• However, as the efficacy and safety of rational dosing regimens are lacking, we evaluated the effectiveness and safety of reduced-dose azacitidine (AZA) vs. decitabine (DAC) in adult MDS patients. (medscimonit.com)
  • Average cosibelimab concentrations were very comparable between 800 mg Q2W and 1200 mg Q3W dosing regimens. (page-meeting.org)
  • Based on an exposure-response analysis performed on data from the same trial, the clinical impact of the identified covariate relationships as well as the clinical relevance of PK differences between the 800 mg Q2W and 1200 mg Q3W dosing regimens are considered negligible. (page-meeting.org)
  • The purpose of this study is to evaluate the dose-response relationship of antiviral activity after 48 weeks treatment with 3 different dose regimens of TMC278. (druglib.com)
  • More commonly, multidrug regimens incorporating drugs with different mechanisms of action and different toxicities are used to increase efficacy, reduce dose-related toxicity, and decrease the probability of drug resistance. (msdmanuals.com)
  • Multidrug regimens typically are given as repetitive cycles of a fixed combination of drugs. (msdmanuals.com)
  • The aim of the present study is to describe the exposure-response relationship between emicizumab concentrations and bleeding frequency, and to confirm adequate bleeding control of the investigated dosing regimens 1. (academic-accelerator.com)
  • We selected three of the reviewed dosing regimens for their pharmacokinetics (PK) characteristics and their exposure-response relationship in three gestational age groups of preterm neonates (28, 32 and 36 gestational age weeks) at risk for development of severe NAS (defined as an umbilical cord methadone concentration of ≤60 ng/mL, following fetal exposure). (academic-accelerator.com)
  • Even in this highly treatment-resistant population, statistically significant and clinically meaningful improvements in seizure frequency were observed following the addition of cannabidiol to existing antiepileptic drug regimens compared with placebo," the investigators report. (medscape.com)
  • Future studies should aim to characterize the relationship between different immunosuppressive regimens (combinations, doses), melanoma risk, incidence of metastatic disease, and survival. (medscape.com)
  • This open-label study of the pharmacokinetics of psilocybin was performed to describe the pharmacokinetics and safety profile of psilocybin in sequential, escalating oral doses of 0.3, 0.45, and 0.6 mg/kg in 12 healthy adults. (researchgate.net)
  • The pharmacokinetics of psilocin were linear within the twofold range of doses, and the elimination half-life of psilocin was 3 h (standard deviation 1.1). (researchgate.net)
  • The pharmacogenetic information contributing to interpatient variability in drug response and toxicity may be broadly classified into factors affecting drug pharmacokinetics and factors affecting pharmacodynamics ( Figure) . (ahdbonline.com)
  • Double-blind, Randomized, Placebo-controlled Study of the Efficacy, Safety/Tolerability, and Pharmacokinetic Profile of UCB0942 in Adults With Highly Drug-resistant Focal Epilepsy. (ucb.com)
  • Dose-response relationships are important in assessing the efficacy and potency of drugs, which can usually be characterized by a 4-parameter logistic (4-PL) model: EC50, slope, lower asymptote, and upper asymptote. (psiweb.org)
  • 2 Several such genetic alterations have been characterized in candidate genes encoding molecules important for pain transmission, which result in impaired function of these gene products to ultimately impact the efficacy and side effect profiles of several analgesics, thus defining the active field of pharmacogenomics in pain medicine. (ahdbonline.com)
  • A year later, a similar workshop was conducted that included biologics and nonclinical models for efficacy, as well as modeling and simulation for dose-finding and dose optimization trials design. (agencyiq.com)
  • In the new guidance document, the FDA outlines why the MTD strategy is particularly inappropriate for targeted therapies, which "demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the MTD may have similar efficacy to the MTD but with fewer toxicities," according to the guidance. (agencyiq.com)
  • Within the context of ever-possible overdose events, OUD is characterized by opioid-taking and opioid-seeking and evolves with expanding dysfunction in limbic-mesocorticostriatal circuitry. (nature.com)
  • There is a great opportunity to improve our basic science understanding of neuroimmune targets involved in response to opioid exposure. (nature.com)
  • Furthermore, our findings of fentanyl-induced CNS innate immune responses suggest that chronic opioid exposure may increase the onset and/or severity of neurocognitive disorders associated with viral brain infections via STING. (nature.com)
