Characterization gene factor. Medical search. Frequent questions

The molecular mechanisms involved in the specific regulation of PDGF alpha R expression are unknown, but transcriptional regulation of the PDGF alpha R gene is most likely to be involved. (nih.gov)
This study describes the molecular cloning of the non-coding exon 1 and approximately 2 kb of 5' flanking region of the human PDGF alpha R gene. (nih.gov)
Molecular Detection and Characterization of Mycoplasma spp. (cdc.gov)
Baracho GV, Nudelman V, Isaac L. Molecular characterization of homozygous hereditary factor I deficiency. (medlineplus.gov)
A comprehensive understanding of the physiological and molecular function of PPARα target genes is needed for the accurate development of therapeutical strategies. (wur.nl)
Then, we pursued to expand our understanding on the physiological and molecular function of two PPARα target genes, Hilpda and Slc25a47. (wur.nl)
Our extensive molecular and genome wide studies as well as analysis of human cancer samples suggest that WDR5-H3T11P interaction integrates epigenetic cross talk in driving androgen receptor target gene expression, prostate cancer cell proliferation and disease progression. (northwestern.edu)
Using recent techniques such as targeted genome editing, whole-brain activity imaging, brain atlas registration, and behavioral profiling, Thyme wants to analyze how these genes contribute to psychiatric disorders through disruption of molecular, cellular, developmental and behavioral processes. (harvard.edu)
Molecular characterization revealed that MWCNT induced substantial ROS production and mitochondrial inner membrane depolarization at sub-toxic doses. (cdc.gov)
Finally, MWCNTs induced the production of fibrogenic growth factors TGFbeta1 and PDGF that function as paracrine signals to promote the transformation of lung fibroblasts into myofibroblasts, a key molecular step in the development of lung fibrosis. (cdc.gov)
Molecular defects of the ACTH receptor gene, consisting of point mutations, are described in approximately 25-40% of patients with FGD. (medscape.com)
Molecular analysis of an MHC class II deficiency patient reveals a novel mutation in the RFX5 gene. (lu.se)
Molecular characterization of major histocompatibility complex class II gene expression and demonstration of antigen-specific T cell response indicate a new phenotype in class II-deficient patients. (lu.se)
Environmental factors that can detect specific IgE antibodies against most low-molecular- affect the initiation of occupational asthma include the intrinsic weight agents has resulted in a search for alternative or characteristics of causative agents as well as the influence of the complementary physiopathologic mechanisms leading to airway level and route of exposure at the workplace. (cdc.gov)
Recent advances have been made in the of host factors, polymorphisms, and candidate genes associated characterization of the immune response to low-molecular- with occupational asthma may improve our understanding of weight agents. (cdc.gov)
By characterization of the genomic, transcriptional, and DNA methylation landscape in lung cancer subgroups defined by histology and other clinicopathological factors in both own and public cohorts we search for new molecular subgroups of potential clinical relevance, additional targets for synergistic treatment, and a deepened understanding of the molecular pathogenesis. (lu.se)

