Chemotactic factor receptors receptors peptide. Medical search. Frequent questions

Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor which belongs to the CXC subfamily of chemokines, and are bound by the cell surface receptors IL-8RA and IL-8RB. (thermofisher.com)
Until recently, SDF-1 and CXCR4 were believed to be a relatively monogamous ligand-receptor pair (other chemokines are promiscuous, tending to use several different chemokine receptors). (wikidoc.org)
Assessment of blister fluid-derived chemokines showed a persistent presence of several chemotactic molecules, including CXCL1 + 2 and CXCL5. (biomedcentral.com)
Receptors for leukocyte chemoattractants, including chemokines, are traditionally considered to be responsible for the activation of special leukocyte functions such as chemotaxis, degranulation, and the release of superoxide anions. (elsevierpure.com)
Chemoattractants stimulate the expression of several inflammatory cytokines and chemokines, which in turn may activate their respective receptors and initiate an autocrine regulatory mechanism for persistent cytokine and chemokine gene expression. (elsevierpure.com)
As a CXC-type chemokine receptor, or a receptor that responds to CXC chemokines, CXCR4 aids in cell chemotaxis when it is stimulated by chemokines [2]. (vanderbilt.edu)
The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)

This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. (bvsalud.org)

IL-8 functions as a chemoattractant and potent angiogenic factor. (thermofisher.com)
Previous studies demonstrated that oligopeptide chemoattractant receptors on PMN and macrophages exist in high and low affinity states which are interconvertible by guanosine di- and triphosphates. (psu.edu)
Treatment of U937 cells with dibutyryl cAMP resulted in the most reproducible and rapid increase in the number of chemoattractant receptors as well as in chemotactic responsiveness. (duke.edu)
Gene transcription through activation of G-protein-coupled chemoattractant receptors. (elsevierpure.com)
Dive into the research topics of 'Gene transcription through activation of G-protein-coupled chemoattractant receptors. (elsevierpure.com)

Membrane-tethered ligands are recombinant proteins comprised of an extracellular peptide ligand, a linker sequence, and an anchoring transmembrane domain. (nih.gov)
CXCL12 (over-)expressing cancers might not sense the CXCL12 gradient released from the metastasis target tissues since the receptor, CXCR4, is saturated with the ligand produced in an autocrine manner. (wikidoc.org)
Osteoclasts and odontoclasts are multinucleated cells derived from hematogenous bone marrow, from the monocyte/macrophage cell lineage, and are formed by the fusion of these cells under the action of colony stimulating factor 1 (CSF-1), macrophage colony stimulating factor (M-CSF), monocyte chemotactic protein-1 (MCP-1) and RANKL (receptor activator of nuclear factor kappa-B ligand), which also have a role in chemotaxis and cell differentiation [1]. (oatext.com)
Stromal cell-derived factor 1 α (SDF-1α), the ligand for G-protein-coupled receptor CXCR4, is a chemotactic factor for T lymphocytes. (neuroprobe.com)
SDF-1 is the natural ligand for the CXCR4 receptor. (vanderbilt.edu)
Once it is activated by its natural ligand and chemokine, Stromal Cell Derived Factor 1 (SDF-1/CXCL12), the CXCR4 ligand stimulates the stem cells to undergo chemotaxis [4]. (vanderbilt.edu)

The receptors on dibutyryl cAMP-treated cells and on dimethyl sulfoxide-treated cells initiated chemotaxis and lysosomal enzyme secretion in response to chemoattractants, but not the formation of superoxide anion. (duke.edu)
CXCR4 is the chemokine receptor which aids in chemotaxis of stem cells, such as those in the bone marrow or the brain. (vanderbilt.edu)

These monocytes responded to all of the three stimuli used: human serum-derived C5a, human lymphocyte-derived chemotactic factor, and a synthetic peptide. (uni-regensburg.de)
Calculations from these data showed that at least 75% of the migrating monocytes have different receptors for all three attractants. (uni-regensburg.de)
The data presented here indicate that chemotactic factor receptors on monocytes utilize an N protein to activate phospholipase C and subsequent biologic responses by the cells. (psu.edu)

