Chemical drugs amines. Medical search. Frequent questions

in other words, this chemical class includes derivative compounds that are formed by replacing one or more hydrogen atoms in the phenethylamine core structure with substituents. (wikipedia.org)
An emergent approach to new drug development is drug repurposing, in which compounds that have already gone through some level of clinical testing are examined for efficacy against diseases divergent than their original application. (biomedcentral.com)
Drug repurposing jumpstarts the drug development process by using compounds that have already gone through some level of clinical testing, rather than attempting to create new unproven drugs. (biomedcentral.com)
Certain amines, chemical compounds derived from ammonia, have been shown to cause visual symptoms, such as blurred or hazy vision in both an industrial and laboratory settings. (cdc.gov)
Amines are chemical compounds typically used as solvents, preservatives, drugs, or herbicides-or in the case of the label production plant, as part of the ink and ink additive. (cdc.gov)
HILIC applications are particularly central in the chemical and biochemical research fields where polar compounds with a low-to-medium molecular mass are the subjects of analysis. (news-medical.net)
Food Industry - to detect food contaminants, marine biotoxins, small polar compounds and biogenic amines (this produced by organisms). (news-medical.net)
Biogenic amines, such as histamine and tyramine, are compounds formed during the course of desired or undesired microbial fermentation of food or as a consequence of food spoilage. (survivingantidepressants.org)
QUATERNARY AMMONIUM COMPOUNDS International Programme on Chemical Safety Poisons Information Monograph G022 (Group PIM) Chemical 1. (inchem.org)
The quaternary ammonium compounds show a variety of physical, chemical, and biological properties and most compounds are soluble in water miscible solvents. (inchem.org)
Target-focused compound libraries have been a key enabling component of the tool kit opening up kinase drug discovery, consisting of collections of compounds designed to interact with a family of related kinase targets (4). (ddw-online.com)
Such libraries are used for screening against therapeutic targets in order to find hit compounds that may be further developed into drugs and/or used as research tools to better understand the underlying biology and its relevance to pharmacological intervention. (ddw-online.com)
However, computational methods for the selection of molecules for drug discovery are constantly evolving and new approaches are now available that can assist the medicinal chemist in selecting new compounds for library synthesis. (ddw-online.com)
These are organic compounds containing an primary aliphatic amine group. (drugbank.com)
The International Agency for Research on Cancer (IARC) is pleased to announce that the IARC Monographs volume on some aromatic amines and related compounds is now available online. (who.int)
The physico-chemical parameters of the synthesized compounds were determined, their structure was confirmed by the methods of elemental analysis, IR spectroscopy method, 1 H and 13 С NMR. (akj.az)
In 2000, List used the amino acid proline to catalyse a Mannich reaction - which combines a carbonyl, an aldehyde, and an amine compound to produce β-amino carbonyl compounds, and is used widely in the synthesis of biologically active molecules, including medicinal drugs. (nature.com)

Glucuronidation removes several toxic and potentially toxic chemicals from our system, such as polycyclic aromatic hydrocarbons, steroid hormones, some nitrosamines, heterocyclic amines, some fungal toxins, and aromatic amines. (wikidoc.org)
The condensation of 1-phenoxy-3-propylthiopropan-2-ol with formaldehyde and secondary aliphatic, as well as heterocyclic amines, has led to the formation of new aminomethoxy derivatives of 1-phenoxy-3-propylthiopropane with 69-77% yields. (akj.az)

Certain foods naturally contain high levels of histamine, tyramine and/or other biogenic amines. (survivingantidepressants.org)
Spoiled food and the associated bacterial breakdown are a common source of biogenic amines. (survivingantidepressants.org)
The biogenic amines, once formed, are not destroyed by heating or re-cooling. (survivingantidepressants.org)

