Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammatory conditions. (wikidoc.org)
2000). "Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity" . (wikidoc.org)
Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif. (lookformedical.com)
We developed a combined nano-cell therapy by using dendrimers complexed with plasmids (dendriplexes) targeting CCL20 and its sole receptor CCR6 to reduce inflammation followed by hMSC transplantation. (bvsalud.org)
Ligand2
The specific ligand of this receptor is CCL25 . (wikidoc.org)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
Lymphocytes1
1999). "Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis" . (wikidoc.org)
Migration1
Comments provided by GtoImmuPdb curators giving more information about why the target is associated with Chemotaxis & migration. (guidetomalariapharmacology.org)
Inflammatory2
Combining with our previous report, indirubin ameliorated psoriasiform dermatitis by breaking CCL20/CCR6 axis-mediated inflammatory loops. (bvsalud.org)
CB 2 receptor on eosinophils mainly mediates anti-inflammatory and immunomodulatory actions e.g. downregulation of pro-inflammatory mediator release. (guidetomalariapharmacology.org)
Family2
The protein encoded by this gene is a member of the beta chemokine receptor family. (wikidoc.org)
The receptors are members of the seven-transmembrane G protein-coupled receptor family. (lookformedical.com)
Immune1
A monocyte chemoattractant protein that has activity towards a broad variety of immune cell types. (lookformedical.com)
Cells2
γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. (explorationpub.com)
All four adenosine receptors are expressed on the surface of mouse invariant NKT (iNKT) cells. (guidetomalariapharmacology.org)
Specific1
A CC-type chemokine that is specific for CCR3 RECEPTORS. (lookformedical.com)
Alternative1
Complement C3a receptor 1 is the receptor for complement factor C3a, a component of the alternative complement cascade. (guidetomalariapharmacology.org)
Seven transmembrane2
They bind to 19 G protein-coupled seven transmembrane receptors that form either homodimers or heterodimers ( 7 - 11 ). (frontiersin.org)
[ 1 ] Chemokines act by interaction with seven transmembrane G-protein-coupled receptors. (medscape.com)
Chemokine ligands2
Stewart and Smyth summarized chemokine receptors, their synonyms, chemokine ligands and receptor-expressing cells. (medscape.com)
In this review, we focus on expression of chemokine receptors and chemokine ligands by MSCs isolated from different tissues. (biomedcentral.com)
Ligands4
Each receptor can bind to several ligands of the same family and vice versa (Figure 1 ). (frontiersin.org)
The expression of these receptors and ligands is finely regulated, both spatially and temporally, revealing distinct functions at steady-state and during inflammatory responses. (frontiersin.org)
Both immune and non-immune cells express these receptors and ligands, and the impact of this expression differs according to cell types. (frontiersin.org)
This superfamily consists of 48 proteins classified into 4 groups (XCL, CCL, CXCL, and CX3CL) based on the position of two cysteine residues in their sequence. (frontiersin.org)
When a chemokine binds to the extracellular N-terminus of its receptor, serine/threonine residues on the cytoplasmic C-terminus get phosphorylated. (medscape.com)
Tumor5
A variety of chemokine receptors are expressed on the surface of both tumor and immune cells rendering them sensitive to multiple stimuli that can subsequently influence their migration and function. (frontiersin.org)
Indeed, particular chemokine receptors expressed on tumor and immune cells are strongly associated with patient prognosis. (frontiersin.org)
Thus, potential targeting of chemokine receptors is highly attractive as a means to quench or eliminate unconstrained tumor cell growth. (frontiersin.org)
On the other hand, overexpression of chemokine receptors on cancer cells facilitates tumor dissemination. (frontiersin.org)
Chemokine receptors (red) influence melanoma tumor cell migration/invasion or immune cell trafficking to the tumor lesions. (frontiersin.org)
Bind1
The chemokine receptors are classified into four families based on the type of chemokine that they bind. (medscape.com)
Invasion1
Binding of a chemokine to its receptor stimulates transcription of genes involved in invasion, motility, extracellular matrix interaction and cell survival. (medscape.com)
Variety1
However, the variety of tissue sources, coupled with different isolation and culture protocols and the intrinsic variability of MSCs from donor to donor has led to wide variability regarding the description of MSC phenotypes and properties through the literature. (biomedcentral.com)
Potential1
These characteristics, coupled with their ease of accessibility and expansion resulted in a growing interest in the therapeutic potential of these cells. (biomedcentral.com)