• In this study, we demonstrated that NSCLC-derived CAFs were innately resistant to cisplatin treatment and CAFs-conditioned medium significantly promoted the survival rate of NSCLC cells after cisplatin treatment. (dovepress.com)
  • 9 , 10 As such, it is urgent to improve the efficacy of chemotherapy to NSCLC and explore the molecular mechanism underlying cisplatin resistance of NSCLC. (dovepress.com)
  • For example, a study using human Burkitt lymphoma cells found that oxidative stress actually interferes with the ability of the chemotherapy drugs doxorubicin, cisplatin, etoposide, and cytarabine to cause cancer cell death. (pinestreetfoundation.org)
  • In gastric cancer, the efficacy of docetaxel combined with cisplatin/fluorouracil remains unsatisfactory, with a clinical response rate of 37%, and some patients suffer form adverse effects without any benefit ( 3 ). (iiarjournals.org)
  • Carboplatin is an alternative for cisplatin in the treatment of urothelial cancers. (shengsci.com)
  • Phase II trial of induction chemotherapy of pemetrexed plus split-dose cisplatin followed by pemetrexed maintenance for untreated non-squamous non-small-cell lung cancer. (shengsci.com)
  • abstract: PURPOSE:We conducted a phase II trial to evaluate the efficacy and safety of induction chemotherapy of pemetrexed plus split-dose cisplatin followed by pemetrexed maintenance for advanced non-squamous non-small-cell lung cancer (NSCLC). (shengsci.com)
  • Metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. (drugs.com)
  • Adjuvant chemotherapy for breast cancer after surgery has effectively lowered metastatic recurrence rates. (bioseek.eu)
  • However, a considerable proportion of women suffer recurrent cancer at distant metastatic sites despite adjuvant treatment. (bioseek.eu)
  • 11 ] demonstrated a substantial overall survival (OS) benefit in patients with PD-L1-positive (PD-L1 + ) metastatic or inoperable locally advanced TNBC through the addition of the anti-PD-L1 agent atezolizumab to first-line chemotherapy with nab-paclitaxel. (biomedcentral.com)
  • In this review article, we describe how TAMs regulate tumor angiogenesis, invasion, metastasis, and then discuss the potential of applying TAMs-targeting treatment as a promising therapeutic strategy for metastatic cancer. (ommegaonline.org)
  • On the basis of evidence from a growing body of research indicating tumor associated macrophages are crucial to cancer metastasis, we summarized the information that is currently at hand and discus the potential therapeutic strategies used to suppress metastatic process, our review highlights the combination therapeutic options to treat cancer metastasis. (ommegaonline.org)
  • It has become clear that hypoxia shapes and induces specific macrophage phenotypes that serve tumor malignancy, as hypoxia promotes immune evasion, angiogenesis, tumor cell survival, and metastatic dissemination. (nutriforce.cn)
  • We review clinical data on the benefit of RASi in primary and metastatic tumors and propose that, by activating immunostimulatory pathways, these inhibitors can enhance immunotherapy of cancer. (nutriforce.cn)
  • BACKGROUND:The correlation of the oncological outcomes of docetaxel and cabazitaxel in Japanese metastatic castration-resistant prostate cancer (mCRPC) patients has not been unclear. (shengsci.com)
  • In this study, we confirmed the importance of mesothelin and examined the relationship between mesothelin and the immune landscape of the tumor microenvironment (TME) in two MPM cohorts. (bvsalud.org)
  • Therefore, novel strategies must be developed to enhance T cell persistence and trafficking within the OC tumor microenvironment. (bvsalud.org)
  • Cancer-associated fibroblasts (CAFs) have been demonstrated to be essential stromal components in the tumor microenvironment, regulating cancer cell growth, migration, invasion, and chemo-response through various mechanisms. (dovepress.com)
  • 11 Chemoresistance, either acquired or intrinsic, is associated with a complicated and multifactorial process, including decreases of intracellular drugs, changes of drug targets, aberrant regulation of cell survival or death, and crosstalks between tumor microenvironment and cancer cells. (dovepress.com)
  • Zhao, Y. Chemotherapy and tumor microenvironment of pancreatic cancer. (eurekaselect.com)
  • Tumor-Associated Macrophages (TAMs) are critical components of the microenvironment of the majority of malignant tumors, associated with poor prognostic notably through various factors secreting. (ommegaonline.org)
  • In the current study, we first analyzed metabolism-associated prognostic DEG genes in bladder cancer, then constructed and validated a new signature across multiple datasets, and finally explored the prognostic value of the model and its relationship with the clinicopathological features, immune microenvironment, and the therapeutic effect of chemotherapy agent and immunotherapy of patients with BCa. (biomedcentral.com)
  • The microenvironment of a developing tumor is composed of proliferating cancer cells, blood vessels, stromal cells, infiltrating inflammatory cells, and a variety of associated tissue cells. (nutriforce.cn)
  • Accumulating data also suggest that hypoxic stress in the tumor microenvironment promotes tumor escape mechanisms through the emergence of immune-resistant tumor variants and immune suppression. (nutriforce.cn)
  • Thus, solid tumors seem to build up a hostile hypoxic microenvironment that hampers cell-mediated immunity and dampen the efficacy of the immune response. (nutriforce.cn)
  • The RAS plays a crucial role in cancer biology and affects tumor growth and dissemination directly and indirectly by remodeling the tumor microenvironment. (nutriforce.cn)
