• Preparation
  • Publications] J.Watanabe,T.Ooya,K.D.Park,Y.H.Kim,N.Yui: 'Preparation and characterization of poly(ethylene glycol) hydrogels crosslinked by hydrolyzable polyrotaxane'J.Biomater.Sci.Polym.Edn. (nii.ac.jp)
  • 4,757,128 and 4,997,904 disclose the preparation of polyanhydrides with improved sustained drug release properties from pure, isolated prepolymers of diacids and acetic acid. (google.es)
  • Novel
  • Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges and Potential Benefits provides a unique and complete overview of novel formulation strategies for improvement of the delivery of NSAIDs via encapsulation in microsized and nanosized carriers composed of different materials of natural and synthetic origin. (elsevier.com)
  • 2001
  • 2001). It has been proposed that SLNs combine numerous advantages over the other colloidal carriers i.e. incorporation of lipophilic and hydrophilic drugs feasible, no biotoxicity of the carrier, avoidance of organic solvents, possibility of controlled drug release and drug targeting, increased drug stability and no problems with respect to large scale production. (wikipedia.org)
  • Synthesis
  • Publications] T.Ooya,K.Arizono,N.Yui: 'Synthesis and characterization of an oligopeptide-terminated polyrotaxane as a drug carrier'Polym.Adv.Tech.. 11(8-12). (nii.ac.jp)
  • Malony-CoA:ACP Transacylase (FabD) is one such individual soluble protein and catalyzes the following reaction: malonyl-CoA + acyl carrier protein ⇌ {\displaystyle \rightleftharpoons } CoA + malonyl-[acyl-carrier-protein] The transfer of malonate to acyl-carrier-protein (ACP) converts the acyl groups into thioester forms which are characteristic of acyl intermediates in fatty acid synthesis and which are strictly required for the condensation reactions catalyzed by β-ketoacyl-ACP synthetase. (wikipedia.org)
  • Enoyl-acyl carrier protein reductase (or ENR) (EC 1.3.1.9), is a key enzyme of the type II fatty acid synthesis (FAS) system. (wikipedia.org)
  • The conventional approaches such as use of permeation enhancers, surface modification, prodrug synthesis, complex formation and colloidal lipid carrier based strategies have been developed for the delivery of drugs to intestinal lymphatics. (wikipedia.org)
  • lipid
  • Drug Distribution in Nanostructured Lipid Particles. (fu-berlin.de)
  • It has been proposed that these nanostructured lipid carriers (NLC) are composed of oily droplets, which are embedded in a solid lipid matrix. (springer.com)
  • The light propagation in lipid nanodispersions was examined by refractometry to obtain further insights into the nanostructural compositions of the carriers. (springer.com)
  • Biological lipids having minimum carrier cytotoxicity and the solid state of the lipid permit better controlled drug release due to increased mass transfer resistance. (wikipedia.org)
  • delivery
  • Characterization of different vitamin E carriers intended for pulmonary drug delivery. (semanticscholar.org)
  • The targeted release of drugs intended for pulmonary delivery is a research field which has been so far rather unexploited but is currently becoming increasingly attractive. (semanticscholar.org)
  • Their unique structures with high surface area and microporosity make SWNHs become a promising material for gas adsorption, biosensing, drug delivery, gas storage and catalyst support for fuel cell. (wikipedia.org)
  • Another example of drug delivery using SLN would be oral solid SLN suspended in distilled water, which was synthesized to trap drugs within the SLN structure. (wikipedia.org)
  • With the excellent nature in biodegradation and biocompatibility, supramolecular polymers show great potential on development of drug delivery, gene transfection and etc. (wikipedia.org)
  • Uptake
  • Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. (wikipedia.org)
  • intestinal
  • Upon indigestion, the SLNs are exposed to gastric and intestinal acids that dissolve the SLNs and release the drugs into the system. (wikipedia.org)
  • Nanofibers
  • The current study reported the construction of electrospun Resveratrol loaded nanofibers with methoxypolyethylene glycol-poly(caprolactone) (mPEG-PCL) block copolymers as drug carriers. (hindawi.com)
  • To overcome these disadvantages, drug loaded nanofibers based on amphiphilic copolymers become an alternative to deliver the drugs. (hindawi.com)
  • There are some studies focusing on the construction of drug loaded nanofibers with herbal medicine as model drugs [ 17 , 18 ]. (hindawi.com)
  • Drug loaded nanofibers have a large surface area-to-volume ratio, which enables an excellent drug loading efficiency. (hindawi.com)
  • interactions
  • The obtained drug-polyrotaxane conjugate formed a specific association under physiological conditions, depending on interactions between drugs and/or terminals of the polyrotaxane in the conjugate. (nii.ac.jp)
  • release
  • Based on this characteristic, we have introduced a model drug (theophylline) into the α-CDs in the polyrotaxane to examine drug release via the supramolecular dissociatio … More n. (nii.ac.jp)
  • More recently, attempts have been made to synthesize polyanhydrides with greater thermal and hydrolytic stability and sustained drug release properties. (google.es)
  • Characterization of Rsv-NPs showed good aqueous stability and loading efficiency and controlled release kinetics. (hindawi.com)
  • The release of CO from carrier agents can be induced photochemically. (wikipedia.org)
  • Biological
  • Therapeutic drugs have historically been developed based on the similar activity of small molecules in biological signaling, examples exist in the case of both H2S and NO-releasing drugs. (wikipedia.org)
  • surface
  • The measured surface hydrophobicities of particles and fat emulsions were well in agreement with the in vivo organ distribution data obtained after i. v. injection of the carriers. (uni-regensburg.de)
  • injection
  • 20. The formulation of claim 11 further comprising a pharmaceutically acceptable carrier for administering the formulation by injection. (google.fr)
  • Mechanisms
  • Transport of folate compounds into mammalian cells can occur via receptor-mediated (see folate receptor 1) or carrier-mediated mechanisms. (wikipedia.org)
  • discovery
  • ENR is an attractive target for narrow-spectrum antibacterial drug discovery because of its essential role in metabolism and its sequence conservation across many bacterial species. (wikipedia.org)
  • Nature Reviews Drug Discovery. (wikipedia.org)