Chemotherapy bone transplantation. Medical search. Frequent questions

It is important to know whether the survival of patients receiving an allogeneic bone marrow transplant (BMT) is better than that of patients receiving "conventional" treatment and, if BMT is better, to know how much better. (ox.ac.uk)
Severe adverse impact on sexual functioning and fertility of bone marrow transplantation, either allogeneic or autologous, compared with consolidation chemotherapy alone: analysis of the MRC AML 10 trial. (ox.ac.uk)
METHODS: A cross-sectional study of sexual health and infertility was conducted in 479 patients with acute myeloid leukemia (AML) in first complete remission (CR) who were entered into the UK MRC AML 10 trial comparing allogeneic BMT (Allo-BMT), autologous BMT (A-BMT), and intensive consolidation chemotherapy (CCT). (ox.ac.uk)
Forty infants have subsequently been treated on a protocol incorporating further intensification with an option for high-dose chemotherapy and autologous or allogeneic bone marrow transplantation. (nih.gov)
However, relapsed ALL remains a leading cause of childhood death despite intensive cytotoxic chemotherapy often including allogeneic bone marrow transplantation. (nature.com)
For allogeneic transplantation, the patient receives bone marrow or stem cells from a donor who may or may not be a relative. (ucsfhealth.org)
An initial appointment was scheduled for 22 March 2020 at An-Najah Hospital in Nablus, in the West Bank, but the hospital only offers autologous transplantation (using the patient's own bone marrow), while Saja needed an allogeneic transplant (with bone marrow from a donor). (who.int)
Chronic graft versus host disease (cGVHD) is the most common consequence of allogeneic bone marrow transplantation, and it is associated with morbidity and mortality. (bvsalud.org)
Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)

2009) Concurrent decline of several antioxidants and markers of oxidative stress during combination chemotherapy for small cell lung cancer. (scirp.org)
The use of combination chemotherapy after initial surgery has dramatically improved the prognosis for many women with these tumors. (kaiserpermanente.org)
A review of the literature in 1979 prior to the widespread use of combination chemotherapy found only 27% of 96 patients with stage I endodermal sinus tumor alive at 2 years after diagnosis. (kaiserpermanente.org)
Extensive-stage SCLC (ie, SCLC that has spread beyond the supraclavicular areas, or with distant metastases) remains incurable with current management options, and patients are treated with combination chemotherapy. (medscape.com)
Nonrandomized trials of combination chemotherapy have shown superior response rates and survival compared with single-agent chemotherapy. (medscape.com)

TRANSPLANTATION: 2-Drug Combination Myeloablative Chemotherapy followed by Radiotherapy followed by Hematopoietic Rescue plus GVHD Prophylaxis. (knowcancer.com)
Aetiology of cancer, influence of nutrition on cancer development, nutrition of oncology patients Pharmacotherapy of malignant diseases and adverse effects of these drugs- Radiotherapy of malignant diseases, adverse effects of radiotherapy Basic information's about most frequent cancer diseases Urological cancer Digestive tract cancer Lung cancer Gynaecologic cancer Bone marrow transplantation, indication, methods, results. (muni.cz)
Blastic NK cell lymphoma is resistant to chemotherapy and radiotherapy. (lymphomainfo.net)
Aggressive chemotherapy associated with radiotherapy followed by bone marrow transplantation still produces poor outcomes. (lymphomainfo.net)
Treatment may include surgery, chemotherapy, radiotherapy and/or bone marrow transplantation. (khcc.jo)

Nevertheless, myelosuppression can be reversed by autologous stem cell transplantation (SCT), even without additional toxicity ( 4 , 5 ). (ijbs.com)

[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
High-dose therapy (HDT) combined with autologous stem-cell transplantation (ASCT) provides superior response and survival outcomes versus standard chemotherapy in patients with newly diagnosed (ND) multiple myeloma (MM). 1 , 2 Standard induction chemotherapy regimens, however, are often associated with hematologic stem-cell toxicity, which may compromise the collection of stem cells for ASCT. (haematologica.org)
Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma. (semanticscholar.org)
Check specific guidelines for restaging and dosage adjustments for chemotherapy and/or radiation therapy depending on positron-emission tomography (PET) scanning throughout the various regimens. (medscape.com)
Regimens that combine chemotherapy and radiation therapy (RT) have replaced RT alone for treatment of early-stage, favorable disease. (medscape.com)
Several platinum-based and non-platinum-based chemotherapy regimens have been used in the treatment of small cell lung cancer (SCLC) with varying results. (medscape.com)
In a systematic review that compared the effectiveness of these regimens, Amarasena et al concluded that platinum-based chemotherapy regimens did not provide a statistically significant benefit over non-platinum-based agents in survival or overall tumor response. (medscape.com)
The investigators suggested that non-platinum-based chemotherapy regimens may have a better risk-benefit profile. (medscape.com)

OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)

Most studies that have attempted to define the value of BMT have been subject to varying degrees of bias because of the problems of identifying a "conventional chemotherapy" control group with which the outcome of patients who have received BMTs can be compared. (ox.ac.uk)
High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
CONCLUSION: The combination of immunotherapy and tyrosine-kinase inhibitors is at least as effective as a tyrosine-kinase inhibitor alone, and superior to conventional chemotherapy for treating metastatic RCC of unknown primary origin. (bvsalud.org)

Only three of 11 children treated by high-dose chemotherapy and transplantation remain alive in remission. (nih.gov)
These results show the susceptibility of infants to the toxicity of intensive chemotherapy and do not support the use of short term high-dose chemotherapy alone in the management of infant leukaemia. (nih.gov)
The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
Background Thalidomide is active in multiple myeloma and is associated with minimal myelosuppression, making it a good candidate for induction therapy prior to high-dose therapy with autologous stem-cell transplantation. (haematologica.org)
High-dose chemotherapy and autologous bone marrow transplantation compared with MACOP-B in aggressive B-cell lymphoma. (semanticscholar.org)
The administration of bone marrow usually occurs after a patient has received high-dose chemotherapy or radiation. (ucsfhealth.org)
For autologous transplantation, the patient receives his or her own bone marrow or stem cells that were collected and frozen before admission for high-dose chemotherapy or radiation. (ucsfhealth.org)

Combination Systemic Chemotherapy plus 3-Drug Combination Intrathecal Chemotherapy. (knowcancer.com)
Systemic Chemotherapy. (knowcancer.com)
Systemic Chemotherapy plus Single-Agent Intrathecal Chemotherapy. (knowcancer.com)
4-Drug Combination Systemic Chemotherapy plus Single-Agent Intrathecal Chemotherapy. (knowcancer.com)
Even in the unfavorable subset, local therapy was combined with systemic chemotherapy in only two cases, and four cases showed no recurrences. (bvsalud.org)

Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)

For the approximately 30% of patients with SCLC who have limited-stage disease at the time of diagnosis (ie, tumors confined to the hemithorax of origin, the mediastinum, or the supraclavicular lymph nodes), management typically involves combination platinum-based chemotherapy and thoracic radiation therapy given with curative intent. (medscape.com)
Cancer of unknown primary has a dismal prognosis, especially following failure of platinum-based chemotherapy. (bvsalud.org)
NCT04131621), patients relapsed or refractory after platinum-based chemotherapy received nivolumab and ipilimumab following TMBhigh vs. TMBlow stratification. (bvsalud.org)

Currently, recipients that undergo BMT are treated with toxic agents such as radiation and chemotherapy in order to in order to eliminate their own blood forming stem cells and permit the donor cells to take and develop. (ca.gov)

Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
Estimate the failure-free survival rate in a cohort of relapsed Hodgkin's lymphoma and non-Hodgkin's lymphoma patients after retrieval therapy which includes peripheral blood stem cell transplantation (PBSCT) in patients who achieve a complete remission or partial remission. (knowcancer.com)
Anthracycline-based chemotherapy as primary treatment for intravascular lymphoma. (semanticscholar.org)
MACOP-B chemotherapy for the treatment of diffuse large-cell lymphoma. (semanticscholar.org)
Bone marrow transplantation (BMT) is the treatment of choice for lymphoma, aplastic anemia, various types of leukemia and immunodeficiency disorders [5]. (bvsalud.org)

4 ] Even patients with incompletely resected dysgerminoma can be rendered disease free following chemotherapy with bleomycin, etoposide, and cisplatin (BEP) or a combination of cisplatin, vinblastine, and bleomycin. (kaiserpermanente.org)

Advanced stages of neuroblastoma are treated with intensive chemotherapy in combination with an autologous bone marrow transplant, which is usually followed by a vitamin A derivative administered orally for 6 months. (khcc.jo)

Several chemotherapy combinations are active in SCLC, but usually a platinum-containing regimen is chosen. (medscape.com)

Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)

Weijl, N.I., Leton, F.J. and Osanto, S. (1997) Free radi- cals and antioxidants in chemotherapy-induced toxicity. (scirp.org)
However, even those who have poor prognostic factors (eg, poor PS, medically significant concomitant conditions) may still be considered for chemotherapy if appropriate precautions are taken to avoid excessive toxicity and further decline in PS. (medscape.com)