  • A gelatin-methacrylate/fibrin-based matrix containing multiple cell types mimics the tumor-microenvironment that promotes spontaneous micro-vessel formation by embedded endothelial cells. (regenhu.com)
  • 55-59 : 17-18 Neoadjuvant chemotherapy is given prior to a local treatment such as surgery, and is designed to shrink the primary tumor. (wikipedia.org)
  • Overexpression of these two genes was associated with poor tumor response to anthracycline treatment in a neoadjuvant chemotherapy trial in women with primary breast cancer. (bioseek.eu)
  • In addition, a deeper characterization of immune infiltrates, including the presence of a high number of cytotoxic (CD8 + ) TILs or a high CD8 + /FOXP3 + ratio, is able to define TNBC patients with a better prognosis following neoadjuvant chemotherapy [ 6 ]. (biomedcentral.com)
  • In addition to conventional radiotherapy, chemotherapy, and surgery, there are currently more and more popular neoadjuvant chemotherapy and molecular targeted therapies. (biomedcentral.com)
  • Neoadjuvant chemotherapy (NAC) is one of the standard care regimens for patients with resectable early-stage breast cancer. (biomedcentral.com)
  • All chemotherapy regimens require that the recipient be capable of undergoing the treatment. (worldsbest.rehab)
  • Current chemotherapy regimens apply drug treatment in cycles, with the frequency and duration of treatments limited by toxicity. (worldsbest.rehab)
  • Chemotherapy is an indispensable element of treatment for gastric cancer patients, and fluoropyrimidines, platinum-containing agents, taxanes, alone or in combinations, are the most effective and commonly used chemotherapy regimens ( 1 ). (iiarjournals.org)
  • Systemic therapy is often used in conjunction with other modalities that constitute local therapy (i.e., treatments whose efficacy is confined to the anatomic area where they are applied) for cancer such as radiation therapy, surgery or hyperthermia therapy. (wikipedia.org)
  • [ 6 ] Chemotherapy combinations, such as gemcitabine plus docetaxel and epirubicin plus interferon, have demonstrated possible efficacy. (medscape.com)
  • Furthermore, immune checkpoint inhibitor therapy has shown limited efficacy in the treatment of patients with OC, and CAR-T therapy has also demonstrated modest results owing to inadequate T cell infiltration. (bvsalud.org)
  • Enhanced drug delivery efficiency and improved treatment efficacy have been observed through CNT-based drug delivery systems. (eurekaselect.com)
  • However, some reports have shown that the simple administration of CNTs can reverse MDR in cancer and enhance chemotherapy efficacy without anticancer agents attached to the surface of the CNTs. (eurekaselect.com)
  • Although docetaxel is arguably among the most effective chemotherapeutic agents available today, intrinsic and acquired drug resistance remain the main obstacles for its anticancer efficacy and clinical application. (iiarjournals.org)
  • continued to use CP either alone or in combination with other agents in cancer chemotherapy due to its efficacy. (researchwap.com)
  • MATERIALS AND METHODS:This study included a total of 47 consecutive Japanese mCRPC patients treated with cabazitaxel and assessed the prognostic significance of cabazitaxel, focusing on patient age and the correlation of efficacy between docetaxel and cabazitaxel. (shengsci.com)
  • 42 Adjuvant chemotherapy is given after a local treatment (radiotherapy or surgery). (wikipedia.org)
  • Background: Chemotherapy is the most important treatment method against cancer, in addition to surgery and radiotherapy. (eurekaselect.com)
  • Despite the advent of effective cancer therapies by developing early diagnosis or applying cancer growth inhibition strategy in the past decades, conventional strategies of cancer therapy include surgical resection, chemotherapy, radiotherapy and immunotherapy, which have made significant contributions to cancer treatment. (ommegaonline.org)
  • Radiotherapy and chemotherapy, as the routine treatment, face substantial challenges of resistance. (biomedcentral.com)
  • Combining some of these neoadjuvant approaches with standard-of-care chemotherapy or radiotherapy appears to "sensitize" tumor cells to treatment. (cancerbiomed.org)
  • Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms. (jcancer.org)
  • The broad spectrum anti-tumor effects of calcitriol and analogs are mostly based on inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis. (jcancer.org)
  • They have complementary mechanisms to hinder the carcinogenic process by searching free radicals, inhibiting survival and multiplication of malignant cells, as well as reducing invasiveness and angiogenesis of tumors. (researchsquare.com)
  • Although, non-psychoactive cannabidiol (CBD) and cannabigerol (CBG) display antineoplastic effects by repressing tumor growth and angiogenesis both in cell line and animal models, their use as chemotherapeutic agents is awaiting further investigation. (frontiersin.org)
  • Weinberg characterized "aberrant metabolic phenotype" with "autologous proliferation signaling, apoptosis resistance, evasion of proliferation inhibition, continuous angiogenesis, infiltration and migration, unlimited replication capacity, immune escape" in tumor cells. (biomedcentral.com)
  • Therefore, inhibition of angiogenesis is an attractive strategy for treatment of cancer. (biomedcentral.com)
  • Thus, angiogenesis is a necessary and required step for transition from a small harmless cluster of cells to a large tumour and is also required for the spread of a tumour, invasion and/or metastasis. (biomedcentral.com)