In addition, mutations in the SCIP/Tst-1 coding region that prevent the factor from binding to DNA with high affinity do not obliterate α3 activation. (elsevierpure.com)
At least 10 mutations in the CFI gene have been identified in people with complement factor I deficiency, a disorder characterized by immune system dysfunction. (medlineplus.gov)
The mutations result in abnormal, nonfunctional, or absent complement factor I. (medlineplus.gov)
Mutations in the CFI gene have also been found in people with glomerulonephritis with isolated C3 deposits. (medlineplus.gov)
The CFI gene mutations identified in this disorder result in an abnormal or nonfunctional version of complement factor I. The defective protein allows uncontrolled activation of the complement system. (medlineplus.gov)
Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome. (medlineplus.gov)
All of these mutations appear in a single copy of the gene, and some of them are found exclusively in noncoding regions, suggesting that AUTS2 expression levels may be a key factor in autism susceptibility. (sfari.org)
Sequence analysis revealed two variant CYP2D6 genes, CYP2D6Ch1 and CYP2D6Ch2, having mutations yielding two and eight amino acid substitutions, respectively. (aspetjournals.org)
In addition, mutations in the 5' flanking region common to both CYP2D6Ch genes were found. (aspetjournals.org)
Furthermore, secondary structure prediction showed that mutations at T471C and C862T apparently lead to change of the gene structure. (jcancer.org)
We are investigating the impact of specific classes of gene mutations, such as ATM, BRCA1, and MYBL2 on genome integrity. (birmingham.ac.uk)
Mutations of the KAL1 gene, which encodes a putative neural cell adhesion molecule (anosmin), have been described in several patients with X-linked Kallmann syndrome. (medscape.com)
Loss-of-function mutations of the gene encoding fibroblast growth factor receptor 1 (FGFR1) have been described in patients with autosomal dominant Kallmann syndrome. (medscape.com)
[ 2 , 3 ] Heterozygous loss-of-function mutations of the gene encoding FGFR1 have also been described in individuals with idiopathic hypogonadotropic hypogonadism, normal smell sense, and normal MRI of the olfactory system. (medscape.com)
Mutations of the gene encoding fibroblast growth factor 8 have been found in a small minority of patients with autosomal dominant Kallmann syndrome. (medscape.com)
[ 3 ] In addition, mutations of the gene encoding chromodomain-helicase DNA-binding protein 7 ( CHD7 ) have been found in some patients with Kallmann syndrome or idiopathic hypogonadotropic hypogonadism, some of whom have features of the CHARGE syndrome (characterized by delayed growth and development, congenital cardiac defects, dysmorphic ears, hearing loss, coloboma of the eyes). (medscape.com)
[ 3 ] In addition, mutations of the gene encoding chromodomain-helicase DNA-binding protein 7 ( CHD7 ) have been found in some patients with Kallmann syndrome or idiopathic hypogonadotropic hypogonadism. (medscape.com)
Mutations of the DAX1 gene, which encodes a nuclear transcription factor, lead to X-linked idiopathic hypogonadotropic hypogonadism associated with adrenal hypoplasia congenita (AHC). (medscape.com)
[ 10 ] Mutations of genes encoding either leptin or the leptin receptor underlie isolated cases of autosomally transmitted idiopathic hypogonadotropic hypogonadism associated with early-onset obesity. (medscape.com)
[ 11 ] Several loss-of-function mutations of the GnRH receptor gene leading to GnRH resistance and autosomally transmitted hypogonadotropic hypogonadism have been described. (medscape.com)
[ 12 ] . In addition, autosomal recessive mutations of the GnRH gene may underlie hypogonadotropic hypogonadism. (medscape.com)
Rarely, hypogonadotropic hypogonadism occurs as a result of isolated follicle-stimulating hormone (FSH) deficiency due to homozygous mutations in the FSH beta subunit gene. (medscape.com)
Analysis of mutations and chromosomal localisation of the gene encoding RFX5, a novel transcription factor affected in major histocompatibility complex class II deficiency. (lu.se)

There were 3954 correlations and a total of 15 correlations for differentially expressed proteins (DEPs) and differentially expressed genes (DEGs) from proteomics and transcriptomics. (hindawi.com)
Additional regulatory proteins are often required to induce the conformational changes that occur during this cycle: guanine nucleotide exchange factors, which catalyze release of bound GDP and promote its replacement by GTP, and GTPase-activating proteins, which accelerate GTP hydrolysis. (biomedcentral.com)
The superfamily of G proteins includes three main classes: Ras-like GTPases, G α subunits of heterotrimeric G proteins, and the translation elongation factors. (biomedcentral.com)
To determine which transcription factors bind to the promoter, we carried out a systematic search for the binding proteins using the 1142 bp Gal-T-II promoter fragment containing both positive and negative regulatory regions in a combination of DNA pull-down assay and transcription factor array analysis. (elsevierpure.com)
Complement factor I and several related proteins protect healthy cells by preventing activation of the complement system when it is not needed. (medlineplus.gov)
As a largest plant-specific transcription factor family, NAC domain proteins play an important role in plant development and regulation of abiotic stress tolerance. (frontiersin.org)
Using a targeted systems biology approach, we identified new factors, HECATE proteins that promote photomorphogenesis by negatively regulating the function of PIF1. (utexas.edu)
One of Chakravarti's major research interests is to determine the mechanisms of steroid hormone and vitamin signaling with special emphasis on the role of the nuclear hormone receptor co-regulatory proteins in gene transcription. (northwestern.edu)
Chakravarti's laboratory identifies and characterizes the role of chromatin signal transducer proteins including the recently identified INHAT proteins in gene regulation. (northwestern.edu)
We, in a dogma changing study demonstrated that key cell cycle genes are regulated by HCFC1 cofactor recruitment not by the E2F proteins but by a THAP11-ZNF143 transcriptional complex. (northwestern.edu)
Secondly, our effort will stimulate future research on further characterization of all THAP domain proteins. (northwestern.edu)
In this study, we characterized HA and NA genes and proteins of 5 Iranian isolate which have been isolated from Commercial broiler chicken in the Iran between 2008 and 2009. (scialert.net)