  • Opioid drug abuse and modulation of immune function: consequences in the susceptibility to opportunistic infections. (nature.com)
  • At the conclusion of this session the participant will be able to outline key talking points to communicate to a patient who has been prescribed opioid therapy, provide practical strategies to help motivate a patient's commitment to opioid therapy adjustment and apply a patient centered six-step process to minimize conflict when communicating opioid dosing recommendations. (cdc.gov)
  • and 3) the relationship of the results to exposure and/or potential disease. (cdc.gov)
  • Even if all of the methodological and toxicological questions can be answered, there are still great gaps in our knowledge as to the relationship between the concentration of a compound/element in hair and environmental exposure, and then between exposure and disease or reduced health status. (cdc.gov)
  • The exposure-molecular response relationship was described using a 4-state, discrete-time Markov model. (medworm.com)
  • Time-to-event models were used to characterize the relationship between exposure and arterial occlusive events (AOEs), Grade ≥3 neutropenia, and thrombocytopenia. (medworm.com)
  • Ponatinib exposure was a significant predictor of AOEs (hazard ratio 2.05 [95%CI, 1.43-2.93] 15-mg dose increase). (medworm.com)
  • In the exposure-safety models for neutropenia and thrombocytopenia, exposure was a significant predictor of Grade ≥3 thrombocytopenia (hazard ratio 1.31 [95%CI, 1.05-1.64] 15-mg dose increase). (medworm.com)
  • This mechanism of action does not explain why, in the clinical setting, carboplatin dosing based on patient renal function over-estimates the carboplatin dose required for target carboplatin exposure. (biomedcentral.com)
  • Simulation of fixed doses using the pharmacokinetic parameters suggest that an oral dose of 25 mg should approximate the drug exposure of a 0.3 mg/kg oral dose of psilocybin. (researchgate.net)
  • The exposure-response relationships were assessed. (academic-accelerator.com)
  • The exposure-response relationship between the daily average temperature and the hospital admission of adult CAP patients was quantified by using a distributed lag non-linear model. (academic-accelerator.com)
  • Many of the OADs exert an exposure-response relationship but still, a 'one-size fits-all' dose is used, ignoring interindividual variability. (academic-accelerator.com)
  • The exposure-response relationships for changes in both annualized growth velocity and the CXM biomarker saturated at 15 μg/kg, while systemic pharmacological activity, as measured by urinary cGMP, was near maximal or saturated at exposures obtained at the highest dose studied (i. (academic-accelerator.com)
  • Although greater and more sustainable B‐cell depletion was observed with higher exposure, inherent limitations to the data (use of one dose level, and time‐dependent and target‐impacted PKs) prevented reliable assessment of exposure-response relationships. (academic-accelerator.com)
  • We estimated exposure-response relationships using indoor air concentrations of two carcinogens in CCE relevant to lung cancer, 5‐methylchrysene (5MC), and benzo[a]pyrene (B[a]P). (academic-accelerator.com)
  • We aimed to analyze the UST exposure-response relationship in CD treatment in the real-world setting. (academic-accelerator.com)
  • An article from NIOSH researchers entitled "Health effects from unintentional occupational exposure to opioids among law enforcement officers: Two case investigations" published in the American Journal of Industrial Medicine seeks to characterize the risk associated with unintentional occupational exposure to drugs. (cdc.gov)
  • The points in the figures showing no-observed-adverse-effect levels (NOAELs) or lowest-observed-adverse-effect levels (LOAELs) reflect the actual doses (levels of exposure) used in the studies. (cdc.gov)
  • The intravenous co-infusion of labradimil, a metabolically stable bradykinin B2 receptor agonist, has been shown to temporarily enhance the transvascular delivery of small chemotherapy drugs, such as carboplatin, across the blood-brain tumor barrier. (biomedcentral.com)
  • The recommended adult intravenous dosage of ZOFRAN is three 0.15-mg/kg doses up to a maximum of 16 mg per dose [see CLINICAL PHARMACOLOGY ]. (globalrph.com)
  • For pediatric patients aged 6 months through 18 years, the intravenous dosage of ZOFRAN is three 0.15-mg/kg doses up to a maximum of 16 mg per dose [see Clinical Studies , CLINICAL PHARMACOLOGY ]. (globalrph.com)
  • A multi-center, randomized, double-blinded, parallel-group, dose-ranging, effect-controlled study, followed by an open-label dose titration of an intravenous infusion of SNP was undertaken in 203 pediatric subjects, who required deliberate hypotension or controlled normotension during anesthesia. (frontiersin.org)
  • Frequent dosing for extended periods may necessitate intravenous implanted access devices. (msdmanuals.com)
