• Immunol
  • Publications] T.Doi, T.watanabe, et al: 'The death signals from B cell antigen receptor target mitochondria, activating necrotic and apoptotic death cascades in murine B-cell line, WEHI-231' J.Immunol. (nii.ac.jp)
  • PMID
  • Interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis [ PMID: 2969618 ]. (ebi.ac.uk)
  • Two types of IL-1 receptor, each with three extracellular immunoglobulin (Ig)-like domains, limited sequence similarity (28%) and different pharmacological characteristics have been cloned from mouse and human cell lines: these have been termed type I and type II receptors [ PMID: 8702856 ]. (ebi.ac.uk)
  • Both IL-1 receptors appear to be well conserved in evolution, and map to the same chromosomal location [ PMID: 1833184 ]. (ebi.ac.uk)
  • The crystal structures of IL1A and IL1B [ PMID: 2602367 ] have been solved, showing them to share the same 12-stranded beta-sheet structure as both the heparin binding growth factors and the Kunitz-type soybean trypsin inhibitors [ PMID: 1738162 ]. (ebi.ac.uk)
  • A novel method for virus immune evasion has been proposed in which the product of one or both of these proteins may bind interleukin-1 and/or interleukin-6, preventing these cytokines reaching their natural receptors [ PMID: 1826022 ]. (ebi.ac.uk)
  • A similar gene product from Cowpox virus (CPV) has also been shown to specifically bind murine IL-1 beta [ PMID: 1339315 ]. (ebi.ac.uk)
  • This entry represents Interleukin-1 receptor type 1 (IL1R1), the crystal structure of the soluble extracellular part of type-I IL1R complexed with IL1RA has been determined to 2.7A resolution [ PMID: 9062194 ]. (ebi.ac.uk)
  • Functional
  • Functional expression of the fractalkine (CX3C) receptor and its regulation by lipopolysaccharide in rat microglia. (springer.com)
  • Cultured rat microglia express functional beta-chemokine receptors. (springer.com)
  • The amplitude of the functional pO 2 response similarly decreased after 3 h post-IL-1β injection, whereas IL-1β had no significant effect on the peak of whisker-stimulation-induced MUA. (biomedcentral.com)
  • IL1R1
  • IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. (sinobiological.com)
  • Genes
  • 1) We established Lyn-kinase-deficient mice with immunoglobulin genes encoding an autoantibody against mouse RBC.We demonstrated by using this system a crucial role of Lyn kinase in regulating peripheral B cell tolerance and in preventing autoantibody production. (nii.ac.jp)
  • The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. (wikipedia.org)
  • novel
  • In summary, dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders. (rupress.org)
  • 2000). "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. (wikipedia.org)
  • Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding protein. (ebi.ac.uk)
  • The P2Z/P2X7 receptor of microglial cells: a novel immunomodulatory receptor. (springer.com)
  • In this study, we identifiled novel dermal thy-1+ dendritic cells (Dermal Thy-1^+DC) and futher studied, 1) the ontogeny of T cells in the skin, 2) cytokine secretion by fetal keratinocytes (KC), 3) interaction between KC and Langerhans cells (LC). (nii.ac.jp)
  • Dermal Thy-1^+DC are novel T cells found in murine dermis. (nii.ac.jp)
  • Publications] Tamaki K, et al: 'Identificabiln and characterization of novel dermal THY-1 antigen Bearing DendRicic cells in murinl skin' Journal of Imvestgatine Deimatology. (nii.ac.jp)
  • interferon
  • Serum immunoglobulin E levels were increased in IL-13Rα2 −/− mice despite the fact that serum IL-13 was absent and immune interferon γ production increased compared with wild-type mice. (rupress.org)
  • This protein is structurally related to interferon receptors. (wikipedia.org)
  • Publications] Chang CH, Furue M Tamaki K: 'B7-1 bypressufn of Langerhaus cells is ufirgulatel by proinflaimmakity cytokinas,and is downrgnlated by interferon-γ on by intesleukin-10' European Journal of Immunology. (nii.ac.jp)
  • It is also component of both the type I and type III interferon signaling pathways. (wikipedia.org)
  • T helper (T H )1 cells produce interferon (IFN)-γ, promoting cell-mediated immunity and control of intracellular pathogens. (springer.com)
  • Expression of CXCL5 has also been observed in eosinophils, and can be inhibited with the type II interferon IFN-γ. (wikipedia.org)
  • kinases
  • It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. (wikipedia.org)
  • Cytokines including interleukins, interferons and hemopoietins activate the Janus kinases, which associate with their cognate receptors. (wikipedia.org)
  • Signalling through IL-4/IL-13 complexes is thought to occur through IL-4Rα-chain, which is responsible for activation of JAK-1 and Tyk2 kinases. (wikipedia.org)
  • CT-1 intracellular signaling pathways include extracellular signal regulated kinases (ERK), mitogen activated protein (MAP) kinases, the janus kinase (JAK)/signal transducers and activators of transcription (STAT) system, and PI3-kinase/Akt. (ahajournals.org)
  • The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. (wikipedia.org)
  • Expression