Transcriptomics focuses on gene transcription and regulation of transcription in cells [ 25 , 26 ]. (hindawi.com)
To study the possible regulation of SseEF1A gene expressions by thyroid hormones (THs), larvae were exposed to the goitrogen thiourea (TU). (biomedcentral.com)
TU and T4 treatments demonstrate that SseEF1A4 is up-regulated by THs, suggesting a role in the translational regulation of the factors involved in the dramatic changes that occurs during Senegalese sole metamorphosis. (biomedcentral.com)
To understand the transcriptional regulation of Gal-T-II gene expression, we cloned a 1448 bp 5′-flanking fragment from the mouse Gal-T-II gene. (elsevierpure.com)
These data indicate that the basal regulation of Gal-T-II gene transcription involves multiple transcription factors, some of which may be present in complexes. (elsevierpure.com)
FAE ( Fatty Acid Elongation ) like genes take part in the biosynthesis of VLCFAs, growth regulation, and stress responses, and are further comprised of KCS ( Ketoacyl-CoA synthase ) and ELO ( Elongation Defective Elongase ) sub-gene families. (nature.com)
Gene-Expression Analysis of Cell-Cycle Regulation Genes in Virus-Infected Rice Leaves. (routledge.com)
These results suggest that differential expression of Apaf-1 and caspase-3 genes may underlie regulation of apoptotic susceptibility during brain development, as well as after acute injury to mature brain, through the intrinsic pathway of caspase activation. (jneurosci.org)
The NAC domain transcription factors in Arabidopsis function in plant development, senescence, and stress regulation. (frontiersin.org)
Peroxisomal proliferator activator receptor alpha (PPARα) is a ligand-activated transcription factor that plays a major role in the regulation of lipid metabolism. (wur.nl)
The role of PPARα in gene regulation in mouse liver is well characterized. (wur.nl)
Our results support the major role of PPARα in regulating hepatic lipid metabolism, highlight the more modest effect of PPARα activation on gene regulation in human liver compared to mouse liver, and indicate that PPARα may have a suppressive effect on DNA synthesis in human liver. (wur.nl)
The lab is also characterizing members of a novel THAP domain protein family regarding their roles in gene regulation, chromatin signaling, cell growth and differentiation and cancer. (northwestern.edu)
This project may also help researchers understand how altered gene regulation predisposes some individuals to autism and other disorders. (sfari.org)
The current focus of Dr. Goldring's laboratory is on the mechanisms of gene regulation by which stress- and inflammation-induced signals induce expression of matrix metalloproteinase 13 (MMP-13), the pivotal collagen-degrading proteinase that marks osteoarthritis progression, as well as other catabolic and anabolic responses in cartilage and other joint tissues. (hss.edu)
Collaborative studies with Dr. HI Roach's group (Southampton, UK) have also identified epigenetic regulation via alterations in the methylation status of specific CpG sites in the promoters of MMP13, IL1B, NOS2, and COL9A1, associated with aberrant gene expression in osteoarthritic cartilage. (hss.edu)
MHC class II deficiency: a disease of gene regulation. (lu.se)

This 5' flanking region is a functional promoter of the PDGF alpha R gene as concluded from its capacity to drive luciferase reporter gene expression in an orientation dependent way. (nih.gov)
In addition, the morphogen retinoic acid, alone or in combination with dibutyryl cAMP, gives a 22-fold induction of PDGF alpha R gene promoter activity in human teratocarcinoma cells. (nih.gov)
These results lead us to propose that α3 activation by SCIP/Tst-1 is achieved via protein-protein interactions between SCIP/Tst-1 and a specific complement of transcription factors that act directly on the promoter. (elsevierpure.com)
The SWI5 gene product was overproduced in yeast from the GAL1-10 promoter, since the SWI5 protein is made at very low levels in wild-type strains, and protein extracts were used to demonstrate that the SWI5 protein binds in vitro to a segment of the HO promoter required for transcriptional activation in vivo. (ox.ac.uk)
Analysis of the promoter sequence revealed a number of potential binding sites for known transcription factors. (elsevierpure.com)
Twenty-seven transcription factors bound to consensus sites in the promoter region. (elsevierpure.com)
The presence of biotic and abiotic stress-related cis-regulatory elements in the promoter region suggests that both KCS and ELO genes might also play their role in stress tolerance. (nature.com)
A putative late gene promoter motif sequence, AGTAT was found in the 3' upstream sequences of these genes. (umass.edu)