  • The inhibition of angiogenesis is emerging as a new, attractive therapeutic approach to control tumour progression [ 1 ]. (biomedcentral.com)
  • In summary, we describe the first bioprinted, micro-vascularized neuroblastoma - tumor-environment model directly printed into fluidic chips and a novel medium-throughput biofabrication platform suitable for studying tumor angiogenesis and metastasis in precision medicine approaches in future. (regenhu.com)
  • At present, a European lab offers a blood test which filters and isolates circulating tumor cells (a.k.a. micrometastatic cells) from a patient's blood, genetically fingerprints them, then pharmacogenetically tests the cells for the effectiveness of various medical therapies. (dunphynunley.com)
  • This test filters circulating tumor cells from a patient's blood sample and gives a numerical probability of metastasis for colon, breast, prostate and ovarian adenocarcinomas. (dunphynunley.com)
  • In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)
  • One example is a human study in which researchers discovered that higher levels of the antioxidant selenium in the blood of patients with aggressive B-cell non-Hodgkin's lymphoma correlated with increased achievable doses of anthracycline based chemotherapy, better treatment response, achievement of long term remission, and longer overall survival. (pinestreetfoundation.org)
  • By using integrated genomics, we identified a small number of overexpressed and amplified genes from chromosome 8q22 that were associated with early disease recurrence despite anthracycline-based adjuvant chemotherapy. (bioseek.eu)
  • Using integrated genomics, we identified a small number of over-expressed and amplified genes from chromosome 8q22 significantly associated with early disease recurrence despite anthracycline-based adjuvant chemotherapy. (bioseek.eu)
  • These micrometastases can be treated with adjuvant chemotherapy and can reduce relapse rates caused by these disseminated cells. (wikipedia.org)
  • To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (wikipedia.org)
  • Also, PKB is overexpressed in 15% of ovarian cancers, 12% of pancreatic cancers and 3% of breast cancers, and was shown to produce a survival signal that protects cells from apoptosis thus contributing to resistance to chemotherapy. (justia.com)
  • The authors of the above-mentioned study on Burkitt lymphoma cells and chemotherapy suggest that including antioxidants in the treatment protocol may enhance chemotherapy-induced apoptosis and phagocytosis. (pinestreetfoundation.org)
  • 2000) A second study, involving the chemotherapy drugs etoposide and calcimycin, confirms this finding: Human Burkitt's lymphoma cells were unable to die quickly by apoptosis in the presence of oxidative stress and instead died using the slower and messier method of necrosis. (pinestreetfoundation.org)
  • CNTs can not only increase drug delivery accuracy and efficiency but also promote drug uptake, decrease drug efflux, improve tumor hypoxia conditions, and induce autophagy and apoptosis in tumor cells, which make the tumor more sensitive to antitumor agents. (eurekaselect.com)
  • Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
  • This type of chemotherapy is used for curative intent. (wikipedia.org)
  • Deletions in the gene coding for the tumor suppressor PTEN also induce the persistent activation of PKB/cAkt since it is the negative regulator of this enzyme. (justia.com)
  • Actually, the entire metabolic network reprograms under the control of oncogenes and tumor suppressor genes, and the flow of nutrient in metabolic networks is also redefined in the process of tumorigenesis. (biomedcentral.com)
  • Although PP2A has historically been identified as a tumor suppressor, inhibition of PP2A has paradoxically demonstrated potential as a therapeutic target for various cancers. (cancerbiomed.org)
  • Mor, G. Targeted cancer therapy--are the days of systemic chemotherapy numbered? (eurekaselect.com)
  • Alternatively, a bladder-sparing approach of TURBT followed by concurrent radiation therapy and systemic chemotherapy (trimodality therapy) may be used. (medscape.com)
  • Rates of tumor progression vary according to the particular study, but more than 75% of patients who initially have a complete response remain disease free for more than 5 years. (medscape.com)
  • Currently, use of cannabinoids is limited to improve adverse effects of chemotherapy and their palliative administration during treatment is curiously concomitant with improved prognosis and regressed progression in patients with different tumor types. (frontiersin.org)
  • Recent studies demonstrated that piperine potentiates curcumin's inhibitory effect on tumor progression via enhancing its delivery and therapeutic activity. (frontiersin.org)
  • The aberrant glucose metabolism is associated with dramatically increased bioenergetics, biosynthetic, and redox demands, which is vital to maintain rapid cell proliferation, tumor progression, and resistance to chemotherapy and radiation. (biomedcentral.com)
  • The crosstalk between stromal cells and malignant cells within this environment crucially determines the fate of tumor progression, its hostility, and heterogeneity. (nutriforce.cn)
  • It is widely accepted that hypoxic stresses occur in most solid tumors. (nutriforce.cn)
  • Preclinical success has led to a profusion of clinical trials on LB100 adjuvant therapies, including a phase I trial in extensive-stage small-cell lung cancer, a phase I/II trial in myelodysplastic syndrome, a phase II trial in recurrent glioblastoma, and a completed phase I trial assessing the safety of LB100 and docetaxel in various relapsed solid tumors. (cancerbiomed.org)
