RectalNeoadjuvantChemoradiationLocallyRegimenResectionConcurrent chemoradiotherapyReceived preoperative chemotherapyOxaliplatinResectableVersusChemotherapy aloneSurvivalPancreatic cancerPerioperativeAdjuvantProtocolsSquamousMultidisciplinaryImprovesCancerStandard-of-cTreatmentSystemicRoutinePatientOutcomesPalliativeSupportive careResponseResultsRadiation therapyHigher
Rectal19
- Preoperative versus postoperative chemoradiotherapy for rectal cancer. (medscape.org)
- Optimal surgery time after preoperative chemoradiotherapy for locally advanced rectal cancer. (edcan.org.au)
- I began my journey in Sweden, a world leader in delivering high quality rectal cancer care. (jamesivassociationsurgeons.com)
- The Swedes also developed, and continuously improve, a prospectively collected national database to monitor quality in rectal cancer care, focusing on the hospital as the unit of analysis. (jamesivassociationsurgeons.com)
- Surgery remains the standard of care for most rectal cancer as it offers the best chance of cure. (wustl.edu)
- Patient selection is important and careful assessment after preoperative chemoradiotherapy can identify good responders, even with advanced rectal cancers. (wustl.edu)
- Some 1194 patients with stage T2 or T3 rectal cancer were randomized to neoadjuvant chemoradiotherapy (standard care) or chemotherapy alone. (bjsacademy.com)
- In 2004, a randomized trial from Germany was published establishing a regimen of preoperative chemoradiotherapy and surgery followed by additional cycles of chemotherapy alone as the standard of care for clinical stages T3 or T4, or for node-positive rectal cancer [ 3 ]. (biomedcentral.com)
- Other clinical studies from the United States, Europe, and Asia have also influenced the treatment strategies for operable rectal cancer, as various approaches using preoperative or postoperative radiotherapy, with or without chemotherapy, have been examined. (biomedcentral.com)
- This study was designed to explore whether an intensified chemoradiotherapy (CRT) led to a better clinical outcome in locally advanced rectal cancer. (biomedcentral.com)
- One of his notable studies explores the effects of oxaliplatin on preoperative chemoradiotherapy and postoperative chemotherapy for advanced rectal cancer. (airomedical.com)
- The aim of this study was to investigate the effect of preoperative chemoradiotherapy (CRT) on nodal disease in locally advanced rectal adenocarcinoma.Thirty-two patients staged uT3N0 and 27 patients staged uT3N1 rectal adenocarcinoma who underwent pre-CRT staging using endoscopic ultrasound or rectal protocol CT were included. (stanfordhealthcare.org)
- This new approach to treating rectal cancer is important because it means that fewer patients will require preoperative chemoradiotherapy (preCRT). (ifpoc.org)
- The implementation of this new, more selective approach to preCRT may lead to improved quality of life for rectal cancer patients and has the potential to decrease wait times for radiotherapy treatment as well as overall health care costs. (ifpoc.org)
- This report concerns the care provided to a woman who presented to an Emergency Department with rectal bleeding on multiple occasions. (hdc.org.nz)
- Evidence supports screening for rectal cancer as a part of routine care for all adults aged 50 years and older, especially for those with first-degree relatives with colorectal cancer. (cancer.gov)
- BACKGROUND: Adding modified FOLFOX6 (folinic acid, fluorouracil, and oxaliplatin) after chemoradiotherapy and lengthening the chemoradiotherapy-to-surgery interval is associated with an increase in the proportion of rectal cancer patients with a pathological complete response. (elsevierpure.com)
- CONCLUSIONS: Adding modified FOLFOX6 after chemoradiotherapy and before total mesorectal excision increases compliance with systemic chemotherapy and disease-free survival in patients with locally advanced rectal cancer. (elsevierpure.com)
- A Nine-Gene Signature for Predicting the Response to Preoperative Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer. (cdc.gov)
Neoadjuvant4
- For medically fit patients, perioperative neoadjuvant chemotherapy or chemoradiotherapy followed by surgery is appropriate. (medscape.com)