One major discovery was that members of the chemokine receptor family serve as cofactors for HIV entry into cells. (cdc.gov)
We describe the role of allelic polymorphism in the gene coding for the CCR5 chemokine receptor with regard to susceptibility to and disease course of HIV infection. (cdc.gov)
C-X-C chemokine receptor type 4 ( CXCR-4 ) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4 gene . (wikidoc.org)
CXCR-4 is an alpha- chemokine receptor specific for stromal-derived-factor-1 ( SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes . (wikidoc.org)
CXCR4 is a chemokine receptor, and is found on a variety cells, including cancerous and stem cells [1]. (vanderbilt.edu)

G-CSF is a growth factor for neutrophils (a common type of white blood cells), and may act by increasing the activity of neutrophil-derived proteases such as neutrophil elastase in the bone marrow leading to proteolytic degradation of SDF-1. (wikidoc.org)
During an infection, chemotactic agents are generated that attract neutrophils to the site of infection, which in turn play a critical role in phagocytosing and killing microorganisms. (medscape.com)
LL-37 also exhibits chemotactic activity, mainly on neutrophils and CD4 T lymphocytes. (peptidesforresearch.com)

These results suggest that the phosphorylation of cofilin by LIMK1 plays a critical role in the SDF-1α-induced chemotactic response of T lymphocytes. (neuroprobe.com)

N-Formylmethionyl-leucyl-phenylalanine (fMLF, fMLP or N-formyl-met-leu-phe) is an N-formylated tripeptide and sometimes simply referred to as chemotactic peptide is a potent polymorphonuclear leukocyte (PMN) chemotactic factor and is also a macrophage activator. (wikipedia.org)
fMLF led to the first discovery of a leukocyte receptor for a chemotactic factor, defined three different types of fMLF receptors that have complementary and/or opposing effects on inflammatory responses as well as many other activities, and helped define the stimulus-response coupling mechanisms by which diverse chemotactic factors and their G protein coupled receptors induce cellular function. (wikipedia.org)

CXCR4 is one of several chemokine receptors that HIV can use to infect CD4+ T cells . (wikidoc.org)
CXCR4 is upregulated during the implantation window in natural and hormone replacement therapy cycles in the endometrium, producing, in presence of a human blastocyst , a surface polarization of the CXCR4 receptors suggesting that this receptor is implicated in the adhesion phase of human implantation . (wikidoc.org)
Drugs that block the CXCR4 receptor appear to be capable of "mobilizing" hematopoietic stem cells into the bloodstream as peripheral blood stem cells . (wikidoc.org)
Plerixafor (AMD3100) is a drug, approved for routine clinical use, [7] which directly blocks the CXCR4 receptor. (wikidoc.org)
Similarities between novel molecule 390 synthesized by the Miller Lab and SDF-1 make this novel small molecule a possible agonist of the CXCR4 receptor. (vanderbilt.edu)
To determine whether 390 is an agonist to the CXCR4 receptor, we transfected cells with CXCR4 and exposed them to no agonist [vehicle control], SDF-1, or varying concentrations of our agonist drug. (vanderbilt.edu)
The results suggest 390 is an agonist or partial agonist of the CXCR4 receptor. (vanderbilt.edu)
390 may be the first small molecule agonist of CXCR4 receptors ever identified and may have a number of uses in medicine. (vanderbilt.edu)
The chemotactic function of CXCR4 is demonstrated in the receptor's role of anchoring hematopoietic stem cells in the bone marrow [3]. (vanderbilt.edu)
Since these stem cells can be moved in the body through agonist interaction with CXCR4, discovering a small molecule receptor stimulant can potentially facilitate organ or tissue transplants [5]. (vanderbilt.edu)
Many types of cancer cells express the CXCR4 receptor and studies have shown that interference with the activation of the receptor by SDF- inhibited the spread of the cancer cells [3]. (vanderbilt.edu)
390 is a novel small organic molecule synthesized by the Miller Lab at Northwestern University, which we have now demonstrated may act on the CXCR4 receptor as an agonist. (vanderbilt.edu)
This suggests that 390 may be both easier and cheaper to produce than other CXCR4 agonist compounds, although peptide alternatives mass-produced in E.coli may be cheaper to produce. (vanderbilt.edu)
The calcium imaging assay was chosen because CXCR4 agonists, such as SDF-1, are known to signal via G proteins in the cell, which result in increased cellular calcium levels when the receptor is activated [8]. (vanderbilt.edu)
Also, internalization of the CXCR4 can occur when the receptor is overstimulated or desensitized i.e., during CXCR4 agonist stimulation on CXCR4 expressing cells [9]. (vanderbilt.edu)
Therefore, an increase in calcium as well as internalization of CXCR4 was used to confirm that drug 390 was an agonist of the receptor. (vanderbilt.edu)

