscape.com)
  • At the same time, cancer cells shape the tumor microenvironment by secreting various cytokines and chemokines, providing the necessary environmental conditions for the reprogramming of neutrophils, which may explain the varied functions of neutrophils in cancer [ 12 ]. (biomedcentral.com)
  • All cases were pathologically diagnosed, and 177 patients were diagnosed with pT1N+ or pT2-3N0 gastric cancer based on the 15th Japanese Classification of Gastric Carcinoma ( Tokyo, Kanehara & CO. Ltd. (2017)">4 ). (cancerdiagnosisprognosis.org)
  • Renal cell carcinoma is one of the most common cancers in the urinary system, causing over 140,000 deaths worldwide each year[ 1 ]. (medsci.org)
  • Indeed, the majority of phase III trials investigating novel molecular agents failed to demonstrate their efficacy, mostly due to inaccurate patient selection (particularly concerning driver gene amplification and copy number) and the lack of preclinical models supporting proof of concepts followed by structured trials. (encyclopedia.pub)
  • The patients in these reports often got relief from either substituting methylprednisolone or by withholding the corticosteroid entirely, without sacrificing antiemetic efficacy. (lww.com)
  • the number of cases: synergistic antitumor and chemotherapy drugs, the treatment group of single disease (with tumor) should not be less than 100 cases, in order to clarify efficacy evaluation. (cancerlive.net)
  • This study compared the in vitro efficacy of furazolidone with metronidazole, clarithromycin, amoxicillin and tetracycline in 70 H. pylori isolates from dyspeptic patients. (who.int)
  • NGS: When limited tissue is available for testing or if the patient cannot undergo traditional biopsy, the use of limited molecular diagnostic panels may quickly exhaust the sample. (medscape.com)
  • Despite recent declining incidence, gastric cancer remains one of the most common cancers worldwide. (scirp.org)
  • It represents the fifth most frequent cancer worldwide (5.6%) and the fourth leading cause of cancer-related death (7.7%) with 768,793 deaths per year in 2020 [ 1 ] . (encyclopedia.pub)
  • However, appropriate predictors for stage I-II gastric cancers remain unclear. (biomedcentral.com)
  • However, the mechanism to explain why some patients develop this adverse event remains unclear. (medscape.com)
  • All 194 patients underwent radical operation plus D2 dissection, and were followed a median time of 23.3 (range 0.4-80.2) months. (springeropen.com)
  • Seanalizaron los resultados de la implantación en 2018 de un programa deconsultas conjuntas de gastroenterología y cirugía pediátrica aplicandoun protocolo basado en las nuevas guías ESPGHAN-NASPGHAN. (bvsalud.org)
  • All patients were treated between January 2012 and June 2018. (biomedcentral.com)
  • We prospectively analyzed the IgG4-RD patients recruited in Peking Union Medical College Hospital from January 2011 to August 2018 and identified patients diagnosed with IgG4-RD complicating malignancies. (nature.com)
  • We consecutively collected data on patients with IgG4-RD and malignancies who were prospectively enrolled in the IgG4-RD cohort in PUMCH from January 2011 and June 2018. (nature.com)
  • Integrative clustering of multi-omics data revealed 2 subgroups of patients with metastatic-like biology that have distinct biology. (almacgroup.com)
  • These findings could improve the discrimination of patients who would benefit from adjuvant treatment. (frontiersin.org)
  • In this context, there is a need for new predictive markers, beyond the tumor stage, to select what patients will benefit from an adjuvant treatment and to better tailor treatment schemes and schedules. (frontiersin.org)
  • During adjuvant treatment, 26% of patients experienced a Grade 3 or 4 adverse event. (mdanderson.org)
  • 1) test purposes to be clear: According to the clear positioning of drug prescriptions, which determine the treatment of cancer adjuvant treatment of drug or drugs. (cancerlive.net)
  • According to treatment guidelines in the regional care pro- recur in spite of chemotherapy. (lu.se)
  • it was subsequently introduced as the standard of care for patients with locally or fAGC displaying HER2 overexpression/amplification [ 12 ] . (encyclopedia.pub)
  • Adding oxaliplatin (OXA) to therapy based on FLs (5-FU and capecitabine) further improves the disease-free (DFS) and OS rates in patients with stage III disease. (frontiersin.org)
  • Radiation therapy is often given with chemotherapy. (medscape.com)