• In HDC, the bone marrow transplantation was used to maximise chemotherapeutic dosage. (wikipedia.org)
  • Evaluate the feasibility and outcome of bone marrow transplantation using family or unrelated donors in infants with the 11q23 abnormality. (knowcancer.com)
  • TRANSPLANTATION: 2-Drug Combination Myeloablative Chemotherapy followed by Radiotherapy followed by Hematopoietic Rescue plus GVHD Prophylaxis. (knowcancer.com)
  • Hu G, Liu P, Feng J, Jin Y. Transplantation with Bone Marrow Stromal Cells Promotes Wound Healing Under Chemotherapy through Altering Phenotypes. (ijbs.com)
  • Stem cell transplantation is a promising strategy for delayed wound healing caused by chemotherapy. (ijbs.com)
  • Severe adverse impact on sexual functioning and fertility of bone marrow transplantation, either allogeneic or autologous, compared with consolidation chemotherapy alone: analysis of the MRC AML 10 trial. (ox.ac.uk)
  • Forty infants have subsequently been treated on a protocol incorporating further intensification with an option for high-dose chemotherapy and autologous or allogeneic bone marrow transplantation. (nih.gov)
  • Only three of 11 children treated by high-dose chemotherapy and transplantation remain alive in remission. (nih.gov)
  • Aetiology of cancer, influence of nutrition on cancer development, nutrition of oncology patients Pharmacotherapy of malignant diseases and adverse effects of these drugs- Radiotherapy of malignant diseases, adverse effects of radiotherapy Basic information's about most frequent cancer diseases Urological cancer Digestive tract cancer Lung cancer Gynaecologic cancer Bone marrow transplantation, indication, methods, results. (muni.cz)
  • p>In addition to childhood cancers and blood disorders, Nemours treats nonmalignant bone marrow disorders, immune system deficiencies and some metabolic disorders with allogeneic blood and bone marrow transplantation. (nemours.org)
  • Consequently, we proceeded with salvage chemotherapy followed by autologous stem cell transplantation. (karger.com)
  • Atkinson K, Meyers J, Storb R, Prentice RL, Thomas ED . Varicella-zoster virus infection after marrow transplantation for aplastic anemia or leukemia. (nature.com)
  • Infection with varicella-zoster virus after marrow transplantation. (nature.com)
  • Han CS, Miller W, Haake R, Weisdorf D . Varicella zoster infection after bone marrow transplantation: incidence, risk factors and complications. (nature.com)
  • Varicella zoster virus infections following allogeneic bone marrow transplantation: frequency, risk factors, and clinical outcome. (nature.com)
  • Blood transfusion also plays a key role in the management of conditions such as haematological disorders (including leukaemia, haemophilia, thalassaemia), cancer chemotherapy, open heart surgery, and bone marrow and organ transplantation. (who.int)
  • Chronic graft versus host disease (cGVHD) is the most common consequence of allogeneic bone marrow transplantation, and it is associated with morbidity and mortality. (bvsalud.org)
  • Bone marrow transplantation (BMT) is the treatment of choice for lymphoma, aplastic anemia, various types of leukemia and immunodeficiency disorders [5]. (bvsalud.org)
  • Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
  • High-dose chemotherapy and bone marrow transplant (HDC/BMT), also high-dose chemotherapy with autologous bone marrow transplant (HDC/ABMT or just ABMT), was an ineffective treatment regimen for metastatic breast cancer, and later high-risk breast cancer, that was considered promising during the 1980s and 1990s. (wikipedia.org)
  • 3 The idea for high-dose chemotherapy (HDC) with autologous bone marrow transplant (ABMT) originated in the 1950s as a leukemia treatment, when E. Donnall Thomas had shown that bone marrow could be harvested from a person and transplanted into the same or another person. (wikipedia.org)
  • The treatment of high-dose chemotherapy with autologous bone marrow transplant had serious, lasting, and sometimes deadly side effects for the patient, including cardiac toxicity, sepsis, pulmonary failure, and nephrotoxicity, among others. (wikipedia.org)
  • Chemotherapy, radiation, bone marrow transplant or avocados? (newstarget.com)
  • Stem cell or bone marrow transplant from another person may also be done. (medlineplus.gov)
  • I work on the inpatient Adult Bone Marrow Transplant Service as a nurse practitioner. (mskcc.org)