  • and microtubule-disturbing agents paclitaxel and docetaxel. (jcancer.org)
  • The use of the newer agents in the taxane class (paclitaxel and docetaxel) is being explored in veterinary medicine as these agents are highly effective in human medicine. (vin.com)
  • Such activity would result in increased cell death of tumor tissue where PKB is elevated, and in decreased resistance to chemotherapy agents. (justia.com)
  • Direct correlation between resistance to chemotherapy and activation of PKB was shown in several prostate cancer cell lines and in human tumorogenic tissues, and elevation of PKB levels in prostate tumor tissues, is clinically associated with HRPC (Yongde et al. (justia.com)
  • The overwhelming majority of studies find a favorable interaction between antioxidants and chemotherapy, providing evidence that antioxidants can decrease chemotherapy side effects, increase treatment effectiveness, and decrease resistance to chemotherapy. (pinestreetfoundation.org)
  • 1. Resistance of tumors to multiple chemotherapeutic agents is often due to the MDR (Multiple Drug Resistance) gene. (examyear.com)
  • Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer. (bioseek.eu)
  • SiRNA-mediated knockdown of either of two of these genes, the antiapoptotic gene YWHAZ and a lysosomal gene LAPTM4B, sensitized tumor cells to anthracyclines, and overexpression of either of the genes induced anthracycline resistance. (bioseek.eu)
  • Overexpression of these two genes may predict anthracycline resistance and influence selection of chemotherapy. (bioseek.eu)
  • Two of these genes, the anti-apoptotic gene YWHAZ , and LAPTM4B , a novel lysosomal gene, sensitized tumor cells to anthracyclines when either was depleted by siRNA knockdown and induced drug resistance when either was over-expressed. (bioseek.eu)
  • However, Multidrug Resistance (MDR) in cancer always results in the failure of chemotherapy. (eurekaselect.com)
  • Limited success has been made in the treatment of metastasis owing to its systemic nature and the resistance of disseminated tumor cells to existing therapeutic agents. (ommegaonline.org)
  • This review summarizes recent progress in our understanding of glucose metabolism in chemo- and radio-resistance malignancy, and highlights potential molecular targets and their inhibitors for cancer treatment. (biomedcentral.com)
  • Among many reasons, the treatment resistance is the one of major drawbacks. (biomedcentral.com)
  • Herein, this review updates the mechanisms of metabolic reprogramming involved in tumor chemo- and radio-resistance. (biomedcentral.com)
  • Additionally, TAMs in the hypoxic niches within the tumor are known to mediate resistance to several anticancer treatments and to promote cancer relapse. (nutriforce.cn)
  • The induced differential stress resistance results in improved resistance to cytotoxicity in normal cells, which, in turn, reduces cytotoxic side-effects due to chemotherapy, as well as improved effectiveness of chemotherapeutic agents. (justia.com)
  • In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)
  • The present invention provides a novel approach to cancer therapy by providing a method to differentially enhance the resistance of normal cells to chemotherapeutic agents, thereby, improving the effectiveness of chemotherapeutic agents in killing cancerous cells. (justia.com)
  • In another aspect, the invention features methods of contacting a cancer cell with a chemotherapy agent and methods of increasing resistance of a non-cancer cell to a chemotherapy agent. (justia.com)
  • Additionally, these treatment options often involve invasive procedures, drug resistance, and systemic toxicity [ 1 ]. (ntno.org)
  • abstract: PURPOSE:M30 and M65 ELISAs are proposed as surrogate biomarkers of tumour cell death in patients and are being applied increasingly in the pharmacodynamic (PD) evaluation of anticancer drugs during clinical trials. (shengsci.com)
  • Traditional chemotherapeutic agents are cytotoxic by means of interfering with cell division (mitosis) but cancer cells vary widely in their susceptibility to these agents. (wikipedia.org)
  • Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy protocols. (oncotarget.com)
  • Because chemotherapy affects cell division, both normal and cancerous cells are susceptible to the cytotoxic effects of chemotherapeutic agents. (justia.com)
  • Plants are natural reservoirs of novel compounds and provide a promising therapeutic approach for treatment of cancer. (researchsquare.com)
  • The administration of anticancer drugs is one crucial approach that is employed for the treatment of cancer, although its therapeutic status is not presently satisfactory. (mdpi.com)
  • Given the lack of effective treatments in this subtype of breast cancer, several efforts have been conducted in recent years to increase the therapeutic opportunities for TNBC patients. (biomedcentral.com)
  • however, it remains a great challenge to localize on-demand release of anticancer drugs in tumor tissues to improve therapeutic effects and minimize the side effects. (biomedcentral.com)
  • They can achieve on-demand release of drugs into tumors of living animals through photothermal, photodynamic, and photoconversion mechanisms, affording obviously amplified therapeutic effects in synergy with phototherapy. (biomedcentral.com)
  • Until recently, the treatment of cancer has been largely focused on the development of therapeutic agents or techniques that kill cancer cells. (justia.com)
  • In addition, we also discuss the existing methods of artificial mitochondrial transfer/transplantation (AMT/T) and their therapeutic effects on diseases to explore the potential applications of mitochondrial transfer and transplantation in the treatment of mitochondrial-related diseases, mitochondrial diseases, and cancer. (biomedcentral.com)
