• novel
  • To address this problem, a novel triblock copolymer has been developed to encapsulate several different hydrophobic drugs into stable polymer micelles. (hindawi.com)
  • Weisenthal LM, Marsden J: A novel dye exclusion assay for predicting response to cancer chemotherapy. (springer.com)
  • However, new small molecules are needed to function as probes to further dissect the known pathways, to discover novel pathways and interactions, to validate potential drug targets, and to function as drugs to treat unmet medical needs, including more targeted therapies. (aacrjournals.org)
  • inhibitors
  • In the intensifying efforts to discover new, hopefully more therapeutically efficacious HDAC inhibitors, molecular modeling-based rational drug design has played an important role in identifying potential inhibitors that vary in molecular structures and properties. (mdpi.com)
  • Negative correlations between 7-ethoxycoumarin O -deethylation and cell line chemosensitivity to a group of topoisomerase inhibitors were also seen, again suggesting P450-dependent drug inactivation. (aspetjournals.org)
  • chemotherapy drugs
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (wikipedia.org)
  • toxicity
  • however, use of these drugs is often associated with patient toxicity and poor tumor delivery. (hindawi.com)
  • Once a small molecule is discovered that selectively and potently alters a target with potential therapeutic importance, it can be modified by medicinal chemists to overcome the pharmacodynamic, pharmacokinetic, toxicity, and efficacy hurdles necessary for bringing a drug to market. (aacrjournals.org)
  • Also, the drugs can often be used at lower doses, reducing toxicity. (wikipedia.org)
  • molecule
  • Nitazoxanide, an FDA-approved antiprotozoal drug with excellent pharmacokinetic and safety profile, is the only molecule among the screening hits that reaches high plasma concentrations persisting for up to a few hours after single oral dose. (aacrjournals.org)
  • synthesis
  • Due to the improvement on methods for isolation, identification, and synthesis during the last century, many drugs have arisen from natural sources. (hindawi.com)
  • cell
  • An ideal delivery system should be composed of biocompatible and biodegradable materials, reproducibly assemble into the desired size range, encapsulate a wide range of drugs and drug classes, maintain particle size in biological media, have the ability to attach cell-specific targeting groups, and release the therapeutic at the site of disease. (hindawi.com)
  • From a mechanistic perspective, the FR functions to concentrate exogenous ligands (e.g. folates and folate-drug conjugates) into the cell cytosol by endocytosis. (wikipedia.org)
  • unmet
  • We ultimately assess the value for antioxidants as neuroprotective drugs and provide our comments on the unmet needs. (mdpi.com)
  • tightly
  • The ICG is a public-access research facility consisting of a tightly integrated team of synthetic and analytical chemists, assay developers, high-throughput screening and automation engineers, computational scientists, and software developers. (aacrjournals.org)
  • Based on the natural high affinity of folate for the folate receptor protein (FR), which is commonly expressed on the surface of many human cancers, folate-drug conjugates also bind tightly to the FR and trigger cellular uptake via endocytosis. (wikipedia.org)
  • targets
  • The pharmaceutical industry has successfully exploited the ability of small molecules to serve as drugs by focusing on a relatively small number of biological targets, a subset of the so-called "druggable genome" ( 6 ). (aacrjournals.org)
  • development
  • The cancer drug development process has become increasingly costly and inefficient resulting in few new highly effective drugs reaching the market yearly ( 1 ). (aacrjournals.org)
  • The special properties of the small molecules described above are important in drug development. (aacrjournals.org)
  • For the past two decades, marine pharmaceutics has been a developing field in the antitumor drug development arena. (mdpi.com)
  • chemically
  • Some have utilized the approach of chemically conjugating the active drug to a polymer to potentially improve stability. (hindawi.com)
  • array
  • Additionally, we demonstrate the effectiveness of this method through antibody-based array analysis and migration/invasion assays. (jove.com)
  • human
  • Smith IE, Courtenay VD, Gordon MY: A colony forming assay for human tumor xenografts using agar in diffusion chambers. (springer.com)
  • P450 enzymes are highly expressed in human liver and in certain extrahepatic tissues and have been studied extensively with respect to their roles in drug metabolism ( Rendic and Di Carlo, 1997 ). (aspetjournals.org)
  • metabolism
  • The cytochrome P450s are a superfamily of hemeprotein monooxygenases that catalyze the oxidative metabolism of a large number of drugs, environmental carcinogens, as well as steroids and other endobiotics. (aspetjournals.org)
  • therefore
  • Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (wikipedia.org)
  • cells
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (wikipedia.org)
  • delivery
  • To receive news and publication updates for Journal of Drug Delivery, enter your email address in the box below. (hindawi.com)
  • Polymer micelles have received much attention over the past thirty years as drug delivery vehicle [ 5 - 11 ]. (hindawi.com)
  • Folate targeting is a method utilized in biotechnology for drug delivery purposes. (wikipedia.org)
  • biological
  • High-throughput screening (HTS), a mainstay of the drug industry, is well suited for this process because it is designed to handle hundreds of thousands of biological measurements per day. (aacrjournals.org)
  • specific
  • Targeted drug therapy is advantageous because it deposits the drug at the specific location where it can be most useful in treating the disease. (wikipedia.org)
  • report
  • This report outlines how the ICG functions, how researchers can take advantage of its screening, chemistry and informatic capabilities, and provides a brief summary of some of the many important research findings. (aacrjournals.org)
  • effect
  • The EPR effect is a consequence of the disorganized nature of the tumor vasculature, which results in increased permeability of polymer therapeutics and drug retention at the tumor site. (hindawi.com)