  • They may also do this if you are going to be immune-suppressed because of chemotherapy or an organ transplant. (medicinenet.com)
  • p>A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases. (nemours.org)
  • This randomized phase III trial studies how well standard-dose combination chemotherapy works compared to high-dose combination chemotherapy and stem cell transplant in treating patients with germ cell tumors that have returned after a period of improvement or did not respond to treatment. (cincinnatichildrens.org)
  • Giving chemotherapy before a stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. (cincinnatichildrens.org)
  • Chemotherapy is then given to prepare the bone marrow for the stem cell transplant. (cincinnatichildrens.org)
  • It is not yet known whether high-dose combination chemotherapy and stem cell transplant are more effective than standard-dose combination chemotherapy in treating patients with refractory or relapsed germ cell tumors. (cincinnatichildrens.org)
  • Bone marrow transplant may also be considered. (ecureme.com)
  • A bone marrow transplant with a good donor is curative 90 percent of the time, but a good donor match for Mustaf could not be found. (ucl.ac.uk)
  • Their recent research aims to help more patients find a cure through expanded bone marrow transplant treatment and gene therapy. (medlineplus.gov)
  • In a more traditional bone marrow transplant, a patient is first treated with chemotherapy. (medlineplus.gov)
  • Then, he or she receives a bone marrow transplant from a healthy donor. (medlineplus.gov)
  • METHODS: A cross-sectional study of sexual health and infertility was conducted in 479 patients with acute myeloid leukemia (AML) in first complete remission (CR) who were entered into the UK MRC AML 10 trial comparing allogeneic BMT (Allo-BMT), autologous BMT (A-BMT), and intensive consolidation chemotherapy (CCT). (ox.ac.uk)
  • As the disease progresses, Chlorambucil is prescribed every three weeks, or CVP combination chemotherapy (Cyclophophamide, Vincristine, and Prednisone). (ecureme.com)
  • Extensive-stage SCLC (ie, SCLC that has spread beyond the supraclavicular areas, or with distant metastases) remains incurable with current management options, and patients are treated with combination chemotherapy. (medscape.com)
  • Nonrandomized trials of combination chemotherapy have shown superior response rates and survival compared with single-agent chemotherapy. (medscape.com)
  • Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue. (nature.com)
  • If this occurs and the bone marrow looks healthy under the microscope, the cancer is said to be in remission. (medlineplus.gov)
  • Chemotherapy is the first treatment tried with the goal of achieving a remission. (medlineplus.gov)
  • Oral chemotherapy may be given after a remission to maintain it. (medlineplus.gov)
  • Patients are simultaneously given supportive care until their bone marrow achieves hematologic remission and is again producing normal hematopoietic cells. (medscape.com)
  • During the course of 3 months after his diagnosis, the patient underwent induction chemotherapy with remission and prolonged periods of count recovery. (cdc.gov)
  • She was treated with the DeAngelis chemotherapy protocol and achieved a complete remission. (karger.com)
  • If possible, people newly diagnosed with AML receive an intensive regimen of multiple chemotherapy drugs, with the goal of pushing the disease into a complete remission -that is, eliminating leukemia cells in the bone marrow . (cancer.gov)
  • For example, George Canellos, one of the original members of the NCI, had noticed that a long-term side effect of megadose chemotherapy regimens was myelodysplasia, a condition that tended to progress to leukemia. (wikipedia.org)
  • We have seen an increase in the number of bone marrow transplants performed, but there has been no major change in myeloablative regimens. (cdc.gov)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • Other chemotherapy regimens may be considered. (ecureme.com)
  • Several platinum-based and non-platinum-based chemotherapy regimens have been used in the treatment of small cell lung cancer (SCLC) with varying results. (medscape.com)
  • In a systematic review that compared the effectiveness of these regimens, Amarasena et al concluded that platinum-based chemotherapy regimens did not provide a statistically significant benefit over non-platinum-based agents in survival or overall tumor response. (medscape.com)