  • One month after a single intravenous dose of rApoAI-PBGDms, the protein was still detectable in the liver, and hepatic PBGD activity remained increased above control values. (unav.edu)
  • A mixture model of two groups with low and high EC50 was used to explain variability in MAP response. (frontiersin.org)
  • The results indicate that, acting by itself, a tenfold reduction in dose from a 5% effect level is associated with effect incidences ranging from slightly less than one in ten thousand, for a median chemical/response, to a few per thousand, for chemicals and responses that have greater human interindivid- ual variability than 19 out of 20 typical chemicals/responses. (cdc.gov)
  • While it has not been reported in animals, the use of high doses of salicylates, as in rheumatic diseases, in conjunction with Furosemide Syrup 1% may result in salicylate toxicity because of competition for renal excretory sites. (drugs.com)
  • Conclusions The small amount of psilocin renally excreted suggests that no dose reduction is needed for subjects with mild-moderate renal impairment. (researchgate.net)
  • It mainly undergoes renal elimination (98% as unchanged drug), and posology adjustments are needed in patients with kidney failure ( Table 1 ) [5]. (fortunepublish.com)
  • Many of these patients also took drugs expected to increase cisapride blood levels by inhibiting the cytochrome P450 3A4 enzymes that metabolize cisapride. (rxlist.com)
  • Cisapride is contraindicated in patients taking any of these drugs. (rxlist.com)
  • QT prolongation, torsades de pointes (cisapride removed from us market) (sometimes with syncope), cardiac arrest, and sudden death have been reported in patients taking cisapride without the above-mentioned contraindicated drugs. (rxlist.com)
  • These AZA- and DCA-naive patients treated with AZA 100 mg/(m²·day) for 5 days to 7 days or DAC 20 mg/(m²·day) for 3 days to 4 days, or 20 mg/(m²·day) 1 day/week for 3 weeks/month were assessed for treatment responses and adverse events. (medscimonit.com)
  • Of the 158 enrolled MDS patients, 120 and 38 patients were administered reduced-dose DAC and AZA, respectively. (medscimonit.com)
  • Patients were randomized to starting doses of 45-, 30-, or 15-mg ponatinib once daily. (medworm.com)
  • Response to radium-223 is heterogeneous, both between patients and between different metastases in the same patient. (bvsalud.org)
  • Systemic and local inflammatory responses were analyzed in plasma, intraperitoneal fluid and urine collected prospectively as part of a phase 1 dose-escalation study of intraperitoneal instillation of the α-emitting therapeutic radiopharmaceutical Radspherin®, at baseline and the first 7 postoperative days from nine patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. (bvsalud.org)
  • SARS is characterized by symptoms of fever, chills, headache, and dry cough, with radiographic evidence of pneumonia in most patients. (cdc.gov)
  • Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. (nih.gov)
  • Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. (nih.gov)
  • Over the course of a typical 10-week controlled trial, the rate of death in drug treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. (nih.gov)
  • The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. (nih.gov)
  • Although cases have been reported even in the absence of predisposing factors, particular caution is advised in treating patients with other QT-prolonging conditions (including electrolyte imbalance [particularly hypokalemia and hypomagnesemia], drugs known to prolong QT, underlying cardiac abnormalities, hypothyroidism, and familial long QT-syndrome). (nih.gov)
  • Dose modification or exclusion of certain drugs may be necessary in patients with lung disease (eg, bleomycin), kidney failure (eg, methotrexate), liver dysfunction (eg, taxanes) or heart disease (daunorubicin, cyclophosphamide). (msdmanuals.com)
  • This is because patients with homozygous familial hypercholesterolemia (HoFH) lack functional LDL receptor activity and most of the current drugs work mainly through upregulation of LDL receptor in the liver. (ijpsr.com)
  • In patients with breast cancer receiving adjuvant 5-fluorouracil/epirubicin/cyclophosphamide followed by docetaxel (FEC-D), we evaluated the impact of chemotherapy total cumulative dose (TCD), and early (FEC) versus late (D only) dose reductions, on survival outcomes. (jnccn.org)
  • The understanding gained from pharmacogenomics holds the potential for the practice of personalized medicine, which will empower healthcare professionals to make rational clinical decisions regarding drug selection, the prediction of therapeutic responses, and the identification of patients at high risk for adverse events. (ahdbonline.com)