- This number stands to grow following the recent publication of data demonstrating a survival benefit, which will likely prompt more centers to adopt neoadjuvant therapy as a standard of preoperative care (4). (chk1inhibitor.com)
- With regard to adjuvant and neoadjuvant treatment of esophageal and gastroesophageal adenocarcinomas, we very much continue to administer preoperative chemoradiation. (cancernetwork.com)
- There exists a significant risk of recurrence after neoadjuvant chemoradiotherapy (NCRT) and surgery among the three-fourth of patients with carcinoma esophagus who do not achieve complete pathological remission (PCR). (thieme-connect.com)
Chemoradiation7
- Success of the preoperative regimen changed the paradigm of anal cancer treatment from surgical to non-surgical and was the advent of definitive chemoradiation (omitting surgery) being accepted as a standard-of-care for anal squamous cell carcinomas. (wikipedia.org)
- This trial confirms that preoperative chemoradiation for resectable esophageal cancer is safe and, compared with surgery alone, is associated with pathological complete responses, higher rates of R0 resection, and prolonged survival. (medscape.com)
- However, the findings support preoperative chemoradiation as one of several care options rather than establishing it as the premier standard of care. (medscape.com)
- Stage I-III (locoregional disease) - Available modalities are endoscopic therapies (eg, mucosal resection or ablation), esophagectomy, preoperative chemoradiation, and definitive chemoradiation. (medscape.com)
- 2. Albert A, Allbright R, Lee A, Vijayakumar S. Preoperative chemoradiation followed by hysterectomy for cervical cancer: patterns of care and survival in a large, hospital database. (koreamed.org)
- The standard of care for esophageal adenocarcinoma remains preoperative chemoradiation. (cancernetwork.com)
- This DFS on the CM577, despite preoperative chemoradiation, R0 resection, and adjuvant nivolumab, is grossly inferior to the DFS on the surgery alone arm of the NEOCRETEC 5010 study. (thieme-connect.com)
Locally4
- The mainstay of treatment for locally advanced disease is primary chemoradiotherapy. (bmj.com)
- To compare patient survival outcomes between completion hysterectomy and conventional surveillance in locally advanced adenocarcinoma of the cervix after concurrent chemoradiotherapy (CCRT). (koreamed.org)
- 4. Yang J, Shen K, Wang J, Yang J, Cao D. Extrafascial hysterectomy after concurrent chemoradiotherapy in locally advanced cervical adenocarcinoma. (koreamed.org)
- Pre- versus postoperative chemoradiotherapy for locally advanced esophageal squamous cell carcinoma. (springer.com)
Regimen3
- Ongoing efforts to improve response rates and identify the ideal preoperative regimen will clarify matters in the next few years. (medscape.com)
- Therefore, we designed this randomized trial to explore whether a combined regimen of oxaliplatin-added chemoradiotherapy and a concomitant boost to the primary tumor would further lead to a better clinical outcome. (biomedcentral.com)
- The ideal biliary stent in this setting Inhibitors,research,lifescience,medical must remain patent for the duration of the pretreatment evaluation, chemoradiotherapy regimen, and post-treatment recovery period. (chk1inhibitor.com)
Resection4
- Only 30% to 40% of patients with Pancoast tumors are eligible to receive preoperative concurrent chemoradiotherapy followed by complete resection. (oncnursingnews.com)
- And osimertinib is a standard of care drug, whether in the stage four setting and now in the early stage after resection, and every patient anywhere and everywhere should have access to it. (ascopost.com)
- However, smokers newly diagnosed with non-small cell lung cancer and scheduled for curative resection are frequently discouraged from stopping smoking in the immediate preoperative period. (thieme-connect.de)
- The standard of care for patients with newly diagnosed GBM comprises maximum safe resection of the tumor followed by radiotherapy (RT) with concomitant and adjuvant temozolomide (TMZ) chemotherapy [ 3 , 4 ]. (springer.com)
Concurrent chemoradiotherapy1
- Results of surgery after concurrent chemoradiotherapy in advanced cervical cancer: comparison of extended hysterectomy and extrafascial hysterectomy. (koreamed.org)
Received preoperative chemotherapy1
- [ 3 ] . For patients who received preoperative chemotherapy, the addition of postoperative radiotherapy has not demonstrated additional benefit. (medscape.com)