Scholars@Duke publication: Changes in actin state and chemotactic peptide receptor expression in granulocytes during cytokine administration after autologous bone marrow transplantation. (duke.edu)
The functional enrichment and gene interaction network analysis emphasized the importance of cytokine/chemokine signalling, T cell receptor signalling route, NF-kappa B signalling pathway and Jak-STAT signalling system. (springeropen.com)

fMLF is the prototypical representative of the N-formylated oligopeptide family of chemotactic factors. (wikipedia.org)
Both dimethyl sulfoxide and dibutyryl cAMP induced expression of receptors for the N-formylated oligopeptide chemoattractants in U937 cells. (duke.edu)

The chemerin receptor (CMKLR1) is a G protein-coupled receptor found on select immune, epithelial, and dorsal root ganglion/spinal cord neuronal cells. (nih.gov)
A parallel approach may be applied to developing therapeutics targeting other peptide hormone G protein-coupled receptors. (nih.gov)
These oligopeptides are known to be, or mimic the actions of, the N-formyl oligopeptides that are (a) released by tissue bacteria, (b) attract and activate circulating blood leukocytes by binding to specific G protein coupled receptors on these cells, and (c) thereby direct the inflammatory response to sites of bacterial invasion. (wikipedia.org)
The discovery of the gene sequences and predicted protein structures, role of CCR5 alleles has prompted studies of but their ligands have not been identified the possible role of many other host genes in (orphan receptors). (cdc.gov)
Previous nomenclature for IL-8 includes neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP) and protein 3-10C. (thermofisher.com)
Peripheral lung inflammation may cause a "spill-over" of cytokines, such as interlukin (IL)-6, IL-1β and tumour necrosis factor (TNF)-α, into the systemic circulation, which may increase acute-phase proteins such as C-reactive protein (CRP). (ersjournals.com)
These peptides are released from bacteria during infection and activate formyl peptide receptor (FPR), a member of G-protein coupled receptors (GPCRs). (alomone.com)
The protein has a predicted molecular mass of 43.56 kDa after removal of the signal peptide. (abeomics.com)
The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. (abeomics.com)
A naturally occurring processed form of this protein has increased chemotactic activity. (abeomics.com)
However, despite encouraging results, these trials revealed that the majority of curative effects resulted from the secretion of various paracrine factors elicited by transplanted cells rather than from donation of the therapeutic protein to the affected cutaneous tissue [ 11 ]. (biomedcentral.com)
Recently, these G-protein-coupled serpentine receptors have been found to transduce signals leading to gene transcription and translation in leukocytes. (elsevierpure.com)
Activation of transcription factors through these receptors involves G-protein coupling and the activation of protein kinases. (elsevierpure.com)
These effects were associated with a significant reduction of NF-κB activation and monocyte chemotactic protein-1 (MCP-1) expression in the carotid arteries of rats treated with the peptide. (unina.it)
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)

LL-37 peptide is a potent killer of different microorganisms. (peptidesforresearch.com)

Characterization of the brain penetrant neuropeptide Y Y 2 receptor antagonist SF-11. (rndsystems.com)

We have studied the relationship between clinical and biochemical parameters and C-peptide and anti-inflammatory IL-10, as well as selected markers of inflammation and endothelial dysfunction such as: CCL2, CRP, sICAM-1, sVCAM-1 and E-selectin in obese women with various degree of glucose metabolism disturbance. (medsci.org)
OBJECTIVE: The objective of our study was to evaluate whether worsening inflammation in the first 3 months postoperatively was a risk factor for developing CAN. (bvsalud.org)
CONCLUSIONS: Among other factors, inflammation may determine the onset of CAN as diagnosed by renal biopsy. (bvsalud.org)
OBJECTIVE: To evaluate the relationship between biomarkers of inflammation, growth factors, metalloproteinases, and the development of subclinical atherosclerosis diagnosed by using CUS. (bvsalud.org)
NF-κB essential modulator-binding domain (NBD) peptide blocks the activation of the IκB kinase complex, selectively abrogating the inflammation-induced activation of NF-κB. (unina.it)