  • In addition, the MTD approach ignores target interactions and off-target toxicities, evaluates too few patients at each dose, offers only a short observation period to observe dose-limiting toxicities (DLTs), and offers limited consideration of safety information beyond DLTs. (agencyiq.com)
  • These challenges may result in approved treatments that may be poorly tolerated by patients, eventually affecting their quality of life and potentially leading to drug discontinuation. (agencyiq.com)
  • during this trial clobazam dose was decreased in 27% of patients in the cannabidiol group," the investigators write. (medscape.com)
  • These pro- has been implicated as contributing apoptosis, inflammation, and several liferating cel s replace dead cel s to the cancer phenotype, through pleiotropic responses. (who.int)
  • Anidulafungin was not an inhibitor of cytochrome P450 enzymes commonly involved in drug metabolism. (nih.gov)
  • FH is considered to be the first genetic disease of lipid metabolism to be characterized at the molecular level 2 . (ijpsr.com)
  • 5 The CYP enzymes comprise a group of proteins that play an important role in the metabolism of several drugs, including those relevant to pain therapy. (ahdbonline.com)
  • CYP2D6 is a well-characterized P450 enzyme that is involved in the metabolism of approximately 25% of all drugs currently in therapeutic use, and it is implicated in the metabolism of several analgesics, including opioids. (ahdbonline.com)
  • Kinetically monitoring bacterial growth at sub-inhibitory concentrations of antimicrobial small molecules generates unique dose response profiles. (mcmaster.ca)
  • Even though the inherent leakiness of the BBTB does allow for the selective transvascular passage of small conventional chemotherapy drugs, such as carboplatin, these drugs do not achieve sufficiently high concentrations within tumor tissue after systemic infusion[ 9 ]. (biomedcentral.com)
  • It has rapid absorption following oral administration, with peak plasma concentrations occurring between 0.7 and 1.3 hours, and shows 90% bioavailability, independently of dose and administration frequency. (fortunepublish.com)
  • At higher concentrations (10 mgrM) both drugs accelerated inactivation of ICa, retarded recovery from inactivation and shifted the voltage dependence of inactivation towards more negative voltages. (unideb.hu)
  • These early behavioral responses were predictive for 17 specific developmental abnormalities and mortality measured at 5 dpf, often at lower (i.e., more potent) concentrations than those at which morphological effects were observed. (oregonstate.edu)
  • End-organ function should be assessed before giving drugs with organ-specific toxicities. (msdmanuals.com)
  • 1 It is well-recognized that interindividual differences exist in the general population in terms of pain perception, response to analgesic treatment, and toxicities experienced. (ahdbonline.com)
  • Methods Eligible healthy adults received 6-8 h of preparatory counseling in anticipation of the first dose of psilocybin. (researchgate.net)
  • The escalating oral psilocybin doses were administered at approximately monthly intervals in a controlled setting and subjects were monitored for 24 h. (researchgate.net)
  • Cytotoxic drugs damage DNA and kill many normal cells as well as cancer cells. (msdmanuals.com)
  • To further characterize the parental compound and its analogues, we developed a high-speed, low-cost, quantitative fluorescence quenching assay. (uzh.ch)
  • 2,8 The lower enzyme activity renders the PM subgroup at increased risk for drug overdose when the parent compound is responsible for the analgesic effect, or therapeutic failure if the parent compound is a prodrug that needs to be converted to an active metabolite. (ahdbonline.com)
  • Herein, we report on the use of cell-based kinetic dose response curves for small molecule characterization in antibiotic discovery efforts. (mcmaster.ca)
  • In contrast, nonspecifically binding compounds did not quench its fluorescence and showed similar IC(50) values with steep dose-response curves. (uzh.ch)
  • The recent availability of Δ 9 - and Δ 8 -THC has allowed pharmacologists and toxicologists to establish dose-response curves relating physiopathological effects to dose administered. (unodc.org)
  • This insolubility makes it very difficult to study Δ 9 -THC in isolated tissue preparations suspended or incubated in the standard electrolyte solutions (such as Krebs Ringer) and obtain dose response curves. (unodc.org)
  • To assess the relationships among quetiapine blood concentration, daily dose, dopamine receptor occupancy, and clinical outcome in order, if possible, to define a target plasma level range in which therapeutic response is enhanced and adverse events are minimized. (psychiatrist.com)
  • Data on plasma concentration-response relationships are not sufficiently robust to allow determination of a therapeutic plasma level range for quetiapine. (psychiatrist.com)