In this PHA, ATSDR scientists determined that current and future exposures to ORR site-related chemicals (individually or in combination) in soil, sediment, surface water, biota (other than fish), and air do not pose a public health hazard. (cdc.gov)
However, current and future exposures to ORR site-related chemicals in soil, sediment, surface water, biota, and air do not pose a public health hazard. (cdc.gov)
Exposure to a potential fetal health hazard can be estimated through ecological assessment (e.g., testing the community water supply), questionnaires (e.g., classifying residents accord- ing to whether they drink bottled or tap water), or biological markers (e.g., testing for exposures to chemicals or solvents found in tap water). (cdc.gov)

A stimuli-responsive fluorophore, encompassing a Lewis acid-base pair, binds to primary amines on mesoporous silica nanoparticles, which may serve as environment-sensitive drug carriers. (rsc.org)

Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. (wikipedia.org)
Aldehydes are reactive parts of a chemical compound that are commonly found in flavors such as vanilla, citrus, and cinnamon. (bakeryandsnacks.com)

Cytochrome P450 enzymes (including enzyme isoforms (forms of cytochrome P450 enzymes with differing substrate specificities)) account for over 95% of oxidative drug metabolism. (pharmacology2000.com)
Monoamine oxidase represents an important non-P450 enzyme that plays an important role in drug metabolism. (pharmacology2000.com)
CYP1, CYP2, and CYP3 represent cytochrome P450 families associated with drug metabolism. (pharmacology2000.com)
Individual forms of cytochrome P450 families have their own designation, such as CYP1A2, CYP2D6, and CYP3A4, all prominent drug metabolism cytochrome P450 isoforms. (pharmacology2000.com)
Buxton ILO Chapter 2: Pharmcokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimiation in Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14e, (Brunton LL H Knollmann BC, eds) McGraw-Hill Education, 2023. (pharmacology2000.com)
Gonzalez FJ Coughtrie M Chapter 5: Drug Metabolism in Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14e, (Brunton LL H Knollmann BC, eds) McGraw-Hill Education, 2023. (pharmacology2000.com)
Guengerich FP Chapter 4: Drug Metabolism in Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. (pharmacology2000.com)
Thank you for sharing this Drug Metabolism & Disposition article. (aspetjournals.org)
Message Body (Your Name) thought you would be interested in this article in Drug Metabolism & Disposition. (aspetjournals.org)
The evidence for the mechanisms of potentiation of peripheral effects of amines by mono-amine oxidase inhibitors, imipramine and amphetamine, is reviewed and the presence of multiple effects of single drugs on amine metabolism acknowledge. (survivingantidepressants.org)
L ike protein phosphorylation by kinases, protein ubiquitylation regulates many aspects of cell function and provides a wealth of drug target opportunities across many therapeutic areas including cancer, cardiovascular, metabolism, inflammation, neurodegeneration and infectious diseases. (ddw-online.com)

This enzyme oxidizes amine-containing chemicals such as catecholamines and tyramine. (pharmacology2000.com)

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. (lookchem.com)
Scalable, Green Synthesis of Heteroaromatic Amine-boranes" published in Organic Process Research & Development. (purdue.edu)
New amine-borane synthesis method published in Dalton Transactions. (purdue.edu)
Consequently, small-molecule drug discovery usually involves an iterative process of molecular design, chemical synthesis, biological assay and data analysis feeding directly into the next cycle, but this process always needs a chemical starting point. (ddw-online.com)
But simple organic molecules such as amino acids recently burst on the scene as a third class of inexpensive catalysts for reactions with enantiomer selectivity, which are required for drug synthesis. (nature.com)

Both are amines with a formal resemblance to well-known sympathomimetic substances. (bmj.com)
Phentermine belongs to the class of drugs known as sympathomimetic amines. (golf-suelfeld.com)

In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace amine-associated receptor 1 (TAAR1) and inhibiting vesicular monoamine transporter 2 (VMAT2) in monoamine neurons. (wikipedia.org)

Shivani presented her seminar on the "Development of Amine-boranes and Derivatives for Reductive Amination. (purdue.edu)