  • If a doctor treats a systemic infection without first doing a culture and sensitivity test to determine which bacteria is involved and which antibiotics the bacteria is sensitive to, then he might prescribe the wrong treatment and thereby strengthen the infection. (dunphynunley.com)
  • Objective: Through an extensive review of previous reports in regard to CNTs and chemotherapy, this paper aims to identify the various mechanisms of CNTs that inhibit MDR in cancer and enhance chemotherapy sensitivity. (eurekaselect.com)
  • The aim of this study was to explore predictive genes involved in docetaxel sensitivity of gastric cancer. (iiarjournals.org)
  • Histoculture drug response assay (HDRA) was used to examine docetaxel sensitivity, while qRT-PCR was used to measure the mRNA levels of the genes in 25 surgically dissected gastric cancer specimens. (iiarjournals.org)
  • Results: Only CXCR4 mRNA levels in gastric cancer tissues were correlated with docetaxel sensitivity (R 2 =0.23, p=0.019) and significantly higher in resistant specimens (p=0.038). (iiarjournals.org)
  • SCLC is a neuroendocrine carcinoma that exhibits aggressive behavior, rapid growth, early spread to distant sites, exquisite sensitivity to chemotherapy and radiation, and frequent association with distinct paraneoplastic syndromes, including hypercalcemia, Eaton-lambert syndrome, syndrome of inappropriate diuretic hormone, and many others. (medscape.com)
  • Altogether, the signature established and validated by us has high predictive power for the prognosis, immunotherapy responsiveness, and chemotherapy sensitivity of BCa. (biomedcentral.com)
  • While there have been improvements to these statistics as a result of targeted treatments, early detection, and behavioral changes, many treatment options continue to be ineffective at preventing recurrence. (ntno.org)
  • Giant cell tumor (GCT) of bone is a benign but locally aggressive tumor with tendency for local recurrence [2]. (jbstjournal.com)
  • Goals of treatment are to achieve satisfactory removal of the tumor, lessen the chance of local recurrence and to preserve as much wrist function as possible. (jbstjournal.com)
  • Conclusion: Tumor mesothelin expression associated with the TME immune landscape predicts the risk of death for patients with MPM and could be a new target for immunotherapy in MPM. (bvsalud.org)
  • The phase III IMpassion130 trial comparing chemotherapy plus atezolizumab versus chemotherapy plus placebo brought breast cancer into the immunotherapy era. (biomedcentral.com)
  • The aim of our review is to present recent advances in TNBC treatment and to discuss open issues in order to better define potential future directions for immunotherapy in TNBC. (biomedcentral.com)
  • New and relevant evidence on the implementation of immune checkpoint-based treatments in TNBC has emerged over the last year, with the results of the IMpassion130 trial bringing breast cancer into the immunotherapy era. (biomedcentral.com)
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (wikipedia.org)
  • This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (wikipedia.org)
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (wikipedia.org)
  • Low tumor mesothelin expression was associated with tumor necrosis and nuclear grade 1, whereas high mesothelin expression was significantly associated with the epithelioid histotype and high density of T cells CD8+, macrophages CD68+, and collagen type I fibers. (bvsalud.org)
  • Furthermore, upon interaction with ovarian tumors, the ability of CR and CAR T cells to release activation markers and functional cytokines increased significantly. (bvsalud.org)
  • Similarly, CR and CAR co-expressing T cells persistently controlled the growth of transplanted ovarian cancer tumors in NSG mice and significantly prolonged the overall survival of tumor-challenged mice. (bvsalud.org)
  • It is suggested that curcumin can selectively kill tumor cells through its multifaceted metabolic effects, that culminate in its anti-oxidant and anti-inflammatory activities ( Hewlings and Kalman, 2017 ). (frontiersin.org)
  • Because only a fraction of the cells in a tumor die with each treatment (fractional kill), repeated doses must be administered to continue to reduce the size of the tumor. (worldsbest.rehab)
  • Effective chemotherapy agents need to be delivered efficiently, distributed mostly in the tumor tissue, and highly internalized by tumor cells to eventually inhibit proliferation or promote death of the tumor cells. (eurekaselect.com)
  • Given that protein aggregates in liver cells are closely linked to alcoholic liver disease, these findings suggest that quercetin could be a useful treatment for patients with this condition. (qualitycounts.com)
  • Materials and Methods: Microarray analysis was performed to explore various gene expression levels between parental and docetaxel-resistant cells. (iiarjournals.org)
  • It results in the arrested growth of tumour cells at G 2 -M phase in a variety of tumours, including non-small cell lung cancer (NSCLC), hormone-refractory prostate cancer, advanced gastric cancer and breast cancer ( 2 ). (iiarjournals.org)
  • In general, TME mainly consists of genetically heterogeneous cancer cells, endothelial cells, cancer-associated fibroblasts(CAFs), and different populations of immune cells [2] , establishing a complex cross-talk with tumor via producing growth factors, chemokines and matrix-degrading enzymes. (ommegaonline.org)
  • Tumor cells reprogram the metabolic pathway to meet the bioenergetic, biosynthetic, and redox demands of malignant cells [ 2 ]. (biomedcentral.com)