Expression of the platelet-derived growth factor alpha receptor (PDGF alpha R) is strictly regulated during mammalian development and tumorigenesis. (nih.gov)

Characterization of Plant Homeodomain Transcription Factor Genes Involved in Flower Development and Multiple Abiotic Stress Response in Pepper. (bvsalud.org)
Plant homeodomain (PHD) transcription factor genes are involved in plant development and in a plant 's response to stress. (bvsalud.org)
However, when applying this concept to genomes of multicellular organisms such as mammals, one has to deal with a large number of false positive predictions since many transcription factor genes are only expressed in specific tissues or cell types. (lu.se)

Gene fusions are chimeric genes that combine at least two parental genes. (biomedcentral.com)

PIF1 binds to a G-box (CACGTG) DNA sequence element present in its direct target genes (e.g., protochlorophyllide oxidoreductase C, PORC) in darkness and regulates their expression. (utexas.edu)
These studies are highly significant because it changes the paradigm that E2F mediated HCFC1 recruitment is critical for expression of cell cycle target genes, and raises the possibility that E2F participates in this process by recruiting factors other than HCFC1, thereby promoting new directions of research in this highly active field. (northwestern.edu)
Luciferase assays showed that T471C and C862T could significantly increase the expression efficiency of downstream target genes. (jcancer.org)

This paper presents the characterization of regulatory elements upstream of the neuronal nicotinic acetylcholine receptor α3 gene. (elsevierpure.com)
Unexpectedly, we found that α3 basal activity and SCIP/Tst-1 activation of α3 is not dependent on the SCIP/Tst-1 binding sites found upstream of the gene. (elsevierpure.com)
The ability of the upstream regions to bind nuclear factors was also evaluated using gel-shift analysis. (aspetjournals.org)
The prediction of transcription factor binding sites in genomic sequences is in principle very useful to identify upstream regulatory factors. (lu.se)

To demonstrate the possibility of large scale genomic manipulations, the major part of the undecylprodigiosin gene cluster was deleted as well. (figshare.com)

A combination of genetic and environmental factors likely determines the risk of developing this complex eye disorder. (medlineplus.gov)
High-Throughput Approaches for Characterization and Efficient Use of Plant Genetic Resources. (routledge.com)
Autism has strong genetic origins, but neither common nor rare gene variants explain the majority of cases. (sfari.org)
Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. (aspetjournals.org)
In our lab, we are trying to identify genetic factors that might play a role in these disorders. (brookes.ac.uk)
developmental language disorders are genetic and is therefore caused (at least in part) by the genes passed on from parents to children. (brookes.ac.uk)
Although there is strong evidence for the role of a genetic component in language disorder, we do not know which genes contribute to this disorder or how the inheritance of language problems work. (brookes.ac.uk)
Rapid Phenotype-Driven Gene Sequencing with the NeoSeq Panel: A Diagnostic Tool for Critically Ill Newborns with Suspected Genetic Disease. (cdc.gov)
Characterization of genetic and phenotypic heterogeneity of obstructive sleep apnea using electronic health records. (cdc.gov)
Here, we present data revealing the genetic network associated with ACVRL1 (the gene encoding for ALK1) expression in human cancer tissues. (lu.se)

The development of large-scale genomics of Senegalese sole has facilitated the identification of five different eEF1A genes, referred to as SseEF1A1 , SseEF1A2 , SseEF1A3 , SseEF1A4 , and Sse42Sp50 . (biomedcentral.com)
Phylogenetic and tissue expression analyses allowed for the identification of SseEF1A1 and SseEF1A2 as the Senegalese sole counterparts of mammalian eEF1A1 and eEF1A2 , respectively, and of Sse42Sp50 as the ortholog of Xenopus laevis and teleost 42Sp50 gene. (biomedcentral.com)

The cloning and characterization of these mutants will help identify the factors, such as the kinase and E3 ligase, responsible for the light-induced degradation of PIF1. (utexas.edu)
In preliminary studies, we created mutants for over one hundred schizophrenia-associated genes. (harvard.edu)
Characterization of these mutants for altered brain anatomy and activity has revealed over one third have phenotypical abnormalities. (harvard.edu)

