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Spectrometry, Mass, Electrospray IonizationMass SpectrometryPhenindioneTandem Mass SpectrometryChromatography, LiquidChromatography, High Pressure LiquidSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationGas Chromatography-Mass SpectrometryAir IonizationMolecular StructureIonsCyclotronsMolecular Sequence DataGasesCalibrationAtmospheric PressureAmino Acid SequenceClick ChemistrySpectrometry, Mass, Fast Atom BombardmentFourier AnalysisSpectrometry, Mass, Secondary IonGlycerophospholipidsReference StandardsReproducibility of ResultsDeuteriumIndicators and ReagentsSensitivity and SpecificityProteomicsPeptidesComplex MixturesCarbohydrate SequenceLimit of DetectionElectrophoresis, CapillaryChemistry, ClinicalIsomerismSolid Phase ExtractionModels, ChemicalMagnetic Resonance SpectroscopyNanotechnologySolventsDeuterium Exchange MeasurementProteinsHydrogen-Ion ConcentrationMicrochemistryProteomePeptide MappingSolutionsModels, MolecularChemistry, OrganicMyoglobinSpectroscopy, Fourier Transform InfraredOligosaccharidesHydrogenSubstance Abuse DetectionElectrophoresis, Gel, Two-DimensionalMolecular WeightOxidation-ReductionChemistry Techniques, AnalyticalMetabolomicsMetals, AlkaliPeptide FragmentsChromatography, Reverse-PhaseExplosive AgentsTrypsinFlame IonizationProtein ConformationBenzyl AlcoholsSpectrophotometry, UltravioletStereoisomerismElectrochemistryPolysaccharidesAcetonitrilesMolecular ConformationMetalsForensic SciencesHydrolysisCrown EthersKineticsCarbohydrate ConformationIsotope LabelingCapillary ActionDrug StabilityProtein BindingBinding SitesCattlePlasmalogensChromatography, Thin LayerAnalytic Sample Preparation MethodsOligonucleotidesChemistryGlycosylationBlood Chemical AnalysisGlycerylphosphorylcholineLipidsPhospholipidsChemistry, PhysicalDisulfidesSulfoglycosphingolipidsMethanolCysteine
Desorption electrospray ionization massTime-of-flight maTandemSpectroscopyChromatographySecondary electrospray ionizationQuadrupole mass spectrometryTriple-quadrupole mass spectrometerAmerican Society forAerosolTrapSpectrometerUses electrosprayNano electrosprayChemical CompoundsSpectrometric2018CompoundsAnalyticalMatrix-Assisted LCapillaryDESIDepartment of ChemisComplexesDetectionSynthesisInstrumentation2002ProteinPeptideAnalytes2021LiquidAnalysisAtmosphericMethodMetabolomicsStructuralImagingMechanism2017JournalFactorsQuantitative
Desorption electrospray ionization mass3
  • Desorption electrospray ionization mass spectrometry (DESI-MS) is a recent and important advance in the field that has extensive applications in surface analysis of solid samples but has also been extended to analysis of liquid samples. (njit.edu)
  • By utilizing a cutting-edge technique called desorption electrospray ionization mass spectrometry imaging (DESI-MSI), they have identified diacylglycerols as potent biomarkers for the rapid detection of breast cancer. (chromatographyonline.com)
  • Desorption electrospray ionization mass spectrometry (DESI-MS) is a powerful method for generating ions at ambient conditions without the need for sample preparation or pretreatment. (nova.edu)
Time-of-flight ma2
  • Addition of 0.1% CYMAL-5 (final concentration) during trypsin treatment was compatible with both matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) and liquid chromatography/tandem mass spectrometry (LC/MS/MS) analysis, and gave a better digestion efficiency than n-octylglucoside, which we previously reported. (nih.gov)
  • Trapped ion mobility spectrometry (TIMS) combined with quadrupole time of flight mass spectrometry (Q-TOF). (lu.se)
Tandem12
  • Gas chromatography/mass spectrometry, liquid chromatography/tandem mass spectrometry, clinical chemistry analysis, dual-energy X-ray absorptiometry, and 16S pyrosequencing were used to characterize blood metabolic, clinical, and fecal microbiome systems, respectively. (hindawi.com)