  • In the early 1920s, German biochemist and physiologist Otto Warburg conducted groundbreaking research and proposed the famous "Warburg effect": Tumor cells prefer to use glycolysis for glucose metabolism even in oxygen-rich conditions, rather than more efficient mitochondrial oxidative phosphorylation for ATP production [ 3 ]. (biomedcentral.com)
  • Metabolic reprogramming refers to the redefinition of the flow and flux of nutrient in tumor cells in the metabolic network to meet the needs of tumor cells for energy and anabolism [ 8 ]. (biomedcentral.com)
  • Moreover, cancer cells found within hypoxic regions are presumed to represent the most aggressive and therapy-resistant fractions of the tumor. (nutriforce.cn)
  • ii) TAMs release survival factors for cancer cells, which protect them from chemotherapeutics. (nutriforce.cn)
  • For example, most chemotherapeutic drugs work by impairing mitosis (cell division), effectively targeting fast-dividing cells. (justia.com)
  • Success of conventional chemotherapeutic regiment is based on the principle that tumors with high growth fractions (such as acute myelogenous leukemia and the lymphomas, including Hodgkin's disease) are more sensitive to chemotherapy because a larger proportion of the targeted cells are undergoing cell division at any given time. (justia.com)
  • By making normal cells more resistant to chemotherapeutic agents, a patient's tolerance for cytotoxicity is improved, which, in turn, also improves the effectiveness of chemotherapy. (justia.com)
  • Successful, non-invasive delivery of biodegradable and non-toxic combination therapies that can target existing cancerous cells and prevent the development of new tumors all in one dose is ideal for clinical treatment. (ntno.org)
  • Docetaxel works by damaging the structure or the "skeleton" that supports cancer cells. (lbbc.org)
  • One strategy to increase cure rates is the identification of patient-specific drug responses in tissue models that mimic the interaction between patient cancer cells and tumor environment. (regenhu.com)
  • We demonstrate that micro-vessels are attracted by and grow into tumor spheroids and that neuroblastoma cells invade the tumor-environment as soon as the spheroids disrupt. (regenhu.com)
  • In addition, mtDNA stress in TFAM-deficient mouse melanoma cells produces tumours that are more resistant to doxorubicin in vivo. (regenerativemedicine.net)
  • The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. (wikipedia.org)
  • Growth factors, such as basic fibroblast growth factor and VEGF, can induce capillary growth into the tumour, which allows tumour expansion. (biomedcentral.com)
  • BRD4 inhibitor reduced the size of the unirradiated tumor indicating that it may induce systemic immune responses. (preprints.org)
  • Numerous phytochemicals and their determined analogs have been recognized as possible contender for anticancer treatment and the present review article sheds light on few of these phytocompounds. (researchsquare.com)
  • Docetaxel is among the second generation of taxanes, demonstrating a stronger anticancer effect than paclitaxel with regard to the promotion of tubulin polymerisation and inhibition of depolymerisation ( 2 ). (iiarjournals.org)
  • Class III β-tubulin (TUBB3), microtubule-associated protein tau (MAPT) and breast cancer 1 early onset (BRCA1) are the most widely studied predictive biomarkers for taxane treatment ( 8 - 10 ). (iiarjournals.org)
  • Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. (wikipedia.org)
  • The connotation of the word chemotherapy excludes more selective agents that block extracellular signals (signal transduction). (wikipedia.org)
  • the agents most commonly used for this purpose are gemcitabine and mitomycin-C (see Chemotherapeutic Agents, below). (medscape.com)
  • Background: The combination of immunobiological agents with immune checkpoint proteins is a promising treatment for malignant pleural mesothelioma (MPM). (bvsalud.org)
  • Understanding the mechanism underlying the role of tumor stroma, especially cancer-associated fibroblasts (CAFs), during chemoresistance would significantly contribute to the clinical application of chemotherapy agents. (dovepress.com)
  • Therapies tested include traditional medical chemotherapeutic agents and new generation targeted therapies, such as monoclonal antibodies and tyrosine kinase inhibitors, hormone blocking therapies, and an array of over forty nutrient, biological and herbal therapies. (dunphynunley.com)
  • Results: CNTs can increase the antitumor effects of chemotherapy agents. (eurekaselect.com)
  • We describe existing clinical trials of antiangiogenic agents and the challenges facing the clinical development and optimal use of these agents for the treatment of breast cancer. (biomedcentral.com)
  • It also has severe limitations on the dosage of chemotherapeutic agents that can be administered to a patient, thus, limiting the effective range of chemotherapy. (justia.com)
  • Chemotherapeutic agents interact with vitamin A in various ways, from adjunctive vitamin A for nutritive support and amelioration of adverse drug effects to cotherapy using retinoids as chemotherapeutic agents. (interactionsguide.com)
  • Numerous epidemiological and preclinical studies support a role of vitamin D compounds in cancer prevention and treatment in colorectal, breast, prostate, ovarian, bladder, lung and skin cancers and leukemia ( 1 , 5 , 6 ). (jcancer.org)
  • Endoscopic surgery, which is the initial treatment of papillary cancers, is not effective for CIS because the disease is often so diffuse and difficult to visualize that surgical removal is not feasible. (medscape.com)
