Anthracyclines, e. g. daunorubicin, doxorubicin, and idarubicin, consist of a tetracycline moiety linked via a glycosidic bond to a sugar residue, usually the aminosugar daunosamine. (lu.se)
Doxorubicin is one such chemotherapeutic agent that can cause cardiotoxicity. (biomedcentral.com)
In the current study, we generated an irradiated tumor cell-based drug delivery system which uses irradiated tumor cells loaded with the chemotherapeutic drug, doxorubicin. (biomedcentral.com)
In particular, the invention relates to the use of a topo II catalytic inhibitor such as the bisdioxopiperazine ICRF-187 for the manufacture of a medicament for the treatment of an accidental extravasation of a topoisomerase II poison and a method for treatment of such extravasation of a topoisomerase poison such as the anthracyclinesdaunorubicin, doxorubicin, epirubicin, or idarubicin. (allindianpatents.com)
The two drugs have a wide range of activity against malignant diseases - daunorubicin primarily in the field of haematological malignancies and doxorubicin against solid tumors. (allindianpatents.com)
Idarubicin1
Idarubicin (4-demethoxydaunorubicin) resembles daunorubicin but lacks a methoxyl group at the C-4 position. (allindianpatents.com)
Cytarabine and daunorubicin4
Among future therapies, the researchers called CPX-351 (Vyxeos), a liposome formulation of cytarabine and daunorubicin, promising. (ajmc.com)
This study aims to analyse the role of HO-1 in regulating apoptosis in AML cells in response to two front-line chemotherapeutic agents used for AML, cytarabine and daunorubicin. (oncotarget.com)
Here we show that HO-1 expression in AML samples was increased in response to both cytarabine and daunorubicin treatment, and micro RNA (miRNA) silenced HO-1 expression in combination with either daunorubicin or cytarabine induced a greater apoptotic responses in AML cells. (oncotarget.com)
However, ROS-dependent induction of HO-1 was limiting the apoptotic response that is seen in AML towards cytarabine and daunorubicin treatment. (oncotarget.com)
Vincristine1
Combination drug testing indicated in vitro synergy between carfilzomib and several conventional chemotherapeutic agents including vincristine, daunorubicin, dexamethasone, L-asparaginase, and 4-hydroperoxycyclophosphamide. (edu.au)
Chemotherapy4
Daunorubicin, also known as daunomycin, is a chemotherapy medication used to treat cancer. (wikipedia.org)
Daunorubicin has been used with other chemotherapy agents to treat the blastic phase of chronic myelogenous leukemia. (wikipedia.org)
Furthermore, chemotherapeutic drugs formulated in these nanoparticles are less toxic, suggesting that high-dose chemotherapeutic drugs can be given to patients to treat leukemia without increasing the horrendous toxicity associated with regular chemotherapy. (ca.gov)
For the 3â +â 7 group, daunorubicin (60 mg/m2) was administered over the first 3 days and cytarabine (200 mg/m2) over the first 7 days, followed by 1-3 additional chemotherapy cycles. (bvsalud.org)
Anthracycline3
Daunorubicin is in the anthracycline family of medication. (wikipedia.org)
It can also be caused by chemotherapeutic agents, especially the anthracycline drugs. (medscape.com)
Daunorubicin, the first anthracycline antibiotic to be discovered in the early 1960"s, was isolated from streptomyces cultures. (allindianpatents.com)
Anthracyclines3
The anthracyclines are efficient chemotherapeutic agents against cancer, but their use is limited due to cardiotoxicity and induction of multidrug resistance. (lu.se)
Anthracyclines are a class of chemotherapeutic agents based upon samine and tetra - hydro - naphthacene - dione . (wikidoc.org)
As well as many of the expected adverse reactions of chemotherapeutic agents, anthracyclines are notorious for causing cardiotoxicity. (wikidoc.org)
Agents8
Effectively targeted chemotherapeutic agents that are currently available include 2 hypomethylating agents: 5-azacytidine (azacytidine) and 5-aza-2' deoxycitidine (decitabine). (ajmc.com)
In this manuscript, we discuss the various cell-based HTS assays that have been developed to aid in the discovery of chemotherapeutic agents, focusing on those that exploit the DNA damage response. (oncotarget.com)
The Bliss Independence model was applied to determine synergy between carfilzomib and the nine conventional chemotherapeutic agents used to treat infants with ALL. (edu.au)
Thus, there is a critical need for alternative approaches to administer chemotherapeutic agents to control advanced stages of ovarian cancer without serious side effects. (biomedcentral.com)
Targeted delivery of chemotherapeutic agents is a new approach for the treatment of cancer, which provides increased selectivity and decreased systemic toxicity. (uni-konstanz.de)
With succeeding generations of tumor cells, differentiation is typically lost, growth becomes less regulated, and tumors become less responsive to most chemotherapeutic agents. (wikidoc.org)