As part of my job, I oversee the care of patients receiving bone marrow transplants. (mskcc.org)
When she was in her early 20s, Yinka and her mother started exploring bone marrow transplants, the only cure for sickle cell disease to date. (medlineplus.gov)

At post transplantation day plus 3, antibiotic drug therapy was switched from piperacillin/tazobactam to meropenem. (cdc.gov)

If marrow involvement is still present at harvest, then 2 additional courses of induction chemotherapy are given. (knowcancer.com)

Stem cell transplantation is a promising strategy for delayed wound healing caused by chemotherapy. (ijbs.com)
Patients who undergo hematopoietic stem cell transplantation frequently have hemorrhagic cystitis because most are exposed to cyclophosphamide, total-body irradiation, or both. (medscape.com)
In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
Bone marrow transplantation (BMT) is the oldest and most common form of stem cell-based therapy. (ca.gov)
OUTLINE: Patients receive 2 courses of reinduction chemotherapy followed by bone marrow biopsy and aspirate prior to peripheral blood stem cell (PBSC) harvest. (knowcancer.com)
Without a stem cell transplantation, the chances of surviving more than a few years is small for some patients. (oslo-universitetssykehus.no)
Therefore a bone marrow transplantation is also known as a stem cell transplantation, and a bone marrow donor is also known as a stem cell donor. (oslo-universitetssykehus.no)
About a week prior to a stem cell transplantation, the patient receives pre-treatment to eradicate the patient's own bone marrow cells. (oslo-universitetssykehus.no)
Stem cell transplantation may be a life saving treatment in these conditions. (oslo-universitetssykehus.no)
These are the important cells that are transferred during bone marrow or stem cell transplantation. (ucsfhealth.org)
However, an alternative is to perform bone marrow or stem cell tx (transplantation). (lu.se)
Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
To the best of our knowledge, only the transmission of malarial parasites has been reported during stem cell transplantation. (cdc.gov)

National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
In the present study, we measured cortisol, the main stress hormone, and total antioxidant capacity (TAC) in serum of 51 cancer patients during chemotherapy. (scirp.org)
Cancer Chemotherapy and Pharmacology, 35,132-136. (scirp.org)
Cancer Chemotherapy and Pharma- cology, 25, 210-212. (scirp.org)
2005) Cancer chemotherapy reduces plasma total antioxidant capacity in children with malignancies. (scirp.org)
Chemotherapy Chemotherapy is a term for many different drugs used to treat cancer. (cancerquest.org)
Five years earlier, a breast cancer was treated by chemotherapy, radiation, and bone marrow transplantation. (liposuction.com)
Blood transfusion also plays a key role in the management of conditions such as haematological disorders (including leukaemia, haemophilia, thalassaemia), cancer chemotherapy, open heart surgery, and bone marrow and organ transplantation. (who.int)
For three years she underwent several rounds of chemotherapy as well as radiation therapy and bone-marrow transplantation, but the cancer did not stay in remission. (worldpressphoto.org)
Occupants receiving chemotherapy for cancer or bone marrow transplantation. (pureaircontrols.com)
In essence, a bone marrow transplant uses very high doses of therapy in attempt to cure the cancer. (ucsfhealth.org)
When these higher doses are used to kill the cancer cells, the normal bone marrow cells will also be destroyed. (ucsfhealth.org)
Advances in the treatment of cancer and improvements in supportive care over the past 10 years have improved the results and tolerability of bone marrow transplantation. (ucsfhealth.org)
AML (Acute Myeloid Leukemia) is a blood cancer (haematological malignancy), and the standard way of treating older AML patients is chemotherapy. (lu.se)

Bone Marrow Transplantation (2000) 26, 877-880. (nature.com)

The transfused stem cells find their way to the patient's bone marrow and 'settle down' there. (oslo-universitetssykehus.no)

Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. (medscape.com)

If you are receiving Nivestym because you are also receiving chemotherapy, your dose of Nivestym should be injected at least 24 hours before or 24 hours after your dose of chemotherapy. (drugs.com)

Herein we characterized human fetal bone marrow stromal cells (hBMSCs) during wound healing in mice treated with cyclophosphamide (CTX). (ijbs.com)
Cyclophosphamide (CTX) is a common drug widely used in chemotherapy. (ijbs.com)

Although C. dubliniensis was first associated with oral candidiasis in HIV-infected persons ( 3 ) , several reports now link the organism to non-HIV patients who were immunosuppressed due to chemotherapy, hematologic malignancy ( 4 ) , and end-stage liver disease ( 1 ) . (cdc.gov)