  • The overall effectiveness ranges from being curative for some cancers, such as some leukemias, to being ineffective, such as in some brain tumors, to being needless in others, like most non-melanoma skin cancers. (worldsbest.rehab)
  • Pharmaceutical compositions that include these protein kinase inhibitors, and methods of using such compositions for treatment of cancers and other diseases associated with protein kinase activity are also disclosed. (justia.com)
  • Clinical trials have shown that patients with prostate, lung, and basal cell carcinoma have benefited from treatment with itraconazole, and there are additional reports of activity in leukaemia, ovarian, breast, and pancreatic cancers. (ecancer.org)
  • Doxorubicin (Dox), a non-selective class I anthracycline antibiotic, is a potent chemotherapeutic agent which is used for the treatment of numerous cancers [ 1 ]. (oncotarget.com)
  • For example, inhibitors of MEK, as Selumetinib also used to treat pancreatic cancer, breast cancer and other cancers such as h Dermatological b Sartigen tumors confinement Investigated Lich multiple myeloma. (nartsignaling.com)
  • Calcitriol has been used in a number of clinical trials and it is important to note that sufficient dose and exposure to calcitriol is critical to achieve anti-tumor effect. (jcancer.org)
  • The effective clinical use of disease chemotherapeutic specialists from higher plants for about 50 years has made the scientists more intrigued to direct such kinds of investigations. (researchsquare.com)
  • Also, see the Clinical Presentations of Lung Cancer: Slideshow and Lung Cancer Staging -- Radiologic Options slideshows for additional information on SCLC staging and treatment. (medscape.com)
  • The most valuable aspect of the research is that our developed model provides more information for the selection of clinical treatment options and prognostic prediction. (biomedcentral.com)
  • This review focusses on clinical aspects of treatment of breast cancer with monoclonal antibodies, and tyrosine kinase and mammalian target of rapamycin (mTOR) inhibitors. (biomedcentral.com)
  • The use of remotely triggered treatments in combination with imaging modalities such as ultrasound, computed tomography, magnetic resonance imaging, and positron emission tomography could prove to address many of the current issues in cancer treatment, possibly leading to significant clinical outcomes [ 10 - 12 ]. (ntno.org)
  • Giant cell tumors (GCT) of the bone are aggressive and are recognised for variable clinical behaviour, which is not always related to radiographic or histological appearance [1]. (jbstjournal.com)
  • When designing these technologies, it is important to focus on adequate circulation time, specific delivery to cancerous tissue only, evasion of normal tissues and accumulation in the organs, lack of an immune response, and concomitant treatment and noninvasive monitoring in order for successful drug delivery to occur. (ntno.org)
  • According to the stage of cancer and the degree of the complication, current treatment methods rely on the success of chemotherapy either alone or combined with surgical resection or radiation therapy. (frontiersin.org)
  • The treatment of non-muscle-invasive bladder cancer (Ta, T1, carcinoma in situ [CIS]) begins with transurethral resection of bladder tumor (TURBT). (medscape.com)
  • We studied 5 consecutive cases of GCT involving the distal radius operated by en-bloc resection of tumor followed by reconstruction with ipsilateral non-vascularized fibular graft with a minimum 1 year follow-up. (jbstjournal.com)
  • Proportion of M1 tumor-associated macrophages (TAMs) increased, and proportion of M2 TAMs decreased upon BRD4 inhibition. (preprints.org)
  • The present study established a docetaxel-resistant gastric cancer cell line and evaluated the alteration of mRNA expression levels globally by microarray, in an attempt to obtain novel predictive biomarkers for docetaxel chemotherapy. (iiarjournals.org)
  • Dong, H. Targeting Tumor-Associated Macrophages (Tams) Reprogramming for Cancer Metastasis Therapy. (ommegaonline.org)
  • The role of tumor-associated macrophages (TAMs) in cancer is often correlated with poor prognosis, even though this statement should be interpreted with care, as the effects of macrophages primarily depend on their localization within the tumor. (nutriforce.cn)
  • CONCLUSION:These results indicate that the introduction of cabazitaxel for Japanese mCRPC patients could result in oncological outcomes without any association with patient's age and the profiles of previous docetaxel therapy. (shengsci.com)
  • Consolidation chemotherapy is given after remission in order to prolong the overall disease-free time and improve overall survival. (wikipedia.org)
  • Most OC cases are typically diagnosed at advanced stages, which has led to a 5-year overall survival rate of less than 35% following conventional treatment. (bvsalud.org)
  • 5 To date, platinum-based chemotherapy is the most effective therapy to treat advanced NSCLC patients, 6 with a significantly higher survival and response rate. (dovepress.com)
  • Theranostics would lead to better survival statistics and quality of life by causing enhanced treatment at the cancer sites while reducing toxic effects. (ntno.org)
  • Tumor metastasis usually goes through a series of sequential and interrelated steps that can be conceptualized as the invasion-metastasis cascade. (ommegaonline.org)
  • Tumor Micro Environment (TME) is intimately involved in all essential steps of the metastasis process through interacting with the tumor. (ommegaonline.org)
  • Treatment of bladder CIS differs from that of papillary transitional cell carcinoma (TCC). (medscape.com)