The fewest CaPHD genes were located on chromosome 4 , while the most were on chromosome 3 . (bvsalud.org)
The developed system was validated by systematically deleting the most highly expressed genes encoding alternative sigma factors and several other regulatory genes within the chromosome of S. lividans TK24. (figshare.com)

Over time U-triangle developed on polyploidization of Brassica 's proved its usefulness in studying the evolution of various genes and phenotypes 3 . (nature.com)
In the present review, the phenotypes of Met gene‑modified mice are summarized. (spandidos-publications.com)

It has been demonstrated that the SWI5 gene, which is an activator of HO expression, plays a critical role in this differential mother/daughter expression of HO. (ox.ac.uk)
Our data reveal the differential expression landscape of 493 transcription factors and 682 lncRNAs and highlight specific expression clusters operating in HSCs. (lu.se)

The lack (deficiency) of functional complement factor I protein allows uncontrolled activation of the complement system. (medlineplus.gov)
was investigated through functional characterization of meiosis gene orthologs. (apsnet.org)
The use of expression levels of transcription factor-encoding genes according to hierarchical anatomical classifications covering different tissues and cell types makes it possible to filter out irrelevant binding site predictions and to identify candidates of potential functional importance for further experimental testing. (lu.se)

The ERGB/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factors. (musc.edu)

Higher water retention and flavonoid accumulation have been observed in BARI2011 but downregulation has been observed in the expression of genes and transcription factors (TFs) which indicated the maintenance of normal homeostasis. (figshare.com)
To assess the role in autism of DNA sequences that regulate the expression of genes, Nadav Ahituv and his colleagues at the University of California, San Francisco, studied the autism susceptibility candidate 2 (AUTS2) gene. (sfari.org)

The yeast HO gene, which encodes an endonuclease involved in initiating mating type interconversion, is expressed in mother cells but not in daughters. (ox.ac.uk)
While each DNA blueprint, or gene, encodes for a different machine or structure, the genome, the collection of DNA wrapped up inside the nucleus, is much more active than a quiet library of neatly stacked blue-prints. (birmingham.ac.uk)

The CFI gene provides instructions for making a protein called complement factor I. This protein helps regulate a part of the body's immune response known as the complement system. (medlineplus.gov)
NAC transcription factors regulate the stress response in plants. (frontiersin.org)
In darkness, PIFs regulate downstream gene expressions to inhibit photomorphogenesis. (utexas.edu)
The regulatory genes primarily the transcription factors that exert their activity by binding to certain cis DNA elements and consequently either up regulated or down regulate to target expression. (scielo.br)
These transcription factors are known as masters regulators because its single transcript regulate more than one gene, in this context the regulon word is fascinating more in compass of transcription factors. (scielo.br)

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid," Genes & Development, 6:329-44, 1992. (the-scientist.com)
David J. Mangelsdorf (Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas): "Nuclear hormone receptors are a family of related transcription factors that are activated by binding small hydrophobic hormones like the steroids, thyroxin, vitamin D3, and all-trans retinoic acid. (the-scientist.com)

The comparative genome-wide analysis and mode of evolution of KCS and ELO gene families have not been investigated in tetraploid Brassica carinata and its diploid progenitors. (nature.com)
The m alpha La gene occurs in a single copy per haploid genome and is specifically expressed in the mammary gland where it is induced during late pregnancy. (eurekamag.com)
We are currently determining genome-wide epigenomic and transcription factor signatures that define uterine fibrosis. (northwestern.edu)
To identify operable lung cancer patients with risk for metastatic relapse we search for new prognostic biomarkers based on analysis of genome-wide gene expression data and conventional protein marker validation based on analysis of primary tumor tissue. (lu.se)

The gold standard in clinical diagnostics is based on the cultivation of bacteria and their phenotypical characterisation. (europa.eu)

Alternative sigma factors control numerous aspects of bacterial life, including adaptation to physiological stresses, morphological development, persistence states and virulence. (figshare.com)
ETEC virulence factors, specifically enterotoxins and colonization factors (CFs), were detected using multiplex PCR, and prevalence in the total isolate population was compared to ESBL-positive isolates. (biomedcentral.com)
more than 1000 clinically relevant antibiotic resistance genes, a few hundred phylogenetic marker genes and virulence factors have to be targeted (including SNP detection). (europa.eu)

Expression analysis showed that the expression of CaPHD genes was quite different in different tissues and in response to various stress treatments . (bvsalud.org)
The five genes exhibit different expression patterns in tissues and during larval development. (biomedcentral.com)
TS-REX covers ESTs from H. sapiens and M. musculus, and allows the characterization of both presence and specificity of transcription factors in user-specified tissues or cell types. (lu.se)
TS-REX was applied to predict regulators of Polycomb group genes in six human tumor tissues and in human embryonic stem cells. (lu.se)