We studied the changes in actin state and chemotactic peptide receptor expression in granulocytes from patients receiving different cytokines following high dose chemotherapy and autologous bone marrow transplantation (ABMT). (duke.edu)
However, in patients receiving granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF) the increase in F-actin content was much greater than in those not receiving these cytokines (159, 149, and 90% for G-CSF, M-CSF, and noncytokine group, respectively). (duke.edu)
Patients receiving granulocyte-macrophage colony-stimulating factor (GM-CSF) had only a 62% increase in the F-actin content, which was not statistically significant from patients undergoing ABMT without any cytokines. (duke.edu)
Although the basal level of F-actin was high following ABMT, granulocytes from all patients showed an additional increase in F-actin content after stimulation with either the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) or phorbol myristate acetate (PMA). (duke.edu)
Treatment of Jurkat cells with S3 peptide inhibited the SDF-1α-induced cofilin phosphorylation, actin reorganization, and chemotactic response of Jurkat cells. (neuroprobe.com)

Earlier HIV infec- receptor gene polymorphism in HIV infection, tion diagnosis, inhibition of ongoing HIV replica- only genes of the HLA system were thought to tion with antiretroviral therapy (in industrialized protect against HIV infection. (cdc.gov)
Infectious virus titres increased in undifferentiated U937 cells following infection with clinical isolates but only when the cells were infected via their Fc receptors. (microbiologyresearch.org)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)

These findings demonstrate that development of the chemotactic and respiratory burst functions during the differentiation of a monocyte-like cell line can occur independently. (duke.edu)

The research peptide LL-37 is antimicrobial and the only known member of the cathelicidin family of peptides expressed in humans. (peptidesforresearch.com)

Neutrophil activation during cardiopulmonary bypass (CPB) surgery may occur because of the release of complement chemotactic products or the local release of interleukin (IL)-8. (medscape.com)

Soluble angiogenic factors 2.4.2. (docksci.com)

Transcription factors, such as NF kappa B and AP-1, are activated upon stimulation of the cells with several chemoattractants at physiologically relevant concentrations. (elsevierpure.com)

CMKLR1 is activated by both lipid and peptide agonists, resolvin E1 and chemerin, respectively. (nih.gov)
Current therapies for comorbid diseases, such as statins and peroxisome proliferator-activated receptor-agonists, may provide unexpected benefits for COPD patients. (ersjournals.com)

This development occurs under the influence of macrophage colony-stimulating factor (M-CSF), which is secreted by various cell types (eg, endothelial cells, fibroblasts). (msdmanuals.com)

In fact, MSCs can secrete various cytokines, growth factors and a series of extracellular matrix molecules including collagens and FN[ 22 - 26 ], which are the main substrates for MSC adhesion to the plastic. (biomedcentral.com)
Extracellular antigens (eg, from many bacteria) that are phagocytosed or endocytosed can be processed into peptides and complexed with surface class II MHC molecules on professional APCs, which specialize in presenting antigens to CD4 helper T (Th) cells. (msdmanuals.com)

OPG (osteoprotegerin) is a soluble TNF receptor-like molecule and the natural inhibitor of osteoclastogenesis [3]. (oatext.com)

While other similar compounds are peptide based and have large molecular weights, molecule 390 is small and compact. (vanderbilt.edu)

The research peptide LL37 is a synthetic version of the human form of cathelicidin LL-37. (peptidesforresearch.com)

In Dictyostelium , the interaction of secreted cAMP with specific cell surface receptors regulates the activation/de-activation of GSK3, which mediates developmental cell patterning. (biologists.com)