  • The investigators suggested that non-platinum-based chemotherapy regimens may have a better risk-benefit profile. (medscape.com)
  • Treatment for patients with acute myeloid leukemia involves intensive chemotherapy to destroy the leukemic cell population as rapidly as possible and to prevent the emergence of a resistant clone. (medscape.com)
  • Hospitalization is necessary in patients with acute myeloid leukemia for managing chemotherapy and for treating complications related to the disease and its treatment, usually infections or febrile neutropenic episodes. (medscape.com)
  • Leukemia is a cancer of the bone marrow, which creates blood cells. (healthline.com)
  • A new initial treatment option may be available to patients with acute myeloid leukemia driven by changes in the IDH1 gene who are unable to have standard chemotherapy. (cancer.gov)
  • Some people with an aggressive blood cancer called acute myeloid leukemia (AML) who are unable to receive intensive chemotherapy as initial treatment for this cancer may soon have a new option. (cancer.gov)
  • There are some gene mutations, some chromosome abnormalities [in] leukemia cells that we know don't yield to intensive chemotherapy, and they are more common in older adults," she said. (cancer.gov)
  • In the United States, before the combination of azacitidine and venetoclax was approved, people who were ineligible for induction chemotherapy-that is, they were too sick or past the age considered safe to receive it-often received azacitidine alone, with the goal of reducing the symptoms of leukemia and extending how long they lived. (cancer.gov)
  • The most common treatment for most types of leukemia is intensive chemotherapy. (aiche.org)
  • To our knowledge, this is the first reported case of primary pituitary lymphoma that relapsed exclusively in the bone marrow and presented with clinical findings of idiopathic anasarca. (karger.com)
  • This treatment can include more IV chemotherapy or radiation to the brain . (medlineplus.gov)
  • He's spent years getting chemotherapy, radiation and bone marrow transplants. (ktvu.com)
  • PLX-RAD will be used for treatment of bone marrow deficiency, genetic diseases, and treatment of acute radiation syndrome. (israel21c.org)
  • For the approximately 30% of patients with SCLC who have limited-stage disease at the time of diagnosis (ie, tumors confined to the hemithorax of origin, the mediastinum, or the supraclavicular lymph nodes), management typically involves combination platinum-based chemotherapy and thoracic radiation therapy given with curative intent. (medscape.com)
  • Randomized clinical trials reported treatment-mortality rates from 0% to 7% for women who received the HDC/BMT treatment, versus no such deaths within the control groups that received the typical chemotherapy regimen. (wikipedia.org)
  • Treatment for this condition remains difficult and largely ineffective, because the growth of cells in the wound is inhibited ( 2 ) and chemotherapy usually leads to myelosuppression, the latter of which further compromises the migration of multipotent cells from the bone marrow ( 3 ). (ijbs.com)
  • As one might expect, Cancer.org reports that typical treatment for AML is two different phases of chemotherapy. (newstarget.com)
  • Conclusion: Bone marrow sparing improves quality of life and adherence of patients to treatment with reduced adverse events. (oncologyradiotherapy.com)
  • Transfer to a pediatric cancer center is usually necessary for initial diagnostic studies and is mandatory for management of chemotherapy and treatment-related complications. (medscape.com)
  • Some patients also become refractory, which means they stop responding to treatment and still have myeloma cells in their bone marrow. (novartis.com)
  • This means that they may have worse side effects or take longer to recover after chemotherapy treatment ends. (cancer.net)
  • It is important to remember that chemotherapy can be a treatment option for patients of any age. (cancer.net)
  • Why can older adults have stronger side effects from chemotherapy treatment? (cancer.net)
  • They will review your medical history and talk to you about why they recommend this chemotherapy treatment. (cancer.net)
  • Treatment with immunosuppressive medicines like steroids and chemotherapy. (medicinenet.com)
  • While chemotherapy treatments have greatly improved over time, there are often still noticeable side effects of treatment. (healthline.com)