  • The common derivatization method of primary amino groups by 2,4,6-trinitrobenzene sulfonate (TNBS) was applied to the detection of free adducts of advanced glycation end-products (AGEs), in combination with liquid chromatography-tandem mass spectrometry-multiple reaction monitoring (LC-MS/MS-MRM). (elsevierpure.com)
  • The analyte ions of interest were guided into an ion trap mass spectrometer for tandem mass analysis. (elsevierpure.com)
  • Tandem mass spectrometry was used to confirm the identification of important compounds in each aerosol drug sample. (elsevierpure.com)
  • Our data demonstrate that nanoEESI tandem mass spectrometry is a fast and sensitive technique for the analysis of aerosol drug preparations, showing promising applications in pharmacology studies and in situ analysis of aerosol drugs on the market. (elsevierpure.com)
  • The levels of oilfield chemicals entering the marine environment via this route were investigated using electrospray ionisation tandem mass spectrometry (ESI-MS/MS) and wet chemical analysis techniques. (hw.ac.uk)
  • Tandem quadrupole mass spectrometry HPLC-ESI-MS/MS CID-MS/MS Multiple reaction monitory (MRM) Quercetin Apigenin Kaempferol a b s t r a c t The presence of three flavonols (quercetin, kaempferol, myricetin) and two flavones (apigenin, luteolin) were investigated in the extract of fresh spinach leaves. (utc.fr)
  • Furthermore, the results were confirmed by HPLC coupled to an electrospray ionisation tandem triple-quadrupole mass spectrometer ESI-MS performing low-energy collision induced dissociation (CID-MS/MS) in the collision cell (HPLC-ESI-MS/MS). Analyses were made in the multiple reaction monitory (MRM) mode. (utc.fr)
  • Heterocyclic aromatic amines in urine are measured by an isotope-dilution high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (ID HPLC-ESI MS/MS). For "total" HCAA assays, the urine samples are fortified with internal standards (ISTD), and hydrolyzed in basic condition at 70°C for 5 hours. (cdc.gov)
  • A high-performance liquid chromatography-tandem mass spectrometric (HPLC-MS-MS) method is presented and evaluated for the determination of S-benzylmercapturic acid (S-BMA) and S-phenylmercapturic acid (S-PMA) in human urine. (cdc.gov)
  • This disadvantage can be overcome by coupling ESI with tandem mass spectrometry (ESI-MS/MS). Another important advantage of ESI is that solution-phase information can be retained into the gas-phase. (cannaqa.wiki)
  • Zhang Y, Wang Q, Zhang G, Jia W, Ren Y, Wu Y. Biomarker analysis of hemoglobin adducts of acrylamide and glycidamide enantiomers for mid-term internal exposure assessment by isotope dilution ultra-high-performance liquid chromatography tandem mass spectrometry. (cdc.gov)
Spectroscopy2
  • Modern analytical techniques have been applied in structural characterization of ARPs, such as circular dichroism, infrared spectroscopy, fluorescence spectroscopy, mass spectrometry, and nuclear magnetic resonance (NMR) spectroscopy [ 12 ]. (hindawi.com)
  • It was isolated and characterized as Na2[WVI2O6(C4O3NH10)2]·6H2O by single-crystal and powder X-ray diffraction, FT-IR spectroscopy, thermogravimetrical analysis (TGA), and elemental analysis in solid state and by electro-spray ionization mass spectrometry (ESI-MS), 13C, and 183W NMR, as well as Raman spectroscopy in solution. (lu.se)
Chromatography8
  • The analysis of protein hydrolysates using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) can be complex. (springer.com)
  • A sensitive and accurate high performance liquid chromatography-mass spectrometric (HPLC-MS) method for the intracellular determination of 14 antiretroviral drugs in peripheral blood mononuclear cells (PBMCs) for HIV+ patients was validated. (unito.it)
  • An optimized method using liquid chromatography coupled with electrospray ionization ion trap mass spectrometry (LC/ESI-ITMS) in negative ion mode has been developed for screening different structural classes of intact glucosinolates in six Chinese medicinal herbs. (unboundmedicine.com)