However, none of the prognostic models incorporates parameters reflecting the status of chromosomal rearrangements and transcriptional disorganization in a patient sample, even though gene fusions are known to drive PCa development and progression [ 8 ]. (biomedcentral.com)

The sub-cellular location, pattern of transcript level changes and results of complementation experiments support a hypothesis that Zfp1 differentially controls effector gene expression by interacting with distinct binding partners. (apsnet.org)

Genes Dev 1995(9): 1021-32 [ PubMed abstract ]. (lu.se)

Eukaryotic translation initiation factor 4E family member 3 is a protein that in humans is encoded by the EIF4E3 gene. (wikipedia.org)
The eukaryotic translation elongation factor 1 alpha, currently termed eEF1A, is a member of the G protein family, and one of the four subunits that compose the eukaryotic elongation factor 1 [ 5 , 6 ]. (biomedcentral.com)
The reported here gene deletion system will further facilitate work on S. lividans strain improvement as a host for either secondary metabolites or protein production and will contribute to basic research in streptomycetes physiology, morphological development, secondary metabolism. (figshare.com)
String-based protein-protein interaction analysis suggested that bZIP53, a transcription factor might be involved in the activation of transcription of ELO / KCS genes. (nature.com)
flanking region indicated the presence of a consensus motif that occurs in all milk-protein-encoding genes, except the kappa-casein-encoding gene. (eurekamag.com)
This substitution caused expression of a more unstable gene product, as evident from comparison of the relative levels of CYP2D6 mRNA, CYP2D6 protein, and bufuralol 1'-hydroxylase activities in pCMV2-CYP2D6-transfected COS-1 cells. (aspetjournals.org)
Moreover, we generated a signature of 8 genes co-expressed with ACVRL1 across different tumor types and characterized the c-type lectin domain containing protein (CLEC)14A as a potential downstream target of ACVRL1. (lu.se)

Genes encoding neuronal nicotinic acetylcholine receptors exhibit restricted patterns of expression in the nervous system. (elsevierpure.com)
Binding of TFIIIC to sine elements controls the relocation of activity-dependent neuronal genes to transcription factories. (nih.gov)
Eldadah and Faden, 2000 ), we hypothesized that suppression of apoptotic capability during maturation of mammalian brain results from repression of genes involved in the caspase-3 activation pathway, and that injury-induced neuronal apoptosis in the mature brain results from reactivation of these genes. (jneurosci.org)

Computational analysis unveiled a hitherto unknown role for ACVRL1 in relation to genes modulating the functionality of the immune cell compartment. (lu.se)

genes with altered transcript levels. (apsnet.org)
Twenty putative pre-microRNA sequences were predicted in Hz-2V by searching stem-loop structures with less than -25kcal/mol of free energy, and one of the microRNA candidates was predicted to target the Hz2V007 gene transcript, which codes for a putative juvenile hormone esterase. (umass.edu)

Activation of NF-kappaB signaling involves rapid degradation of IkapaBalpha, nuclear accumulation of NF-kappaBp65, binding of NF-kappaB to specific DNA-binding sequences, and transactivation of target gene promoters. (cdc.gov)

Phylogenetic analysis HA and NA genes showed that they share a common ancestor Qa/HK/G1/97 isolate which had contributed internal genes of H5N1 virus. (scialert.net)
We delineated the genomes, receptor binding profile and HB sites of NA gene of these field isolates and we also established their phylogenetic relationship to the other Asian H9N2 lineages. (scialert.net)

The predicted amino acid sequence derived from the cloned SWI5 gene shows homology with the repeated DNA-binding domains ('zinc fingers') of Xenopus transcription factor TFIIIA. (ox.ac.uk)
PCR was used for detection of pcaA gene and its nucleotide sequence was also determined. (scielo.br)
Exon 9 of the CYP2D6Ch2 gene contained a sequence of 49 bases originating from the pseudogene CYP2D7P. (aspetjournals.org)
We developed TS-REX, a database/software system that supports the analysis of tissue and cell type-specific transcription factor-gene networks based on expressed sequence tag abundance of transcription factor-encoding genes in UniGene EST libraries. (lu.se)