  • When a combination of papillary tumor and CIS is present, the papillary tumor is removed before treatment of the CIS is initiated. (medscape.com)
  • 55-59 Combined modality chemotherapy is the use of drugs with other cancer treatments, such as surgery, radiation therapy, or hyperthermia therapy. (wikipedia.org)
  • Limited-stage cancer is treated with chemotherapy and radiation. (medscape.com)
  • Matthias Pinter1,2 and Rakesh K. Jain1,* 1Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA. (nutriforce.cn)
  • Giant cell tumor is a benign bone tumor, locally aggressive with low malignant potential. (jbstjournal.com)
  • There are six general classes of chemotherapy drugs, based on their mechanisms of action. (vin.com)
  • This paper reviews intercellular spontaneous mitochondrial transfer modes, mechanisms, and the latest methods of AMT/T. Furthermore, potential application value and mechanism of AMT/T in disease treatment are also discussed. (biomedcentral.com)
  • Many research studies, encompassing cell culture tests in the laboratory and also animal and some human studies, are coming to a conclusion often very different from the conventional perspective that chemotherapy and antioxidants should never be combined. (pinestreetfoundation.org)
  • It is clear, Raf inhibitors may be therapeutically useful selective B, the pre-screening patients may be required for RAS mutations, and perhaps also for which added embroidered treatment. (nartsignaling.com)
  • Renin-angiotensin system (RAS) inhibitors (RASi) widely prescribed for the treatment of cardiovascular diseases have considerable potential in oncology. (nutriforce.cn)
  • Targeting these pathways via small molecule inhibitors or monoclonal antibodies has been a focus of more contemporary approaches to cancer treatment. (cancerbiomed.org)
  • As a steroid hormone that regulates mineral homeostasis and bone metabolism, 1α, 25-dihydroxycholecalciferol (calcitriol) also has broad spectrum anti-tumor activities as supported by numerous epidemiological and experimental studies. (jcancer.org)
  • Tumor Metabolism is strongly correlated with prognosis. (biomedcentral.com)
  • Calcitriol has been studied in various combination treatments and shown synergistic or additive antitumor activities. (jcancer.org)
  • iii) The hypoxic tumor environment is immunosuppressive and prevents an antitumor response. (nutriforce.cn)
  • CAFs are the dominant cell type in the tumor stroma, which exhibits mesenchymal-like features and are likely mesoderm-derived. (ommegaonline.org)
  • Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (wikipedia.org)
  • 55-59 Salvage chemotherapy or palliative chemotherapy is given without curative intent, but simply to decrease tumor load and increase life expectancy. (wikipedia.org)
  • The overexpression and knockdown of PUM2 promoted and inhibited tumor growth of xenograft mice, respectively. (dovepress.com)
  • Overexpression of LAPTM4B resulted in sequestration of the anthracycline doxorubicin, delaying its appearance in the nucleus. (bioseek.eu)
  • Our findings revealed that different genetic backgrounds of HCT116 and HT29 cell lines resulted in divergent responses to the combination treatments. (frontiersin.org)
  • Triple treatment showed synergism in terms of exhibiting anti-tumorigenic effects by activating the Hippo YAP signaling pathway in the HCT116 cell line. (frontiersin.org)
  • Chemoresistance is a significant barrier to the treatment and management of non-small cell lung cancer (NSCLC). (dovepress.com)
  • Another method of the invention comprises administering a cell growth inhibitor to the subject and administering to the subject a chemotherapy agent. (justia.com)
  • Non-Vascularised Ipsilateral Fibular strut - A Modality to Treat Giant cell tumor of lower end radius using Anterior Approach. (jbstjournal.com)
  • Juxta-articular giant cell tumors of the lower end radius are common and present a special problem of reconstruction after tumor excision. (jbstjournal.com)
  • Campanacci's staging system for giant cell tumour of the bone [5] was used for cortical breach. (jbstjournal.com)
  • Neuroblastoma is an extracranial solid tumor which develops in early childhood and still has a poor prognosis. (regenhu.com)
  • According to the data provided, it appears that dasatinib can sensitize KRAS mutant tumors, cetuximab. (nartsignaling.com)
  • 55-59 Combination chemotherapy involves treating a person with a number of different drugs simultaneously. (wikipedia.org)
  • In this article, we turn our focus to lymphoma, conducting a systematic search for published research that would support or discourage the use of antioxidants in combination with chemotherapy. (pinestreetfoundation.org)
  • The results not only help the practitioner and patient choose an effective combination of therapies, but also helps them understand which cancer genes (oncogenes) are blocked by which treatments. (dunphynunley.com)
  • Table 1 summarises the results from phase II trials utilizing bevacizumab in combination with chemotherapy, many of which are still preliminary. (biomedcentral.com)
  • The combination of BRD4 inhibitor and RT significantly suppressed tumor growth compared to RT alone. (preprints.org)
  • AMD3100, a CXCR4 antagonist, enhanced the docetaxel cytotoxicity in vitro. (iiarjournals.org)
  • These are particularly potent drugs, with doxorubicin used most commonly in veterinary medicine. (vin.com)
  • Core needle biopsy (CNB) specimens and resected tumors were obtained from all patients before and after NAC, respectively. (biomedcentral.com)
  • Expression of HIF-1α and PD-L1 in tumor was significantly downregulated by the BRD4 inhibitor. (preprints.org)