  • Therapeutic drug monitoring procedures are thus probably not routinely useful in optimizing quetiapine dose. (psychiatrist.com)
  • Although doses of 0.6 mg/kg are in excess of likely therapeutic doses, no serious physical or psychological events occurred during or within 30 days of any dose. (researchgate.net)
  • The case of a critically ill patient with AKI undergoing Therapeutic Drug Monitoring of Pregabalin in course of Continuous, Prolonged Intermittent KRT (CKRT and PIKRT, respectively), and conventional intermittent hemodialysis (IHD) is presented here for the first time. (fortunepublish.com)
  • We're not asking anything more than [we are for] any other therapeutic areas," Pazdur explained, adding that OCE is " going to start making it more of a requirement " that companies conduct dose-finding to facilitate optimization and that it is in companies' "best interest" to follow this approach. (agencyiq.com)
  • A halogenated analog of methcathinone, 4-BMAP, increased swim time but did not stimulate locomotor activity, even at the highest dose tested. (erowid.org)
  • MTD seeks to find the tolerability and safety of treatment at the highest dose that can both be tolerated and treat the cancer. (agencyiq.com)
  • The Project was first unveiled in an interview in 2021 when Richard Pazdur, the Director of the FDA's OCE, explained that the field of oncology has long suffered from a cultural bias that "more is better" when it comes to dosing oncology products, under the idea that the highest dose that a patient can withstand is preferable to a lower dose. (agencyiq.com)
  • Subsequent doses (0.15 mg/kg up to a maximum of 16 mg per dose) are administered 4 and 8 hours after the first dose of ZOFRAN. (globalrph.com)
  • Initial dosing is based on patient weight with subsequent empirical adjustment of dose (infusion rate and duration) largely guided by the individual mean arterial pressure (MAP) response over time. (frontiersin.org)
  • Metabolically stable bradykinin B2 receptor agonists, methionine-lysine-bradykinin and labradimil, enhance the transvascular delivery of small chemotherapy drugs across the BBTB of malignant gliomas by increasing the blood half-life of the co-infused drug. (biomedcentral.com)
  • This permits the selective entry of small conventional chemotherapy drugs or contrast agents into malignant glioma tumor tissue[ 5 ]. (biomedcentral.com)
  • For chemotherapy drugs, one of the best characterized resistance mechanisms is overexpression of MDR1 , a cell membrane transporter that causes efflux of certain drugs (eg, vinca alkaloids, taxanes, anthracyclines). (msdmanuals.com)
  • CONCLUSIONS: DWI is useful for assessment of disease response in bone. (bvsalud.org)
  • Commonly available as capsules and oral solution, it is characterized by a predominant kidney elimination. (fortunepublish.com)
  • Four police officers (Officers 2-5) developed symptoms while responding to a 911 call about an unconscious person with a possible drug overdose in a hotel room. (cdc.gov)
  • She previously led CDC's Prescription Drug Overdose Team and served as advisor to New York City Health Commissioner. (cdc.gov)
  • Pregabalin is an anti-epileptic drug which also represents one of the most frequently prescribed medications for neuropathic pain management worldwide. (fortunepublish.com)
  • Pregabalin is an anti-epileptic drug representing one of the most frequently prescribed medications for neuropathic pain management worldwide, whereas its use as an anti-convulsant is currently limited [1]. (fortunepublish.com)
  • The new draft guidance document has few surprises, making crystal clear that a rational dose optimization plan is now a prerequisite in trials for oncology products. (agencyiq.com)
  • METHODS: We conducted a phase 2 randomized trial to assess disease response to radium-223. (bvsalud.org)
  • There is thus an increased pressure on regulatory agencies to be able to efficiently and reliably identify, characterize and risk assess EDCs. (5dok.org)
  • Cannabis, also known as marijuana among other names, is a psychoactive drug from the cannabis plant. (wikipedia.org)
  • Differences in the psychoactive effects of these two drugs result from small variations in their chemical structures, but the relationship between chemical structure and psychoactivity has not been characterized. (erowid.org)
  • 8. Agree to refrain from using any psychoactive drugs, including alcoholic beverages within 24 hours of each drug administration. (who.int)
  • In 2015, the FDA, along with the American Association for Cancer Research (AACR), held a workshop on dose optimization for small molecules. (agencyiq.com)
  • See CONTRAINDICATIONS , WARNINGS , PRECAUTIONS , and DRUG INTERACTIONS . (rxlist.com)
  • The purpose of these studies was to characterize the clearance mechanism and potential for drug interactions of anidulafungin. (nih.gov)