This compound provides a prototype membrane-anchored peptide for the treatment of inflammatory disease. (nih.gov)
Janowska J, Chudek J, Olszanecka-Glinianowicz M, Semik-Grabarczyk E, Zahorska-Markiewicz B. Interdependencies among Selected Pro-Inflammatory Markers of Endothelial Dysfunction, C-Peptide, Anti-Inflammatory Interleukin-10 and Glucose Metabolism Disturbance in Obese Women. (medsci.org)
Currently increasing importance is attributed to the inflammatory process as a crucial factor responsible for the progressive damage to vascular walls and progression of atherosclerosis in obese people. (medsci.org)
The results suggest the probable active participation of higher concentrations of C-peptide in the intensification of inflammatory and atherogenic processes in obese patients with type 2 diabetes. (medsci.org)
genetic and environmental factors seem to increase the susceptibility of some individuals in developing this severe inflammatory disease (1) ( Fig. 1 ). (bvsalud.org)
Progression of this disease occurs due to a combination of factors, including the presence of periodontopathic bacteria, high levels of proinflammatory cytokines, matrix metalloproteinases (MMPs), prostaglandin E2 (PGE2), low levels of anti-inflammatory cytokines including inter- leukin-10 (IL-10), transforming growth factor (TGF- β ) and tissue inhibitors of MMPs (TIMPs) (2,3). (bvsalud.org)
Here, the circulating phagocytic hemocytes were chemically depleted by injecting the snails with clodronate liposomes, and the effects on the cephalic tentacle regeneration onset and on Pc-Hemocyanin, Pc-transglutaminase (Pc-TG) and Pc-Allograft Inflammatory Factor-1 (Pc-AIF-1) gene expressions were investigated. (unimore.it)

However, liver cirrhosis and intestinal stricture formation are not common in mast cell disease, indicating that besides mast cells additional factors or specific stimulation of mast cells may be necessary to induce severe fibrosis. (bmj.com)
While an agonist activates a receptor, an anatagonist prevents agonist-mediated stimulation of a receptor. (vanderbilt.edu)

In human, the FPR family consists mainly of three receptors, FPR1, FPR2/ALX (formerly FPRL1), and FPR3 (formerly FPRL2) which all couple to the G i subtype of G-proteins and ultimately lead to the activation of phospholipase C and intracellular Ca 2+ increase. (alomone.com)
17 Furthermore, it has been reported that LL-37 can induce angiogenesis, as demonstrated in an in vitro and in vivo model, by activating the FPRL1 receptor expressed in endothelial cells, resulting in more significant proliferation and formation of similar structures to the blood vessels. (peptidesforresearch.com)

IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg amino acid sequence) and signals through the CXCR1 and CXCR2 receptors. (thermofisher.com)
The majority of blister-originated chemotactic signals were associated with preferential recruitment of CD45 + CXCR2 + and CD11b + CXCR2 + leukocytes. (biomedcentral.com)

The chemotactic peptide receptor expression was significantly higher in patients treated with ABMT alone or ABMT plus G-CSF. (duke.edu)
Expression of this receptor in cancer cells has been linked to metastasis to tissues containing a high concentration of CXCL12, such as lungs, liver and bone marrow. (wikidoc.org)
Its expression induces the migration and proliferation of keratinocytes by activating the epidermal growth factor receptor (EGFR), STAT1 / STAT3). (peptidesforresearch.com)
PCR was performed to detect the expression of the protease-activated receptors (PARs) in MSCs. (biomedcentral.com)
In a PCR array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of signal transducer and activator of transcription 3 (STAT3). (cdc.gov)

Several lines of evidence showed that most migrating cells had receptors for all three chemotaxins tested. (uni-regensburg.de)
Collectively, these studies demonstrate that recruitment of mADSC into DEB skin is tightly controlled by disease-site chemotactic activities and suggest a potential mechanism for effective application of therapeutic stem cells for DEB. (biomedcentral.com)
Unstimulated U937 cells contained no detectable receptors. (duke.edu)
In the 1960s and 1970s, the revolution of modern cell biology and biochemistry provided a series of novel techniques which became available to investigate the migratory responder cells and subcellular fractions responsible for chemotactic activity. (wikidoc.org)
There was an increase in calcium in the cells when 390 was added, indicating that the receptor was being activated. (vanderbilt.edu)
This receptor is also used by the HIV-1 virus to infect human body cells [6]. (vanderbilt.edu)
The COL4A1-VEGFD fusion leads to production of mature VEGFD after proteolytic processing, which may act as an autocrine growth factor for tumour cells. (cusabio.com)
Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)
they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)

Using this technology, we established that a 9-amino acid-tethered chemerin fragment (amino acids 149-157) activates both mouse and human CMKLR1 with efficacy exceeding that of the full-length peptide (amino acids 21-157). (nih.gov)
Several human chemokine receptors have been sons than for those homozygous for the wild classified as such on the basis of similarity of type CCR5 (12,17-19,23). (cdc.gov)
A group of small, histidine-rich, cationic peptides in human SALIVA which are antibacterial and antifungal. (lookformedical.com)

trypsin-sensitive virus receptors and trypsin-resistant immune complex receptors. (microbiologyresearch.org)