  • We also present a novel method for characterization of the materials using liquid chromatography mass spectrometry to quantify the analytes of interest. (cdc.gov)
  • We describe a novel method to measure petroleum distillates in BAL fluid using gas chromatography-mass spectrometry (GC/MS). METHODS: n-Hexane, n-heptane, n-octane, methylcyclopentane, and cyclohexane were measured in BAL fluid specimens by headspace solid-phase microextraction/gas chromatography/mass spectrometry. (cdc.gov)
  • Gas chromatography in combination with chemical ionization and electron ionization and liquid chromatography in combination with electrospray ionization, atmospheric pressure chemical ionization and atmospheric pressure photo ionization will be covered. (lu.se)
  • Practical parts include analysis of own or supplied samples by chromatography and mass spectrometry, with subsequent data analysis and identification of sample components. (lu.se)
  • Gas chromatography mass spectrometry is also available for the analysis of volatile compounds, as well as a state-of-the-art pipetting robot for automated sample preparation. (lu.se)
Secondary electrospray ionization2
  • Laser ablation electrospray ionization (LAESI) is an ambient ionization method for mass spectrometry that combines laser ablation from a mid-infrared (mid-IR) laser with a secondary electrospray ionization (ESI) process. (wikipedia.org)
  • Here, secondary electrospray ionization ultrahigh-resolution mass spectrometry is used to obtain real-time measurements of VOCs formed during the heterogeneous reaction of gas phase NO 2 and a solution containing gallic acid as a model for moderately acidic aerosol particles. (nature.com)
Quadrupole mass spectrometry1
  • Chromatographic separations were performed using a gradient program with a mixture of water (0.05% formic acid), as mobile phase A and acetonitrile (0.05% formic acid), as mobile phase B. Analytes quantification was performed by electro-spray ionisation-single quadrupole mass spectrometry using the selected ion recording (SIR) detection mode. (unito.it)
Triple-quadrupole mass spectrometer1
  • This sensitive and robust triple quadrupole mass spectrometer is used for analysis of low (ppb) levels of environmental compounds and biomarkers. (lu.se)
American Society for2
Aerosol7
  • Heterogeneous reaction of NO 2 with atmospheric humic like substances is a potentially important source of volatile organic compounds, but the role of ubiquitous water-soluble aerosol components in this chemistry remains largely unexplored. (nature.com)
  • A novel sensitive method utilizing nano extractive electrospray ionization mass spectrometry (nanoEESI-MS) has been developed for the rapid analysis of aerosol drug samples with quantitative information. (elsevierpure.com)
  • Without any sample pretreatment, aerosol drugs were manually sprayed into the primary ion plume created by a nano electrospray emitter for direct ionization under ambient conditions. (elsevierpure.com)
  • Roach received his Ph.D. in 2009, shortly before joining PNNL to work in developing EMSL's desorption electrospray ionization (DESI) mass spectrometry facility for application to study aerosol chemistry. (pnnl.gov)
  • Electrospray ionization ( ESI ) is a technique used in mass spectrometry to produce ions using an electrospray in which a high voltage is applied to a liquid to create an aerosol . (cannaqa.wiki)
  • The liquid containing the analytes of interest is dispersed by electrospray , [16] into a fine aerosol. (cannaqa.wiki)
  • [18] The aerosol is sampled into the first vacuum stage of a mass spectrometer through a capillary carrying a potential difference of approximately 3000 V, which can be heated to aid further solvent evaporation from the charged droplets. (cannaqa.wiki)
Trap6
  • Electrospray ionization-ion trap mass spectrometry for structural analysis of complex N-linked glycoprotein oligosaccharides. (consensus.app)