A class of indole alkaloid drugs/chemicals, many of which are psychoactive. (urbandictionary.com)

Heterocyclic aromatic amines (HAA) are environmental and food contaminants that are potentially carcinogenic for humans. (peerj.com)
Heterocyclic aromatic amines (HAA) are environmental and food contaminants that are formed during cooking of meat and fish, burning of tobacco and diesel exhaust ( International Agency for Research on Cancer, 1987 ). (peerj.com)

The selective reduction of nilutamide to its hydroxylamino derivative by the NOSs could explain some of the toxic effects of this drug. (mcmaster.ca)

The amine end is hydrophilic, and the aromatic end is lipophilic. (medscape.com)
Most local anesthetic agents share the same basic chemical structure, which consists of an aromatic ring, linked to an intermediate chain, linked to a hydrophilic amine segment. (medscape.com)

Methemoglobinemia may not resolve or may rebound after initial response to therapy with methylene blue in patients with methemoglobinemia associated with aryl amines (e.g., aniline) or sulfa drugs (e.g., dapsone). (drugs.com)

All local anesthetics have an intermediate chain linking an amine on one end to an aromatic ring on the other. (medscape.com)

The hypothesis is advanced that depressive illness occurs when the level of amines is reduced at reactive sites in the brain, and that anti-depressant drugs will be those which increase the levels of amines at these sites. (survivingantidepressants.org)
Benjamin List's group at the Max Planck Institute for Coal Research in Mülheim an der Ruhr, Germany, have managed to tame the highly reactive molecule and use it in the Mannich reaction (a process for forming carbon-carbon bonds), opening the door to a broad range of applications in drug design. (nature.com)

The result is a suite of drug candidates that often look very similar to one another, crowded into a tiny corner of the 'chemical space' that represents all possible molecules. (acs.org)
Titanium-Mediated Reduction of Carboxamides to Amines with Borane-Ammonia" published in Molecules. (purdue.edu)
Began work with Prof. Daleem to discover new anti-biotic drug molecules. (purdue.edu)
Many of these toxic and otherwise therapeutic substances (xenobiotics, drugs) disrupt the glucuronidation by impairing it, stopping it, or causing the binds to be rupture, separating the bound molecules from its inert transport. (wikidoc.org)

Although the widespread use of target-focused libraries has led to the rapid expansion of novel chemistry as research tools in drug discovery to exploit many classes of drug target, the ubiquitin system still remains a largely untapped medicinal chemistry opportunity. (ddw-online.com)

They react readily with acids, amines, alcohol metals, and other aldehydes, often resulting in undesirable effects such as browning. (bakeryandsnacks.com)

Medically reviewed by Drugs.com on Feb 8, 2023. (drugs.com)

Monotrifluoroacetoxyborane-amines as new chemoselective reagents for reductive aminations published in Chemical Communications. (purdue.edu)

Phenethylamine is a primary amine, the amino-group being attached to a benzene ring through a two-carbon, or ethyl group. (wikipedia.org)
The second pathway leads, via side chain degradation by N-dealkylation, to the corresponding primary amines (IV, V, and VI). (aspetjournals.org)

Small-molecule Peptide-Influenced Drug Repurposing (SPIDR) was developed to identify small molecule drugs that target a specific receptor by exploring the conformational binding space of peptide ligands. (biomedcentral.com)

This, glucuronidation represents a major means of converting most drugs, steroids, and many toxic and endogenous substances to metabolites that can then be excreted into the urine or bile. (wikidoc.org)
What Drugs, Substances, or Supplements Interact with Fludara? (rxlist.com)
Substances established by the European Directorate for the Quality of Medicines and Health Care, which is the custodian centre for International Chemical Reference Substances. (who.int)
They had optimized the reaction and were able to synthesize a newly approved anti-AIDS drug and several other biologically active substances. (nature.com)