  • Stimulation and activation of ECs by the proinflammatory cytokine interleukin (IL)-1 causes multiple responses within the endothelium but most notably induces the expression of adhesion molecules, which promote monocyte recruitment and infiltration into the arterial wall. (ahajournals.org)
  • Expression of Th2 cytokines such as IL-4, IL-5, IL-9, and IL-13, and inflammation are strongly associated with parasitic infections and asthma ( 1 , 2 ). (rupress.org)
  • Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. (wikipedia.org)
  • Expression and signaling of group I metabotropic glutamate receptors in astrocytes and microglia. (springer.com)
  • IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. (wikipedia.org)
  • Publications] Furue M, Tamaki K et al: 'Dysregulated expression of transformig growtn factor β and its type I and tyte II receptass in baoal-cell carcinoma' International Jornal of Cancer. (nii.ac.jp)
  • Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. (springer.com)
  • Sallusto F, Lenig D, Mackay CR, Lanzavecchia A: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. (springer.com)
  • This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. (wikipedia.org)
  • Cardiac CT-1 expression is increased by hypoxia, where it protects cardiac myocytes from ischemic and reperfusion injury and apoptosis. (ahajournals.org)
  • Thus, increased myocardial expression of CT-1 immediately became a candidate for the molecular basis of pathological hypertrophy and remodeling in dilated cardiomyopathy phenotypes. (ahajournals.org)
  • The tissue expression of CT-1 is not confined to the fetal or adult heart. (ahajournals.org)
  • Mechanical stretch of cardiac myocytes increases the expression of CT-1 and activates the JAK/STAT pathway, 9 providing a link from the biological properties of CT-1 to its potential role in remodeling in response to hemodynamic overload. (ahajournals.org)
  • 10 Myocardial gene expression of CT-1 is increased in heart failure animal models, 11,12 ⇓ and in humans with chronic heart failure, circulating levels of CT-1 are increased. (ahajournals.org)
  • 13 Importantly, in animal models, CT-1 expression precedes the development of pathological hypertrophy. (ahajournals.org)
  • 14 In model systems, norepinephrine markedly increases the expression of CT-1 in cardiac myocytes in vitro and in vivo, via a cAMP response element in the 5′ flanking region of the CT-1 gene. (ahajournals.org)
  • Fetal gene induction in the failing human heart is under partial β 1 -adrenergic control, 17 and so β-adrenergic stimulation of CT-1 gene expression is a candidate for the molecular mechanism of adrenergically-driven pathological remodeling in the failing human heart. (ahajournals.org)
  • In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. (wikipedia.org)
  • murine
  • The highest degree of similarity is to the human and murine interleukin-1 receptors, although both proteins are related to a wide range of Ig superfamily members, including the interleukin-6 receptor. (ebi.ac.uk)
  • 3) The death signals from B cell antigen receptor target mitochondria, activating necrotic and apoptotic death cascade in a murine B-cell line, WEHI-23I cell. (nii.ac.jp)
  • Tyk2 has broader and profound functions in humans than previously appreciated on the basis of analysis of murine models, which indicate that Tyk2 functions primarily in IL-12 and type I-IFN signaling. (wikipedia.org)
  • Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL: Two types of murine helper T cell clone. (springer.com)
  • cell antigen receptor
  • Transmembrane signal transduction initiated by the B cell antigen receptor (BCR) is essential for various B cell activities, including cell activation, proliferation, anergy and deletion. (nii.ac.jp)
  • cytoplasmic domain
  • IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. (sinobiological.com)
  • human
  • While human leukocyte antigen typing, autoantibody measurement, and thecharacterization of many regions affording genetic susceptibility have contributedtremendously to our ability to predict the onset of, comprehend the etiologyof, and track the progression of type 1 diabetes, these approaches are far fromcomplete in terms of their understanding. (ufl.edu)
  • Individuals with high risk human leukocyte antigen, autoantibody, andgenotypic profiles still escape overt disease, while in contrast individualswith low risk factors can progress to type 1 diabetes. (ufl.edu)
  • Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates. (springer.com)
  • Molecular characterization of colony-stimulating factors and their receptors: human interleukin-3. (wikipedia.org)
  • Effect of human immunodeficiency virus type-1 envelope glycoprotein gp160 on cytokine production from cord-blood T cells. (wikipedia.org)
  • Feng Y, Klein BK, McWherter CA, Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3. (wikipedia.org)
  • Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. (springer.com)
  • Carballido JM, Faith A, Carballido-Perrig N, Blaser K: The intensity of T cell receptor engagement determines the cytokine pattern of human allergen-specific T helper cells. (springer.com)
  • V. Identification of an interleukin 2-producing human leukemia T cell line. (atcc.org)
  • intracellular