  • Characterizing the drug-drug interactions is important, and I think that's really been done nicely by GW Pharmaceuticals and by all the sites involved in the expanded access program," said Dr Thiele. (medscape.com)
  • Fentanyl self-administration impacts brain immune responses in male Sprague-Dawley rats. (nature.com)
  • presenters also provided strategies for the use of non-clinical pharmacology and model-informed drug development (MIDD) to bolster dose optimization work during drug development. (agencyiq.com)
  • We investigate wintertime indoor air quality and personal exposures to carbon monoxide (CO) in a rural village in Jilin province, where relatively homogeneous climatic and sociocultural factors facilitate investigation of household structural, fuel-related, and behavioral determinants of air pollution as well as relationships between different measures of air quality. (who.int)
  • This study aims to investigate the relationship between triglyceride glucose index (TyG) and erectile dysfunction (ED) among United States (US) adult males. (frontiersin.org)
  • A logistic regression analysis, subgroup analysis, and the computation of the dose-response curve were used to investigate the relationship between TyG index and ED prevalence among participants from the 2001-2004 National Health and Nutrition Examination Survey (NHANES) database. (frontiersin.org)
  • and determine vulnerable populations or patient subtypes that may elicit dosing modifications. (frontiersin.org)
  • Model development (using NONMEM version 7.3) was based on data from a Phase 1, open-label, multicenter, multiregional, dose-escalation and cohort-expansion study of cosibelimab administered intravenously (IV) to subjects with advanced cancer [1]. (page-meeting.org)
  • LAI115428 is a Phase I, randomized, repeat dose escalation study to determine the safety, tolerability, and PK profile of intramuscular and subcutaneous injections of GSK1265744 in a long acting parenteral (LAP) formulation in healthy subjects. (druglib.com)
  • The clinical patterns of adverse drug reactions of the oral cavity include xerostomia, swelling, nonspecific ulceration, vesiculobullous or ulcerative mucositis that mimics other disease states, nonspecific vesiculoulcerative mucositis, pigmentation, gingival enlargement, and medication-related osteonecrosis of the jaws. (medscape.com)
  • In this open-label, randomized, crossover study, healthy volunteers received a single, oral 75 mg dose of rilpivirine either with a normal-fat breakfast (reference), under fasting conditions, with a high-fat breakfast, or with a protein-rich nutritional drink. (druglib.com)
  • Pregabalin is available in US and Europe as capsules (25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, 300 mg) and as an oral solution (20 mg/ml), with recommended doses between 150 mg and 600 mg a day, split into 2 or 3 separate doses. (fortunepublish.com)
  • Although effective oral and injectable drugs have been introduced for the treatment of erectile dysfunction, these medications have not been demonstrated to restore natural erectile physiology, and in some cases these drugs are contraindicated, intolerable, expensive, or ineffective. (frontiersin.org)
  • Waskow and associates found no decrement on the Wechsler Memory Scale at moderate doses of oral THC. (druglibrary.net)
  • Xerostomia, or dry mouth, is the most common adverse drug-related effect in the oral cavity. (medscape.com)
  • However, a structure-activity relationship study that ensued did not yield more potent leads. (uzh.ch)
  • Pharmacotherapy, which remains the cornerstone of chronic pain management, includes analgesics such as nonsteroidal anti-inflammatory drugs (NSAIDs), the more potent opioids, and adjunct therapies such as antidepressants and anticonvulsants. (ahdbonline.com)
  • EC50, the concentration of a drug that induces a response halfway between the baseline and maximum, is a key quantity to evaluate drug potency. (psiweb.org)
  • Potency is a property of the material to be measured, e.g., the drug, not a property of the response. (pharmacologycorner.com)
  • The potency of one preparation (the "unknown") can be measured only in relationship to the potency of a second preparation (the "standard" or "reference drug") that elicits a similar biologic response. (pharmacologycorner.com)
  • The following two HHEs were conducted by NIOSH at the request of law enforcement agencies to evaluate incidents involving drugs where officers experienced health effects. (cdc.gov)
  • Cosibelimab, which is currently in clinical development for the treatment of subjects with advanced cutaneous squamous cell carcinoma (cSCC) and other cancers, could prevent PD-1/PD-L1 binding and reactivate the anti-tumor immune response. (page-meeting.org)
  • Treatment with IFN-gamma produced a dose- and time-dependent up-regulation of CD38 in monocytes and monocytic lines, which was paralleled by increased ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase activities. (nih.gov)
  • Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. (nih.gov)
  • The study group was characterized in detail, taking into account demographic, comorbid and addiction characteristics, heroin use history, treatment history, and clinical and paraclinical evaluation. (intechopen.com)
  • Despite the current revolutionary advances in the field of cancer immunotherapy, clinical response in breast cancer is frequently below expectations, in part due to various mechanisms of cancer immune escape that produce tumor variants that are resistant to treatment. (unav.edu)
  • Over the last decade intensive research has been undertaken to discover novel drug targets that could be modulated favorably for the treatment of FH. (ijpsr.com)
  • It has been shown that the better outcomes of chronic obstructive pulmonary disease (COPD) are closely associated with adherence to drug therapy, independent of the treatment administered. (mdpi.com)
  • Initial response to treatment was generally good, but definitely not uniformly so. (ersjournals.com)
  • The researchers had data to characterize the TNC2 status of their mothers and found that for homozygous mothers, with intact cobalamin transport, there was a linear "dose-response" relationship between eating meat and lower rates of substance abuse. (acsh.org)
  • The researchers suggest that 'temporal disintegration', seen at higher doses, can account for this phenomenon and may play a significant underlying role in a number of other cannabis effects, including depersonalization, a sense of timelessness, and perhaps acute psychotic or panic reactions. (druglibrary.net)
  • You must declare any conflicts of interest related to your comments and responses. (medscape.com)
  • Online ahead of print.ABSTRACTOPTIC was a randomized, phase 2 dose-optimization trial of ponatinib in chronic phase-chronic myeloid leukemia (CP-CML) resistant to ≥2 tyrosine kinase inhibitors or with T315I mutation. (medworm.com)
  • Familial Hypercholesterolemia (FH) is an autosomal dominant disorder caused by mutation in the LDL receptor gene and characterized by raised LDL-C, tendon xanthomata and premature atherosclerosis. (ijpsr.com)
  • The rigorous scientific study of cannabis as a medicine has been hampered by production restrictions and by the fact that it is classified as an illegal drug by many governments. (wikipedia.org)
  • Our study showed a predominately local rather than systemic inflammatory response to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. (bvsalud.org)
  • The current study also confirms prior observations of a potential interaction between CBD and the antiepileptic drug clobazam. (medscape.com)
  • model-based dosing guidance agrees with current practice. (frontiersin.org)
  • 10. A woman of childbearing potential must agree to practice an effective means of birth control during their participation in the clinical trial, up to and including the 90-day follow-up after their last DMT dose. (who.int)
  • ZOFRAN® Injection is indicated for the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including high-dose cisplatin [see Clinical Studies ]. (globalrph.com)
  • In this talk, attendees will hear from Weiliang and Cheng who will be presenting their investigations on EC50 estimation based on multi-donor dose-response data via different approaches. (psiweb.org)
  • For multi-donor dose-response data, it is often the interest to estimate the overall EC50 and its 95% confidence interval (CI). (psiweb.org)
  • Native to Central or South Asia, the cannabis plant has been used as a drug for both recreational and entheogenic purposes and in various traditional medicines for centuries. (wikipedia.org)
  • Cannabis is mostly used recreationally or as a medicinal drug, although it may also be used for spiritual purposes. (wikipedia.org)
  • In the U.S., the recreational use of cannabis is legalized in 23 states, 3 territories, and the District of Columbia, though the drug remains federally illegal. (wikipedia.org)
  • Cannabis temporarily alters a variety of intellectual and cognitive functions, and these changes are related to dose, past experience, and other psychological and social variables. (druglibrary.net)
  • The intellectual effects of acute cannabis use are rarely detectable by the casual observer, and experienced users generally have little trouble functioning socially without detection, even after relatively high doses. (druglibrary.net)
  • Even a number of studies employing what would appear to be high doses have been inconsistent in detecting cannabis effects on standard tests of cognitive and intellectual functioning. (druglibrary.net)
  • One area of emphasis of this early work was investigating the relationship between product dosage and % drag-reduction. (liquidpower.com)
  • The drug should be infused intravenously over 15 minutes. (globalrph.com)