  • Electrospray ionization-ion trap mass spectrometry effectively reveals the structural characterization of complex N-linked glycoprotein oligosaccharides, enabling detailed analysis of their linkages and structures. (consensus.app)
  • Electrospray ionization-ion trap mass spectrometry, with its capacity to perform multiple stages of fragmentation (MSn), is demonstrated as an effective method for the structural characterization of permethylated N-linked complex glycoprotein oligosaccharides. (consensus.app)
  • Using ion trap mass spectrometry, removal of these substituents permits determination of branching patterns and intersaccharide linkages by MS3 and MS4. (consensus.app)
  • Higher-order experiments further illustrate the potential of electrospray ionization-quadrupole ion trap mass spectrometry for carbohydrate analysis, as MS8 is used to produce significant and otherwise unobtainable branching information for an oligosaccharide from chicken ovalbumin. (consensus.app)
  • These studies constitute further evidence of the unique role that ion trap mass spectrometry can assume in the area of oligosaccharide analysis. (consensus.app)
Spectrometer3
  • In summary, metabolites from each blood sample were extracted and analyzed by GC/MS (Thermo Fischer, DSQ mass spectrometer) and LC/MS (Thermo Fischer, LTQ mass spectrometers). (hindawi.com)
  • DESI mass spectrometry bombards a sample with a jet of charged droplets that desorb and ionize analyte molecules, which are then picked up by the mass spectrometer for analysis. (pnnl.gov)
  • It involves the use of a high-energy spray of charged solvent droplets that desorb and ionize molecules from the sample, which are then transferred into a mass spectrometer for analysis. (chromatographyonline.com)
Uses electrospray1
  • The chromatographic analysis consists of a reversed-phase gradient system, which uses electrospray ionization in negative-ion mode with a triple-quadrupole mass spectrometric detector. (cdc.gov)
Nano electrospray1
  • His technique improved the speed and spatial resolution of DESI by adding a second capillary that turns molecules dissolved in the deposited liquid into ions by nano-electrospray ionization. (pnnl.gov)
Chemical Compounds1
  • Sigman, M. E. "Major chemical compounds in the Ignitable Liquids Reference Collection and Substrate databases", Forensic Chemistry ( 2017 ) Vol. 5, p91-108. (ucf.edu)
Spectrometric3
  • The electrospray ionisation mass spectrometric behaviour of various complexes of beryllium have been investigated in this thesis. (waikato.ac.nz)
  • In this study, we describe a liquid chromatographic /mass spectrometric method with a simple column switching technique to determine diastereomeric flurbiprofen acyl glucuronides in human urine specimens. (elsevierpure.com)
  • Mass spectrometry for small molecules includes an overview of mass spectrometric techniques that can be used for analysis of low molecular weight analytes in both the gas and liquid phase. (lu.se)
20181
  • Sigman, M. E. "Model-effects on likelihood ratios for fire debris analysis", Forensic Chemistry ( 2018 ) Vol. 7, p38-46. (ucf.edu)
Compounds2
  • Because the ion formation involves extensive solvent evaporation (also termed desolvation), the typical solvents for electrospray ionization are prepared by mixing water with volatile organic compounds (e.g. methanol [17] acetonitrile). (cannaqa.wiki)
  • Routine work includes determination of molecular formula and accurate mass with an accuracy of ± 1 mDa of compounds with m/z up to 3000 mDa. (lu.se)
Analytical4
  • Analytical Chemistry. (wikipedia.org)
  • Cedric received his master's degree in Analytical Chemistry from Purdue University (2002) and his Juris Doctorate from Indiana University School of Law-Indianapolis (2005). (cornell.edu)
  • Analytical Chemistry , 85 (9), 4289-4295. (elsevierpure.com)
  • In a pioneering study published in Analytical Chemistry , researchers from Sri Venkateswara Institute of Medical Sciences and the Indian Institute of Science Education and Research have made significant progress in the field of breast cancer diagnosis (1). (chromatographyonline.com)