Pharmaceutical drugs that are substituted phenethylamines include phenelzine, phenformin, and fanetizole, among many others. (wikipedia.org)
P rotein kinases, on the other hand, have become one of the most important classes of drug targets for the pharmaceutical industry over the last decade, following on from the exploitation of kinase-focused libraries for at least the last two decades. (ddw-online.com)
However, over the same period protein kinases have rapidly become one of the most significant classes of drug targets for the pharmaceutical industry, with the global market for kinase therapies being about US$15 billion per annum in 2010 and this value is predicted to double by 2020 (3). (ddw-online.com)
Research on protein kinases is now reported to account for approximately 30% of the drug discovery programmes in the pharmaceutical industry and more than 50% of cancer research and development (3). (ddw-online.com)
Exposure to these chemicals may occur variously through cigarette smoking, in industrial settings including manufacture of plastics, rubber, pharmaceutical drugs, and dyes and pigments used in consumer products such as paper and textiles, and via tattoo inks. (who.int)
List says pharmaceutical companies have already expressed an interest in this work and a number of researchers, including himself, are trying to use acetaldehyde in other types of chemical reactions. (nature.com)

The NIOSH evaluation concluded that DMIPA, an amine that more readily evaporates at room temperature, was likely the culprit in these vision problems. (cdc.gov)

Dömling says this is a particular problem in drug discovery, where researchers rely heavily on a small set of tried and true reactions and shy away from novel synthetic methods. (acs.org)
Chemical reactions that produce one enantiomer only were thought to be catalysed by either enzymes or heavy metals. (nature.com)
The biggest challenge was not really a technical or chemical one but rather having to give up the notion that it was impossible to use acetaldehyde in these types of reactions," he says. (nature.com)

In manufacturing these industrial chemicals, AAs are used as raw materials or intermediates, and therefore, they should not occur in the final products. (cdc.gov)
As such, occupational exposure to AAs can occur by inhalation or skin contact during the production of chemicals that use AAs as raw materials or intermediates. (cdc.gov)

Historically, only 1 in 10 drug candidates that enter clinical trials yields a marketable drug that is both highly effective and induces few if any undesirable side effects [ 1 , 2 ]. (biomedcentral.com)

The amine functional groups may be metabolized in the liver to the acetylated and / or glucuronidated forms, or they may be oxidized to a hydroxylamine form, which undergoes further conversion via an acetylation reaction to form a N-acetoxy metabolite. (cdc.gov)
Although all applications can be impacted, products containing functional or active ingredients are particularly susceptible as aldehydes may also inactivate enzymes, functional ingredients or drug actives. (bakeryandsnacks.com)

The major challenge in the oral drug delivery of poorly permeable drug is their transport across intestine [ 1 , 2 ]. (omicsonline.org)

Other drugs promote histamine release from immune cells, including some opioids, muscle relaxants, x-ray contrast media, as well as alcohol. (survivingantidepressants.org)

I want to get the latest chemistry news from C&EN in my inbox every week. (acs.org)
Is novel chemistry the final frontier for ubiquitin system drug discovery? (ddw-online.com)

An easy way to rememberwhich drug belongs in which category is that all of the amino amides contain the letter "i" twice, as does the term "amino amides. (medscape.com)
A simple way to help decipher which drug belongs to which class is to remember that the letter i appears twice in the spelling of the amino amides. (medscape.com)

For usual absorption of drug it is soluble then it will reach intestinal wall in dissolved state and later absorbed in gut membranes combining all above transport mechanisms. (omicsonline.org)

The structures of all of these metabolites were confirmed by chemical syntheses, which are described in this paper. (aspetjournals.org)

After taking workers' job and medical histories, performing eye examinations, taking air samples, reviewing the literature on visual effects associated with chemicals commonly found in printing and other industrial processes, and analyzing samples of the ink used at the plant, the investigators arrived at a plausible association between the workers' jobs and their symptoms. (cdc.gov)
Applying 0.025% capsaicin, the active chemical in capsicum, to the skin can improve symptoms of osteoarthritis. (medlineplus.gov)