Gene expression studies performed on PPARα null mice have shed light into a variety of genes regulated by PPARα. (wur.nl)
Conditional Met KO mice were generated using Cre‑loxP methodology and characterization of these mice indicated that the HGF‑Met signaling pathway is essential in regeneration, protection, and homeostasis in various tissue types and cells. (spandidos-publications.com)

In one patient, isolated bioinactive luteinizing hormone (LH) was present as a result of a homozygous mutation in the LH beta subunit gene, which prevented binding of LH to its receptor. (medscape.com)
A second patient had a different homozygous mutation in the LH beta subunit gene that prevented LH heterodimerization and secretion. (medscape.com)

This study will provide the basis for further research into the function of CaPHD genes in plant development and responses to abiotic stresses and hormones . (bvsalud.org)
The main tool used in transcriptomics is total RNA sequencing, which is a powerful tool for analyzing gene expression changes in response to various environmental stresses [ 27 ]. (hindawi.com)
Plant/ crop productivity effected by the environmental strains such as water deficit condition (drought), Low temperature (cold), salt and High temperature (heat) these stresses disturb the signal transduction of gene regulatory systems of plants. (scielo.br)

Human transcription factor IIIC box B binding subunit. (nih.gov)
Purification and characterization of two forms of human transcription factor IIIC. (nih.gov)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (nih.gov)
Modulation of chromatin modification is essential for gene expression and therefore its alteration has been linked to human diseases including cancer. (northwestern.edu)
Moreover, whole metagenome sequencing depth affects critically the recovery of microbial genes, including virulome and resistome, while less than 5 million reads per sample is sufficient for taxonomy profiling in human fecal metagenomic samples. (frontiersin.org)

The diagnosis of GHD is a multifaceted process requiring comprehensive clinical and auxologic assessment combined with biochemical testing of the GH-insulinlike growth factor (IGF) axis and radiologic evaluation. (medscape.com)
The datasets included transcriptome-wide expression and matched clinical follow-up data to detect and characterize gene fusions in PCa. (biomedcentral.com)
The pcaA gene was detected in M. tuberculosis clinical isolates but not in saprophyte strains such as M. kansasi. (scielo.br)
This study confirmed the widespread existenceof pcaA gene in almost all the clinical isolates. (scielo.br)
The requirement for tumor angiogenesis has been therapeutically exploited in the clinical setting mainly by means of inhibition of the vascular endothelial growth factor family of ligands and receptors. (lu.se)

Following detection, we annotated the gene fusions using published databases for gene fusions in cancer. (biomedcentral.com)
Considering the lack of reagents for ALK1 detection that has hampered the field to date, our work provides the opportunity to validate the 8-gene signature and CLEC14A as biomarkers for ALK1 activity. (lu.se)

Correlation analysis between expression of flavonoid biosynthetic genes and TFs indicated the role of AhMYB111 and AhMYB7 as an inhibitor for AhF3H and AhFLS, respectively, and AhMYB7, AhTTG1, and AhCSU2 as a positive regulator for the expression of Ah4CL, AhCHS, and AhF3H, respectively. (figshare.com)
However, AhbHLH and AhGL3 revealed nil-to-little relation with the expression of flavonoid biosynthetic pathway genes. (figshare.com)

Enhancers are regulatory elements that control when, where and at what levels genes are expressed. (sfari.org)

Our results indicated that CmNAC1 is a critical factor in ABA signaling pathways and it can be utilized in transgenic breeding to improve the abiotic stress tolerance of crops. (frontiersin.org)
As a proangiogenic response effecter, the interaction of Sema4D with plexin-B1 is dependent on the COOH-terminal PDZ-binding motif of plexin-B1, which binds two guanine nucleotide exchange factors (GEFs) for Rho and is mediated by the activation of Rho-initiated (Ras homolog gene family) pathways ( 4 - 8 ). (jcancer.org)

Here we showed that PIF1 directly and indirectly regulates key genes involved in chlorophyll biosynthesis to optimize the greening process in Arabidopsis. (utexas.edu)

The isolated M. tuberculosis strains have been characterized by performing susceptibility tests against four first-line antituberculosis drugs and were then subjected to spoligotyping characterization. (scielo.br)

In addition, important genes related to osmoregulation, such as ion transport and carbonic anhydrase, were also detected in the correlation analysis for same trend DEPs_DEGs. (hindawi.com)
Gene structure analysis indicated that the maximum number of genes were intron-less and remained conserved during evolution. (nature.com)
The expression analysis of both gene family members reflect their preferential seed-specific expression, especially during the mature embryo development stage. (nature.com)