Oxaliplatin1
- The combination of Oxaliplatin with Capecitabine represents a new standard of care for metastatic colorectal cancer. (wjgnet.com)
Resectable3
- Current options for resectable esophageal cancer include preoperative cisplatin-based radiotherapy and preoperative or perioperative chemotherapy alone (either 5-fluorouracil/cisplatin, as in the UK Medical Research Council study, [ 1 ] or epirubicin, cisplatin and fluorouracil, as in the MAGIC study [ 2 ] ). (medscape.com)
- Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial. (edcan.org.au)
- In this article, we review the data surrounding the use of chemotherapy (CT) and chemoradiotherapy (CRT) in patients with resectable pancreatic cancer. (cancernetwork.com)
Versus3
- Larger doses of radiation are used in modern chemoradiotherapy protocols versus the original Nigro protocol radiotherapy dose. (wikipedia.org)
- Surgery alone versus chemoradiotherapy followed by surgery for stage I and II esophageal cancer: final analysis of randomized controlled phase III trial FFCD 9901. (springer.com)
- Patterns of recurrence after oesophagectomy and postoperative chemoradiotherapy versus surgery alone for oesophageal squamous cell carcinoma. (springer.com)
Chemotherapy alone1
- Five-year disease-free survival was 80.8 per cent after chemotherapy alone compared to 78.6 per cent after standard care, P=0.005 for noninferiority. (bjsacademy.com)
Survival3
- We aimed to investigate manifestations and patterns of care for patients with brain metastasis (BM) from breast cancer (BC) and compared their overall survival (OS) from 2005 through 2014 in Korea. (e-crt.org)
- Completion hysterectomy after CCRT was associated with better survival outcome compared with the current standard of care. (koreamed.org)
- Therefore, myelosuppression and gastrointestinal side effects caused by preoperative DCF therapy may worsen postoperative infections leading to life-threatening diseases in high-risk patients with esophageal cancer and may reduce long-term survival benefits by increasing the incidence of postoperative infections. (biomedcentral.com)
Pancreatic cancer1
- Until the past decade, the use of SEMS was discouraged in preoperative pancreatic cancer patients owing to concerns that these stents might interfere with reconstruction during pancreaticoduodenectomy. (chk1inhibitor.com)
Perioperative2
- During the past 12 years, numerous observational studies have investigated the impact of preoperative smoking cessation on perioperative risk for thoracic and non-thoracic surgery. (thieme-connect.de)
- In view of the post-cessation recovery time-course of pathophysiological alterations relevant to the occurrence of perioperative complications, a smoke-free preoperative interval of 2 - 6 weeks appears most favourable. (thieme-connect.de)
Adjuvant1
- The mean number of total chemotherapy cycles differed among the 4 groups (p = 0.002), because one third of patients in the group assigned to no preoperative FOLFOX did not receive any adjuvant chemotherapy. (elsevierpure.com)
Protocols1
- Our new analysis of RTOG 0247 provides us with favorable efficacy results of two preoperative chemotherapy regimens used in conjunction with radiation therapy protocols," said Neal J. Meropol, MD, co-author of the study, and the Dr. Lester E. Coleman Jr., Professor of Cancer Research and Therapeutics and chief of the Division of Hematology and Oncology at University Hospitals Case Medical Center and Case Western Reserve University in Cleveland. (appliedradiationoncology.com)
Squamous1
- Nigro protocol is the preoperative use of chemotherapy with 5-fluorouracil and mitomycin and medical radiation for squamous cell carcinomas of the anal canal. (wikipedia.org)
Multidisciplinary1
- 90% regarding preoperative imaging and ≥80% regarding preoperative multidisciplinary team (MDT) discussion. (jnccn.org)
Improves2
- Special interest radiology improves the perceived preoperative stage of gastric cancer. (helsedirektoratet.no)
- Provincial Health Services Authority (PHSA) improves the health of British Columbians by seeking province-wide solutions to specialized health care needs in collaboration with BC health authorities and other partners. (bccancer.bc.ca)
Cancer6
