• Lymphocytes
  • While the expression of these chemokines has been identified in a variety of cell types in the mouse, little is known about their expression with murine B-lymphocytes. (biomedcentral.com)
  • Some chemokines control cells of the immune system during processes of immune surveillance, such as directing lymphocytes to the lymph nodes so they can screen for invasion of pathogens by interacting with antigen-presenting cells residing in these tissues. (wikipedia.org)
  • mediate
  • Moreover, the potential relevance of these findings is supported by the poor ability of LPS-activated aged B cells to specifically mediate CXCL1-dependent leukocyte recruitment when compared to younger B cells. (biomedcentral.com)
  • The chemokine GRO-α (CXCL1) has been found to mediate the proliferation of glia progenitor cells during neural development. (oup.com)
  • ELISA
  • The rectal release of GRO-α and MIG was determined by enzyme-linked immunosorbent assay (ELISA), and tissue expression of the chemokines was detected in colonic tissue by immunohistochemistry. (diva-portal.org)
  • mice
  • An initial study in mice showed evidence that CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function. (wikipedia.org)
  • known
  • In addition to being known for mediating chemotaxis, chemokines are all approximately 8-10 kilodaltons in mass and have four cysteine residues in conserved locations that are key to forming their 3-dimensional shape. (wikipedia.org)
  • These are known as homeostatic chemokines and are produced and secreted without any need to stimulate their source cell(s). (wikipedia.org)
  • expression
  • Materials and methods The expression of CXC-chemokines was studied in eight controls and in 11 patients suffering from ulcerative colitis in the distal part of the colon, before and during topical treatment with corticosteroids. (diva-portal.org)
  • important
  • Conclusions CXC-chemokines are likely to be important in the pathophysiology of ulcerative colitis and may become targets for novel treatment strategies. (diva-portal.org)
  • found
  • Chemokines are found in all vertebrates, some viruses and some bacteria, but none have been described for other invertebrates. (wikipedia.org)