Various growth factors, cytokines, and prostaglandins upregulate HGF gene expression, including basic fibroblast growth factor, oncostatin M, hypoxia-inducible factor 1α and nuclear factor-κB (NF-κB) ( 9 ). (spandidos-publications.com)

Loss of one of these genes, an uncharacterized transcription factor, resulted in a reduction of GABAergic inhibitory neurons in the forebrain and increased brain activity. (harvard.edu)

Semaphorin 4D (Sema4D) has been proven to be one of the hypoxia effectors regulated by hypoxia inducible factor (HIF-1) in multiple cells, and play a role in angiogenesis like VEGF. (jcancer.org)

It was determined that 42.5% of the ESBL-positive isolates carried multiple resistance genes. (biomedcentral.com)
Persistent surveillance and characterization of enteric ETEC isolates are vital for tracking the community presence of MDR bacterial species in order to recommend effective treatment strategies and help mitigate the spread of resistant pathogens. (biomedcentral.com)
It is imperative that both archived and current bacterial isolates from underdeveloped regions undergo extensive MDR characterization to inform national strategies designed to halt the continuing spread of these dangerous pathogens. (biomedcentral.com)

Eukaryotic elongation factor 1 alpha (eEF1A) is one of the four subunits composing eukaryotic translation elongation factor 1. (biomedcentral.com)
In this study, 53 KCS genes were identified in B. carinata compared to 32 and 33 KCS genes in B. nigra and B. oleracea respectively, which suggests that polyploidization might has impacted the fatty acid elongation process during Brassica evolution. (nature.com)
The current study provides a basis to understand the evolution of both KCS and ELO genes in fatty acid elongation and their role in stress tolerance. (nature.com)

We show, in transient transfection assays, that the POU domain transcription factor, SCIP/Tst-1, specifically activates α3 in a neural context. (elsevierpure.com)

Plants respond to various stimuli under abiotic or biotic stress condition and express certain genes either structural or regulatory genes which maintain the plant integrity. (scielo.br)

Here we demonstrate that, during brain maturation, the potential of the intrinsic apoptotic pathway is progressively reduced and that such repression is associated with downregulation of apoptotic protease-activating factor-1 (Apaf-1) and caspase-3 gene expression. (jneurosci.org)

Notwithstanding its characterization as an endothelial cell marker, the full spectrum of biological processes associated with ALK1 is essentially unexplored. (lu.se)

Some of the genes involved in the pathogenesis of Kallmann syndrome and idiopathic hypogonadotropic hypogonadism have been identified. (medscape.com)

A putative function has been assigned, using the gene ontology approach, to the set of genes harboring at least one SSR. (researchgate.net)

No difference was observed in overall enterotoxin characterization between the total ETEC and ESBL-positive populations. (biomedcentral.com)

In this study the prevalence of pcaA gene was determined in M. tuberculosis strains typed by spoligotyping. (scielo.br)
Thyme's research uses zebrafish to study the genes associated with schizophrenia. (harvard.edu)
Prognostic Value of DNA Methylation-Driven Genes in Clear Cell Renal Cell Carcinoma: A Study Based on Methylation and Transcriptome Analyses. (cdc.gov)

On the other hand, the systematic deletion of sigma factors encoding genes demonstrates the complexity and conservation of regulatory processes conducted by sigma factors in streptomycetes. (figshare.com)

Anatomy5

Chemicals and Drugs21

Phenomena and Processes5

Disciplines and Occupations1

Information Science2

Molecular16

Mutations23

Proteins12

Regulation17

Promoter8

Regulated during ma1

Transcription Factor Genes3

Chimeric genes1

Target genes3

Upstream4

Genomic1

Genetic10

Identification2

Mutants3

Chromosome2

Phenotypes2

Differential2

Functional3

Isolation1

Expression of ge2

Encodes2

Regulate5

Retinoic acid2

Genome4

Phenotypical1

Virulence3

Tissues4

Chromosomal1

Differentially1

Abstract1

Protein7

Neuronal3

Immune1

Transcript2

Sequences1

Phylogenetic2

Sequence4

Mice2

Homozygous2

Stresses3

Human5

Clinical5

Detection2

Biosynthetic2

Regulatory elements1

Pathways2

Arabidopsis1

Susceptibility1

Analysis3

Nuclear1

Neurons1

Hypoxia-induci1

Isolates3

Elongation3

Neural1

Biotic1

Maturation1

Marker1

Idiopathic1

Putative1

Populations1

Study3

Systematic1