Zhang QY, Foucar K. Bone marrow involvement by Hodgkin and non-Hodgkin lymphomas. (medscape.com)
MACOP-B chemotherapy for malignant lymphomas and related conditions: 1987 update and additional observations. (semanticscholar.org)

Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)

Treatment for this condition remains difficult and largely ineffective, because the growth of cells in the wound is inhibited ( 2 ) and chemotherapy usually leads to myelosuppression, the latter of which further compromises the migration of multipotent cells from the bone marrow ( 3 ). (ijbs.com)
Nivestym (filgrastim-aafi) is a recombinant human granulocyte colony-stimulating factor biosimilar to Neupogen indicated for the treatment of neutropenia associated with chemotherapy and related conditions. (drugs.com)
During this time, she is undergoing a costly treatment, which includes chemotherapy and autologous bone marrow transplantation. (gofundme.com)
She needs a bone marrow transplant, not available in the Gaza Strip, and has not been able to access the treatment she needs since March 2020. (who.int)
Saja received her initial chemotherapy in Rabat, before returning home to Gaza in February 2020 to continue her treatment and undergo bone marrow transplantation in the occupied Palestinian territory. (who.int)

Do you want to become a bone marrow donor? (oslo-universitetssykehus.no)
Registration as a bone marrow donor also takes place in the blood bank. (oslo-universitetssykehus.no)
This is an English translation of the recruitment and consent brochure published in Norwegian by The Norwegian Bone Marrow Donor Registry (NBMDR), Department of Immunology, Oslo University Hospital. (oslo-universitetssykehus.no)
As a volunteer in The Bone Marrow Donor Registry you may be asked to donate stem cells to a patient. (oslo-universitetssykehus.no)
After you have been tissue typed, your data will be entered into the database of The Norwegian Bone Marrow Donor Registry. (oslo-universitetssykehus.no)
When a patient has a bone marrow transplantation done, that means that the patient receives healthy stem cells from a donor. (oslo-universitetssykehus.no)
First, the bone marrow donor receives full anaesthesia. (oslo-universitetssykehus.no)
A bone marrow transplant is the replacement of diseased or damaged bone marrow cells with new bone marrow cells that have been stored, frozen or obtained from a bone marrow donor. (ucsfhealth.org)
The 24-year-old woman, who was registered as a volunteer donor in the German Bone Marrow Donor Registry, was selected. (cdc.gov)
A second apheresis or a bone marrow collection was considered, but neither was performed because the clinical condition of the donor worsened. (cdc.gov)

Patients with malignancies and those undergoing chemotherapy are often immunocompromised and are at high risk of acquiring bacterial and viral infections that can cause hemorrhagic cystitis. (medscape.com)
Cisplatin-based chemotherapy for ovarian germ cell malignancies: the Australian experience. (kaiserpermanente.org)

A number of randomized trials have tried to answer questions concerning the superiority of combination over single-agent chemotherapy, the number of drugs to be used in combination, and dose intensity. (medscape.com)

Bone marrow aspirate demonstrating plasma cells of multiple myeloma. (medscape.com)
In addition to all these services, other specialised tests like HPLC (onboard D10 instrument) and bone marrow aspirate reporting are also performed in the department. (jaslokhospital.net)

However, having a bone marrow transplant remains a dangerous and difficult procedure. (ucsfhealth.org)

Elderly patients with SCLC who have a good performance status (PS) (ie, Eastern Cooperative Oncology Group [ECOG] PS 0 or 1) and intact organ function should receive standard carboplatin-based chemotherapy. (medscape.com)

When bone marrow or blood stem cells are infused into the recipient, they are administered through an intravenous catheter or central venous catheter, just like a blood transfusion. (ucsfhealth.org)

Anatomy4

Organisms1

Diseases16

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Phenomena and Processes11

Information Science1

Named Groups2

Health Care10

Allogeneic9

Combination Chemotherapy5

Radiotherapy5

Reversed by autologous stem cell trans1

Regimens8

Treated with autologous stem cell trans1

Conventional chemotherapy3

High-dose10

Systemic Chemotherapy5

Autologous peripheral blood1

Platinum-based chemotherapy3

Radiation and chemotherapy1

Lymphoma7

Etoposide1

Intensive1

Regimen1

ASCT1

Toxicity2

Transplants2

Post-transplantation1

Induction chemotherapy1

Stem Cell15

Cancer14

20001

Patient's1

Hematopoietic cell1

Least 241

Cyclophosphamide2

Hematologic1

Lymphomas2

INTENSIFICATION1

Treatment5

Donor10

Malignancies2

Dose1

Marrow aspirate2

Having a bone marrow tra1

Organ1

Blood stem1