Matrix-Assisted L1
  • ESI is different from other ionization processes (e.g. matrix-assisted laser desorption/ionization (MALDI)) since it may produce multiple-charged ions, effectively extending the mass range of the analyser to accommodate the kDa-MDa orders of magnitude observed in proteins and their associated polypeptide fragments. (cannaqa.wiki)
Capillary2
  • An L-shaped capillary was adopted as the interface of the droplet array and ESI-MS , using its inlet end as a sampling probe for droplets and its outlet with a tip size of ∼20 μm as an electrospray emitter, without the need for any droplet extraction device. (rsc.org)
  • The liquid sample DESI typically employs a piece of fused silica capillary to transfer liquid sample for ionization. (njit.edu)
DESI1
  • Cedric is currently a PhD Candidate at Purdue University Department of Chemistry (R. Graham Cooks, advisor) focused on cancer diagnosis by desorption electrospray ionization (DESI) mass spectrometry imaging. (cornell.edu)
Department of Chemis3
  • The idea to pursue the research began in January 2011 when Van Ryswyk visited Carleton's Department of Chemistry as an external reviewer. (hmc.edu)
  • Course organizer Peter Spégel Center for Analysis and Synthesis Department of Chemistry Lund University course gives theoretical and practical knowledge on how mass spectrometry can be used in qualitative and quantitative analyses of small molecules. (lu.se)
  • The Department of Chemistry offers a range of general doctoral courses. (lu.se)
Complexes1
  • The key aim of this project was to develop the concept of electrospray-friendly ligands as a new ionisation method for the analysis of neutral metal complexes by electrospray mass spectrometry (ESMS). (waikato.ac.nz)
Detection3
  • This paper describes a multifunctional semi-closed droplet-array chip coupled with electrospray ionization mass spectrometry ( ESI-MS ) detection for multiple sample pretreatment and analysis. (rsc.org)
  • 1000 for methylglyoxal-derived hydroimidazolone) with a detection limit of 1.0 nM (10 fmol/injection volume), which was due to the high ionization efficiency of the derived trinitrophenol moiety and its hydrophobicity. (elsevierpure.com)
  • In this publication we report on the development of a quantitative enzymatic method for the detection of four botulinum neurotoxin (BoNT) serotypes responsible for human botulism by MALDI-TOF mass spectrometry. (cdc.gov)
Synthesis2
  • We currently welcome submissions to Collections on On-surface synthesis, Coacervation in systems chemistry, Chemoenzymatic synthesis, Plasmon-mediated chemistry, and Mechanically interlocked molecules. (nature.com)
  • Maynard 2005, 2006 ), material synthesis (Nakaso that electrospray from a suspension of higher nanotube et al. (cdc.gov)
Instrumentation1
  • The emphasis is on understanding the fundamental processes involved, the instrumentation used, including different ionization sources and mass analyzers, and interpretation of generated data. (lu.se)
20022
  • [4] The development of electrospray ionization for the analysis of biological macromolecules [5] was rewarded with the attribution of the Nobel Prize in Chemistry to John Bennett Fenn and Koichi Tanaka in 2002. (cannaqa.wiki)
  • [13] [14] John Bennett Fenn was awarded the 2002 Nobel Prize in Chemistry for the development of electrospray ionization mass spectrometry in the late 1980s. (cannaqa.wiki)
Protein1
  • In their paper, titled "Examination and Manipulation of Protein Surface Charge in Solution with Electrospray Ionization Mass Spectrometry," the chemists describe SNAPP-MS-selective non-covalent adduct protein probing mass spectrometry-a technique that allows for the detailed examination of surface charges on proteins in solution. (hmc.edu)
Peptide1