- Health-related quality of life of cancer and noncancer patients in Medicare managed care. (medscape.org)
- Support Care Cancer 2002;10:494-501. (medscape.org)
- 5. Platt SL, Patel A, Humphrey PJ, Al-Booz H, Bailey J. Completion surgery after chemoradiotherapy for cervical cancer - is there a role? (koreamed.org)
- At the time of events, the woman was under the care of the Haematology Department at the public hospital (Southern District Health Board (SDHB)) as she was receiving chemotherapy for a relapse of cancer of the lymphatic system (lymphoma). (hdc.org.nz)
- Since there is no scientific evidence demonstrating a negative impact of preoperative smoking cessation on prognosis, patients newly diagnosed with lung cancer should be encouraged to make an attempt to quit while waiting for thoracic surgery. (thieme-connect.de)
- Each year the Network develops, organizes and hosts a medical education program profiling a specific area of cancer surgery and care. (bccancer.bc.ca)
Standard-of-c1
- However, newer options such as targeted therapy, anti-vascular endothelial growth factor (VEGF) receptor antibodies, and immunotherapy may have the potential to alter the standard of care. (cancernetwork.com)
Treatment6
- 70% of women had primary LEPAND surgery before chemoradiotherapy with the remainder having primary treatment before surgery. (bmj.com)
- 67% of these women had primary LEPAND followed by chemoradiotherapy with the others proceeding straight to primary treatment prior to surgery. (bmj.com)
- Surgical treatment in palliative care. (icebe.es)
- It includes an entirely new section on the principles of treatment of significant polyps and early cancers and a total of 14 new chapters, including one on the early integration of palliative care. (icebe.es)
- Immunosuppression induced by a preoperative chemotherapeutic treatment can increase postoperative infections. (biomedcentral.com)
- Chemoradiotherapy (CRT) is an alternative treatment approach. (biomedcentral.com)
Systemic1
- Stage IV - Systemic chemotherapy with palliative/supportive care for patients with ECOG performance score of 2 or less and palliative/supportive care only for patients with ECOG performance score of 3 or more. (medscape.com)
Routine1
- Improvement might be expected from optimized preoperative imaging, routine MDT discussions, and further specialization and centralization of care. (jnccn.org)
Patient2
- The Commissioner also recommended that SDHB consider instigating a process where if a patient presents to ED but is an existing patient under the active care of another specialty, that specialty be informed during the presentation or at discharge. (hdc.org.nz)
- Owing to methodological limitations and considerable heterogeneity of the included patient groups, the existing data are insufficient to support or refuse any recommendation regarding cessation advice for patients during the immediate preoperative phase. (thieme-connect.de)
Outcomes1
- Despite the relatively good outcomes conferred by state-of-the-art chemoradiotherapy, further improving disease control and reducing toxicity has proven challenging. (bvsalud.org)
Palliative1
- Join us April 22nd for the 2023 Spring Update which highlights Palliative Oncology and Geriatric care. (bccancer.bc.ca)
Supportive care2
- Faithfull, S. and M. Wells, Supportive care in radiotherapy. (edcan.org.au)
- Unfortunately, the literature lacks supportive care guidelines specific to pain management in these patients. (oncnursingnews.com)
Response1
- Personnel and Lone Worker - Stay up to date with your staff in the field meet your duty of care to personnel including lone workers improve response times and efficiency. (tuladobueno.com)
Results1
- Based on these results, the use of preoperative DCF therapy for advanced ESCC has been increasing. (biomedcentral.com)
Radiation therapy1
- All patients received preoperative pelvic radiation therapy of 50.4 Gy over five-and-a-half weeks, with 45 Gy delivered in 25 fractions (1.8 Gy per fraction, five fractions per week for five weeks) and a boost of 5.4 Gy in three fractions. (appliedradiationoncology.com)
Higher2
- A concomitant boost to oxalipatin-combined preoperative chemoradiotherapy demonstrated a slightly higher pCR rate but delayed incision healing after surgery. (biomedcentral.com)
- 6, higher likelihood of Sick Newborn Care Unit admission and neonatal death. (who.int)