  • After her third chemotherapy treatment, Jamie Kratz-Gullickson found herself at a literal loss for words. (uwhealth.org)
  • Nivestym (filgrastim-aafi) is a recombinant human granulocyte colony-stimulating factor biosimilar to Neupogen indicated for the treatment of neutropenia associated with chemotherapy and related conditions. (drugs.com)
  • 25 Could help provide a No More Chemo party to celebrate the end of a patient's chemotherapy treatment. (brooksbrothers.com)
  • 500 Could help cover the cost of a share of bone marrow treatment for a St. Jude patient. (brooksbrothers.com)
  • Prior chemotherapy treatment for castration-sensitive or castration-resistant prostate cancer (docetaxel or cabazitaxel). (orlandohealth.com)
  • Chemotherapy for cancer treatment may also affect the production of new red blood cells, resulting in anemia. (medicalnewstoday.com)
  • Ultimately, Dr. Rodgers and Dr. Tisdale hope to work towards more affordable, accessible treatment options-such as bone marrow repair. (medlineplus.gov)
  • However, the Hematological Toxicity (Hem T) increases with the addition of chemotherapy and the risk may be severe [ 5 ]. (oncologyradiotherapy.com)
  • These results show the susceptibility of infants to the toxicity of intensive chemotherapy and do not support the use of short term high-dose chemotherapy alone in the management of infant leukaemia. (nih.gov)
  • It is your own cells, and often the difference between the toxicity of chemotherapy against the cancer and against normal cells is all too often not that great. (scienceblogs.com)
  • However, even those who have poor prognostic factors (eg, poor PS, medically significant concomitant conditions) may still be considered for chemotherapy if appropriate precautions are taken to avoid excessive toxicity and further decline in PS. (medscape.com)
  • When a buildup of myeloma cells occurs, it can overwhelm the production of healthy cells, causing damage to the bone as well as low blood counts. (novartis.com)
  • Myeloma cells destroy bone , which releases calcium, a condition called hypercalcemia. (webmd.com)
  • Myeloma cells produce excess abnormal proteins, called paraproteins, in the bone marrow that can cause your blood to become so thick that it flows sluggishly in your body, a condition called hyperviscosity. (webmd.com)
  • We determined the incidence and the prognostic significance of HZ and its correlation with VZV serology in 191 consecutive myeloma patients undergoing high-dose melphalan chemotherapy with ASCT. (nature.com)
  • Because of the patient's need for intense chemotherapy and supportive care, guaranteed venous access is critical. (medscape.com)
  • Chemotherapy drugs are a specific class of medications called cytotoxic agents. (healthline.com)
  • After chemotherapy is given, normal cells often would receive various degrees of damage from the cytotoxic agents. (vin.com)
  • Adults over age 65 with cancer can have a stronger reaction to chemotherapy treatments. (cancer.net)
  • Older adults have distinct needs before, during, and after chemotherapy treatments. (cancer.net)
  • This is a set of tools that help your doctors recommend the best type of cancer treatments for you, including chemotherapy. (cancer.net)
  • Some illnesses and treatments can prevent the bone marrow from making blood (for example, chemotherapy lowers production of new blood cells). (kidshealth.org)
  • If you are receiving Nivestym because you are also receiving chemotherapy, your dose of Nivestym should be injected at least 24 hours before or 24 hours after your dose of chemotherapy. (drugs.com)
  • In a large international study of people with this form of AML who can't have intensive chemotherapy , combining a drug called ivosidenib (Tibsovo) with the chemotherapy drug azacitidine was substantially more effective at producing remissions than azacitidine alone . (cancer.gov)
  • The drug was approved for use alone in people age 75 or older or for those with other health conditions that would prevent them from receiving intensive chemotherapy. (cancer.gov)
  • Combination Systemic Chemotherapy plus 3-Drug Combination Intrathecal Chemotherapy. (knowcancer.com)
  • Systemic Chemotherapy. (knowcancer.com)
  • Systemic Chemotherapy plus Single-Agent Intrathecal Chemotherapy. (knowcancer.com)
  • 4-Drug Combination Systemic Chemotherapy plus Single-Agent Intrathecal Chemotherapy. (knowcancer.com)
