• TOXICITY
  • IPBC Toxicity and Safety Tests show it to be generally safe: When used properly in leave-on skin products, IPBC is extremely safe [Steinberg, (wikipedia.org)
  • Previous to being approved for cosmetic use in 1996, extensive safety and toxicity tests were conducted on IPBC and their results were gathered along with earlier studies in a report of the Safety Assessment of IPBC by the Cosmetic Ingredient Review [CIR Final Report, Lanigan (wikipedia.org)
  • bergamot
  • Generally adulteration is to "cut" the oil, i.e. adding distilled essences of poor quality and low cost, for example of bitter orange and bergamot mint and/or mixtures of terpenes, natural or synthetic, or "reconstruct" the essence from synthetic chemicals, coloring it with chlorophyll. (wikipedia.org)
  • Natural source analysis based on the Carbon-14 method can identify adulterated essences by detecting synthetic chemicals manufactured from petroleum that are used to mimic the chemical profile of bergamot oil and other essential oils. (wikipedia.org)
  • In several studies, application of some sources of bergamot oil directly to the skin via patch test was shown to have a concentration-dependent phototoxic effect of increasing redness after exposure to ultraviolet light (due to the chemical bergapten, and possibly also citropten, bergamottin, geranial, and neral). (wikipedia.org)
  • dermatology
  • Methods: In preparations from 12 dermatology departments and two suppliers of patch-test allergens, we determined the isocyanate content as the isocyanate-dibutylamine derivative, using liquid chromatography and mass spectrometry. (lu.se)
  • include
  • Product manufacturers can change their formulas and include different chemicals - and they may not be required to tell you about it. (emaxhealth.com)
  • recognize
  • When the skin is again exposed to the antigen, the memory t-cells in the skin recognize the antigen and produce cytokines (chemical signals), which cause more T-cells to migrate from blood vessels. (wikipedia.org)
  • concentration
  • Most human patch tests performed before 2004 were with 0.1% IPBC solutions, i.e. 10 times the concentration used in many cosmetic products. (wikipedia.org)
  • In 2004, it was suggested that a better concentration for tests of this substance would be 0.2% [Brasch et al. (wikipedia.org)
  • substance
  • Cobalt chloride has been classified as a substance of very high concern by the European Chemicals Agency as it is a suspected carcinogen. (wikipedia.org)
  • Cobalt chloride is a banned substance under the Australian Thoroughbred Racing http://www.chemindustry.com/chemicals/0519906.html. (wikipedia.org)
  • A patch test is a method used to determine whether a specific substance causes allergic inflammation of a patient's skin. (wikipedia.org)
  • physical
  • It is not feasible to provide a meaningful opinion without taking additional history, physical examination and may be some tests. (healthtap.com)
  • Studies done in the last decade have shown that itch can be inhibited by many other forms of painful stimuli, such as noxious heat, physical rubbing/scratching, noxious chemicals, and electric shock. (wikipedia.org)