  • Receptor-mediated changes in the free cytoplasmic Ca 2+ concentration ([Ca 2+ ] c ) represent one of the major signal transduction pathways by which information from extracellular signals is transferred to intracellular sites. (springer.com)
  • Receptor-activated Ca 2+ inflow in animal cells: a variety of pathways tailored to meet different intracellular Ca 2+ signalling requirements. (springer.com)
  • responses
  • These results are consistent with a phenotype of enhanced IL-13 responsiveness and demonstrate a role for endogenous IL-13 and IL-13Rα2 in regulating immune responses in wild-type mice. (rupress.org)
  • Publications] Y.Banu and T.Watanabe: 'Augumentation of antigen receptor-mediated responses by histamine H1 receptor signaling. (nii.ac.jp)
  • Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. (wikipedia.org)
  • Although allergic agents are numerous and the inflammatory responses produced are complex, clinical and experimental studies have strongly suggested the involvement of T helper type 2 (T H 2) lymphocytes, and the cytokines that they produce, in the pathogenesis of allergic asthma [ 4 , 5 ]. (pubmedcentralcanada.ca)
  • regulation
  • From the study of the regulation of the cytokines, Mantovani was able to identify the operating principle of the decoy receptor for interleukin - 1. (wikipedia.org)
  • Though the basic paradigm was discovered more than 15 years ago, new discoveries continue to be made that offer fresh insights into the regulation of this process (1). (springer.com)
  • pathway
  • This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. (wikipedia.org)
  • We investigated twopathways: the Vitamin D pathway and the interleukin-2/interleukin-2 receptor pathway;this, based on a variety of efforts that hinted at their potential involvement. (ufl.edu)
  • 4) We showed the first direct evidence of a cross-talk between G-protein mediated signal pathway and antigen-receptor mediated signal transduction pathway in T and B cells. (nii.ac.jp)
  • gp130
  • Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion. (wikipedia.org)
  • The members of the IL-6 receptor family all complex with gp130 for signal transduction. (wikipedia.org)
  • There are many other proteins which associate with gp130, such as cardiotrophin 1 (CT-1), leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), and IL-11. (wikipedia.org)
  • Members of this group include LIF-R, OSM-R, and G-CSF-R. gp130 is an important part of many different types of signaling complexes. (wikipedia.org)
  • IL-4R and IL-13R), the gp130 receptor family (e.g. (wikipedia.org)
  • CT-1 has hypertrophic and cardioprotective properties and acts through LIF receptor β/glycoprotein 130 (gp130)-coupled signaling pathways. (ahajournals.org)
  • 4 Mice with genetic ablation of gp130 have hypoplastic hearts, 5 which suggests a role for CT-1 or other IL-6-type cytokines in normal cardiac development. (ahajournals.org)
  • signal transducer
  • 1 μmol/L). Growth suppression of INA-6 correlated with an increase in the percentage of apoptotic cells and inhibition of signal transducer and activator of transcription 3 phosphorylation. (aacrjournals.org)
  • Stimulation
  • In this study, we set out to investigate if increased cerebral levels of IL-1 have a negative effect on the neurovascular coupling in the cortex in response to sensory stimulation. (biomedcentral.com)
  • We used two approaches to measure the neuronal activity and haemodynamic changes in the anaesthetised rat barrel somatosensory cortex in response to mechanical whisker stimulation, before and for 6 h after intra-striatal injection of interleukin-1β or vehicle. (biomedcentral.com)
  • 2D-OIS data revealed that the size of the haemodynamic response to mechanical whisker stimulation declined over the 6 h following IL-1β injection whereas the vehicle group remained stable, significant differences being seen after 5 h. (biomedcentral.com)
  • Moreover, the size of the transient increases of neuronal LFP activity in response to whisker stimulation decreased after IL-1β injection, significant changes compared to vehicle being seen for gamma-band activity after 1 h and beta-band activity after 3 h. (biomedcentral.com)
  • The stimulation-evoked increases in gamma power and pO 2 correlated significantly throughout the 6 h in the vehicle group, but such a correlation was not observed in the IL-1β-injected group. (biomedcentral.com)
  • Several studies have documented the acute pro-inflammatory effects of IL-1β on neutrophil infiltration and blood-brain barrier (BBB) permeability [ 2 , 9 , 10 ], but few have investigated the effects of IL-1β on the functionally relevant increases in neuronal activity in response to sensory stimulation and the associated haemodynamic response. (biomedcentral.com)
  • In multiple myeloma, JAKs may be persistently activated due to a constant stimulation by interleukin (IL)-6, which is produced in the bone marrow environment. (aacrjournals.org)
  • Clone E6-1 cells produce large amounts of IL-2 after stimulation with phorbol esters and either lectins or monoclonal antibodies against the T3 antigen (both types of stimulants are needed to induce IL-2 production. (atcc.org)
  • It is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. (wikipedia.org)