• Synthesis
  • Synthesis, characterization, and antioxidant activity of some ebselen analogues. (springer.com)
  • Publications] T.Ooya,K.Arizono,N.Yui: 'Synthesis and characterization of an oligopeptide-terminated polyrotaxane as a drug carrier'Polym.Adv.Tech.. 11(8-12). (nii.ac.jp)
  • Malony-CoA:ACP Transacylase (FabD) is one such individual soluble protein and catalyzes the following reaction: malonyl-CoA + acyl carrier protein ⇌ {\displaystyle \rightleftharpoons } CoA + malonyl-[acyl-carrier-protein] The transfer of malonate to acyl-carrier-protein (ACP) converts the acyl groups into thioester forms which are characteristic of acyl intermediates in fatty acid synthesis and which are strictly required for the condensation reactions catalyzed by β-ketoacyl-ACP synthetase. (wikipedia.org)
  • Enoyl-acyl carrier protein reductase (or ENR) (EC 1.3.1.9), is a key enzyme of the type II fatty acid synthesis (FAS) system. (wikipedia.org)
  • The conventional approaches such as use of permeation enhancers, surface modification, prodrug synthesis, complex formation and colloidal lipid carrier based strategies have been developed for the delivery of drugs to intestinal lymphatics. (wikipedia.org)
  • Novel
  • Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges and Potential Benefits provides a unique and complete overview of novel formulation strategies for improvement of the delivery of NSAIDs via encapsulation in microsized and nanosized carriers composed of different materials of natural and synthetic origin. (elsevier.com)
  • lipid carriers
  • The ability of lipid carriers to enhance solubility, absorption and thereby the bioavailability of poorly soluble molecules by selective mechanism makes these systems a unique delivery option for certain classes of drugs. (springer.com)
  • Araújo J, Garcia ML, Mallandrich M, Souto EB, Calpena AC (2012) Release profile and transscleral permeation of triamcinolone acetonide loaded nanostructured lipid carriers (TA-NLC): in vitro and ex vivo studies. (springer.com)
  • delivery
  • Characterization of different vitamin E carriers intended for pulmonary drug delivery. (semanticscholar.org)
  • The targeted release of drugs intended for pulmonary delivery is a research field which has been so far rather unexploited but is currently becoming increasingly attractive. (semanticscholar.org)
  • The control of the amount of drug delivered over time and the spatial localization of that delivery are paramount in overcoming the challenges of providing optimal therapy. (springer.com)
  • 2006). "Polymer micelles with cross-linked ionic cores for delivery of anticancer drugs. (springer.com)
  • Callus cultures pectic gels can be proposed as potential systems for colon-targeted drug delivery. (deepdyve.com)
  • In this chapter, focus will be on different lipid-based carrier systems, their role in nano delivery and the advantages offered in improvement of solubility, absorption, and bioavailability with relevant case studies. (springer.com)
  • Another example of drug delivery using SLN would be oral solid SLN suspended in distilled water, which was synthesized to trap drugs within the SLN structure. (wikipedia.org)
  • Their unique structures with high surface area and microporosity make SWNHs become a promising material for gas adsorption, biosensing, drug delivery, gas storage and catalyst support for fuel cell. (wikipedia.org)
  • With the excellent nature in biodegradation and biocompatibility, supramolecular polymers show great potential on development of drug delivery, gene transfection and etc. (wikipedia.org)
  • interactions
  • Dendrimer-drug interactions. (springer.com)
  • The obtained drug-polyrotaxane conjugate formed a specific association under physiological conditions, depending on interactions between drugs and/or terminals of the polyrotaxane in the conjugate. (nii.ac.jp)
  • mechanism
  • The mechanism of energy coupling is not established, but homology with the MATE family suggests that they are secondary carriers. (wikipedia.org)
  • lipids
  • Biological lipids having minimum carrier cytotoxicity and the solid state of the lipid permit better controlled drug release due to increased mass transfer resistance. (wikipedia.org)
  • Biological
  • Therapeutic drugs have historically been developed based on the similar activity of small molecules in biological signaling, examples exist in the case of both H2S and NO-releasing drugs. (wikipedia.org)
  • Uptake
  • Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. (wikipedia.org)
  • aspects
  • This book presents the latest research on advances and limitations of both microsized and nanosized drug carriers and NSAIDs before discussing the formulation aspects of these drug carriers that are intended for oral, dermal, and transdermal administration of NSAIDs. (elsevier.com)
  • intestinal
  • Upon indigestion, the SLNs are exposed to gastric and intestinal acids that dissolve the SLNs and release the drugs into the system. (wikipedia.org)
  • vitro
  • From in vitro degradation tests, it was found that drug-immobilized α-CDs are completely released by hydrolysis of the terminal peptide linkages in the polyrotaxane without any steric hindrance. (nii.ac.jp)
  • Amidon GL, Lennernäs H, Shah VP, Crison JR (1995) A Theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. (springer.com)
  • release
  • Based on this characteristic, we have introduced a model drug (theophylline) into the α-CDs in the polyrotaxane to examine drug release via the supramolecular dissociatio … More n. (nii.ac.jp)
  • Application of a binary polymer system in drug release rate modulation. (deepdyve.com)
  • The release of CO from carrier agents can be induced photochemically. (wikipedia.org)
  • systems
  • Manufacturing methods of different carrier systems will be elaborated with a brief overview of scale up feasibility. (springer.com)
  • Mechanisms
  • Transport of folate compounds into mammalian cells can occur via receptor-mediated (see folate receptor 1) or carrier-mediated mechanisms. (wikipedia.org)
  • therapeutic
  • The use of a drug as a therapeutic agent is often a delicate balance between therapeutic efficacy and detrimental side effects including toxicity. (springer.com)
  • Temperature
  • Measuring how the retention time changes as a function of probe molecule chemistry, probe molecule size, probe molecule concentration, column temperature, or carrier gas flow rate can elucidate a wide range of physico-chemical properties of the solid under investigation. (wikipedia.org)