Their current application in oncology has revolutionized cancer treatment by improving the antitumor activity of several chemotherapeutic agents. (mdpi.com)
Chemotherapeutic agents can cause direct mucosal injury (mucositis) or predispose to distension and necrosis, thereby altering intestinal motility, the authors write. (medscape.com)
These findings suggest concurrent inhibition of HO-1 expression in conjunction with chemotherapeutic treatment would improve the number of cases who reach complete remission. (oncotarget.com)
Ovarian3
Thus, the employment of drug-loaded irradiated tumor cells represents a potentially innovative approach for the delivery of chemotherapeutic drugs for the control of ovarian tumors. (biomedcentral.com)
Thus, local delivery of chemotherapeutic drugs by tumor may represent a potentially innovative approach for the control of ovarian tumors. (biomedcentral.com)
a commonly prescribed chemotherapeutic combination, experience ovarian failure or report no resumption in menses. (dreamsfertility.com)
Apoptosis1
Chemotherapeutic-induced apoptosis: a phenotype for pharmacogenomics studies. (uchicago.edu)
Cardiac toxicity2
However, by 1967, it was recognized that daunorubicin could produce fatal cardiac toxicity. (wikipedia.org)
Daunorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication. (wikipedia.org)
Drugs4
Inside of these nanoparticles, we can load chemotherapeutic drugs, such as daunorubicin that is one of the two drugs used for the upfront treatment of acute leukemia. (ca.gov)
This study evaluated the in vitro effects of the combination of PKC412 and ara-C or daunorubicin, studying the effect of co-incubation, pre-incubation and sequential incubation of the drugs in patient samples and cell lines. (lu.se)
In conclusion, the combination of PKC412 together with chemotherapeutic drugs is more effective in FLT3/ITD positive AML cells. (lu.se)
Broadly, most chemotherapeutic drugs work by impairing mitosis ( cell division ), effectively targeting fast-dividing cells . (wikidoc.org)
Tumors1
or gemcitabine plus erlotinib however their anti-tumor effects are remarkably lower than for other solid tumors, and there is currently no chemotherapeutic regimen that provides meaningful clinical outcome beyond the first salvage therapy, underscoring the urgent need for novel therapeutic strategies. (emadicancerlab.com)
Leukemia8
Small volumes of daunorubicin can be wrapped up in these minuscule pods, which can then be released into a leukemia cell-filled environment. (wikipedia.org)
When we attached the stem cell-targeting molecules on the surface of nanoparticles, these nanoparticles work like "small missiles" that can seek and delivery daunorubicin into leukemia stem cells. (ca.gov)
We have shown that these "smart" nanoparticle can delivery chemotherapeutic drug daunorubicin to leukemia cells directly isolated from clinical patient specimens, and kills these cells more efficient that the regular nanoparticles. (ca.gov)
In that sense, the first modern chemotherapeutic agent was Paul Ehrlich 's arsphenamine , an arsenic compound discovered in 1909 and used to treat syphilis . (wikidoc.org)
Drug1
Mice that received daunorubicin, a normal chemotherapeutic drug, lived a bit longer than mice without any treatment, but still died. (medicalnewsbulletin.com)
The recommended initial intensive treatment for AML outside a clinical study is DA, i.e., daunorubicin, i.v. infusion 60 mg/m 2 /8h daily for 3 days in combination with cytarabine, i.v. infusion 1 g/m 2 /2h b.i.d daily for 5 days. (cancercentrum.se)
Genetic1
Genetic variants contributing to daunorubicin-induced cytotoxicity. (uchicago.edu)
Compound1
Since a group of French researchers discovered the same compound at about the same time, the two teams named the compound daunorubicin, combining the name Dauni, a pre-Roman tribe that occupied the area of Italy where the compound was isolated, with the French word for ruby, rubis, describing the color. (wikipedia.org)
Agent1
A study has shown that Adipocytes can absorb and metabolise the chemotherapeutic agent daunorubicin, reducing its ability to kill cancer cells. (europeanpharmaceuticalreview.com)
Cells1
Cells were transfected with sh-RBM39 or sh-control, and then treated with daunorubicin (DNR) or homoharringtonine (HHT) at varied concentrations. (bvsalud.org)
Treatment1
Daunorubicin (DAN) is mostly used in the treatment of leukaemia and some solid tumour such as glioma. (farmaciajournal.com)
Combination1
The combination of daunorubicin and PKC412 resulted in more synergistic and less antagonistic effects compared to combinations with ara-C, in both patient material and cell lines. (lu.se)
Treat1
citation needed] In addition to its major use in treating AML, daunorubicin is also used to treat neuroblastoma. (wikipedia.org)