The differentiation of the osteoclast precursor into a mature osteoclast requires RANKL binding to its receptor RANK (receptor activator of nuclear factor kappa-B). However, OPG binding to RANKL will block RANKL binding to RANK, which will result in inhibition of osteoclastogenesis (Figure 1) [3]. (oatext.com)

S3 peptide inhibited the kinase activity of LIMK1 in vitro. (neuroprobe.com)

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi. (lookformedical.com)
The hormones that play vital role in the first phase of descent are insulin-like hormone 3 (INSL3), Anti-müllerian hormone as well as testosterone, whereas androgens, genitofemoral nerve and its neurotransmitter calcitonin gene-related peptide (CGRP) influence the second phase. (springeropen.com)

BHR, but factors such as airway remodeling also influence the potential of a chemical to induce respiratory allergy. (cdc.gov)

Comprehensive analysis of chemotactic activity of the eukaryotic protozoon Tetrahymena pyriformis and consensus sequences of appearance of amino acids in the primordial soup suggest that there was a good correlation between the chemotactic character of these relative simple organic molecules and their development on the Earth. (wikidoc.org)
This peptide prevents immunostimulatory effects of bacterial wall molecules such as lipopolysaccharide. (peptidesforresearch.com)
molecules cleaved from the ECM may be distributed in patterns that are not conducive to chemotactic migration buy Thiazovivin toward a tumor, depending on the spatial distribution of MMP molecules. (proteasomesignaling.com)

These observations suggest that guanine nucleotide regulatory (N) proteins play a role in phagocyte activation by chemotactic factors. (psu.edu)

In the internalization assay, both SDF-1 and 390 internalized the receptor. (vanderbilt.edu)
During this experiment, we conducted two assays: a calcium imaging assay and a receptor internalization assay. (vanderbilt.edu)

We used a cell-permeable peptide (S3 peptide) that contains the phosphorylation site (Ser-3) of cofilin to inhibit the cellular function of LIMK1. (neuroprobe.com)

Also, the therapeutic relevance of identified chemotactic pathways was investigated in vivo, providing a basis for future clinical investigations. (biomedcentral.com)
In addition, the NBD peptide (0.01 to 1 μM) reduced rat SMC proliferation, migration, and invasion in vitro, processes contributing to the injury-induced neointimal formation in vivo. (unina.it)

In this study, we investigated the effect of NBD peptide on neointimal formation using two animal models of arterial injury: rat carotid artery balloon angioplasty and wire-induced carotid injury in apolipoproteinE-deficient (apoE-/-) mice. (unina.it)

TNF, tumour necrosis factor. (docksci.com)

Our results demonstrate that the NBD peptide reduces neointimal formation and SMC proliferation/migration, both effects associated with the inhibition of NF-κB activation. (unina.it)

The receptors are widely distributed on homozygous for the CCR5 32 bp deletion. (cdc.gov)

LL-37, a peptide originating from its precursor hCAP-18, has a chain of 37 amino acids. (peptidesforresearch.com)

The antimicrobial peptide, beta-defensin-1, has antiviral activity against both enveloped and non-enveloped viruses. (cdc.gov)

Anatomy1

Chemicals and Drugs15

Phenomena and Processes5

Information Science3

Chemokines7

Antimicrobial peptides1

Chemoattractant5

Ligand6

Chemotaxis2

Monocytes3

Chemokine receptor5

Neutrophils3

Lymphocytes1

Leukocyte2

CXCR416

Cytokine2

Oligopeptide2

Protein15

Potent1

Antagonist1

Inflammation5

Actin5

Infection3

Monocyte1

Humans1

Neutrophil1

Angiogenic1

Chemoattractants1

Agonists2

Macrophage1

Extracellular2

Soluble1

Molecule1

Cathelicidin1

Mediates1

Inflammatory7

Stimulation2

FPRL12

CXCR22

Expression5

Cells9

Human3

Immune1

Activator1

Kinase1

Gene2

Induce1

Molecules3

Proteins1

Assay2

Cellular function1

Vivo2

Mice1

Tumour necros1

Migration1

Deletion1

Precursor1

Activity1