  • Although mass spectrometry (MS) can be used to quantify proteins in a complex mixture, the quantitative information on the peptide-level is sparse. (aau.dk)
Analytes2
  • The award is presented in recognition of his 'insightful and creative contributions to the development of a novel ionization method' coupled with mass spectrometry-called NanoDESI-the development of application methodology for a broad range of analytes, according to Robby Robinson, chair of the EMSL selection committee. (pnnl.gov)
  • This course covers modern mass spectrometry with a particular focus on the analysis of low molecular weight analytes. (lu.se)
20213
  • Sigman, M. E. "Classification of ground-truth fire debris samples using artificial neural networks" Forensic Chemistry ( 2021 ) Vol. 23. (ucf.edu)
  • Wood, T. "Validation of ground truth fire debris classification by supervised machine learning", Forensic Chemistry ( 2021 ) Vol. 26. (ucf.edu)
  • Communications Chemistry has a 2-year impact factor of 7.211 (2022), and mean decision times of 3 days to first editorial decision and 31 days to first post-review decision (2021). (nature.com)
Liquid2
  • Sigman, M. E. "Biodegradation of representative ignitable liquid components on soil", Forensic Chemistry ( 2017 ) Vol. 6, p19-27. (ucf.edu)
  • Diagram of electrospray ionization in positive mode: under high voltage, the Taylor cone emits a jet of liquid drops. (cannaqa.wiki)
Analysis4
  • Sigman, M. E. "Application of likelihood ratios and optimal decision thresholds in fire debris analysis based on a partial least squares discriminant analysis (PLS-DA) model", Forensic Chemistry ( 2019 ) Vol. 16. (ucf.edu)
  • Cedric thesis research is using multivariate statistical analysis of mass spectra to statistically differentiate cancer and non-cancerous tissue in dog bladder cancer (urothetial cell carcinoma, aka transitional cell carcinoma "TCC") and human oral squamous cell carcinoma. (cornell.edu)
  • These results demonstrate that pDESI-MS offers the potential to transform current approaches for implementing spray-based ambient ionization techniques in chemical analysis and imaging. (nova.edu)
  • For accurate quantitative or qualitative analysis, mass spectrometry is today combined with different chromatographic techniques. (lu.se)
Atmospheric2
  • Van Ryswyk, whose research focuses on solar energy conversion, and Gross, whose expertise is in atmospheric chemistry, had mutual interest in the novel ESI-MS technique and decided to team up on the research. (hmc.edu)
  • Ionisation modes include electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI). (lu.se)
Method2
  • Interpretation of mass spectra and data treatment will also be covered, together with practical aspects of mass spectrometry method development. (lu.se)
  • HiPCOTM) process are difficult to aerosolize, in the reported the generation of SWCNT particles using nanometer size range, directly from the powder phase electrospray method. (cdc.gov)
Metabolomics1
Structural1
  • This can be advantageous in the sense that the molecular ion (or more accurately a pseudo molecular ion) is almost always observed, however very little structural information can be gained from the simple mass spectrum obtained. (cannaqa.wiki)
Imaging4
Mechanism1
  • Because molecules and aerosols are ionized by interacting with an electrospray plume, LAESI's ionization mechanism is similar to SESI and EESI techniques. (wikipedia.org)
20171
  • Sigman, M. E. "Investigative probabilistic inferences of smokeless powder manufacturers utilizing a Bayesian network", Forensic Chemistry (2017) Vol. 3, p41-51. (ucf.edu)
Journal2
Factors1
  • This data, other figures of merit and other factors, such as ion suppression of the electrospray ionization source, are discussed. (cdc.gov)
Quantitative1
  • Sequential window acquisition of all theoretical fragment ion spectra (SWATH) is a label-free mass spectrometry quantitative technique, which can retain complete fragment ion data and has good accuracy as well as reproducibility. (ncl.edu.tw)