Chemical structure of the 2 classes of local anesthetics, amino esters and amino amides. (medscape.com)
Both were first produced in Germany, rely largely on German animal and unsatisfactory clinical literature and have a certain similarity in chemical structure. (bmj.com)
These methods may also incorporate simple calculated properties, for example the so-called 'Rule of 5' (5) to ensure libraries stay within sufficiently druglike areas of chemical space as well as existing structure activity relationship data describing the interaction of the chemical matter with the principle biological target, as well as related targets. (ddw-online.com)
The reaction has also been used in the context of late-stage functionalization to reliably generate structure diversity with amine-containing drugs. (organic-chemistry.org)
The chemical structure of this intermediate group classifies the agent into the amide group or the ester group. (medscape.com)

This software contains an intuitive graphical interface for peptide mutant screening workflow and facilitates mapping, clustering, and searching of local molecular databases, making DockoMatic a valuable tool for researchers in drug design and repurposing. (biomedcentral.com)
However, most low-molecular-weight chemical sensitizers induce asthma through mechanisms that are poorly understood, despite a phenotype suggesting sensitization. (cdc.gov)

The drug-repurposing paradigm accounted for nearly 30% of United States Food and Drug Administration (FDA) approved drugs between 1999 and 2008 [ 6 ]. (biomedcentral.com)

Two factors govern the total oral absorption of drug i.e. drug's solubility and permeability across intestine. (omicsonline.org)

Poor oral bioavailability of BCS class 4 drug is due to poor aqueous solubility and poor permeability across intestine. (omicsonline.org)
Present work was undertaken to increase oral bioavailability of BCS class 4 drug i.e. (omicsonline.org)

Later additions to clinically available local anesthetics, namely ropivacaine and levobupivacaine, represent exploitation of the S enantiomer of these chemicals to create anesthetics that are less toxic, more potent, and longer acting. (medscape.com)

Some drugs also inhibit the action of these enzymes. (survivingantidepressants.org)

In this article, we propose that chemical libraries which target the ubiquitin system are the missing keys to unlock the therapeutic potential of ubiquitin system drug discovery. (ddw-online.com)

The mechanisms by wchich toxic effects are produced by single drugs and combination is examined. (survivingantidepressants.org)

Conventional de novo drug design is costly and time consuming, making it accessible to only the best resourced research organizations. (biomedcentral.com)

Minimize exposure to drugs with known renal toxicity during the 5 days of Clolar administration since the risk of renal toxicity may be increased. (guidelinecentral.com)

In passive mechanism, diffusion of drug through close junctions of epithelial cells occurs depending on its size and charge while in active transport, uptake of drug is mediated by carrier i.e. active proteins [ 3 - 5 ]. (omicsonline.org)

Anatomy6

Organisms10

Diseases2

Chemicals and Drugs130

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes49

Disciplines and Occupations8

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture10

Information Science5

Health Care12

Compounds17

Heterocyclic amines2

Biogenic3

Exposures3

Mesoporous silica1

Compound2

Metabolism11

Tyramine1

Synthesis5

Sympathomimetic2

Monoamine1

Derivatives1

Alkaloid1

Food contaminants2

Derivative1

Hydrophilic2

Aniline1

Intermediate chain1

Reactive2

Molecules4

Untapped medicinal1

Acids1

20231

Reagents1

Primary2

Small molecule1

Substances4

Pharmaceutical6

Readily1

Reactions3

Intermediates2

Undesirable1

Functional2

Delivery of poorly1

Alcohol1

Chemistry2

Belongs2

Soluble1

Metabolites1

Symptoms2

Structure5

Molecular2

19991

Absorption1

Class2

Enantiomer1

Enzymes1

Therapeutic1

Toxic effects1

Research1

Renal1

Occurs1