  • The patients were 2 men and 1 woman (ages 53, 56, and 63 years, respectively) who had received myeloablative chemotherapy. (cdc.gov)
  • All 3 patients had grades 1-2 mucositis, which in the presence of neutropenia, is a known risk factor for anaerobic bacteremia in patients undergoing chemotherapy for hematologic malignancies ( 3 , 7 , 8 ). (cdc.gov)
  • Neutropenia and thrombocytopenia are the early signs of bone marrow suppression. (vin.com)
  • For many years, most children in the United States were treated with chemotherapy protocols developed by the Children's Cancer Group and the Pediatric Oncology Group. (medscape.com)
  • Elderly patients with SCLC who have a good performance status (PS) (ie, Eastern Cooperative Oncology Group [ECOG] PS 0 or 1) and intact organ function should receive standard carboplatin-based chemotherapy. (medscape.com)
  • To belabour the point further Hortobagyi, using data from the University of Texas M. D. Anderson Cancer Center in Houston, reported in May 1995 that those eligible for high-dose chemotherapy survived 65% longer on conventional chemotherapy than those who would not have been eligible for the protocol. (wikipedia.org)
  • Results: There was statistically significant difference in favor of IMRT bone marrow sparing plans regarding a lower dose to organs at risk, total pelvic bone and bowel. (oncologyradiotherapy.com)
  • Patients receiving zoledronic acid for bone-targeted therapy must be on stable dose for 4 weeks prior to randomization. (orlandohealth.com)
  • A number of randomized trials have tried to answer questions concerning the superiority of combination over single-agent chemotherapy, the number of drugs to be used in combination, and dose intensity. (medscape.com)
  • p>Our combined expertise allows us to diagnose and treat common, rare and complex bone tumors in children. (nemours.org)
  • Nieder C, Mehta MP, Jalali R: Combined radio and chemotherapy of brain tumors in adult patients. (karger.com)
  • They then believed that STAMP produced more durable remissions than those by conventional chemotherapy, and so Peters left to set up a randomized clinical trial at Duke University. (wikipedia.org)
  • choice of chemotherapy, intensity and duration often depends on either the availability of a clinical trial, the treating physician's experience or the collective experience of the treating centre, with significant international protocol variability. (aiche.org)
  • National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
  • Twenty-nine consecutive cases with a t(8;21)(q22;q22) in the bone marrow (BM) karyotype were retrospectively studied concerning clinical, morphological and cytogenetic data. (lu.se)
  • A second apheresis or a bone marrow collection was considered, but neither was performed because the clinical condition of the donor worsened. (cdc.gov)
  • However, the most commonly reported infection is bacteremia in the setting of chemotherapy for hematologic malignancies ( 1 , 2 ). (cdc.gov)
  • Orthopedists (bone specialists) and orthopedic surgeons at Nemours Center for Cancer and Blood Disorders make our pediatric orthopedics programs among the largest and most respected in the world. (nemours.org)
  • For instance, heart problems , lung problems, diabetes , and arthritis can all impact how chemotherapy affects you. (cancer.net)
  • Paclitaxel, carboplatin, and gemcitabine (PCG) versus gemcitabine and vinorelbine (GV) in chemotherapy naïve patients (pts) with advanced non-small cell lung cancer (NSCLC): A phase III trial of the Minnie Pearl Cancer Research Network (MPCRN). (asbestos.com)
  • infection with axillary temperature, bone pain, and headache. (cdc.gov)
  • These protocols, which used different multiagent chemotherapies, were associated with improved results as therapy was intensified. (medscape.com)
  • The combination of gene therapy with mild chemotherapy is likely to be a useful approach for many other immunological and haematological diseases such as thallasaemia. (ucl.ac.uk)
  • To address these limitations, Dr. Rodgers, Dr. Tisdale, and their research teams are studying how to repair bone marrow through gene therapy. (medlineplus.gov)
  • Chemotherapy is given into the veins (by IV) and sometimes into the fluid around the brain (the spinal fluid). (medlineplus.gov)
  • Not all people who receive a diagnosis of breast cancer will need chemotherapy. (healthline.com)