  • Most cancer drugs are given systemically, usually intravenously or subcutaneously, but some are given by mouth. (msdmanuals.com)
  • Furthermore, changes in growth kinetics have the potential to offer insight into the mechanistic action of novel molecules and can be used to predict off-target effects generated through structure-activity relationship studies. (mcmaster.ca)
  • Our Propulsid (cisapride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • The ideal drug would target only cancer cells and have no adverse effects on normal cells. (msdmanuals.com)
  • Regulatory agencies commonly gave more weight to standard than non-standard studies in risk assessment of BPA, despite the growing amount of research indicating that toxic effects at low doses were being overlooked. (5dok.org)
  • We expect that our studies will provide information about the short-term and long-term effects of stimulant drugs and alcohol on synapses and on the way that different brain regions talk to each other and integrate information. (nih.gov)
  • Several of the new drugs may be effective antidepressants in humans with fewer stimulant-like side effects compared to bupropion. (erowid.org)
  • Performance on complex tasks apparently requiring sustained attention and short-term memory are most often impaired in laboratory studies, although significant effects have also been found on simple tests at very high doses. (druglibrary.net)
  • Therefore, this system can provide rapid characterization of chemical-elicited behavioral responses at an early developmental stage that are predictive of observable adverse effects later in life. (oregonstate.edu)
  • 3. HEALTH EFFECTS the effects vary with dose and/or duration, and place into perspective the possible significance of these effects to human health. (cdc.gov)
  • Despite the usage, dosing guidance has been empirically-based and varies across institutions and practices. (frontiersin.org)
  • The new guidance is aimed at sponsors of both prescription drugs and biologics to help them identify optimal doses of their products during the development process, before regulatory submission for approval. (agencyiq.com)
  • In addition, we hope our findings will lead to the identification of neuronal markers associated with higher vulnerability to addiction and aid in the development of new therapies to treat drug abuse and dependence. (nih.gov)
  • Our time-resolved wintertime measurements of carbon monoxide and respirable particles (RSP) enable exploration of peak pollution periods in a village in Jilin Province, China, characterized by household use of both coal and biomass, as well as several "improved" (gas or electric) fuels. (who.int)
  • Subjects received cosibelimab in fixed doses of 200 mg, 400 mg, or 800 mg dosed once every two weeks (Q2W), or 1200 mg dosed once every three weeks (Q3W) as an IV infusion over 60 minutes. (page-meeting.org)
  • Continuous infusion may increase cell kill with some cell cycle-specific drugs (eg, fluorouracil). (msdmanuals.com)
  • Friends of Cancer Research (FOCR) has also been working to improve tolerability and dose optimization programs in collaboration with various stakeholders. (agencyiq.com)
  • 95% confidence interval = 23% to 56%), with marked interpatient and intrapatient heterogeneity of response. (bvsalud.org)
  • The time course and magnitude of the postoperative cytokine response after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy displayed a modest systemic response in plasma, in contrast to a substantial local intraperitoneal response. (bvsalud.org)
  • In contrast, other drugs (eg, DNA cross-linkers, also known as alkylating agents) have a linear dose-response relationship, killing more cancer cells at higher doses. (msdmanuals.com)
  • All published reports of quetiapine plasma or serum concentration were considered for inclusion if reported in relation to a dose, clinical outcome, or dopamine occupancy. (psychiatrist.com)
  • There was a weak correlation between quetiapine dose and measured plasma concentration (from trough samples). (psychiatrist.com)
  • Further examination of the relationship between peak quetiapine plasma concentration and clinical response is necessary. (psychiatrist.com)
  • The system was used to generate full concentration-response behavioral profiles at 24 hpf across 1060 ToxCast™ chemicals. (oregonstate.edu)
  • Higher than recommended doses of any formulation of haloperidol appear to be associated with a higher risk of QT-prolongation and Torsades de Pointes. (nih.gov)
  • At baseline, they had previously not responded to a median of six antiepileptic drugs, were taking a median of three concomitant antiepileptic drugs, and had a median of 73.8 drop seizures every 28 days. (medscape.com)
  • It is the most commonly used largely-illegal drug in the world, with the highest use among adults in Zambia, the United States, Canada, and Nigeria. (wikipedia.org)